LOCUS       NM_012939               1496 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cathepsin H (Ctsh), mRNA.
ACCESSION   NM_012939 XM_006243522
VERSION     NM_012939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Oda,K., Luo,Y., Yoshihara,A., Ishido,Y., Sekihata,K., Usukura,K.,
            Sue,M., Hiroi,N., Hirose,T. and Suzuki,K.
  TITLE     Follicular thyroglobulin induces cathepsin H expression and
            activity in thyrocytes
  JOURNAL   Biochem Biophys Res Commun 483 (1), 541-546 (2017)
   PUBMED   27998776
  REMARK    GeneRIF: cathepsin H is an active participant in lysosome-mediated
            pre-hormone degradation, and follicular Tg stimulates mobilization
            of pre-hormones by activating cathepsin H-associated proteolysis
            pathways
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Floyel,T., Brorsson,C., Nielsen,L.B., Miani,M.,
            Bang-Berthelsen,C.H., Friedrichsen,M., Overgaard,A.J.,
            Berchtold,L.A., Wiberg,A., Poulsen,P., Hansen,L., Rosinger,S.,
            Boehm,B.O., Ram,R., Nguyen,Q., Mehta,M., Morahan,G., Concannon,P.,
            Bergholdt,R., Nielsen,J.H., Reinheckel,T., von Herrath,M., Vaag,A.,
            Eizirik,D.L., Mortensen,H.B., Storling,J. and Pociot,F.
  TITLE     CTSH regulates beta-cell function and disease progression in newly
            diagnosed type 1 diabetes patients
  JOURNAL   Proc Natl Acad Sci U S A 111 (28), 10305-10310 (2014)
   PUBMED   24982147
  REMARK    GeneRIF: The data provide strong evidence that CTSH is an important
            regulator of beta-cell function during progression of T1D
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Irwin,L.N. and Byers,D.M.
  TITLE     Novel odors affect gene expression for cytokines and proteinases in
            the rat amygdala and hippocampus
  JOURNAL   Brain Res 1489, 1-7 (2012)
   PUBMED   23103411
  REMARK    GeneRIF: In the amygdala significant up-regulation of interleukin-1
            receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast
            growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in
            males in response to the odor of cornnuts only.
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Wu,S.M., Huang,Y.H., Yeh,C.T., Tsai,M.M., Liao,C.H., Cheng,W.L.,
            Chen,W.J. and Lin,K.H.
  TITLE     Cathepsin H regulated by the thyroid hormone receptors associate
            with tumor invasion in human hepatoma cells
  JOURNAL   Oncogene 30 (17), 2057-2069 (2011)
   PUBMED   21217776
  REMARK    GeneRIF: CTSH overexpression in a subset hepatoma may be thyroid
            hormone receptor dependent and suggests that this overexpression
            has an important role in hepatoma progression.
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Gocheva,V., Chen,X., Peters,C., Reinheckel,T. and Joyce,J.A.
  TITLE     Deletion of cathepsin H perturbs angiogenic switching,
            vascularization and growth of tumors in a mouse model of pancreatic
            islet cell cancer
  JOURNAL   Biol Chem 391 (8), 937-945 (2010)
   PUBMED   20731543
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Rothe,M. and Dodt,J.
  TITLE     Studies on the aminopeptidase activity of rat cathepsin H
  JOURNAL   Eur J Biochem 210 (3), 759-764 (1992)
   PUBMED   1483460
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Cataldo,A.M., Paskevich,P.A., Kominami,E. and Nixon,R.A.
  TITLE     Lysosomal hydrolases of different classes are abnormally
            distributed in brains of patients with Alzheimer disease
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 10998-11002 (1991)
   PUBMED   1837142
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2509]
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Ishii,Y., Hashizume,Y., Watanabe,T., Waguri,S., Sato,N.,
            Yamamoto,M., Hasegawa,S., Kominami,E. and Uchiyama,Y.
  TITLE     Cysteine proteinases in bronchoalveolar epithelial cells and lavage
            fluid of rat lung
  JOURNAL   J Histochem Cytochem 39 (4), 461-468 (1991)
   PUBMED   2005374
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Qian,F., Frankfater,A., Miller,R.V., Chan,S.J. and Steiner,D.F.
  TITLE     Molecular cloning of rat precursor cathepsin H and the expression
            of five lysosomal cathepsins in normal tissues and in a rat
            carcinosarcoma
  JOURNAL   Int J Biochem 22 (12), 1457-1464 (1990)
   PUBMED   2276418
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Dahlmann,B., Kuehn,L., Heinrich,P.C., Kirschke,H. and
            Wiederanders,B.
  TITLE     ATP-activated, high-molecular-mass proteinase-I from rat skeletal
            muscle is a cysteine proteinase-alpha 1-macroglobulin complex
  JOURNAL   Biochim Biophys Acta 991 (2), 253-262 (1989)
   PUBMED   2470410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1, FM059929.1, FN800263.1 and FM135658.1.
            
            On Mar 9, 2017 this sequence version replaced NM_012939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228686.1, FQ223707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000008.1  99488756-99488867
            113-421             FM059929.1         1-309
            422-820             FN800263.1         300-698
            821-1480            FM135658.1         25-684
            1481-1496           JAXUCZ010000008.1  99507624-99507639
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1496
                     /gene="Ctsh"
                     /note="cathepsin H"
                     /db_xref="GeneID:25425"
                     /db_xref="RGD:2447"
     exon            1..223
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1140
                     /gene="Ctsh"
                     /EC_number="3.4.22.16"
                     /note="pro-cathepsin H; cathepsin B3; cathepsin BA"
                     /codon_start=1
                     /product="pro-cathepsin H precursor"
                     /protein_id="NP_037071.1"
                     /db_xref="GeneID:25425"
                     /db_xref="RGD:2447"
                     /translation="MWTALPLLCAGAWLLSAGATAELTVNAIEKFHFTSWMKQHQKTY
                     SSREYSHRLQVFANNWRKIQAHNQRNHTFKMGLNQFSDMSFAEIKHKYLWSEPQNCSA
                     TKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMM
                     TLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEK
                     AVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDK
                     VNHAVLAVGYGEQNGLLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACASYPIPQV"
     exon            224..255
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            256..361
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            362..432
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            433..537
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            538..624
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            625..680
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            681..762
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            763..831
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            832..938
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1064
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1496
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagagaag gagtgtaatg gccgcagggg gcgggagagg aactagcatc tctttggcgg
       61 aggccagagt cgccccacct ccttcccaca ggctgggctc aaagggcact ccgcggggac
      121 cgagcagtga gcgccgcgat gtggactgcg ctgcccctgc tgtgcgctgg ggcctggctg
      181 ctgagtgctg gggccaccgc tgagctgacc gtgaatgcca tagaaaagtt tcactttacg
      241 tcatggatga aacagcatca aaagacgtac agctcgaggg agtacagcca caggctgcag
      301 gtgtttgcca acaactggag gaagattcaa gcccacaacc agaggaacca cacatttaaa
      361 atgggattga accagttttc agatatgagc tttgccgaaa taaaacacaa atacctctgg
      421 tcagagcctc agaattgctc agccaccaaa agtaactacc tccgtggtac tggcccctac
      481 ccatcctcca tggactggag gaagaaagga aatgtcgttt caccagtgaa gaaccagggg
      541 gcctgtggca gctgctggac tttctcaacc actggggccc tagagtcagc tgtggctatt
      601 gccagtggga aaatgatgac cttggctgag cagcagctgg tggattgtgc ccagaacttc
      661 aacaatcatg gctgccaagg aggtctcccc agccaggcct tcgagtacat cctgtacaac
      721 aagggcatca tgggagagga cagctaccct tacataggca agaatggtca gtgcaaattc
      781 aacccagaaa aggccgtcgc gttcgtcaag aatgttgtca acatcacact caatgatgag
      841 gctgcaatgg tagaggctgt ggccctatac aatcctgtga gctttgcctt tgaggtgact
      901 gaagatttta tgatgtataa aagtggtgtc tactccagta actcctgtca taaaactcca
      961 gataaagtaa accatgcagt cctggctgtt ggctatggag aacagaatgg attactctac
     1021 tggattgtga aaaactcttg gggctccaac tgggggaaca atgggtactt cctcattgag
     1081 cgtggaaaga acatgtgtgg cctggctgcc tgtgcctcct accccatccc tcaggtataa
     1141 gccacggctg cacaggcaac tgcttggcag acaaagggag gaactggtcc tacgatgaga
     1201 atgccgccct ggagaaagtt gttcagaaat ccacccagag gccctctcac tcctgagtct
     1261 agacgcctaa agacagtaag gaagaacttg accagcaaca agcccgcccg tgtgacgaca
     1321 tcaccagcca tacgctttgt ttgaatatgg tttttaaatg acccaaaacc atgtggacct
     1381 agaatcttct cttttcagct ctcttcatat agggaaagct ccgatggcta ccttttctat
     1441 gttgtatatt caataaatgc agtgaacgcc tgcctgggct gggcctagac ccctaa
//
