LOCUS       NM_001106041            1006 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cathepsin G (Ctsg), mRNA.
ACCESSION   NM_001106041 XM_001058499 XM_214205
VERSION     NM_001106041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Liu,X., Tian,Y., Meng,Z., Chen,Y., Ho,I.H., Choy,K.W., Lichtner,P.,
            Wong,S.H., Yu,J., Gin,T., Wu,W.K., Cheng,C.H. and Chan,M.T.
  TITLE     Up-regulation of Cathepsin G in the Development of Chronic
            Postsurgical Pain: An Experimental and Clinical Genetic Study
  JOURNAL   Anesthesiology 123 (4), 838-850 (2015)
   PUBMED   26270939
  REMARK    GeneRIF: CTSG is a pronociceptive mediator in animal models of
            chronic postsurgical pain.
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Tsuchiya,Y., Okada,G., Kobayashi,S., Chikuma,T. and Hojo,H.
  TITLE     4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate
            dehydrogenase is degraded by cathepsin G in rat neutrophils
  JOURNAL   Oxid Med Cell Longev 2011, 213686 (2011)
   PUBMED   21904640
  REMARK    GeneRIF: The results suggest that cathepsin G plays a crucial role
            in the degradation of 4-hydroxy-2-nonenal-modified
            glyceraldehyde-3-phosphate dehydrogenase.
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Si-Tahar,M., Renesto,P., Falet,H., Rendu,F. and Chignard,M.
  TITLE     The phospholipase C/protein kinase C pathway is involved in
            cathepsin G-induced human platelet activation: comparison with
            thrombin
  JOURNAL   Biochem J 313 (Pt 2) (Pt 2), 401-408 (1996)
   PUBMED   8573071
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Avril,L.E., Di Martino-Ferrer,M., Pignede,G., Seman,M. and
            Gauthier,F.
  TITLE     Identification of the U-937 membrane-associated proteinase
            interacting with the V3 loop of HIV-1 gp120 as cathepsin G
  JOURNAL   FEBS Lett 345 (1), 81-86 (1994)
   PUBMED   8194606
REFERENCE   8  (bases 1 to 1006)
  AUTHORS   Wasiluk,K.R., Skubitz,K.M. and Gray,B.H.
  TITLE     Comparison of granule proteins from human polymorphonuclear
            leukocytes which are bactericidal toward Pseudomonas aeruginosa
  JOURNAL   Infect Immun 59 (11), 4193-4200 (1991)
   PUBMED   1937776
REFERENCE   9  (bases 1 to 1006)
  AUTHORS   Maison,C.M., Villiers,C.L. and Colomb,M.G.
  TITLE     Proteolysis of C3 on U937 cell plasma membranes. Purification of
            cathepsin G
  JOURNAL   J Immunol 147 (3), 921-926 (1991)
   PUBMED   1861080
REFERENCE   10 (bases 1 to 1006)
  AUTHORS   Bjork,P. and Ohlsson,K.
  TITLE     Purification and N-terminal amino-acid sequence analysis of rat
            polymorphonuclear leukocyte cathepsin G
  JOURNAL   Biol Chem Hoppe Seyler 371 (7), 595-601 (1990)
   PUBMED   2222858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214205.4, XM_001058499.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1006
                     /gene="Ctsg"
                     /note="cathepsin G"
                     /db_xref="GeneID:290257"
                     /db_xref="RGD:1307681"
     exon            1..188
                     /gene="Ctsg"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..886
                     /gene="Ctsg"
                     /EC_number="3.4.21.20"
                     /codon_start=1
                     /product="cathepsin G precursor"
                     /protein_id="NP_001099511.1"
                     /db_xref="GeneID:290257"
                     /db_xref="RGD:1307681"
                     /translation="MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPE
                     GLSACGGFLVREDFVLTAGHCFGSSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNP
                     PPVIQNDIMLLQLRSRARRSRAVKPVALPQATKRVQPGALCTVAGWGLVSQRRGTNVL
                     QEVKLRVQTDQTCANRFQFYNSQTQICVGNPRERKSAFKGDSGGPLVCNNVAQGIVSY
                     GSSSGNPPAVFTRIQSFMPWIKRTMRRLSSRY"
     exon            189..336
                     /gene="Ctsg"
                     /inference="alignment:Splign:2.1.0"
     exon            337..475
                     /gene="Ctsg"
                     /inference="alignment:Splign:2.1.0"
     exon            476..730
                     /gene="Ctsg"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1006
                     /gene="Ctsg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgaaaccta tcacgggagc agggaaatgg acctgtggtc cctcagcaca cccttccttc
       61 ctctccaggg gaggataaaa gtctggcaga gaaaagtaaa agcagcagct gacttagcaa
      121 cggttctgga aagatgcagc cactcctgtt tctgttgatc tttgttctat tccaagaaga
      181 tgaggcagga aagatcattg gaggccgaga agccaggcca aattcccacc cctacatggc
      241 atttcttctg atccagagtc cagaagggct gagtgcttgt ggagggtttc tggtgcgaga
      301 agactttgtc ctcacagcag gtcactgctt tggaagctcc ataaatgtta ccctaggggc
      361 ccacaacatt cgaaggcaag aagggaccca gcaacacatc actgttctca gagccatccg
      421 ccatcctgat tacaatcccc cgccagtcat ccagaatgac atcatgctac tgcagctgag
      481 gagtagagcc cggaggagtc gagcggtgaa gcccgtggct ctgcctcaag ccaccaagag
      541 agtacaacca ggggctttgt gcacagtggc tggctggggc ctggtgagcc agcgcagggg
      601 gacaaatgta ctccaggagg tgaagctaag agtgcagacg gaccaaacgt gcgccaatcg
      661 tttccaattc tacaacagcc agactcagat ctgtgtggga aacccgagag aaaggaagtc
      721 tgccttcaag ggtgattctg gtggtcctct ggtatgtaat aatgtggccc agggcatcgt
      781 ctcctatgga agcagcagtg gtaaccctcc agctgtgttc accagaatcc agagcttcat
      841 gccctggatc aaaagaacaa tgagacgtct ttcctcaagg tattagggac ttgctgactc
      901 cctgtctcag acgtagacca gctttaggga atttccatag cccttattaa tgtctcctgg
      961 acagtgtaaa ttttcattta ttaaatatca tttggcactg tcttaa
//
