LOCUS       NP_001029282             462 aa            linear   ROD 20-MAR-2023
DEFINITION  cathepsin F precursor [Rattus norvegicus].
ACCESSION   NP_001029282
VERSION     NP_001029282.1
DBSOURCE    REFSEQ: accession NM_001034110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A,
            Teunissen CE, de Wit H and Jimenez CR.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Maubach G, Lim MC and Zhuo L.
  TITLE     Nuclear cathepsin F regulates activation markers in rat hepatic
            stellate cells
  JOURNAL   Mol Biol Cell 19 (10), 4238-4248 (2008)
   PUBMED   18667530
  REMARK    GeneRIF: nuclear cathepsin F regulates activation markers in rat
            hepatic stellate cells
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Kang D, Oh S, Ahn SM, Lee BH and Moon MH.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099780.1, EU253481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..462
                     /product="cathepsin F precursor"
                     /EC_number="3.4.22.41"
                     /calculated_mol_wt=49710
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2138
     Region          165..221
                     /region_name="Inhibitor_I29"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     smart00848"
                     /db_xref="CDD:214853"
     Region          249..460
                     /region_name="Peptidase_C1"
                     /note="Papain family cysteine protease; pfam00112"
                     /db_xref="CDD:425470"
     Site            order(267,273,409,429)
                     /site_type="active"
                     /db_xref="CDD:239068"
     Site            order(315..316,381,407,410,455)
                     /site_type="active"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     CDS             1..462
                     /gene="Ctsf"
                     /coded_by="NM_001034110.1:32..1420"
                     /db_xref="GeneID:361704"
                     /db_xref="RGD:1308181"
ORIGIN      
        1 malllqllwl ltliatvvls pvpakpwadd eqawslssqe llaparfald mynygrtavt
       61 ravlgavhgr vrragrgslf sleatleepp cndplvclhp etkktmlcsf evleelkehl
      121 llrkdcspvn akvtesgnet fraflpmldk dplpqdfsvk matlfkdfmt tynrtyesre
      181 eaqwrltvfa rnmiraqkiq aldrgtaqyg itkfsdltee efhtiylnpl lqkesggkms
      241 laksindlap pewdwrkkga vtevkdqgmc gscwafsvtg nvegqwflnr gtllslseqe
      301 lldcdkmdka cmgglpsnay taiknlggle teddygyqgh vqacnfstqm akvyindsve
      361 lsrdenkiaa wlaqkgpisv ainafgmqfy rhgiahpfrp lcspwfidha vllvgygnrs
      421 nipywaikns wgrdwgeegy yylyrgsgac gvntmassav vn
//
