LOCUS       NM_001401267            2082 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cathepsin E (Ctse), transcript variant 2, mRNA.
ACCESSION   NM_001401267 XM_006249748
VERSION     NM_001401267.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Harada,Y., Takayama,F., Tanabe,K., Ni,J., Hayashi,Y., Yamamoto,K.,
            Wu,Z. and Nakanishi,H.
  TITLE     Overexpression of Cathepsin E Interferes with Neuronal
            Differentiation of P19 Embryonal Teratocarcinoma Cells by
            Degradation of N-cadherin
  JOURNAL   Cell Mol Neurobiol 37 (3), 437-443 (2017)
   PUBMED   27116544
  REMARK    GeneRIF: These observations suggest that the overexpression of CatE
            interferes with neuronal differentiation of P19 cells through an
            impairment of cell aggregate formation, possibly through
            proteolytic degradation of N-cadherin.
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Xu,H.R., Wang,X.H., Ma,X.B., Hou,W.N., Zhu,L., Xiang,J.C. and
            Sun,R.J.
  TITLE     [Screen and validation of differentially expressing genes related
            to silicotic pulmonary fibrosis in rats]
  JOURNAL   Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30 (1), 45-51 (2012)
   PUBMED   22730688
  REMARK    GeneRIF: The mRNA and protein expression levels of MMP-12 and
            Cathepsin E were significantly up-regulated in lung tissues of rats
            with silicotic pulmonary fibrosis.
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Zhou,W., Scott,S.A., Shelton,S.B. and Crutcher,K.A.
  TITLE     Cathepsin D-mediated proteolysis of apolipoprotein E: possible role
            in Alzheimer's disease
  JOURNAL   Neuroscience 143 (3), 689-701 (2006)
   PUBMED   16997486
REFERENCE   4  (bases 1 to 2082)
  AUTHORS   Tsukuba,T., Ikeda,S., Okamoto,K., Yasuda,Y., Sakai,E., Kadowaki,T.,
            Sakai,H. and Yamamoto,K.
  TITLE     Characterization of rat cathepsin E and mutants with changed
            active-site residues and lacking propeptides and N-glycosylation,
            expressed in human embryonic kidney 293T cells
  JOURNAL   FEBS J 273 (1), 219-229 (2006)
   PUBMED   16367762
  REMARK    GeneRIF: These data indicate that the catalytic activity,
            propeptides, and N-glycosylation of this protein are all essential
            for its processing, maturation, and trafficking.
REFERENCE   5  (bases 1 to 2082)
  AUTHORS   Yee,C.S., Yao,Y., Li,P., Klemsz,M.J., Blum,J.S. and Chang,C.H.
  TITLE     Cathepsin E: a novel target for regulation by class II
            transactivator
  JOURNAL   J Immunol 172 (9), 5528-5534 (2004)
   PUBMED   15100295
REFERENCE   6  (bases 1 to 2082)
  AUTHORS   Okamoto,K., Yu,H., Misumi,Y., Ikehara,Y. and Yamamoto,K.
  TITLE     Isolation and sequencing of two cDNA clones encoding rat spleen
            cathepsin E and analysis of the activation of purified procathepsin
            E
  JOURNAL   Arch Biochem Biophys 322 (1), 103-111 (1995)
   PUBMED   7574663
REFERENCE   7  (bases 1 to 2082)
  AUTHORS   Fowler,S.D., Kay,J., Dunn,B.M. and Tatnell,P.J.
  TITLE     Monomeric human cathepsin E
  JOURNAL   FEBS Lett 366 (1), 72-74 (1995)
   PUBMED   7789521
REFERENCE   8  (bases 1 to 2082)
  AUTHORS   Finley,E.M. and Kornfeld,S.
  TITLE     Subcellular localization and targeting of cathepsin E
  JOURNAL   J Biol Chem 269 (49), 31259-31266 (1994)
   PUBMED   7983070
REFERENCE   9  (bases 1 to 2082)
  AUTHORS   Bennett,K., Levine,T., Ellis,J.S., Peanasky,R.J., Samloff,I.M.,
            Kay,J. and Chain,B.M.
  TITLE     Antigen processing for presentation by class II major
            histocompatibility complex requires cleavage by cathepsin E
  JOURNAL   Eur J Immunol 22 (6), 1519-1524 (1992)
   PUBMED   1601038
REFERENCE   10 (bases 1 to 2082)
  AUTHORS   Yonezawa,S., Takahashi,T., Ichinose,M., Miki,K., Tanaka,J. and
            Gasa,S.
  TITLE     Structural studies of rat cathepsin E: amino-terminal structure and
            carbohydrate units of mature enzyme
  JOURNAL   Biochem Biophys Res Commun 166 (2), 1032-1038 (1990)
   PUBMED   2105725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 7, 2022 this sequence version replaced XM_006249748.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062002.1, SRR26643299.51542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000013.1  45644215-45644436
            223-416             JAXUCZ010000013.1  45655648-45655841
            417-573             JAXUCZ010000013.1  45656361-45656517
            574-691             JAXUCZ010000013.1  45657049-45657166
            692-810             JAXUCZ010000013.1  45658060-45658178
            811-1010            JAXUCZ010000013.1  45661806-45662005
            1011-1133           JAXUCZ010000013.1  45662105-45662227
            1134-1275           JAXUCZ010000013.1  45663642-45663783
            1276-1374           JAXUCZ010000013.1  45663882-45663980
            1375-2082           JAXUCZ010000013.1  45666015-45666722
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2082
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /note="cathepsin E"
                     /db_xref="GeneID:25424"
                     /db_xref="RGD:2446"
     exon            1..222
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            223..416
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1539
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /EC_number="3.4.23.34"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="cathepsin E isoform 2 preproprotein"
                     /protein_id="NP_001388196.1"
                     /db_xref="GeneID:25424"
                     /db_xref="RGD:2446"
                     /translation="MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQL
                     SDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSS
                     NLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGL
                     TVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFS
                     VYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSE
                     GCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLINGVSY
                     TLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVG
                     LAPAVP"
     exon            417..573
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            574..691
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            692..810
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1010
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1133
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1275
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1374
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2082
                     /gene="Ctse"
                     /gene_synonym="CEA; CEB; Ctsea"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactgcag atgccctgtg tgactccaga agcggttaga aggatcaggc gtggctatct
       61 ccatttgcag ctgaggtggc caagagataa gagttgctta aggccatagt tagcaaacaa
      121 caaaacgggt ttccacacag agatcggtct ctgagcctga ccatccactt actgcaggag
      181 aacgaaattc ttgacatttt ggtttatctg gtagcttcaa agactgggca gggcaggtct
      241 gggcaccagg aagagctggt gctcctgccc tgtgcacaag aagaaagaaa ggtggaaggg
      301 agatcgaagc agagtgagag agaagctgcc actcacacca caatgaaacc tctcttcgtg
      361 ctgctgctgc tgctgctgct cctggacctg gcacaggccc aaggggtgct gcacagggtg
      421 cccctcagaa gacatcagtc cctccggaag aaactacggg cccaaggcca gctctcagac
      481 ttctggagat ctcataactt ggacatgatc gaattcagcg agtcctgtaa tgtggataag
      541 ggtatcaatg agcccctcat caactacctg gatatggaat actttggcac cgtctccatc
      601 ggctccccat cgcagaactt caccgtcatc tttgacacgg gctcatccaa cctctgggtc
      661 ccttctgtgt actgcaccag cccagcatgc aaggcacacc cggtgttcca cccatcgcag
      721 tccagcacct acatggaggt agggaatcac ttctccatcc agtatggtac tgggagcctg
      781 acaggaatca ttggagctga ccaagtctct gtggaagggt tgactgtgga aggccagcaa
      841 tttggagaaa gtgtcaagga gcctggtcag acctttgtga atgcggagtt tgacgggatt
      901 ctgggcctgg gatacccctc attggctgtt ggaggagtga ccccagtgtt tgataacatg
      961 atggcccaga accttgtggc tctgcctatg ttttctgtct acttgagcag tgacccacaa
     1021 ggtggctcag gcagtgaact gactttcgga ggctatgacc cctctcattt ctctgggagc
     1081 ctcaattgga tcccagtcac caagcaaggc tactggcaga ttgccctgga tggaatccag
     1141 gtgggagaca ctgtgatgtt ctgctctgag ggctgccagg ccatagtgga cacagggacc
     1201 tccctcatca ctggcccccc caagaagatc aaacagcttc aagaggccat tggggccaca
     1261 cccatggatg gagaatatgc ggtggattgt gccactctca acatgatgcc aaacgtcacc
     1321 ttcctcatca acggggtttc atacaccctc agcccaactg cctacatcct gccggacttg
     1381 gtggatggaa tgcagttctg cggcagtggc tttcaaggac ttgacattca acctccggct
     1441 ggacccctct ggatcctggg ggatgtcttc atccgaaagt tttactcagt ctttgatcgt
     1501 ggaaataacc aagtgggatt ggcccccgca gtcccttaaa gagggctgta tgccttcatg
     1561 tggatgtctg atttaacctt tgtaactatc aaaactgtca tttcccatgg gatgtagcta
     1621 ttccaaacag agtaatcaga ccaaacaaag catgagagcc cacccagcct cccagtcgct
     1681 gtacatggac acacgcacca cctctaccat caccatgatg aaagttctgt ctatagtctt
     1741 cattgcttat tgttgacttc ctgttatgaa aatctctaaa catagacact agaaataatg
     1801 gtgtgataaa tagccacgca gctatgcctc acgtcacaac ccatccatgt gtggctcagc
     1861 ccctctattt tccatccgtc tggttttatg cctctagatt tgtaagcaaa ttctaagtac
     1921 catgccgttc tatctaatgt ctaatagtct taaaaatcag aatttaaata tgtctcactc
     1981 tctcataaat gtggacctgt ttttacagtt ggtttatctg tatcaggatt caaaccagat
     2041 ctataactgg acaaaaaaat cataaactga attgatttga aa
//
