LOCUS       NM_134334               1989 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cathepsin D (Ctsd), mRNA.
ACCESSION   NM_134334
VERSION     NM_134334.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Carvelli,L., Aguilera,A.C., Zyla,L., Pereyra,L.L., Morales,C.R.,
            Hermo,L. and Sosa,M.A.
  TITLE     Castration causes an increase in lysosomal size and upregulation of
            cathepsin D expression in principal cells along with increased
            secretion of procathepsin D and prosaposin oligomers in adult rat
            epididymis
  JOURNAL   PLoS One 16 (4), e0250454 (2021)
   PUBMED   33914781
  REMARK    GeneRIF: Castration causes an increase in lysosomal size and
            upregulation of cathepsin D expression in principal cells along
            with increased secretion of procathepsin D and prosaposin oligomers
            in adult rat epididymis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Kobayashi,S., Zhao,F., Kobayashi,T., Hagiwara,M., Kaminaris,A.,
            Li,C., Cai,F., Huang,Y. and Liang,Q.
  TITLE     Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal
            membrane injury and aberrant expression of cathepsin D
  JOURNAL   Biochem Biophys Res Commun 523 (1), 239-245 (2020)
   PUBMED   31862139
  REMARK    GeneRIF: Hyperglycemia-induced cardiomyocyte death is mediated by
            lysosomal membrane injury and aberrant expression of cathepsin D.
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Li,X., Qin,L., Li,Y., Yu,H., Zhang,Z., Tao,C., Liu,Y., Xue,Y.,
            Zhang,X., Xu,Z., Wang,Y., Lou,H., Tan,Z., Saftig,P., Chen,Z.,
            Xu,T., Bi,G., Duan,S. and Gao,Z.
  TITLE     Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of
            GABAergic Synaptic Vesicles
  JOURNAL   Cell Rep 28 (4), 1015-1028 (2019)
   PUBMED   31340140
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Monickaraj,F., McGuire,P. and Das,A.
  TITLE     Cathepsin D plays a role in endothelial-pericyte interactions
            during alteration of the blood-retinal barrier in diabetic
            retinopathy
  JOURNAL   FASEB J 32 (5), 2539-2548 (2018)
   PUBMED   29263022
  REMARK    GeneRIF: Cathepsin D plays a role in endothelial-pericyte
            interactions during alteration of the blood-retinal barrier in
            diabetic retinopathy.
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   Cao,W., Li,Y., Li,M., Zhang,X. and Liao,M.
  TITLE     Txn1, Ctsd and Cdk4 are key proteins of combination therapy with
            taurine, epigallocatechin gallate and genistein against liver
            fibrosis in rats
  JOURNAL   Biomed Pharmacother 85, 611-619 (2017)
   PUBMED   27894668
  REMARK    GeneRIF: This study highlights the importance of differentially
            expressed proteins Txn1, Ctsd and Cdk4 against liver fibrosis,
            which may provide a more precise and comprehensive perspective for
            clarifying the roles of combination therapy as a potential agent
            for treatment of liver fibrosis.
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Cataldo,A.M., Paskevich,P.A., Kominami,E. and Nixon,R.A.
  TITLE     Lysosomal hydrolases of different classes are abnormally
            distributed in brains of patients with Alzheimer disease
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 10998-11002 (1991)
   PUBMED   1837142
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2509]
REFERENCE   7  (bases 1 to 1989)
  AUTHORS   Fujita,H., Tanaka,Y., Noguchi,Y., Kono,A., Himeno,M. and Kato,K.
  TITLE     Isolation and sequencing of a cDNA clone encoding rat liver
            lysosomal cathepsin D and the structure of three forms of mature
            enzymes
  JOURNAL   Biochem Biophys Res Commun 179 (1), 190-196 (1991)
   PUBMED   1883350
REFERENCE   8  (bases 1 to 1989)
  AUTHORS   Birch,N.P. and Loh,Y.P.
  TITLE     Cloning, sequence and expression of rat cathepsin D
  JOURNAL   Nucleic Acids Res 18 (21), 6445-6446 (1990)
   PUBMED   2243802
REFERENCE   9  (bases 1 to 1989)
  AUTHORS   Cataldo,A.M. and Nixon,R.A.
  TITLE     Enzymatically active lysosomal proteases are associated with
            amyloid deposits in Alzheimer brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3861-3865 (1990)
   PUBMED   1692625
REFERENCE   10 (bases 1 to 1989)
  AUTHORS   Cataldo,A.M., Thayer,C.Y., Bird,E.D., Wheelock,T.R. and Nixon,R.A.
  TITLE     Lysosomal proteinase antigens are prominently localized within
            senile plaques of Alzheimer's disease: evidence for a neuronal
            origin
  JOURNAL   Brain Res 513 (2), 181-192 (1990)
   PUBMED   2350688
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134334.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062032.1, X54467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000001.1  206968643-206968821 c
            180-339             JAXUCZ010000001.1  206966360-206966519 c
            340-463             JAXUCZ010000001.1  206964357-206964480 c
            464-582             JAXUCZ010000001.1  206963646-206963764 c
            583-800             JAXUCZ010000001.1  206961895-206962112 c
            801-923             JAXUCZ010000001.1  206958440-206958562 c
            924-1068            JAXUCZ010000001.1  206958047-206958191 c
            1069-1167           JAXUCZ010000001.1  206957857-206957955 c
            1168-1989           JAXUCZ010000001.1  206956945-206957766 c
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1989
                     /gene="Ctsd"
                     /note="cathepsin D"
                     /db_xref="GeneID:171293"
                     /db_xref="RGD:621511"
     exon            1..179
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1335
                     /gene="Ctsd"
                     /EC_number="3.4.23.5"
                     /codon_start=1
                     /product="cathepsin D precursor"
                     /protein_id="NP_599161.2"
                     /db_xref="GeneID:171293"
                     /db_xref="RGD:621511"
                     /translation="MQTPGVLLLILGLLAASSSALIRIPLRKFTSIRRTMTEVGGSVE
                     DLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSN
                     LWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPC
                     KSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNNVLPVFDNLMKQKL
                     VEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGS
                     ELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIIT
                     FKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVF
                     DREYNRVGFAKAATL"
     exon            180..339
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            340..463
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            464..582
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            583..800
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            801..923
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1068
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1167
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1989
                     /gene="Ctsd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgaggggc aaacaagcgg atcagctgac tccgccggac tgcggtgtca tcctgcctat
       61 aagccggcga cctctggcat taagctttgc tctcttcggg ccgtcgcgac catgcagacc
      121 cccggcgtct tgctgctcat tctcggcctc ctggctgcgt cctcctccgc gcttatcaga
      181 atccccctgc gcaagttcac atccatccgt cggactatga cggaagtggg aggctctgtg
      241 gaagacctga tccttaaagg tcccataacc aagtactcca tgcagtcatc tcctaggacc
      301 aaggagccag tgtcagagtt actaaaaaac tacctggatg cccagtacta tggtgagatc
      361 ggcattggga ctcccccaca gtgtttcaca gtcgtctttg acactggctc ctctaacctg
      421 tgggtcccct ccattcattg caagctgctg gacatagcct gctgggtcca ccacaagtac
      481 aacagtgaca agtccagcac ctatgtgaag aatggcacat ccttcgacat ccactacggc
      541 tcaggtagcc tctctgggta cctgagccag gacactgtgt cggttccatg taagtcagac
      601 ttaggaggta tcaaggtgga gaaacagatc tttggggaag ccaccaagca gcctggagtc
      661 gtattcatcg cagccaagtt tgatggcatc ttgggcatgg gctacccttt tatctctgtt
      721 aacaatgtgc tcccggtctt cgacaacctg atgaaacaga agctggtgga aaagaacatc
      781 ttctccttct acctgaacag ggacccaacc gggcaacctg gaggagaact aatgcttggc
      841 ggcactgact ccagatacta ccacggggag ctgtcctacc tgaacgtcac ccgaaaggcc
      901 tactggcagg tgcacatgga ccagctggag gtgggcagcg agctgactct gtgcaaggga
      961 ggctgtgagg ctattgtgga cacagggacg tctcttctgg tggggcctgt ggacgaggtg
     1021 aaggaactac agaaggccat tggggcagtg cctctcatcc agggcgagta tatgatccct
     1081 tgtgagaagg tgtccagcct gcccattatc acctttaagc taggaggcca aaactatgaa
     1141 ctacacccag agaagtacat actcaaggta tcgcaggctg gaaagacgat ctgcctgagt
     1201 ggcttcatgg ggatggacat accccctccc agtgggccgc tctggatcct gggcgatgtc
     1261 tttattggct gctactacac cgtgtttgac agagaataca atagggtcgg ctttgccaag
     1321 gctgccacac tctaacttgc tccttcttca ctgtcaggga actggatcag agtccagtag
     1381 agaaagccag ccagccccat ccctccacct gccccactca cacatattca cactcgccta
     1441 gtgttgctgg gcccttggga ggcctggctg gagctggtcc agctgttctg ttctgtggtc
     1501 cctgtccctg ggttcagatt gctgccctcc gcctgtctga aggaggccaa ggcctaccca
     1561 gtacaaaagg ctgcctttaa aggcccctac tggcttggta gctgccggga tggattgtct
     1621 tgtcctgctg ccctttgctg cgtgggcagc actctgaagc aggcaaatgg gtcttgggat
     1681 ccctcccaga aacctgctct gaccagaccc tcaggcagcc tggggatggc accaagctct
     1741 actgccccac tatctctggc ctggcaaagg cctgaaggtg agcagaagga gcaagaggac
     1801 agaagcaaaa ctatatgaac ctgggggggg ttacctggga cctgacccca ccctcctggg
     1861 aaggcatgct tcagcctggg gcagaggtag gatggctgac tggttttggc tggcctctgc
     1921 tgccctcatc ctgggctagt cagatgggag ccaaagttga tatacaaata aagttgtttt
     1981 gggcctctt
//
