LOCUS       NM_017097               1843 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cathepsin C (Ctsc), mRNA.
ACCESSION   NM_017097
VERSION     NM_017097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Floyel,T., Frorup,C., Storling,J. and Pociot,F.
  TITLE     Cathepsin C Regulates Cytokine-Induced Apoptosis in beta-Cell Model
            Systems
  JOURNAL   Genes (Basel) 12 (11), 1694 (2021)
   PUBMED   34828301
  REMARK    GeneRIF: Cathepsin C Regulates Cytokine-Induced Apoptosis in
            beta-Cell Model Systems.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Audzeyenka,I., Rachubik,P., Rogacka,D., Typiak,M., Kulesza,T.,
            Angielski,S., Rychlowski,M., Wysocka,M., Gruba,N., Lesner,A.,
            Saleem,M.A. and Piwkowska,A.
  TITLE     Cathepsin C is a novel mediator of podocyte and renal injury
            induced by hyperglycemia
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (8), 118723 (2020)
   PUBMED   32302668
  REMARK    GeneRIF: Cathepsin C is a novel mediator of podocyte and renal
            injury induced by hyperglycemia.
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Chu,Y., Guo,Y., Walls,A.F. and Zhou,X.
  TITLE     The regulatory role of Dipeptidyl peptidase I on the activation of
            immune granulocytes
  JOURNAL   Cell Biol Int 41 (10), 1093-1102 (2017)
   PUBMED   28665049
  REMARK    GeneRIF: Findings demonstrate the role of DPPI in regulating MCs
            and NPs activation, and modulating proteolysis in the process of
            RA.
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K.,
            Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
  TITLE     The balance between cathepsin C and cystatin F controls
            remyelination in the brain of Plp1-overexpressing mouse, a chronic
            demyelinating disease model
  JOURNAL   Glia 65 (6), 917-930 (2017)
   PUBMED   28251676
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Hamon,Y., Legowska,M., Herve,V., Dallet-Choisy,S.,
            Marchand-Adam,S., Vanderlynden,L., Demonte,M., Williams,R.,
            Scott,C.J., Si-Tahar,M., Heuze-Vourc'h,N., Lalmanach,G.,
            Jenne,D.E., Lesner,A., Gauthier,F. and Korkmaz,B.
  TITLE     Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic
            Process and Secreted by Activated Cells during Inflammatory Lung
            Diseases
  JOURNAL   J Biol Chem 291 (16), 8486-8499 (2016)
   PUBMED   26884336
  REMARK    GeneRIF: Neutrophilic Cathepsin C Is Maturated by a Multistep
            Proteolytic Process and Secreted by Activated Cells during
            Inflammatory Lung Diseases.
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Kominami,E., Ishido,K., Muno,D. and Sato,N.
  TITLE     The primary structure and tissue distribution of cathepsin C
  JOURNAL   Biol Chem Hoppe Seyler 373 (7), 367-373 (1992)
   PUBMED   1515062
  REMARK    Review article
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Nikawa,T., Towatari,T. and Katunuma,N.
  TITLE     Purification and characterization of cathepsin J from rat liver
  JOURNAL   Eur J Biochem 204 (1), 381-393 (1992)
   PUBMED   1740150
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Wolinsky,H., Capron,L., Goldfischer,S., Capron,F.,
            Coltoff-Schiller,B. and Kasak,L.E.
  TITLE     Hydrolase activities in the rat aorta. II. Effects of hypertension
            alone and in combination with diabetes mellitus
  JOURNAL   Circ Res 42 (6), 831-839 (1978)
   PUBMED   657443
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Wolinsky,H., Goldfischer,S., Capron,L., Capron,F.,
            Coltoff-Schiller,B. and Kasak,L.
  TITLE     Hydrolase activities in the rat aorta. I. Effects of diabetes
            mellitus and insulin treatment
  JOURNAL   Circ Res 42 (6), 821-831 (1978)
   PUBMED   148980
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Marks,N., Grynbaum,A. and Levine,S.
  TITLE     Proteolytic enzymes in ordinary, hyperacute, monocytic and passive
            transfer forms of experimental allergic encephalomyelitis
  JOURNAL   Brain Res 123 (1), 147-157 (1977)
   PUBMED   843913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017097.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90404.1, FQ218311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000001.1  151441049-151441269
            222-367             JAXUCZ010000001.1  151443621-151443766
            368-534             JAXUCZ010000001.1  151458158-151458324
            535-687             JAXUCZ010000001.1  151461043-151461195
            688-803             JAXUCZ010000001.1  151463842-151463957
            804-935             JAXUCZ010000001.1  151470169-151470300
            936-1843            JAXUCZ010000001.1  151471523-151472430
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1843
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /note="cathepsin C"
                     /db_xref="GeneID:25423"
                     /db_xref="RGD:2445"
     exon            1..221
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1438
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /EC_number="3.4.14.1"
                     /note="dipeptidyl peptidase 1; cathepsin J; dipeptidyl
                     transferase; dipeptidyl peptidase I"
                     /codon_start=1
                     /product="dipeptidyl peptidase 1 precursor"
                     /protein_id="NP_058793.1"
                     /db_xref="GeneID:25423"
                     /db_xref="RGD:2445"
                     /translation="MGPWTHSLRAALLLVLLGVCTVSSDTPANCTYPDLLGTWVFQVG
                     PRHPRSHINCSVMEPTEEKVVIHLKKLDTAYDEVGNSGYFTLIYNQGFEIVLNDYKWF
                     AFFKYEVKGSRAISYCHETMTGWVHDVLGRNWACFVGKKMANHSEKVYVNVAHLGGLQ
                     EKYSERLYSHNHNFVKAINSVQKSWTATTYEEYEKLSIRDLIRRSGHSGRILRPKPAP
                     ITDEIQQQILSLPESWDWRNVRGINFVSPVRNQESCGSCYSFASLGMLEARIRILTNN
                     SQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEENCFPYTATDAPCKPKE
                     NCLRYYSSEYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGL
                     SDPFNPFELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGESGYFRIRRGTDECAIE
                     SIAMAAIPIPKL"
     exon            222..367
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            368..534
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            535..687
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            688..803
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            804..935
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1843
                     /gene="Ctsc"
                     /gene_synonym="CATC; DPP-I; DPPI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctagttg ttgttttctc tgccatctgc tctccgggcg ccgtcaacca tgggtccgtg
       61 gacccactcc ttgcgcgccg ccctgctgct ggtgcttttg ggagtctgca ccgtgagctc
      121 cgacactcct gccaactgca cttaccctga cctgctgggt acctgggttt tccaggtggg
      181 ccctagacat ccccgaagtc acattaactg ctcggtaatg gaaccaacag aagaaaaggt
      241 agtgatacac ctgaagaagt tggatactgc ctatgatgaa gtgggcaatt ctgggtattt
      301 caccctcatt tacaaccaag gctttgagat tgtgttgaat gactacaagt ggtttgcgtt
      361 tttcaagtat gaagtcaaag gcagcagagc catcagttac tgccatgaga ccatgacagg
      421 gtgggtccat gatgtcctgg gccggaactg ggcttgcttt gttggcaaga agatggcaaa
      481 tcactctgag aaggtttatg tgaatgtggc acaccttgga ggtctccagg aaaaatattc
      541 tgaaaggctc tacagtcaca accacaactt tgtgaaggcc atcaattctg ttcagaagtc
      601 ttggactgca accacctatg aagaatatga gaaactgagc atacgagatt tgataaggag
      661 aagtggccac agcggaagga tcctaaggcc caaacctgcc ccgataactg atgaaataca
      721 gcaacaaatt ttaagtttgc cagaatcttg ggactggaga aacgtccgtg gcatcaattt
      781 tgttagccct gttcgaaacc aagaatcttg tggaagctgc tactcatttg cctctctggg
      841 tatgctagaa gcaagaattc gtatattaac caacaattct cagaccccaa tcctgagtcc
      901 tcaggaggtt gtatcttgta gcccgtatgc ccaaggttgt gatggtggat tcccatacct
      961 cattgcagga aagtatgccc aagattttgg ggtggtggaa gaaaactgct ttccctacac
     1021 agccacagat gctccatgca aaccaaagga aaactgcctc cgttactatt cttctgagta
     1081 ctactatgtg ggtggtttct atggtggctg caatgaagcc ctgatgaagc ttgagctggt
     1141 caaacacgga cccatggcag ttgcctttga agtccacgat gacttcctgc actaccacag
     1201 tgggatctac caccacactg gactgagcga ccctttcaac ccctttgagc tgaccaatca
     1261 tgctgttctg cttgtgggct atggaaaaga tccagtcact gggttagact actggattgt
     1321 caagaacagc tggggctctc aatggggtga gagtggctac ttccggatcc gcagaggaac
     1381 tgatgaatgt gcaattgaga gtatagccat ggcagccata ccgattccta aattgtagga
     1441 cctagctccc agtgtcccat acagcttttt attattcaca gggtgattta gtcacaggct
     1501 ggagactttt acaaagcaat atcagaagct taccactagg tacccttaaa gaattttgcc
     1561 cttaagttta aaacaatcct tgattttttt cttttaatat cctccctatc aatcaccgaa
     1621 ctacttttct ttttaaagta cttggttaag taatactttt ctgaggattg gttagatatt
     1681 gtcaaatatt ttttgctggt cacctaaaat gcagccagat gtttcattgt taaaaatcta
     1741 tataaaagtg caagctcctt ttttaaatta cataaatccc atgaatacat ggccaaaata
     1801 gttatttttt aaagacttta aaataaatga tttaatcgat gct
//
