LOCUS       NM_022597               1967 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus cathepsin B (Ctsb), mRNA.
ACCESSION   NM_022597 XM_346477
VERSION     NM_022597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Zhou,Y., Dong,W., Wang,L., Ren,S., Wei,W. and Wu,G.
  TITLE     Cystatin C Attenuates Perihematomal Secondary Brain Injury by
            Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model
            of Intracerebral Hemorrhage
  JOURNAL   Mol Neurobiol 61 (11), 9646-9662 (2024)
   PUBMED   38676809
  REMARK    GeneRIF: Cystatin C Attenuates Perihematomal Secondary Brain Injury
            by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat
            Model of Intracerebral Hemorrhage.
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Hassan,D.M., El-Kamel,A.H., Allam,E.A., Bakr,B.A. and Ashour,A.A.
  TITLE     Chitosan-coated nanostructured lipid carriers for effective brain
            delivery of Tanshinone IIA in Parkinson's disease: interplay
            between nuclear factor-kappa beta and cathepsin B
  JOURNAL   Drug Deliv Transl Res 14 (2), 400-417 (2024)
   PUBMED   37598133
  REMARK    GeneRIF: Chitosan-coated nanostructured lipid carriers for
            effective brain delivery of Tanshinone IIA in Parkinson's disease:
            interplay between nuclear factor-kappa beta and cathepsin B.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Katsumata-Kato,O., Yokoyama,M. and Fujita-Yoshigaki,J.
  TITLE     The secretory ability of newly formed secretory granules is
            regulated by pro-cathepsin B and amylase in parotid glands
  JOURNAL   Biochem Biophys Res Commun 666, 45-51 (2023)
   PUBMED   37178504
  REMARK    GeneRIF: The secretory ability of newly formed secretory granules
            is regulated by pro-cathepsin B and amylase in parotid glands.
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Liu,C., Cai,Z., Hu,T., Yao,Q. and Zhang,L.
  TITLE     Cathepsin B aggravated doxorubicin-induced myocardial injury via
            NF-kappaB signalling
  JOURNAL   Mol Med Rep 22 (6), 4848-4856 (2020)
   PUBMED   33173960
  REMARK    GeneRIF: Cathepsin B aggravated doxorubicininduced myocardial
            injury via NFkappaB signalling.
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Boutte,A.M., Hook,V., Thangavelu,B., Sarkis,G.A., Abbatiello,B.N.,
            Hook,G., Jacobsen,J.S., Robertson,C.S., Gilsdorf,J., Yang,Z.,
            Wang,K.K.W. and Shear,D.A.
  TITLE     Penetrating Traumatic Brain Injury Triggers Dysregulation of
            Cathepsin B Protein Levels Independent of Cysteine Protease
            Activity in Brain and Cerebral Spinal Fluid
  JOURNAL   J Neurotrauma 37 (13), 1574-1586 (2020)
   PUBMED   31973644
  REMARK    GeneRIF: Penetrating Traumatic Brain Injury Triggers Dysregulation
            of Cathepsin B Protein Levels Independent of Cysteine Protease
            Activity in Brain and Cerebral Spinal Fluid.
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Rowan,A.D., Mason,P., Mach,L. and Mort,J.S.
  TITLE     Rat procathepsin B. Proteolytic processing to the mature form in
            vitro
  JOURNAL   J Biol Chem 267 (22), 15993-15999 (1992)
   PUBMED   1639824
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Cataldo,A.M., Paskevich,P.A., Kominami,E. and Nixon,R.A.
  TITLE     Lysosomal hydrolases of different classes are abnormally
            distributed in brains of patients with Alzheimer disease
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 10998-11002 (1991)
   PUBMED   1837142
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2509]
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Tagawa,K., Kunishita,T., Maruyama,K., Yoshikawa,K., Kominami,E.,
            Tsuchiya,T., Suzuki,K., Tabira,T., Sugita,H. and Ishiura,S.
  TITLE     Alzheimer's disease amyloid beta-clipping enzyme (APP secretase):
            identification, purification, and characterization of the enzyme
  JOURNAL   Biochem Biophys Res Commun 177 (1), 377-387 (1991)
   PUBMED   1645961
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Ishii,Y., Hashizume,Y., Watanabe,T., Waguri,S., Sato,N.,
            Yamamoto,M., Hasegawa,S., Kominami,E. and Uchiyama,Y.
  TITLE     Cysteine proteinases in bronchoalveolar epithelial cells and lavage
            fluid of rat lung
  JOURNAL   J Histochem Cytochem 39 (4), 461-468 (1991)
   PUBMED   2005374
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Cataldo,A.M., Thayer,C.Y., Bird,E.D., Wheelock,T.R. and Nixon,R.A.
  TITLE     Lysosomal proteinase antigens are prominently localized within
            senile plaques of Alzheimer's disease: evidence for a neuronal
            origin
  JOURNAL   Brain Res 513 (2), 181-192 (1990)
   PUBMED   2350688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB697852.1 and BC072490.1.
            
            On Dec 1, 2005 this sequence version replaced NM_022597.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072490.1, X82396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CB697852.1         12-48
            38-1967             BC072490.1         1-1930
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1967
                     /gene="Ctsb"
                     /note="cathepsin B"
                     /db_xref="GeneID:64529"
                     /db_xref="RGD:621509"
     exon            1..107
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            108..258
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1152
                     /gene="Ctsb"
                     /EC_number="3.4.22.1"
                     /note="RSG-2; cathepsin B1"
                     /codon_start=1
                     /product="cathepsin B preproprotein"
                     /protein_id="NP_072119.2"
                     /db_xref="GeneID:64529"
                     /db_xref="RGD:621509"
                     /translation="MWWSLIPLSCLLALTSAHDKPSFHPLSDDMINYINKQNTTWQAG
                     RNFYNVDISYLKKLCGTVLGGPKLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQ
                     GSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWN
                     FWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTS
                     YKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMG
                     GHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQ
                     YWGRF"
     exon            259..344
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            345..459
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            460..578
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            579..664
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            665..808
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            809..925
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1054
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1943
                     /gene="Ctsb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccagcggc gggcggagct gcgccgtact taggggtgca ccggagaggc caggagtggc
       61 tcggttcggc tcagcgactg cgggcccagg ttgtcgcgct gcgctcggtg agtgcaggat
      121 ccagcttcca ggatgtggtg gtccttgatc cctctctctt gcctgctggc actgaccagt
      181 gcccatgaca agccttcctt tcacccactg tcggacgaca tgattaacta tatcaacaaa
      241 cagaatacaa catggcaggc tggacgcaac ttctacaatg ttgacataag ctatctgaag
      301 aagctgtgtg gaactgtcct gggtggaccc aagctgccgg aaagggttgg gttcagcgag
      361 gacataaatc tacctgaatc ctttgatgca cgggaacagt ggtccaattg cccgaccatc
      421 gcacagatca gagaccaggg gtcctgtggc tcttgttggg catttggggc agtggaagcc
      481 atgtctgacc gaatctgcat tcacaccaat ggccgagtca atgtggaggt gtctgctgag
      541 gacctgctta cctgctgtgg tatccagtgt ggggatggct gtaatggtgg ctatccctct
      601 ggagcatgga acttctggac tagaaaaggc ctggtttctg gtggagtata caattctcat
      661 ataggctgct taccctacac catccctccc tgtgaacacc atgtcaatgg ctcccgtccc
      721 ccatgcactg gagaaggaga tactcccaag tgcaacaaga tgtgtgaggc tggctactcc
      781 acatcctaca aggaagataa gcactatggg tacacttcct acagtgtgtc tgacagcgag
      841 aaggagatca tggcggaaat ctacaaaaat ggcccagtgg agggtgcttt tactgtgttt
      901 tctgacttct tgacttacaa atcaggcgta tacaagcatg aagccggtga tgtgatggga
      961 ggccatgcca tccgcattct gggctgggga atagagaatg gagtacccta ctggctggta
     1021 gcaaactcct ggaacgttga ctggggtgat aatggtttct ttaaaatcct cagaggagag
     1081 aaccactgtg gaattgaatc agaaatcgtg gctggaatcc cacgcactca gcagtactgg
     1141 ggaagattct aatctgctgg gacttgattg tatagtcctt aggagacttt ttccaaaatt
     1201 tagcaatgca ggcagggagt gaggcagata ggagtctttg attctttgag ttcacctaac
     1261 atgcatgaag ctttcagcaa ggtttgggtg actggaccag agctgccccc catcagagcc
     1321 accctacctg gctcccttct agcctatccc atgacagtga tcacagccta catcctagcc
     1381 tctccctaga ctagtgctgt gtgtagcgcc tgctgctgtg gctctgtctg ccatccctcc
     1441 cacccccacc tcagcatccc cagaccaagg gctttggctg caggatttcc aaaggaatga
     1501 acaccaacta catgatgaga ggacagatgc cacccgccag ctgcaccttg aagctagtca
     1561 cttctaggac tgtggcaggc tttgatggcc caatgcagtt ctctggagaa aactaccttt
     1621 ccccaaggca tctgcaccca ttgacaatgg taatgtgccc atctctcctt ggtcctgccc
     1681 tcaaccgatg cttttccagt cagggttttg ttttttgttt tgttttgtgt acctcaactg
     1741 agttatgaag atttgtactg gttttacaga tcatctcatc gtatggatta gaacaagctt
     1801 cgtggtcagt ttgctgggtg accggcagac accacaatca aactagtctg ggaaaaacct
     1861 gcttttttgt tgtaggtgcc acgtaaccct gtcagtttaa caaggaatga ccgtgccaat
     1921 aaaccaattc tccctctgct tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
