LOCUS       NM_001011959            1988 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus cathepsin A (Ctsa), mRNA.
ACCESSION   NM_001011959 XM_006235534 XM_215920
VERSION     NM_001011959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Linz,D., Hohl,M., Dhein,S., Ruf,S., Reil,J.C., Kabiri,M.,
            Wohlfart,P., Verheule,S., Bohm,M., Sadowski,T. and Schotten,U.
  TITLE     Cathepsin A mediates susceptibility to atrial tachyarrhythmia and
            impairment of atrial emptying function in Zucker diabetic fatty
            rats
  JOURNAL   Cardiovasc Res 110 (3), 371-380 (2016)
   PUBMED   27032673
  REMARK    GeneRIF: Suggest CatA is an important mediator for susceptibility
            to atrial fibrillation in Zucker rat model of type 2 diabetes..
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Cuervo,A.M., Mann,L., Bonten,E.J., d'Azzo,A. and Dice,J.F.
  TITLE     Cathepsin A regulates chaperone-mediated autophagy through cleavage
            of the lysosomal receptor
  JOURNAL   EMBO J 22 (1), 47-59 (2003)
   PUBMED   12505983
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Shimmoto,M., Fukuhara,Y., Itoh,K., Oshima,A., Sakuraba,H. and
            Suzuki,Y.
  TITLE     Protective protein gene mutations in galactosialidosis
  JOURNAL   J Clin Invest 91 (6), 2393-2398 (1993)
   PUBMED   8514852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Jun 20, 2015 this sequence version replaced
            XM_006235534.1, NM_001011959.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1264083.1,
                                           SRR22582419.2376200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000003.1  173988443-173988650
            209-387             JAXUCZ010000003.1  173988822-173989000
            388-499             JAXUCZ010000003.1  173989114-173989225
            500-550             JAXUCZ010000003.1  173989489-173989539
            551-637             JAXUCZ010000003.1  173989628-173989714
            638-793             JAXUCZ010000003.1  173989939-173990094
            794-885             JAXUCZ010000003.1  173990383-173990474
            886-970             JAXUCZ010000003.1  173991145-173991229
            971-1062            JAXUCZ010000003.1  173991705-173991796
            1063-1138           JAXUCZ010000003.1  173991900-173991975
            1139-1281           JAXUCZ010000003.1  173992057-173992199
            1282-1357           JAXUCZ010000003.1  173992735-173992810
            1358-1447           JAXUCZ010000003.1  173993369-173993458
            1448-1552           JAXUCZ010000003.1  173993591-173993695
            1553-1988           JAXUCZ010000003.1  173993885-173994320
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1988
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /note="cathepsin A"
                     /db_xref="GeneID:296370"
                     /db_xref="RGD:1309070"
     exon            1..208
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1636
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /EC_number="3.4.16.5"
                     /note="protective protein for beta-galactosidase;
                     lysosomal protective protein"
                     /codon_start=1
                     /product="lysosomal protective protein precursor"
                     /protein_id="NP_001011959.2"
                     /db_xref="GeneID:296370"
                     /db_xref="RGD:1309070"
                     /translation="MTSSPKAAPGEQGHKEAEMPRAALSPLLLLLLLSWASRDEAAPD
                     QDEIDCLPGLAKQPSFRQYSGYLKASDSKHFHYWFVESQNDPKNSPVVLWLNGGPGCS
                     SLDGLLTEHGPFLIQPDGVTLEYNPYSWNLIANMLYIESPAGVGFSYSDDKMYVTNDT
                     EVAENNYQALKDFYHLFPEYKDNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVG
                     NGLSSYEQNDNSLVYFAYYHGLLGNRLWTSLQTHCCSQNKCNFYDNKDPDCVNNLQEV
                     SRIVGKSGLNIYNLYAPCAGGVPGRDRSEDTLVVQDFGNIFTRLPLKRRFPEALLLRS
                     GDKVRLDPPCTNTTAPSTYLNNPYVRKALHIPESLPRWDMCNLMVNLQYRRLYESMNS
                     QYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVDYGESGEQV
                     AGFVKECSHITFLTIKGAGHMVPTDKPRAAFTMFSRFLNKEPY"
     exon            209..387
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            388..499
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            500..550
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            551..637
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            638..793
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            794..885
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..970
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1062
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1138
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1281
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1357
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1447
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1552
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1988
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaccaaaa tcatctgatt tctggcaccc tgactgtgca ctttgggctg tgcactttga
       61 cctggtaatt gaccgccccc gaccctcaga taaaaaaagt gaacgctgag caagctgtca
      121 cgtgctgcag aagctcacgt gaccagaact acacatgact tccagtccaa aggcggctcc
      181 aggagagcaa ggacacaagg aagcagagat gccccgagca gcactgtctc cactgctcct
      241 gctgctgctc ctatcctggg cgtcccggga cgaagcagct ccggaccagg atgaaatcga
      301 ttgcctcccg ggcctggcca agcagccctc tttccggcag tactccggct atctcaaagc
      361 atcggattcc aagcacttcc actactggtt tgtggaatcg cagaacgacc ctaagaacag
      421 ccccgtggtg ctttggctca atgggggtcc tggctgcagc tccctagatg ggttacttac
      481 agagcacggt cccttcctga tccagccaga tggtgtcacc ctggagtaca acccctattc
      541 ttggaacctg attgccaaca tgctgtatat cgagtcccca gctggggtgg gcttctccta
      601 ctcggatgac aagatgtatg tgaccaatga cacagaggtg gctgagaaca attatcaagc
      661 ccttaaagac ttctaccacc tctttccgga gtacaaggac aacaaacttt tcctgaccgg
      721 agagagctat gctggcatct acatccccac cttggctgta ctggtcatgc aggatcccag
      781 catgaacctt caggggctgg ctgtgggcaa tggactctcc tcctatgagc agaatgacaa
      841 ctccctggtc tactttgcct actaccatgg tcttctgggg aacaggcttt ggacttcact
      901 ccagacccac tgctgttctc agaacaagtg taacttctat gacaacaaag atccagattg
      961 tgtaaacaat ctccaggaag tgtctcgaat tgtgggcaaa tctggcctca acatatacaa
     1021 tctctacgcc ccgtgtgctg gtggggtacc cggccgtgat aggtctgagg acacacttgt
     1081 agtccaggat tttggcaata tcttcactcg cttgccactc aagaggagat ttcctgaggc
     1141 tctactgctt cggtctgggg acaaggtacg cttggatcct ccatgcacca acaccacagc
     1201 cccctccacc tacctcaaca acccatatgt tcggaaggct ctccacatcc cggagtcgct
     1261 gccccgctgg gacatgtgca acctcatggt gaacttacag taccgccgtc tctacgaaag
     1321 catgaactcc cagtacctga agttgctcag ctcacagaaa taccagatcc tgctttacaa
     1381 tggcgatgtg gacatggcct gcaacttcat gggggatgag tggtttgtgg attccctcaa
     1441 ccagaagatg gaggtgcagc gccggccctg gctagtggac tacggggaga gtggagagca
     1501 ggtagctggc tttgtgaagg aatgctcaca cattaccttc ctcaccatca agggtgccgg
     1561 acacatggtc cccacggaca agcctcgagc tgcttttacc atgttctctc gattcctgaa
     1621 caaggagcct tactgatagc ttcgaggacc catggaagtc ctcagcacct gatcagaccc
     1681 tcaaagcctc tctcgatgtc gaggactcct cctttatgca aagtgctccc gtggggcaag
     1741 tcctgcttta aaaatgccca ggcttcctac agccctgtgc atcccagcct gggccttggg
     1801 gcttcacaga cagtctggga ccaaatgaac actttgttct ggctttgata ggatggcttt
     1861 ccctggtctg cataaaaaat gccccatccc aggaccccaa cagagctcta gagaagccca
     1921 aggagagggt tggatggatt gtaattgatg gttgactgat tatggaatta aatcgggtat
     1981 agcttcca
//
