LOCUS       NP_001011959             493 aa            linear   ROD 28-MAR-2024
DEFINITION  lysosomal protective protein precursor [Rattus norvegicus].
ACCESSION   NP_001011959 XP_006235596 XP_215920
VERSION     NP_001011959.2
DBSOURCE    REFSEQ: accession NM_001011959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Linz,D., Hohl,M., Dhein,S., Ruf,S., Reil,J.C., Kabiri,M.,
            Wohlfart,P., Verheule,S., Bohm,M., Sadowski,T. and Schotten,U.
  TITLE     Cathepsin A mediates susceptibility to atrial tachyarrhythmia and
            impairment of atrial emptying function in Zucker diabetic fatty
            rats
  JOURNAL   Cardiovasc Res 110 (3), 371-380 (2016)
   PUBMED   27032673
  REMARK    GeneRIF: Suggest CatA is an important mediator for susceptibility
            to atrial fibrillation in Zucker rat model of type 2 diabetes..
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Cuervo,A.M., Mann,L., Bonten,E.J., d'Azzo,A. and Dice,J.F.
  TITLE     Cathepsin A regulates chaperone-mediated autophagy through cleavage
            of the lysosomal receptor
  JOURNAL   EMBO J 22 (1), 47-59 (2003)
   PUBMED   12505983
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Shimmoto,M., Fukuhara,Y., Itoh,K., Oshima,A., Sakuraba,H. and
            Suzuki,Y.
  TITLE     Protective protein gene mutations in galactosialidosis
  JOURNAL   J Clin Invest 91 (6), 2393-2398 (1993)
   PUBMED   8514852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Jun 20, 2015 this sequence version replaced
            XP_006235596.1, NP_001011959.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1264083.1,
                                           SRR22582419.2376200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     Protein         1..493
                     /product="lysosomal protective protein precursor"
                     /EC_number="3.4.16.5"
                     /note="protective protein for beta-galactosidase;
                     lysosomal protective protein"
                     /calculated_mol_wt=51413
     sig_peptide     1..41
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4374
     Region          52..489
                     /region_name="Peptidase_S10"
                     /note="Serine carboxypeptidase; pfam00450"
                     /db_xref="CDD:459815"
     CDS             1..493
                     /gene="Ctsa"
                     /gene_synonym="Ppgb"
                     /coded_by="NM_001011959.2:155..1636"
                     /db_xref="GeneID:296370"
                     /db_xref="RGD:1309070"
ORIGIN      
        1 mtsspkaapg eqghkeaemp raalspllll lllswasrde aapdqdeidc lpglakqpsf
       61 rqysgylkas dskhfhywfv esqndpknsp vvlwlnggpg cssldgllte hgpfliqpdg
      121 vtleynpysw nlianmlyie spagvgfsys ddkmyvtndt evaennyqal kdfyhlfpey
      181 kdnklfltge syagiyiptl avlvmqdpsm nlqglavgng lssyeqndns lvyfayyhgl
      241 lgnrlwtslq thccsqnkcn fydnkdpdcv nnlqevsriv gksglniynl yapcaggvpg
      301 rdrsedtlvv qdfgniftrl plkrrfpeal llrsgdkvrl dppctnttap stylnnpyvr
      361 kalhipeslp rwdmcnlmvn lqyrrlyesm nsqylkllss qkyqillyng dvdmacnfmg
      421 dewfvdslnq kmevqrrpwl vdygesgeqv agfvkecshi tfltikgagh mvptdkpraa
      481 ftmfsrflnk epy
//
