LOCUS       NM_001077649             898 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus chymotrypsin C (Ctrc), mRNA.
ACCESSION   NM_001077649 XM_001073208 XM_001076330
VERSION     NM_001077649.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Lacruz,R.S., Smith,C.E., Smith,S.M., Hu,P., Bringas,P. Jr.,
            Sahin-Toth,M., Moradian-Oldak,J. and Paine,M.L.
  TITLE     Chymotrypsin C (caldecrin) is associated with enamel development
  JOURNAL   J Dent Res 90 (10), 1228-1233 (2011)
   PUBMED   21828354
  REMARK    GeneRIF: possibly involved in enamel development
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Yoshino-Yasuda,I., Kobayashi,K., Akiyama,M., Itoh,H., Tomomura,A.
            and Saheki,T.
  TITLE     Caldecrin is a novel-type serine protease expressed in pancreas,
            but its homologue, elastase IV, is an artifact during cloning
            derived from caldecrin gene
  JOURNAL   J Biochem 123 (3), 546-554 (1998)
   PUBMED   9538241
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Tomomura,A., Akiyama,M., Itoh,H., Yoshino,I., Tomomura,M.,
            Nishii,Y., Noikura,T. and Saheki,T.
  TITLE     Molecular cloning and expression of human caldecrin
  JOURNAL   FEBS Lett 386 (1), 26-28 (1996)
   PUBMED   8635596
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Tomomura,A., Tomomura,M., Fukushige,T., Akiyama,M., Kubota,N.,
            Kumaki,K., Nishii,Y., Noikura,T. and Saheki,T.
  TITLE     Molecular cloning and expression of serum calcium-decreasing factor
            (caldecrin)
  JOURNAL   J Biol Chem 270 (51), 30315-30321 (1995)
   PUBMED   8530454
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Kang,J., Wiegand,U. and Muller-Hill,B.
  TITLE     Identification of cDNAs encoding two novel rat pancreatic serine
            proteases
  JOURNAL   Gene 110 (2), 181-187 (1992)
   PUBMED   1537555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S80379.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001077649.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S80379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               S80379.1           2-899
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..898
                     /gene="Ctrc"
                     /note="chymotrypsin C"
                     /db_xref="GeneID:362653"
                     /db_xref="RGD:1308379"
     exon            1..52
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..819
                     /gene="Ctrc"
                     /EC_number="3.4.21.2"
                     /note="preprocaldecrin; caldecrin; serum
                     calcium-decreasing factor"
                     /codon_start=1
                     /product="chymotrypsin-C precursor"
                     /protein_id="NP_001071117.1"
                     /db_xref="GeneID:362653"
                     /db_xref="RGD:1308379"
                     /translation="MLGITVLAAILACASCCGNPAFPPNLSTRVVGGEDAVPNSWPWQ
                     VSLQYLKDDTWRHTCGGSLITTSHVLTAAHCINKDFTYRVGLGKYNLTVEDEEGSVYA
                     EVDTIYVHEKWNRLFLWNDIAIIKLAEPVELSNTIQVACIPEEGSLLPQDYPCYVTGW
                     GRLWTNGPIAEVLQQGLQPIVSHATCSRLDWWFIKVRKTMVCAGGDGVISACNGDSGG
                     PLNCQAEDGSWQVHGIVSFGSSSGCNVHKKPVVFTRVSAYNDWINEKIQL"
     exon            53..144
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            243..368
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            369..505
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            506..651
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            652..804
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
     exon            805..880
                     /gene="Ctrc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacacctgaa ccatgttggg aattacggtc ctcgctgcca tcctggcctg cgcctcttgc
       61 tgcgggaacc ccgccttccc acctaacctg tcaaccagag tggtaggagg agaggatgct
      121 gtccccaaca gctggccttg gcaggtctct ctccagtacc tcaaggacga cacatggagg
      181 cacacctgtg ggggaagtct catcaccacc agccacgtcc tcactgccgc ccactgcatc
      241 aacaaagact tcacttaccg tgtgggcctg gggaagtata atctgacagt ggaggatgag
      301 gaaggctccg tgtacgctga ggtggacacc atctacgtcc atgagaagtg gaaccgactc
      361 ttcctgtgga acgacatcgc tatcattaag ttggctgagc ctgtggaact gagcaacacc
      421 atccaggtgg cctgcatccc agaggaaggt tccctgctgc ctcaggacta tccctgctat
      481 gtcacgggct ggggtcgcct ctggaccaat ggtcccatcg ctgaagtgct ccagcagggc
      541 ctgcagccca tcgtgagcca tgccacgtgc tccaggttgg actggtggtt catcaaggtc
      601 cggaagacga tggtgtgcgc tgggggtgat ggcgtcatct ctgcctgtaa cggagattct
      661 ggcggcccac tgaactgcca agcagaagac ggctcatggc aggtgcacgg catcgtgagc
      721 ttcggttcca gtagcggctg caacgtacac aagaaaccgg tagtcttcac ccgagtgtct
      781 gcctacaatg actggatcaa cgagaaaata caactgtgaa gaggccgttc cagaagtctc
      841 gctgcccgtc tcccaacagc aataaagctt cttccatgat aaaaaaaaaa aaaaaaaa
//
