LOCUS       NM_001134873            2691 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CTP synthase 1 (Ctps1), mRNA.
ACCESSION   NM_001134873 XM_001053648 XM_233467
VERSION     NM_001134873.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Martin,E., Palmic,N., Sanquer,S., Lenoir,C., Hauck,F.,
            Mongellaz,C., Fabrega,S., Nitschke,P., Esposti,M.D.,
            Schwartzentruber,J., Taylor,N., Majewski,J., Jabado,N., Wynn,R.F.,
            Picard,C., Fischer,A., Arkwright,P.D. and Latour,S.
  TITLE     CTP synthase 1 deficiency in humans reveals its central role in
            lymphocyte proliferation
  JOURNAL   Nature 510 (7504), 288-292 (2014)
   PUBMED   24870241
  REMARK    Erratum:[Nature. 2014 Jul 17;511(7509):370]
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Tang,R., Cui,X.B., Wang,J.N. and Chen,S.Y.
  TITLE     CTP synthase 1, a smooth muscle-sensitive therapeutic target for
            effective vascular repair
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (10), 2336-2344 (2013)
   PUBMED   24008161
  REMARK    GeneRIF: CTPS1 inhibition selectively blocks smooth muscle cell
            proliferation without disturbing or even promoting
            re-endothelialization for effective vascular repair after injury.
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Liu,Z.Q., Tian,Y.Q., Hu,Y.F., Li,X.L., Ma,F.R. and Li,G.Y.
  TITLE     Alteration of gene expression during nasopharyngeal carcinogenesis
            revealed by oligonucleotide microarray after microdissection of
            tumor tissue and normal epithelia from nasopharynx
  JOURNAL   Chin Med J (Engl) 122 (4), 437-443 (2009)
   PUBMED   19302751
REFERENCE   6  (bases 1 to 2691)
  AUTHORS   Han,G.S., Sreenivas,A., Choi,M.G., Chang,Y.F., Martin,S.S.,
            Baldwin,E.P. and Carman,G.M.
  TITLE     Expression of Human CTP synthetase in Saccharomyces cerevisiae
            reveals phosphorylation by protein kinase A
  JOURNAL   J Biol Chem 280 (46), 38328-38336 (2005)
   PUBMED   16179339
REFERENCE   7  (bases 1 to 2691)
  AUTHORS   Hansel,D.E., Rahman,A., Hidalgo,M., Thuluvath,P.J., Lillemoe,K.D.,
            Schulick,R., Ku,J.L., Park,J.G., Miyazaki,K., Ashfaq,R.,
            Wistuba,I.I., Varma,R., Hawthorne,L., Geradts,J., Argani,P. and
            Maitra,A.
  TITLE     Identification of novel cellular targets in biliary tract cancers
            using global gene expression technology
  JOURNAL   Am J Pathol 163 (1), 217-229 (2003)
   PUBMED   12819026
  REMARK    Erratum:[Am J Pathol. 2017 Apr;187(4):936. PMID: 28342446]
REFERENCE   8  (bases 1 to 2691)
  AUTHORS   Huang,M. and Graves,L.M.
  TITLE     De novo synthesis of pyrimidine nucleotides; emerging interfaces
            with signal transduction pathways
  JOURNAL   Cell Mol Life Sci 60 (2), 321-336 (2003)
   PUBMED   12678497
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 13, 2008 this sequence version replaced
            XM_001053648.1, XM_233467.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161954.1, FQ217494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000005.1  139439267-139439382 c
            117-294             JAXUCZ010000005.1  139436182-139436359 c
            295-465             JAXUCZ010000005.1  139434225-139434395 c
            466-566             JAXUCZ010000005.1  139432135-139432235 c
            567-683             JAXUCZ010000005.1  139431396-139431512 c
            684-767             JAXUCZ010000005.1  139428483-139428566 c
            768-848             JAXUCZ010000005.1  139427996-139428076 c
            849-1000            JAXUCZ010000005.1  139424525-139424676 c
            1001-1133           JAXUCZ010000005.1  139423235-139423367 c
            1134-1222           JAXUCZ010000005.1  139419365-139419453 c
            1223-1317           JAXUCZ010000005.1  139418231-139418325 c
            1318-1380           JAXUCZ010000005.1  139417442-139417504 c
            1381-1424           JAXUCZ010000005.1  139415325-139415368 c
            1425-1521           JAXUCZ010000005.1  139414177-139414273 c
            1522-1577           JAXUCZ010000005.1  139413265-139413320 c
            1578-1674           JAXUCZ010000005.1  139413084-139413180 c
            1675-1819           JAXUCZ010000005.1  139412264-139412408 c
            1820-1908           JAXUCZ010000005.1  139411698-139411786 c
            1909-2691           JAXUCZ010000005.1  139410249-139411031 c
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2691
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /note="CTP synthase 1"
                     /db_xref="GeneID:313560"
                     /db_xref="RGD:1311060"
     exon            1..116
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            117..294
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1904
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /EC_number="6.3.4.2"
                     /note="cytidine 5'-triphosphate synthase"
                     /codon_start=1
                     /product="CTP synthase 1"
                     /protein_id="NP_001128345.1"
                     /db_xref="GeneID:313560"
                     /db_xref="RGD:1311060"
                     /translation="MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYIN
                     IDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKER
                     KGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFI
                     EAFRQFQFKVKKENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRC
                     SNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPVER
                     QSRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEI
                     KYIDSTDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARKQK
                     KPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPKTSHPVVIDMPEHNPGQMGGTMRL
                     GKRRTLFQTKNSVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGER
                     MEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDT
                     YSDRSGSSSPDSEITELKFPSISQD"
     exon            295..465
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            466..566
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            567..683
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            684..767
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            768..848
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1000
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1133
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1222
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1317
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1380
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1424
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1521
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1577
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1674
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1819
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1908
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2691
                     /gene="Ctps1"
                     /gene_synonym="Ctps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctctcag aaagacggct ggcgcatgcg gcccggctga gcactggctc cgcgagcctc
       61 accgcgcgcg cgtcggcctt gctgtggctg acacgagact ctgaagccgg ctccaggtta
      121 aaagaaaaat gaagtacatt ctagttactg gtggtgttat atcaggaatt ggaaaaggag
      181 ttatcgccag cagtgtgggc acaatactca agtcatgcgg tttacatgta acgtcaatta
      241 aaattgaccc ctatattaac atcgatgcag gaacattctc tccttatgaa catggagaag
      301 tctttgtgct ggatgatggt ggagaagttg accttgactt gggaaactat gagcggttcc
      361 ttgatatccg cctcaccaag gacaataacc tgaccacagg gaagatatac cagtacgtca
      421 ttaacaagga gcgcaaagga gattacttag ggaaaactgt tcaggttgtc cctcacatca
      481 cagatgcaat tcaagagtgg gtgatgagac aggcgttaat acctgtagac gaagatggct
      541 tagaacctca agtgtgtgtt attgagcttg gtggcacagt gggagacatt gaaagcatgc
      601 ccttcattga ggccttccgc cagttccagt tcaaggtcaa gaaggagaac ttttgtaata
      661 tccatgtcag tctggttcct cagccaagtt caacagggga acagaagaca aaacccactc
      721 agaacagtgt tcgggaactt agaggactcg ggctgtctcc agacttagtg gtgtgcagat
      781 gctcaaatcc tcttgacaca tctgtgaaag agaaaatatc aatgttctgc catgtggaac
      841 ctgaacaagt gatctgcgtt cacgacgtct catccatcta ccgggtgccc ttgctgttag
      901 aagagcaagg ggtggtggac tactttcttc ggagactcga ccttcccgtt gagagacagt
      961 cacggaagat gctgatgaag tggaaggaga tggcagacag atatgatcgc ttgctggaga
     1021 cctgctctat cgctcttgtg ggcaaataca ccaaattctc agattcgtat gcctctgtca
     1081 ttaaagctct agagcactct gcattggcta ttaaccacaa gttggagatc aagtacatcg
     1141 attccacaga cctggagccg agcaccctgc aggaagagcc tgtgcgctac catgaggcct
     1201 ggcagaagct ctgcagtgct catggagtgc tggttccagg aggatttggt gttcggggaa
     1261 cagaagggaa aattcaagca attgcctggg ctcggaaaca gaagaagcct tttttgggtg
     1321 tgtgcttagg aatgcagcta gcagtggtag aattttcaag aaatgtgctg ggatggcaag
     1381 atgccaattc tacagagttt gaccctaaga ctagtcatcc tgtggtcata gacatgccag
     1441 agcataaccc tgggcaaatg ggaggaacca tgaggctggg caagaggaga accctgttcc
     1501 agaccaagaa ctcagtcatg aggaaactct atggagacac agactacttg gaagaaaggc
     1561 accgccaccg atttgaggtg aatccagtcc tgaaaaagtg cttggaagag caaggcttga
     1621 agtttgttgg ccaggatgtt gaaggcgaga ggatggagat cgtggagctg gaagaccatc
     1681 cgtttttcgt tggagtgcag tatcaccccg agttcctgtc caggccaatc aagccctccc
     1741 caccctactt tggcctcctc ctggcctctg tggggcggct cccacattac cttcagaaag
     1801 gttgccggct gtcacccagg gacacttaca gtgacagaag tgggagcagc tcccctgact
     1861 ctgaaatcac tgaactgaag tttccatcaa taagtcagga ctgatctgga tgattcttca
     1921 agaaagcttt caacttttga tagtttataa ctatgatttt acaccctggc ttttgacact
     1981 tcttttaaat tatgttttta ttaagattat tttattatgg gggaaaggca tttggaaaac
     2041 tttgtcactt gcatgttccg tcatttatac tggatcctgc aacacatgta tttgtgccac
     2101 aatacctttg cagtttgtgt gcttctacga taggaagcag gactctggag gggacctgat
     2161 ggtggccact ggctggatat caaccttgct tttccaacca cttgggtcac ggtcattgga
     2221 atgaattgct gttatttccc tggggtgcca ggactccagt gctgggctgt aactgggtgt
     2281 tgctggggtc tcagtgctgc tgagctttag gggactagat gccagccatg gttgccctca
     2341 ccatccagag ggctgtttgg ttctttggca catcaggcaa gctgtgtctg tataaagtgt
     2401 cacataaaaa ccctgggtct ctggctacac tttcagttcc tggggctgag aaaactcctt
     2461 gcatcaaggg gtcaagaaac aaggaatttt agggtaactg gttctaaagc cctctcttgt
     2521 gtgtgcacat tgatttgagg gtatgttttc ttcagaatgg tgttagtgca gttgagatgc
     2581 aatttgaagt tattttctta atgtgacata gccatgggca tggccatgtg cgtacaatat
     2641 ggtggctgac ttgatgtata ctcctaactt aataaataat gtgcaaccat c
//
