LOCUS       NM_001173388            2565 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus catenin, beta-interacting protein 1 (Ctnnbip1),
            mRNA.
ACCESSION   NM_001173388 XM_001075213 XM_001078135 XM_002729566
VERSION     NM_001173388.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Wang W, Zhang X, Deng K, Huang S, Mao X, Fu Y, Yi Z, Yan Y and Qiu
            Z.
  TITLE     ICAT as a potential enhancer of monocytic differentiation:
            implications from the comparative proteome analysis of the HL60
            cell line stimulated by all-trans retinoic acid and NSC67657
  JOURNAL   Cell Biochem Funct 27 (6), 329-337 (2009)
   PUBMED   19569129
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Kim YJ, Kim JT, Bae YC, Suh KT and Jung JS.
  TITLE     ICAT participates in proliferation and osteogenic differentiation
            of human adipose tissue-derived mesenchymal stem cell
  JOURNAL   Life Sci 83 (25-26), 851-858 (2008)
   PUBMED   18977368
REFERENCE   3  (bases 1 to 2565)
  AUTHORS   Guo M, Breslin JW, Wu MH, Gottardi CJ and Yuan SY.
  TITLE     VE-cadherin and beta-catenin binding dynamics during
            histamine-induced endothelial hyperpermeability
  JOURNAL   Am J Physiol Cell Physiol 294 (4), C977-C984 (2008)
   PUBMED   18287330
REFERENCE   4  (bases 1 to 2565)
  AUTHORS   Hasegawa Y, Satoh K, Iizuka-Kogo A, Shimomura A, Nomura R, Akiyama
            T and Senda T.
  TITLE     Loss of ICAT gene function leads to arrest of ureteric bud
            branching and renal agenesis
  JOURNAL   Biochem Biophys Res Commun 362 (4), 988-994 (2007)
   PUBMED   17803964
REFERENCE   5  (bases 1 to 2565)
  AUTHORS   Quasnichka H, Slater SC, Beeching CA, Boehm M, Sala-Newby GB and
            George SJ.
  TITLE     Regulation of smooth muscle cell proliferation by
            beta-catenin/T-cell factor signaling involves modulation of cyclin
            D1 and p21 expression
  JOURNAL   Circ Res 99 (12), 1329-1337 (2006)
   PUBMED   17122440
REFERENCE   6  (bases 1 to 2565)
  AUTHORS   Kanamori M, Sandy P, Marzinotto S, Benetti R, Kai C, Hayashizaki Y,
            Schneider C and Suzuki H.
  TITLE     The PDZ protein tax-interacting protein-1 inhibits beta-catenin
            transcriptional activity and growth of colorectal cancer cells
  JOURNAL   J Biol Chem 278 (40), 38758-38764 (2003)
   PUBMED   12874278
REFERENCE   7  (bases 1 to 2565)
  AUTHORS   Daniels DL and Weis WI.
  TITLE     ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription
            factors and the general coactivator p300 using independent
            structural modules
  JOURNAL   Mol Cell 10 (3), 573-584 (2002)
   PUBMED   12408825
REFERENCE   8  (bases 1 to 2565)
  AUTHORS   Graham TA, Clements WK, Kimelman D and Xu W.
  TITLE     The crystal structure of the beta-catenin/ICAT complex reveals the
            inhibitory mechanism of ICAT
  JOURNAL   Mol Cell 10 (3), 563-571 (2002)
   PUBMED   12408824
REFERENCE   9  (bases 1 to 2565)
  AUTHORS   Tutter AV, Fryer CJ and Jones KA.
  TITLE     Chromatin-specific regulation of LEF-1-beta-catenin transcription
            activation and inhibition in vitro
  JOURNAL   Genes Dev 15 (24), 3342-3354 (2001)
   PUBMED   11751639
REFERENCE   10 (bases 1 to 2565)
  AUTHORS   Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi
            S, Ohwada S, Morishita Y, Shibuya H and Akiyama T.
  TITLE     Inhibition of Wnt signaling by ICAT, a novel
            beta-catenin-interacting protein
  JOURNAL   Genes Dev 14 (14), 1741-1749 (2000)
   PUBMED   10898789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB611569.1 and BC098773.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001078135.2, XM_002729566.1, XM_001075213.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK840513.1, AI576395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               CB611569.1         18-546
            530-2565            BC098773.1         380-2415
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2565
                     /gene="Ctnnbip1"
                     /note="catenin, beta-interacting protein 1"
                     /db_xref="GeneID:503000"
                     /db_xref="RGD:1562749"
     exon            1..119
                     /gene="Ctnnbip1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..204
                     /gene="Ctnnbip1"
                     /inference="alignment:Splign:2.1.0"
     exon            205..325
                     /gene="Ctnnbip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..475
                     /gene="Ctnnbip1"
                     /codon_start=1
                     /product="beta-catenin-interacting protein 1"
                     /protein_id="NP_001166859.1"
                     /db_xref="GeneID:503000"
                     /db_xref="RGD:1562749"
                     /translation="MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTY
                     AGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ"
     exon            326..416
                     /gene="Ctnnbip1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2540
                     /gene="Ctnnbip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgctc ctggtgctgc tgccgccgcc gcggctgctt ctccggctga gcgcgccccg
       61 gaacaggccg ccgcgctccg gacccgcagc ccccggcgcc gcgcgttcgg gcggcccagg
      121 gcggcacctt cctatttctt ctcagccaca gccctcccct tagagttcag catctgtttg
      181 cctgaagtta atttccagaa gcaggggtcc ccagaactgg gccacgggga tgaaccgtga
      241 gggagcaccc gggaagagtc cggaggagat gtacattcag cagaaggtcc gcgtgctgct
      301 catgctgagg aagatggggt caaatctgac tgccagcgag gaggaattcc tgcgcaccta
      361 tgcaggggtc gtcaacagcc agctcagcca gctgccacag cactccatcg accagggtgc
      421 agaggacgtg gtgatggcgt tttccagatc ggagacggaa gaccggaggc agtagctgga
      481 agcccctggc aacccctgga agctaccgat ggccaagaga tctgtatggc tcctctgccg
      541 gtcgagtggc agcaaaccac cgtcttctta ccccttgctc ccctcacccc atccaaccct
      601 ccccagccag ccactcagca gggctggcat caaggtggtt tgtgattggc ttgaagggat
      661 ggacttgtga ttggctgcag aaagaaacct ttttattttt aaaccttgac caacggaaac
      721 cttttatttt tatttctgac tctttatttt tttaaaagtt tgcgcctcgg tatctggctt
      781 ccctggaagc tgtccgagct ctggtgcttt atttaggtca tttttaggaa tgtgaagagg
      841 cccaattggc tgcttaaact ggaaaaaggt tgtgattggc tggctagtgg gacatggtct
      901 tttctttgat tggctgcggg tgttctgctc acatcatcaa cttcctctgt tctgaatgca
      961 gaaaacaggg tttgggatat tgattgttat agttgacttg aaaaaaaaaa agaagaaaag
     1021 aaagaaatgg aatgagcctt gcaatattta ttacacaaaa ggctggctgc tgccgtcact
     1081 gggtgggttt gcgtttgcat ttgattggca gtaagtgtgt gggcttggtc tcccattggc
     1141 tcacccctaa ctcctgtcac cgtaggctca cttccgctcg gctgcttatt tgaggcctga
     1201 ggctacacct ggagattgca tgtgctttaa tgaccacacc tgcctccacc agcaaaggga
     1261 ccccagggac ccagagcagg gtccacagct ggagaacacg gcccccaagg agctttgcgt
     1321 tgtcctgagc cagcagccca gagctcagag gtgaccagga ggcagggttg atgtactcga
     1381 ttctgagagt tggcagctgg ccagtttcct gaagcgcatg gattgtgcag agctcctcag
     1441 gcctccctgg ccagcccatg ctaagtacca gagcgccgac tggcagctcc ggcctctctg
     1501 ctgccccctg tgtctcactt ccccaggcct tggcatcccc agatcctgaa cattatgtgg
     1561 ggtctttgcc agagccttga acccaagcag atatcccagt ttcacttcca gaaccccaga
     1621 ggctccaagc ttgactccaa gcacaaccta accaggctac ccaggcaggg gctgttgcca
     1681 gtgggagtat gtcctggaca gcagatgtgg agcccaagcc cccattacat tgtatctcac
     1741 cgtgtcagca tagaagggag agtagcatgg acgaccagct agactttcac acagtagccc
     1801 cgcaggctcc tcagatccag ccccagggtc acattttaga gcagctcctg agaaggatct
     1861 gggtcatcat tccacccctg ccacaccatc cctgagagca agagaaatgc ctttctgatc
     1921 ctgtcggagt atcttttccc ttctcggggc ttagacctcc catgtcaggg agtgtgcagg
     1981 agcccagtgc cagcctgtct tgagaccaag ccctagggca cctactggtt gggggatggc
     2041 ttgagcctac cagccttgtt ccaggagaat ctgaacgtca cgtccttcag cacctgggcc
     2101 ctgttaacgg atgtgacatg ctttacccaa tgagctccgg ggagcgagga cagtggagaa
     2161 gcatcaccaa ccccggcctg ccagcaagag cccgaggaga cagcatcctg gagaggaacc
     2221 atgcgtgtgc aggcccggcg tgagctcaca cactgacagc ctgctctgct ggctcagtgt
     2281 ggcctggcga tgtgactggg ccccccgggc taatgggttg ttcagtctcc actcacttgt
     2341 gtgattgtaa actcgggtgt tgccagcttc agttggttcc cgtggctgcc tcaaggccaa
     2401 gtgctgatgg tgtgtgctct aagcagtggt tctcaggtca gccggtgagg aagaaagatg
     2461 caagtgtcgc tctggcttct tattccaact gaaagtctta tctaatggag gaaaaattaa
     2521 caataaagat ttctcacagc aaaaaaaaaa aaaaaaaaaa aaaaa
//
