LOCUS       NM_053357               2352 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus catenin beta 1 (Ctnnb1), mRNA.
ACCESSION   NM_053357
VERSION     NM_053357.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Li,K., Liu,L., Liu,H., Xing,J., Hu,P. and Song,J.
  TITLE     LATS1/YAP1 Axis Controls Bone Regeneration on Distraction
            Osteogenesis by Activating Wnt/beta-Catenin
  JOURNAL   Tissue Eng Part A 30 (3-4), 154-167 (2024)
   PUBMED   37930731
  REMARK    GeneRIF: LATS1/YAP1 Axis Controls Bone Regeneration on Distraction
            Osteogenesis by Activating Wnt/beta-Catenin.
REFERENCE   2  (bases 1 to 2352)
  AUTHORS   Krimpenfort,R.A., van der Meulen,S.A., Verhagen,H., Driessen,M.,
            Filonova,G., Hoogenboezem,M., van den Akker,E., von Lindern,M. and
            Nethe,M.
  TITLE     E-cadherin/beta-catenin expression is conserved in human and rat
            erythropoiesis and marks stress erythropoiesis
  JOURNAL   Blood Adv 7 (23), 7169-7183 (2023)
   PUBMED   37792794
  REMARK    GeneRIF: E-cadherin/beta-catenin expression is conserved in human
            and rat erythropoiesis and marks stress erythropoiesis.
REFERENCE   3  (bases 1 to 2352)
  AUTHORS   Yuan,J., Li,S., Han,Y., Li,F., Shi,H., Shi,W. and Cui,W.
  TITLE     Restoration of miR-328a-5p function curtails hypoxic pulmonary
            hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis
  JOURNAL   Int Immunopharmacol 123, 110599 (2023)
   PUBMED   37567011
  REMARK    GeneRIF: Restoration of miR-328a-5p function curtails hypoxic
            pulmonary hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis.
REFERENCE   4  (bases 1 to 2352)
  AUTHORS   Dong,W., Weng,J.F., Zhu,J.B., Zheng,Y.F., Liu,L.L., Dong,C.,
            Ruan,Y., Fang,X., Chen,J., Liu,W.Y., Peng,X.P. and Chen,X.Y.
  TITLE     CREB-binding protein and HIF-1alpha/beta-catenin to upregulate
            miR-322 and alleviate myocardial ischemia-reperfusion injury
  JOURNAL   FASEB J 37 (9), e22996 (2023)
   PUBMED   37566526
  REMARK    GeneRIF: CREB-binding protein and HIF-1alpha/beta-catenin to
            upregulate miR-322 and alleviate myocardial ischemia-reperfusion
            injury.
REFERENCE   5  (bases 1 to 2352)
  AUTHORS   Yin,X., Liu,X., Xiao,X., Yi,K., Chen,W., Han,C., Wang,L., Li,Y. and
            Liu,J.
  TITLE     Human neural stem cells repress glioma cell progression in a
            paracrine manner by downregulating the Wnt/beta-catenin signalling
            pathway
  JOURNAL   FEBS Open Bio 13 (9), 1772-1788 (2023)
   PUBMED   37410396
  REMARK    GeneRIF: Human neural stem cells repress glioma cell progression in
            a paracrine manner by downregulating the Wnt/beta-catenin
            signalling pathway.
REFERENCE   6  (bases 1 to 2352)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
REFERENCE   7  (bases 1 to 2352)
  AUTHORS   Haegel,H., Larue,L., Ohsugi,M., Fedorov,L., Herrenknecht,K. and
            Kemler,R.
  TITLE     Lack of beta-catenin affects mouse development at gastrulation
  JOURNAL   Development 121 (11), 3529-3537 (1995)
   PUBMED   8582267
REFERENCE   8  (bases 1 to 2352)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   9  (bases 1 to 2352)
  AUTHORS   Rubinfeld,B., Souza,B., Albert,I., Munemitsu,S. and Polakis,P.
  TITLE     The APC protein and E-cadherin form similar but independent
            complexes with alpha-catenin, beta-catenin, and plakoglobin
  JOURNAL   J Biol Chem 270 (10), 5549-5555 (1995)
   PUBMED   7890674
REFERENCE   10 (bases 1 to 2352)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF121265.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_053357.3.
            
            On Apr 2, 2004 this sequence version replaced NM_053357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF121265.1, FQ222424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2352
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /note="catenin beta 1"
                     /db_xref="GeneID:84353"
                     /db_xref="RGD:70487"
     exon            1..19
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2352
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /note="beta-catenin; catenin (cadherin associated
                     protein), beta 1, 88kDa"
                     /codon_start=1
                     /product="catenin beta-1"
                     /protein_id="NP_445809.2"
                     /db_xref="GeneID:84353"
                     /db_xref="RGD:70487"
                     /translation="MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAP
                     SLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPET
                     LDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLL
                     NDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTL
                     HNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLA
                     GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYE
                     KLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGPHLTDPSQRLVQNCLWTLRNLSDAA
                     TKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRT
                     VLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIK
                     ATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRM
                     EEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQD
                     KEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSL
                     FRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMG
                     GHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL"
     exon            20..247
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            248..501
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            502..740
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            741..942
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1087
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1191
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1530
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1689
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1809
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1960
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2082
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2143
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2352
                     /gene="Ctnnb1"
                     /gene_synonym="Catnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggacaatgg ctactcaagc tgacctcatg gagttggaca tggccatgga gccagacaga
       61 aaggccgctg tcagccactg gcagcagcaa tcttacctgg attctggaat ccactctggt
      121 gccaccacca cagctccttc cctgagtggc aagggcaatc ctgaggaaga agatgtggac
      181 acctcccaag tcctttatga gtgggagcaa ggcttttccc agtccttcac gcaagagcaa
      241 gtagctgaca ttgacggtca gtacgccatg actcgggctc agagggtccg agctgccatg
      301 ttccctgaga cactagatga gggcatgcag atcccatcca cgcagtttga tgccgctcat
      361 cccactaatg tccagcgctt ggctgaaccg tcacagatgc tgaaacatgc agttgtcaat
      421 ttgattaact atcaggatga cgcggaactt gccacccgtg caattcctga gctgaccaaa
      481 ctgctaaatg acgaggacca ggtggtcgtt aataaagctg ctgttatggt tcaccagctt
      541 tccaaaaagg aagcttccag acacgccatc atgcgctccc ctcagatggt gtctgccata
      601 gtgcgcacca tgcagaatac aaatgacgta gaaacagccc gttgtaccgc tgggacccta
      661 cacaaccttt cccaccatcg agagggcttg ttggccatct ttaaatctgg cggcatccca
      721 gcgctggtga aaatgcttgg gtcgccagtg gattccgtac tgttctacgc catcaccacg
      781 ctgcataatc tcctgctaca tcaggaagga gctaaaatgg cagtgcgcct agctggtggg
      841 ctgcagaaaa tggttgcttt gctcaacaaa acaaacgtga agttcttggc tattacgaca
      901 gactgccttc agatcttagc ttacggcaat caggaaagca agctcatcat tctggccagt
      961 ggtggacccc aagccttagt aaacataatg agaacctaca cgtacgagaa gctcctgtgg
     1021 accacaagca gagtgctgaa ggtgctgtct gtctgctcta gcaacaagcc ggccatcgtg
     1081 gaagctggtg ggatgcaggc actggggcct cacctgacag acccgagtca gcgacttgtt
     1141 caaaactgtc tttggactct gagaaacttg tccgatgcag cgactaagca ggaagggatg
     1201 gaaggcctcc ttgggactct agtgcagctt ctgggttctg atgatataaa tgtggtcacc
     1261 tgcgcagctg gaattctctc taacctcact tgcaataatt acaaaaacaa gatgatggtg
     1321 tgccaagtgg gtggcataga ggctcttgtg cgcactgtcc ttcgtgctgg tgacagggag
     1381 gacattaccg agcctgccat ctgtgctctt cgtcatctga ccagccgaca tcaggaagct
     1441 gagatggccc agaatgccgt tcgccttcat tatggactac ctgttgtggt taaactcctg
     1501 cacccaccat cccactggcc tctgataaag gcaactgttg gattgatccg aaaccttgcc
     1561 ctttgcccag caaatcatgc gcctttgcgg gaacagggtg cgatcccacg actagttcag
     1621 ctgcttgtac gagcacatca ggacacccag cggcgcacgt ccatgggtgg aacacagcag
     1681 cagttcgtgg agggcgtccg catggaggag atagttgaag ggtgcactgg ggctctccac
     1741 atcctcgctc gggatgttca caaccggatt gtgatccgag gactcaatac cattccactg
     1801 tttgtgcagt tgctttattc tcccattgaa aatatccaaa gagtagctgc aggggtcctc
     1861 tgtgaacttg ctcaggacaa ggaggctgca gaggccattg aggctgaggg agccacagct
     1921 cccctgacag agttgctcca ctccaggaat gaaggcgtgg caacatatgc ggctgctgtt
     1981 ctattccgaa tgtctgagga caagccacag gactacaaga aacggctttc ggttgagctg
     2041 accagttccc tcttcaggac agagccaatg gcttggaatg agactgctga tctcggactg
     2101 gacattggtg cccagggaga agcccttgga tatcgccagg acgatcccag ctaccgttct
     2161 tttcactctg gtggatacgg ccaggacgcc ttggggatgg accctatgat ggagcatgag
     2221 atgggtggcc accaccctgg tgctgactat ccagttgatg ggctgcctga cctgggacac
     2281 gcccaggacc tcatggacgg gctgcctcca ggtgatagca atcagctggc ctggtttgat
     2341 accgacctgt aa
//
