LOCUS       NM_001415843            4093 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus catenin alpha 2 (Ctnna2), transcript variant 3,
            mRNA.
ACCESSION   NM_001415843
VERSION     NM_001415843.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Schaffer,A.E., Breuss,M.W., Caglayan,A.O., Al-Sanaa,N.,
            Al-Abdulwahed,H.Y., Kaymakcalan,H., Yilmaz,C., Zaki,M.S.,
            Rosti,R.O., Copeland,B., Baek,S.T., Musaev,D., Scott,E.C.,
            Ben-Omran,T., Kariminejad,A., Kayserili,H., Mojahedi,F., Kara,M.,
            Cai,N., Silhavy,J.L., Elsharif,S., Fenercioglu,E., Barshop,B.A.,
            Kara,B., Wang,R., Stanley,V., James,K.N., Nachnani,R., Kalur,A.,
            Megahed,H., Incecik,F., Danda,S., Alanay,Y., Faqeih,E.,
            Melikishvili,G., Mansour,L., Miller,I., Sukhudyan,B., Chelly,J.,
            Dobyns,W.B., Bilguvar,K., Jamra,R.A., Gunel,M. and Gleeson,J.G.
  TITLE     Biallelic loss of human CTNNA2, encoding alphaN-catenin, leads to
            ARP2/3 complex overactivity and disordered cortical neuronal
            migration
  JOURNAL   Nat Genet 50 (8), 1093-1101 (2018)
   PUBMED   30013181
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Desai,R., Sarpal,R., Ishiyama,N., Pellikka,M., Ikura,M. and
            Tepass,U.
  TITLE     Monomeric alpha-catenin links cadherin to the actin cytoskeleton
  JOURNAL   Nat Cell Biol 15 (3), 261-273 (2013)
   PUBMED   23417122
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Daneman,R., Agalliu,D., Zhou,L., Kuhnert,F., Kuo,C.J. and
            Barres,B.A.
  TITLE     Wnt/beta-catenin signaling is required for CNS, but not non-CNS,
            angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 106 (2), 641-646 (2009)
   PUBMED   19129494
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6422]
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Lallemand,D., Curto,M., Saotome,I., Giovannini,M. and
            McClatchey,A.I.
  TITLE     NF2 deficiency promotes tumorigenesis and metastasis by
            destabilizing adherens junctions
  JOURNAL   Genes Dev 17 (9), 1090-1100 (2003)
   PUBMED   12695331
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Togashi,H., Abe,K., Mizoguchi,A., Takaoka,K., Chisaka,O. and
            Takeichi,M.
  TITLE     Cadherin regulates dendritic spine morphogenesis
  JOURNAL   Neuron 35 (1), 77-89 (2002)
   PUBMED   12123610
REFERENCE   8  (bases 1 to 4093)
  AUTHORS   Park,C., Falls,W., Finger,J.H., Longo-Guess,C.M. and Ackerman,S.L.
  TITLE     Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and
            hippocampal lamination defects and impaired startle modulation
  JOURNAL   Nat Genet 31 (3), 279-284 (2002)
   PUBMED   12089526
REFERENCE   9  (bases 1 to 4093)
  AUTHORS   Sorenson,C.M.
  TITLE     Nuclear localization of beta-catenin and loss of apical brush
            border actin in cystic tubules of bcl-2 -/- mice
  JOURNAL   Am J Physiol 276 (2), F210-F217 (1999)
   PUBMED   9950951
REFERENCE   10 (bases 1 to 4093)
  AUTHORS   Uchida,N., Honjo,Y., Johnson,K.R., Wheelock,M.J. and Takeichi,M.
  TITLE     The catenin/cadherin adhesion system is localized in synaptic
            junctions bordering transmitter release zones
  JOURNAL   J Cell Biol 135 (3), 767-779 (1996)
   PUBMED   8909549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMEA5760433
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000004.1  112001172-112001351 c
            181-282             JAXUCZ010000004.1  111940928-111941029 c
            283-389             JAXUCZ010000004.1  111869801-111869907 c
            390-585             JAXUCZ010000004.1  111773233-111773428 c
            586-752             JAXUCZ010000004.1  111675358-111675524 c
            753-872             JAXUCZ010000004.1  111657471-111657590 c
            873-1139            JAXUCZ010000004.1  111653007-111653273 c
            1140-1343           JAXUCZ010000004.1  111618334-111618537 c
            1344-1424           JAXUCZ010000004.1  111154873-111154953 c
            1425-1577           JAXUCZ010000004.1  111123197-111123349 c
            1578-1670           JAXUCZ010000004.1  110968909-110969001 c
            1671-1827           JAXUCZ010000004.1  110967807-110967963 c
            1828-2028           JAXUCZ010000004.1  110956795-110956995 c
            2029-2180           JAXUCZ010000004.1  110931889-110932040 c
            2181-2294           JAXUCZ010000004.1  110914904-110915017 c
            2295-2476           JAXUCZ010000004.1  110904902-110905083 c
            2477-2582           JAXUCZ010000004.1  110893545-110893650 c
            2583-2717           JAXUCZ010000004.1  110889020-110889154 c
            2718-2861           JAXUCZ010000004.1  110876283-110876426 c
            2862-4093           JAXUCZ010000004.1  110852265-110853496 c
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q33"
     gene            1..4093
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /note="catenin alpha 2"
                     /db_xref="GeneID:297357"
                     /db_xref="RGD:1305060"
     exon            1..180
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..282
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..389
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..3149
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     catenin (cadherin associated protein), alpha 2"
                     /codon_start=1
                     /product="catenin alpha-2 isoform 1"
                     /protein_id="NP_001402772.1"
                     /db_xref="GeneID:297357"
                     /db_xref="RGD:1305060"
                     /translation="MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNK
                     GPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGET
                     MRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEAL
                     EAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNAT
                     MLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISSAAQATSPTDEAKGHTGIGEL
                     AAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAE
                     CNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSF
                     LETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRM
                     AATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDD
                     FLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVY
                     TEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIR
                     KAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAK
                     IAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSD
                     VINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAE
                     VQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDS
                     SMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKK
                     PLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF"
     exon            390..585
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..752
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..872
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1139
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1343
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1424
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1577
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1670
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1827
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2028
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2180
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2294
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2476
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2582
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2717
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2861
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..4093
                     /gene="Ctnna2"
                     /gene_synonym="Catna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccctgagt gaggcggaga cccgggcgga gcgggcggca ccgcacctcg accagaagca
       61 gctgcagcag ctgccctagt ccctaccgcc gcctctccag tcgcttctgt cattccgtgc
      121 cagctgctgc agacagagga cgaggaggag gaggcgagaa actcccaccg acccacagag
      181 aggctgtgag aacaattgtt agcattcaag tcaggaagct catagctcca gtgccaggag
      241 attttattat gacagatatt cactcaagct acatatatac agggagcatg acttcggcaa
      301 cctcacctat cattttaaaa tgggatccca aaagtttgga aatccggaca ctcacggtgg
      361 aaagactgtt ggagccactt gtaacacagg tgacaacgct tgtcaacaca agcaacaaag
      421 gtccgtctgg taaaaagaaa gggaggtcaa agaaagccca tgtgctggca gcatctgtag
      481 aacaagctac tcagaatttc cttgaaaagg gtgagcagat cgctaaggag agccaggacc
      541 tcaaagaaga gttggtggct gctgtagagg atgtgcggaa gcaaggtgag actatgcgga
      601 tcgcctcctc agagtttgct gacgaccctt gctcttcggt caagcgtggc acaatggtgc
      661 gggcagcacg ggctctgcta tcggctgtga cacgcttgct cattctggct gacatggcag
      721 atgtcatgag acttttatcg catctgaaaa ttgtcgagga ggccttggaa gctgtcaaaa
      781 acgctacaaa tgaacaagac cttgcaaacc gctttaaaga gtttggaaaa gagatggtga
      841 aactgaacta tgtagcggca agacgacaac aggagctgaa ggaccctcac tgtagggatg
      901 aaatggctgc tgcccgagga gccctcaaga agaacgccac catgctgtac acagcctccc
      961 aagccttcct ccgccaccca gatgtcgcag ctacaagagc caaccgagat tatgtattca
     1021 aacaagtcca ggaggccata gctgggatct ccagtgctgc gcaggccacc tcgcccaccg
     1081 atgaagccaa aggccacaca ggcatcggcg agctggctgc agccctgaat gaatttgata
     1141 ataagatcat cctggaccct atgacattca gcgaagccag gttccggcca tccctggagg
     1201 agagactgga gagcatcatc agtggggctg ccctcatggc agattcctcc tgcacacgtg
     1261 atgatcgccg tgaacgtatt gtggccgagt gcaacgcagt ccgccaggcg ctgcaggacc
     1321 tgctaagcga gtacatgaat aacactggaa ggaaagagaa aggagaccct ctcaacattg
     1381 cgattgacaa aatgaccaag aaaaccagag atctgaggag acagcttcgg aaagctgtga
     1441 tggatcacat atcagattct ttcttggaaa ccaatgtccc tttgctggtt ctcattgagg
     1501 ctgcaaagag tgggaatgaa aaggaggtga aggaatatgc ccaagttttt cgtgaacatg
     1561 ccaacaagct ggtggaggtt gccaatttgg cttgttccat ctccaacaat gaggaagggg
     1621 tgaagttagt caggatggca gctacccaga ttgacagcct gtgtccccag gtcatcaatg
     1681 ctgccctcac tctggctgct cggccacaga gtaaagttgc tcaggacaac atggatgtct
     1741 tcaaagatca gtgggaaaag caggtccgag tactcactga ggctgtggat gacatcacct
     1801 cagtggatga ctttctctct gtctcagaaa atcatatctt ggaggatgtg aacaaatgtg
     1861 tgattgcctt gcaagaggga gacgtggaca cactggatcg cacagctggg gccatacgag
     1921 gccgggcagc ccgggtcatt cacatcatca atgccgagat ggaaaactac gaagccgggg
     1981 tctatacgga gaaagtgctg gaagccacaa aattgctttc agaaacagtg atgccacgct
     2041 ttgctgaaca agttgaggtt gccatcgaag ccctgagtgc caatgtccct caaccattcg
     2101 aggagaatga gttcatcgat gcctcgcgcc tggtgtatga tggtgttcgg gatatcagaa
     2161 aggctgtgct gatgatcagg actccagaag agctagaaga tgattctgac tttgagcaag
     2221 aggattatga tgtgcgtagt cggacaagtg ttcagaccga ggatgaccag ctcattgctg
     2281 ggcagagtgc acgggccatc atggcgcaac taccacagga ggagaaagca aaaatagctg
     2341 agcaggtgga aattttccac caagaaaaaa gcaagctgga tgctgaagtg gccaagtggg
     2401 atgacagcgg caatgacatc attgtgctgg ccaagcagat gtgtatgatc atgatggaga
     2461 tgacagactt cacaagaggc aaaggcccac tgaaaaatac atctgatgtc attaatgctg
     2521 ccaagaagat tgcagaagca ggctctcgaa tggacaaatt agcgcgcgct gtggctgatc
     2581 agtgtcctga ttcagcatgt aagcaggatt tattagccta ccttcagcgg attgccttgt
     2641 actgccatca gcttaacatc tgcagcaaag tgaaggctga agttcagaat ctgggaggag
     2701 aactcattgt gtcagggaca ggagttcaga gcactttcac taccttttat gaggtagatt
     2761 gtgatgtcat agatgggggc agggctagtc aactttctac ccacctccca acctgtgctg
     2821 agggagctcc aatcgggagt ggaagcagtg actcctccat gctggacagt gctacatcac
     2881 tcatccaggc agccaaaaac ctgatgaatg cggttgtcct cacggtgaaa gcatcttatg
     2941 tagcctcaac caaataccag aaggtctatg gaacagcagc tgtcaactct ccagttgtat
     3001 cttggaagat gaaggctcct gaaaagaagc cccttgtgaa gagagagaag cctgaagaat
     3061 tccagacacg agttcgacgg gggtctcaaa agaaacacat ttcacctgtg caggctttaa
     3121 gtgaattcaa ggcaatggat tccttttagg acaataggct tcaaacaaga aagctttttc
     3181 tttctccctc cctcccccct ctctgtcccc tttctttttc attttgattc catttttgta
     3241 agcatacctg ctgacttgta tgcctctggc atggggaaat taagagaaca gtgtctgttt
     3301 gcatgttaga tgagatgaga tcaatgctac tgctccatca gtagcctggg aaggaagggg
     3361 gacaggtgat gatttctgtc ctgaggtggc acagagctgt cctttgcaac attctcttta
     3421 aagttgggca aagagttcac actgtgatgt tcacgggagt gggagggatg gggaaaataa
     3481 acttaaactc tacaaaagca aactctaatg catgcaagaa tcattaggtt ggcaggtata
     3541 ttcataagtg aaaaacctgg aagtgttatg gtagagcata aaacctgtac tgcttctgtt
     3601 tcggtgcaaa aatgtactag ccaatacgct gaagtgtgtg gcccacaaat tgaacaattt
     3661 aacctcaacg tcacatatcc atgctatcat gcggattctt aactgaggag aaactaactc
     3721 atcccgtctc aaatgtttct ttaatctgca ttctgttctt tcttcctggt agtgccatta
     3781 ctagtgttcc tcttatttta tcctctctgc tgaagacagg aaacattcct tggagacact
     3841 tggatccttc tgcggacccc gatgatacaa agtggagctc aactgtcctt ccttttattc
     3901 ctttcttttt ttctttctaa atttgaactc tgactttgct agacatagaa ggctcaatgg
     3961 tggaatgtta gagcaatggg gattgacagt atgtgaaggt ttagaggcaa acgcataggt
     4021 gtgtagctgg gagtgctggt atctaatata ccattgtatt cactgacaca aaaataaaca
     4081 catttaatct tga
//
