LOCUS       NM_001007145            3643 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus catenin alpha 1 (Ctnna1), mRNA.
ACCESSION   NM_001007145 XM_226048
VERSION     NM_001007145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M,
            Stucke EM, Amin L, Tai H, Putnam PE, Jimenez-Dalmaroni MJ, Wormald
            MR, Porollo A, Abonia JP and Rothenberg ME.
  TITLE     Cadherin 26 is an alpha integrin-binding epithelial receptor
            regulated during allergic inflammation
  JOURNAL   Mucosal Immunol 10 (5), 1190-1201 (2017)
   PUBMED   28051089
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Liu S, Gao Y, Yu X, Zhao B, Liu L, Zhao Y, Luo Z and Shi J.
  TITLE     Annexin-1 Mediates Microglial Activation and Migration via the CK2
            Pathway during Oxygen-Glucose Deprivation/Reperfusion
  JOURNAL   Int J Mol Sci 17 (10), 1770 (2016)
   PUBMED   27782092
  REMARK    GeneRIF: ANXA1 promotes microglial activation and migration during
            oxygen-glucose deprivation/reperfusion via FPR, and CK2 target
            alpha-E-catenin phosphorylation is involved in this process.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Bear MD, Liu T, Abualkhair S, Ghamloush MA, Hill NS, Preston I,
            Fanburg BL, Kayyali US and Toksoz D.
  TITLE     Alpha-Catulin Co-Localizes With Vimentin Intermediate Filaments and
            Functions in Pulmonary Vascular Endothelial Cell Migration via ROCK
  JOURNAL   J Cell Physiol 231 (4), 934-943 (2016)
   PUBMED   26377600
  REMARK    GeneRIF: alpha-catulin has a unique function in co-localization
            with vimentin filaments that contributes to vascular endothelial
            cells migration via a pathway that may involve ROCK signaling.
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Wang X, Grunz-Borgmann EA and Parrish AR.
  TITLE     Loss of alpha(E)-catenin potentiates cisplatin-induced
            nephrotoxicity via increasing apoptosis in renal tubular epithelial
            cells
  JOURNAL   Toxicol Sci 141 (1), 254-262 (2014)
   PUBMED   24973089
  REMARK    GeneRIF: Taken together, these data suggest that loss of
            alpha(E)-catenin increases apoptosis of tubular epithelial cells
            which may contribute to the increased nephrotoxicity induced by
            cisplatin in aged kidney.
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Ohsugi M, Hwang SY, Butz S, Knowles BB, Solter D and Kemler R.
  TITLE     Expression and cell membrane localization of catenins during mouse
            preimplantation development
  JOURNAL   Dev Dyn 206 (4), 391-402 (1996)
   PUBMED   8853988
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Hertig CM, Butz S, Koch S, Eppenberger-Eberhardt M, Kemler R and
            Eppenberger HM.
  TITLE     N-cadherin in adult rat cardiomyocytes in culture. II.
            Spatio-temporal appearance of proteins involved in cell-cell
            contact and communication. Formation of two distinct
            N-cadherin/catenin complexes
  JOURNAL   J Cell Sci 109 (Pt 1), 11-20 (1996)
   PUBMED   8834786
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Sacco PA, McGranahan TM, Wheelock MJ and Johnson KR.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Rubinfeld B, Souza B, Albert I, Munemitsu S and Polakis P.
  TITLE     The APC protein and E-cadherin form similar but independent
            complexes with alpha-catenin, beta-catenin, and plakoglobin
  JOURNAL   J Biol Chem 270 (10), 5549-5555 (1995)
   PUBMED   7890674
REFERENCE   10 (bases 1 to 3643)
  AUTHORS   Byers SW, Sujarit S, Jegou B, Butz S, Hoschutzky H, Herrenknecht K,
            MacCalman C and Blaschuk OW.
  TITLE     Cadherins and cadherin-associated molecules in the developing and
            maturing rat testis
  JOURNAL   Endocrinology 134 (2), 630-639 (1994)
   PUBMED   7507830
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085789.1.
            
            On Nov 22, 2004 this sequence version replaced XM_226048.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085789.1, SRR8487227.27012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3643
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /note="catenin alpha 1"
                     /db_xref="GeneID:307505"
                     /db_xref="RGD:1359485"
     exon            1..66
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..173
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2795
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /note="catenin (cadherin associated protein), alpha 1;
                     catenin (cadherin-associated protein), alpha 1, 102kDa;
                     catenin alpha-1-like"
                     /codon_start=1
                     /product="catenin alpha-1"
                     /protein_id="NP_001007146.1"
                     /db_xref="GeneID:307505"
                     /db_xref="RGD:1359485"
                     /translation="MTAVHTGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNS
                     KGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVDDVRKQGD
                     LMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDG
                     ILKLRNAGNEQDLGIQYRALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNV
                     PILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQQQGGGGG
                     GGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRER
                     IVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHV
                     SDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVK
                     LVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDIT
                     SIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYE
                     PGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGI
                     RDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQ
                     KAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKN
                     TSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKV
                     KAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNL
                     PAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI"
     exon            174..369
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..536
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..656
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..932
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1136
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1217
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1370
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1463
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1620
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1821
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1973
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2084
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2266
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2372
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2507
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..3619
                     /gene="Ctnna1"
                     /gene_synonym="Catna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaaagcg gtggccgtcg gcttggcgcc tcaggagtcg tccagcgctc gccccgttcg
       61 ccgcagaaat gactgccgtc cacacaggca acataaactt caaatgggac cccaaaagtc
      121 tagagattag aactctggct gttgaaagac tgttggagcc tcttgttaca caggtgacaa
      181 ccctggtaaa caccaatagt aaaggaccct ctaataaaaa gagaggccgt tctaagaagg
      241 cccatgtttt ggctgcatct gttgaacaag caactgagaa tttcttggaa aagggggaca
      301 aaatagcaaa agagagtcag tttcttaagg aggagcttgt ggctgctgtg gacgatgttc
      361 gaaaacaagg agatctgatg aagagcgctg ctggggagtt tgcagatgat ccgtgctctt
      421 ctgtgaagcg aggtaacatg gttcgggcag ctcgagctct gctttccgcc gttacccggc
      481 tgctgattct ggctgacatg gcagatgtct acaagttact tgttcagctg aaagttgtgg
      541 aagacggcat attgaagctg aggaatgctg gcaacgagca ggatctaggg atacagtaca
      601 gagctctgaa accagaagta gataagctga acatcatggc agcaaaacga caacaggaac
      661 tgaaagatgt gggccatcgt gatcaaatgg ctgcagctag aggaatcctg cagaaaaatg
      721 ttcccatcct ctacactgca tcccaggcat gcctgcagca ccccgatgta gcagcctaca
      781 aggccaaccg ggacttgata tacaagcagc tgcagcaggc cgtcacgggg atctctaatg
      841 ctgcccaggc tactgcatca gatgacgcct cccagcagca gggtggcggc ggcggcgggg
      901 gagagctggc gtatgctctc aacaactttg ataaacaaat cattgtggac cccttgagct
      961 tcagcgagga acgctttaga ccttcactgg aagaacgcct ggaaagcata attagcggag
     1021 ctgccctgat ggccgactca tcctgcacac gtgatgaccg gcgtgagcgc attgtggcag
     1081 agtgtaatgc tgtccgccag gctctacagg acctgctatc agaatacatg ggcaatgctg
     1141 gacgcaagga gaggagcgac gcactcaact ctgccataga taaaatgacc aagaagacca
     1201 gggacctgcg tcgacagctt cgcaaagctg tcatggacca cgtatcagat tccttcctgg
     1261 agaccaatgt ccctctttta gtactgattg aagctgcaaa gaatggaaac gagaaggagg
     1321 ttaaggagta tgcccaggtt tttcgtgaac acgccaacaa actgattgag gtcgccaact
     1381 tggcctgttc aatctccaat aatgaagaag gcgtgaagct cgttcggatg tctgcaagtc
     1441 agttagaagc gctctgtcct caggttatca atgctgcgtt ggctttagcg gcaaagccac
     1501 agagtaaact ggcccaagag aacatggatc tttttaaaga gcagtgggaa aaacaagtcc
     1561 gtgttctcac agatgctgtt gatgacatta cttccattga tgacttcttg gctgtctcag
     1621 agaaccacat tttggaagat gtgaacaagt gtgttatcgc tctccaagag aaagacgtgg
     1681 atgggctgga tcgcactgct ggggccattc gaggccgggc agcccgagtc attcatgtcg
     1741 tcacctcaga gatggacaac tacgagccag gagtttacac agaaaaggtt ctagaagcca
     1801 ccaaactcct ctccaacaca gtcatgccgc gtttcactga gcaagtggaa gcagctgtgg
     1861 aagccctcag ctcagacccc gcccagccta tggatgagaa tgagttcatc gacgcctccc
     1921 gtctggtata cgacggcatc cgggacatcc gcaaggccgt gctgatgata aggacccccg
     1981 aggagttgga cgactctgac ttcgagactg aagactttga tgtcagaagc aggaccagtg
     2041 tccagacaga agatgaccag ctgatagctg gacagagcgc ccgggcgatc atggctcagc
     2101 ttcctcagga gcagaaggca aagatcgcag agcaggtggc cagcttccag gaggagaaga
     2161 gcaagctgga cgctgaggtg tccaagtggg acgacagcgg caatgacatc attgtgctgg
     2221 ccaagcagat gtgcatgatc atgatggaga tgaccgactt cacccgaggc aaagggccac
     2281 tcaaaaacac atcggatgtg atcagtgctg ccaagaaaat tgctgaggca ggatccagga
     2341 tggataagct tggccggacc atcgcagacc actgcccaga ctccgcctgc aagcaggacc
     2401 tgctggccta ccttcagcgc atcgcgctct actgccacca gctcaacatc tgcagcaagg
     2461 tcaaggctga agtacagaac ctcggtggag agcttgtcgt ctctggggtg gacagcgcca
     2521 tgtccctgat ccaggcagcc aagaacttga tgaacgctgt agtgcagaca gtgaaggcgt
     2581 cctacgtggc ttccaccaaa taccagaagt cacaggggat ggcgtccctc aaccttcctg
     2641 ctgtgtcatg gaaaatgaaa gcccccgaga agaagccctt ggtgaagaga gagaagcagg
     2701 atgagacaca gaccaagatc aagcgggcct cccagaagaa gcacgtgaac cctgtgcagg
     2761 ccctcagcga gttcaaggcc atggacagca tctgagctcc gtagcccatg ggggtcccga
     2821 aaagtcggtc acatacttct ccactcagat gtgtttgcta agtagagagc tctgttgtat
     2881 tccacaggga gggagcagat ttcaaactca gccaggtggt gaattttgca aggacatgtt
     2941 tgtgttaaag ctggttagaa aaaaagcttt tagaattcaa aatatatttc tagctatatt
     3001 tttataagct taattgaaat aaaaattctg taatcagaga gtgccacatt aacttcttgg
     3061 tccatttctg aacaggccgg ggtgagcacc caagggagag gttgccttta gccctactgt
     3121 ggggcagtat ggaatcaaat ggccaagggt gacccagggt aaaccatggg gcaccttaaa
     3181 ctgtgtgaga aagaaggtcc agaaacctga ggaataaaac aatggattac cctggaaatt
     3241 gattggtttc tttatgaagc agaatgggaa ttatgattca cggctaagtt actaatgtgc
     3301 tctgctgtag gacactaata gagttgcttt tctcgggcta gaacgttgtg atgctgtaat
     3361 cagaacatgc ttcccctgtt attccagctg gaaatgcaaa ttcatcgtcg ggctctcgta
     3421 ataatcgcag tgtttcctgc tttgggctgg ctaaggagcc ttgacagcag tgttcgctta
     3481 ggcaataatt tagactccac cttacttgtg attactatag caattaccat agctacaaga
     3541 taagatttta ctgtcttatt taaattttat gaatctgttt tttacactaa ttttcccaat
     3601 aaagtctatt atgaaccaaa aaaaaaaaaa aaaaaaaaaa aaa
//
