LOCUS       NM_172333               1216 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus collagen triple helix repeat containing 1
            (Cthrc1), transcript variant 1, mRNA.
ACCESSION   NM_172333
VERSION     NM_172333.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Zhu,B., Ekman,M., Svensson,D., Lindvall,J.M., Nilsson,B.O.,
            Uvelius,B. and Sward,K.
  TITLE     Array profiling reveals contribution of Cthrc1 to growth of the
            denervated rat urinary bladder
  JOURNAL   Am J Physiol Renal Physiol 314 (5), F893-F905 (2018)
   PUBMED   29357417
  REMARK    GeneRIF: Cthrc1 has role in bladder growth following denervation.
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Zhang,Q., Yin,Z.S., Zhang,F.W., Cao,K. and Sun,H.Y.
  TITLE     CTHRC1 mediates IL-1beta-induced apoptosis in chondrocytes via
            JNK1/2 signaling
  JOURNAL   Int J Mol Med 41 (4), 2270-2278 (2018)
   PUBMED   29393342
  REMARK    GeneRIF: CTHRC1 downregulation suppresses IL-1beta-induced JNK1/2
            activation.
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Wang,C., Gu,W., Sun,B., Zhang,Y., Ji,Y., Xu,X. and Wen,Y.
  TITLE     CTHRC1 promotes osteogenic differentiation of periodontal ligament
            stem cells by regulating TAZ
  JOURNAL   J Mol Histol 48 (4), 311-319 (2017)
   PUBMED   28647773
  REMARK    GeneRIF: Overexpression of CHTRC1 increased osteogenic
            differentiation of periodontal ligament stem cells, which could be
            abolished by TAZ siRNA.
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Kimura,H., Kwan,K.M., Zhang,Z., Deng,J.M., Darnay,B.G.,
            Behringer,R.R., Nakamura,T., de Crombrugghe,B. and Akiyama,H.
  TITLE     Cthrc1 is a positive regulator of osteoblastic bone formation
  JOURNAL   PLoS One 3 (9), e3174 (2008)
   PUBMED   18779865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1216)
  AUTHORS   Yamamoto,S., Nishimura,O., Misaki,K., Nishita,M., Minami,Y.,
            Yonemura,S., Tarui,H. and Sasaki,H.
  TITLE     Cthrc1 selectively activates the planar cell polarity pathway of
            Wnt signaling by stabilizing the Wnt-receptor complex
  JOURNAL   Dev Cell 15 (1), 23-36 (2008)
   PUBMED   18606138
REFERENCE   8  (bases 1 to 1216)
  AUTHORS   Leclair,R.J., Wang,Q., Benson,M.A., Prudovsky,I. and Lindner,V.
  TITLE     Intracellular localization of Cthrc1 characterizes differentiated
            smooth muscle
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (7), 1332-1338 (2008)
   PUBMED   18467647
  REMARK    GeneRIF: Intracellular localization of Cthrc1 characterizes
            differentiated smooth muscle.
REFERENCE   9  (bases 1 to 1216)
  AUTHORS   LeClair,R.J., Durmus,T., Wang,Q., Pyagay,P., Terzic,A. and
            Lindner,V.
  TITLE     Cthrc1 is a novel inhibitor of transforming growth factor-beta
            signaling and neointimal lesion formation
  JOURNAL   Circ Res 100 (6), 826-833 (2007)
   PUBMED   17322174
  REMARK    GeneRIF: Cthrc1 is a cell-type-specific inhibitor of transforming
            growth factor-beta, which in turn impacts collagen type I and III
            deposition, neointimal formation, and dedifferentiation of smooth
            muscle cells.
            Erratum:[Circ Res. 2012 May 11;110(10):e72]
REFERENCE   10 (bases 1 to 1216)
  AUTHORS   Pyagay,P., Heroult,M., Wang,Q., Lehnert,W., Belden,J., Liaw,L.,
            Friesel,R.E. and Lindner,V.
  TITLE     Collagen triple helix repeat containing 1, a novel secreted protein
            in injured and diseased arteries, inhibits collagen expression and
            promotes cell migration
  JOURNAL   Circ Res 96 (2), 261-268 (2005)
   PUBMED   15618538
  REMARK    GeneRIF: CTHRC1 is transiently expressed in the arterial wall in
            response to injury where it may contribute to vascular remodeling
            by limiting collagen matrix deposition and promoting cell
            migration.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 13, 2012 this sequence version replaced NM_172333.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY136824.1, SRR26643294.29101.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000007.1  72007372-72007641
            271-492             JAXUCZ010000007.1  72011364-72011585
            493-709             JAXUCZ010000007.1  72014987-72015203
            710-1216            JAXUCZ010000007.1  72017148-72017654
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..1216
                     /gene="Cthrc1"
                     /note="collagen triple helix repeat containing 1"
                     /db_xref="GeneID:282836"
                     /db_xref="RGD:628801"
     exon            1..270
                     /gene="Cthrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..852
                     /gene="Cthrc1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagen triple helix repeat-containing protein
                     1"
                     /codon_start=1
                     /product="collagen triple helix repeat-containing protein
                     1 isoform 1 precursor"
                     /protein_id="NP_758836.1"
                     /db_xref="GeneID:282836"
                     /db_xref="RGD:628801"
                     /translation="MHPQGRAASPQLLLGLFLVLLLLLQLSAPSSASENPKVKQKALI
                     RQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEE
                     SWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWY
                     FTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIGAGLVDVAIWVG
                     TCSDYPKGDASTGWNSVSRIIIEELPK"
     exon            271..492
                     /gene="Cthrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..709
                     /gene="Cthrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1216
                     /gene="Cthrc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagtgaaag gcgcattgat gcggccggcc gcagagctgg gccagacgct gagcagggcc
       61 gggctctgcc gacccctttg cctcctgctc tgcgcttcgc agctaccgca cacgatgcac
      121 ccccaaggcc gcgccgcctc cccacagctg ctgctcggcc tcttccttgt gctactgctg
      181 cttctgcagc tgtccgcgcc gtccagcgcc tctgagaatc ccaaggtgaa gcaaaaagcg
      241 ctgatccggc agagggaagt ggtagacctg tataatggga tgtgcctaca aggaccagca
      301 ggagttcctg gtcgcgatgg gagccctggg gccaatggca ttcctggcac accgggaatc
      361 ccaggtcggg atggattcaa aggagagaaa ggggagtgct taagggaaag ctttgaggaa
      421 tcctggaccc caaactacaa gcagtgttca tggagttcac ttaattatgg catagatctt
      481 gggaaaattg cggaatgtac attcacaaag atgcgatcca acagcgctct tcgagttctg
      541 ttcagtggct cgcttcggct caaatgcagg aatgcttgct gtcaacgctg gtattttacc
      601 tttaatggag ctgaatgttc aggacctctt cccattgaag ctatcatcta tctggaccaa
      661 ggaagccctg agttaaattc aactattaat attcatcgta cttcctccgt ggaaggactc
      721 tgtgaaggga ttggtgctgg actggtagac gtggccatct gggtcggcac ctgttcagat
      781 taccccaaag gagacgcttc tactgggtgg aattctgtgt cccgcatcat cattgaagaa
      841 ctaccaaaat aaagcccctg aaggtttcat tccctgcctc atttacttgt taaatcaagc
      901 ctctggatgg gtcatttaaa tgacatttca gaagtcactt atgtgctcag ccaaatgaaa
      961 aagcaaagtt aaatacgttt acagaccaaa gtgtgatctc acactttaag atctagcatt
     1021 atccatttta tttcaaccaa agatggtttc aggattttat ttctcattga ttactttttg
     1081 agcctatata ccggaatgct gttatagtct ttaatatttc ctactgttga cattttgaaa
     1141 catataaaag ttatgtcttt gtaagagctg tatagaatta ttttatatgt taaataaaat
     1201 gcttcaaaca acctta
//
