LOCUS       NM_017074               1786 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus cystathionine gamma-lyase (Cth), mRNA.
ACCESSION   NM_017074
VERSION     NM_017074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Liang,T., Xu,S., Liu,R. and Xia,X.
  TITLE     Activating transcription factor 6 alleviates secondary brain injury
            by increasing cystathionine gamma-lyase expression in a rat model
            of intracerebral hemorrhage
  JOURNAL   Aging (Albany NY) 16 (8), 6990-7008 (2024)
   PUBMED   38613810
  REMARK    GeneRIF: Activating transcription factor 6 alleviates secondary
            brain injury by increasing cystathionine gamma-lyase expression in
            a rat model of intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Li,H., Wei,Y., Xi,Y., Jiao,L., Wen,X., Wu,R., Chang,G., Sun,F. and
            Hao,J.
  TITLE     DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells
            damage induced by high glucose
  JOURNAL   Acta Cardiol 78 (5), 594-606 (2023)
   PUBMED   36197015
  REMARK    GeneRIF: DR1-CSE/H2S pathway upregulates autophagy and inhibits
            H9C2 cells damage induced by high glucose.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Cui,C., Fan,J., Zeng,Q., Cai,J., Chen,Y., Chen,Z., Wang,W.,
            Li,S.Y., Cui,Q., Yang,J., Tang,C., Xu,G., Cai,J. and Geng,B.
  TITLE     CD4+ T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide
            Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote
            T Regulatory Cell Differentiation and Proliferation
  JOURNAL   Circulation 142 (18), 1752-1769 (2020)
   PUBMED   32900241
  REMARK    GeneRIF: CD4(+) T-Cell Endogenous Cystathionine gamma
            Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating
            Liver Kinase B1 to Promote T Regulatory Cell Differentiation and
            Proliferation.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Grigoryuk capital A, Cyrilliccapital,A. Cyrillic and Kotsyuba
            capital A, Cyrilliccapital,I.E. Cyrillic.
  TITLE     Activity of Gas Transmitters in Vessels of the Anterior Abdominal
            Wall after Implantation of a Polypropylene Mesh
  JOURNAL   Bull Exp Biol Med 169 (6), 811-814 (2020)
   PUBMED   33123916
  REMARK    GeneRIF: Activity of Gas Transmitters in Vessels of the Anterior
            Abdominal Wall after Implantation of a Polypropylene Mesh.
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Chen,Y., Zhao,L., Jiang,S., Hu,Z., Hu,B., Tong,F. and Shen,R.
  TITLE     Cystathionine gamma-Lyase Is Involved in the Renoprotective Effect
            of Brief and Repeated Ischemic Postconditioning After Renal
            Ischemia/Reperfusion Injury in Diabetes Mellitus
  JOURNAL   Transplant Proc 50 (5), 1549-1557 (2018)
   PUBMED   29880385
  REMARK    GeneRIF: indings show that brief and repeated ischemic
            postconditioning increased the expression of CSE after
            ischemia/reperfusion in diabetes mellitus
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Martinez,M., Cuskelly,G.J., Williamson,J., Toth,J.P. and
            Gregory,J.F. 3rd.
  TITLE     Vitamin B-6 deficiency in rats reduces hepatic serine
            hydroxymethyltransferase and cystathionine beta-synthase activities
            and rates of in vivo protein turnover, homocysteine remethylation
            and transsulfuration
  JOURNAL   J Nutr 130 (5), 1115-1123 (2000)
   PUBMED   10801907
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Steegborn,C., Clausen,T., Sondermann,P., Jacob,U., Worbs,M.,
            Marinkovic,S., Huber,R. and Wahl,M.C.
  TITLE     Kinetics and inhibition of recombinant human cystathionine
            gamma-lyase. Toward the rational control of transsulfuration
  JOURNAL   J Biol Chem 274 (18), 12675-12684 (1999)
   PUBMED   10212249
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   House,J.D., Brosnan,M.E. and Brosnan,J.T.
  TITLE     Characterization of homocysteine metabolism in the rat kidney
  JOURNAL   Biochem J 328 (Pt 1) (Pt 1), 287-292 (1997)
   PUBMED   9359866
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Nishi,N., Tanabe,H., Oya,H., Urushihara,M., Miyanaka,H. and Wada,F.
  TITLE     Identification of probasin-related antigen as cystathionine
            gamma-lyase by molecular cloning
  JOURNAL   J Biol Chem 269 (2), 1015-1019 (1994)
   PUBMED   8288556
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Erickson,P.F., Maxwell,I.H., Su,L.J., Baumann,M. and Glode,L.M.
  TITLE     Sequence of cDNA for rat cystathionine gamma-lyase and comparison
            of deduced amino acid sequence with related Escherichia coli
            enzymes
  JOURNAL   Biochem J 269 (2), 335-340 (1990)
   PUBMED   2201285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 1, 2020 this sequence version replaced NM_017074.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078869.1, D17370.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000002.1  249660872-249661066 c
            196-277             JAXUCZ010000002.1  249657095-249657176 c
            278-373             JAXUCZ010000002.1  249656382-249656477 c
            374-483             JAXUCZ010000002.1  249654846-249654955 c
            484-615             JAXUCZ010000002.1  249651730-249651861 c
            616-673             JAXUCZ010000002.1  249649213-249649270 c
            674-751             JAXUCZ010000002.1  249647498-249647575 c
            752-904             JAXUCZ010000002.1  249645805-249645957 c
            905-1026            JAXUCZ010000002.1  249644619-249644740 c
            1027-1079           JAXUCZ010000002.1  249642898-249642950 c
            1080-1218           JAXUCZ010000002.1  249637995-249638133 c
            1219-1786           JAXUCZ010000002.1  249634731-249635298 c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..1786
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /note="cystathionine gamma-lyase"
                     /db_xref="GeneID:24962"
                     /db_xref="RGD:2443"
     exon            1..195
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1227
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /EC_number="4.4.1.1"
                     /EC_number="4.4.1.2"
                     /note="PRB-RA; gamma-cystathionase; probasin-related
                     antigen; CTL target antigen; cysteine-protein sulfhydrase;
                     cystathionase (cystathionine gamma-lyase); cysteine
                     desulfhydrase; homocysteine desulfhydrase"
                     /codon_start=1
                     /product="cystathionine gamma-lyase"
                     /protein_id="NP_058770.2"
                     /db_xref="GeneID:24962"
                     /db_xref="RGD:2443"
                     /translation="MQKDASSSGFLPSFQHFATQAIHVGQEPEQWSSRAVVLPISLAT
                     TFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFASGLAATTTITHLLKA
                     GDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTN
                     PTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSD
                     VVMGLVSVNSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVA
                     RFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLF
                     ALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQA
                     LKAAHP"
     exon            196..277
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            278..373
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            374..483
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            484..615
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            616..673
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            674..751
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            752..904
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1026
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1079
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1218
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1786
                     /gene="Cth"
                     /gene_synonym="CGL; CSE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaaagcc acacactccc cggccccagc atgcagaagg acgcctcctc cagcggcttc
       61 ctgcccagct tccagcactt tgccactcag gccatccacg tgggacaaga gccggagcaa
      121 tggagttcgc gtgctgtggt gctgcccatt tcgctggcca ccacgttcaa acaggactct
      181 ccaggccagt cctcgggttt tgtatacagc cgctctggaa atccgacgag gaattgcttg
      241 gaaaaagcag tggctgcact ggatggggca aagcactgtt tgaccttcgc ctcggggctt
      301 gccgccacca caacgattac ccatctttta aaagcaggag atgaagtcat ttgcatggat
      361 gaagtgtatg gaggcaccaa caggtacttc aggagggtgg catccgagtt tggactgaag
      421 atttcttttg tggattgttc caaaaccaaa ttgctggagg cagcgatcac accacagacc
      481 aagcttgttt ggattgaaac acccacaaac ccaaccttga agttggccga catcaaagcc
      541 tgcgcacaaa ttgtccacaa acacaaagac atcattctgg ttgtagataa cactttcatg
      601 tctgcatatt tccagagacc tttggctctg ggtgctgata tttgtatgtg ttctgccaca
      661 aaatacatga acggccacag tgatgttgtc atgggcttag tgtctgttaa ttccgatgac
      721 ctcaacgaac ggcttcgttt cctgcagaat tctctcgggg cagttccttc tcctttcgat
      781 tgttacctct gctgccgagg cctgaagaca ctgcagatcc ggatggagaa acacttcagg
      841 aatgggatgg cagtggcccg tttcctggag tctaatcccc gggtagaaaa ggttatttat
      901 cctgggctac cgtctcaccc tcagcatgag ctcgccaaac gtcagtgcac gggctgcccc
      961 gggatggtca gtttctatat caagggtact ctgcagcatg ctcaggtctt cctcaaaaat
     1021 ataaagctgt ttgctctggc tgagagcctg ggaggatatg agagtctggc tgagcttcca
     1081 gcaatcatga cccatgcctc cgtgcctgag aaggacagag ctaccctcgg gatcagtgac
     1141 acactgatcc gactttctgt gggcctagag gatgaaaagg accttctcga agacctgggt
     1201 caagctttaa aggcagcgca cccttaaagt tcgagtcaaa accggcattc cagtgctgcc
     1261 atcagcagca gcatccaagg ggccagacct tctgaataac tggacagacc attaaggagc
     1321 atctgcagaa cttcgcagtg aacattttaa gaccctagtg attttacagc tgtaacctta
     1381 cggggatctt cccttaagga ctgtcttctg ctaacaggtt gttctgttag tatcattctg
     1441 atagttttgc tgtatttgtg ttcaaggaag agagttgtat tattttgggg atcatgttgc
     1501 ttcttttttc ctttttcttt cttcggtagc ctaagatatg ttttaatcat gtttacaaaa
     1561 tttagtattg atgttttatg aagttaaatt attcaatgaa cggtcttaaa tcaactgtag
     1621 ggtttttttt ttttgaaaaa ttattgaaag tggggggttt ttatttaatt accataagcc
     1681 aaaaaaatca aatatttgga atatctactg tgaaattcta gtgattaaag gttgtacttg
     1741 atacttgttg tttttcttaa ataaatataa ttaccaaatg taccta
//
