LOCUS       NM_017129               1398 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cardiotrophin 1 (Ctf1), mRNA.
ACCESSION   NM_017129
VERSION     NM_017129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Chen,K.C., Hsieh,C.L., Peng,C.C. and Peng,R.Y.
  TITLE     Exercise rescued chronic kidney disease by attenuating cardiac
            hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3
            pathway
  JOURNAL   Eur J Prev Cardiol 21 (4), 507-520 (2014)
   PUBMED   23064267
  REMARK    GeneRIF: In the chronic kidney disease-cardiac hypertrophy model
            exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp
            130/JAK/STAT3 pathway.
REFERENCE   2  (bases 1 to 1398)
  AUTHORS   Maayah,Z.H., Ansari,M.A., El Gendy,M.A., Al-Arifi,M.N. and
            Korashy,H.M.
  TITLE     Development of cardiac hypertrophy by sunitinib in vivo and in
            vitro rat cardiomyocytes is influenced by the aryl hydrocarbon
            receptor signaling pathway
  JOURNAL   Arch Toxicol 88 (3), 725-738 (2014)
   PUBMED   24247421
REFERENCE   3  (bases 1 to 1398)
  AUTHORS   Asrih,M., Gardier,S., Papageorgiou,I. and Montessuit,C.
  TITLE     Dual effect of the heart-targeting cytokine cardiotrophin-1 on
            glucose transport in cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 56, 106-115 (2013)
   PUBMED   23277190
  REMARK    GeneRIF: Cardiotrophin-1 modulates glucose transport in
            cardiomyocytes positively or negatively depending on its
            concentration.
REFERENCE   4  (bases 1 to 1398)
  AUTHORS   Ruiz-Hurtado,G., Gomez-Hurtado,N., Fernandez-Velasco,M.,
            Calderon,E., Smani,T., Ordonez,A., Cachofeiro,V., Bosca,L.,
            Diez,J., Gomez,A.M. and Delgado,C.
  TITLE     Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and
            arrhythmogenesis in adult rat ventricular myocytes
  JOURNAL   Cardiovasc Res 96 (1), 81-89 (2012)
   PUBMED   22787135
  REMARK    GeneRIF: Cardiomyocytes treated with CT-1 present high spontaneous
            Ca(2+) release during diastole, a mechanism linked to
            arrhythmogenicity in the pathologic heart.
REFERENCE   5  (bases 1 to 1398)
  AUTHORS   Lopez-Andres,N., Rousseau,A., Akhtar,R., Calvier,L., Inigo,C.,
            Labat,C., Zhao,X., Cruickshank,K., Diez,J., Zannad,F., Lacolley,P.
            and Rossignol,P.
  TITLE     Cardiotrophin 1 is involved in cardiac, vascular, and renal
            fibrosis and dysfunction
  JOURNAL   Hypertension 60 (2), 563-573 (2012)
   PUBMED   22733458
  REMARK    GeneRIF: Cardiotrophin 1 is involved in cardiac, vascular, and
            renal fibrosis and dysfunction.
REFERENCE   6  (bases 1 to 1398)
  AUTHORS   Naeem,A., Abbas,L. and Guthrie,S.
  TITLE     Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the
            branchial arches on the growth of embryonic cranial motor neurons
  JOURNAL   J Neurobiol 51 (2), 101-114 (2002)
   PUBMED   11932952
  REMARK    GeneRIF: Cardiotrophin-1 promotes the outgrowth of embryonic
            cranial motor neurons in isolated stage E12 hindbrain explants.
REFERENCE   7  (bases 1 to 1398)
  AUTHORS   Railson,J.E., Liao,Z., Brar,B.K., Buddle,J.C., Pennica,D.,
            Stephanou,A. and Latchman,D.S.
  TITLE     Cardiotrophin-1 and urocortin cause protection by the same pathway
            and hypertrophy via distinct pathways in cardiac myocytes
  JOURNAL   Cytokine 17 (5), 243-253 (2002)
   PUBMED   12027405
  REMARK    GeneRIF: CT1 has a role in hypertrophy of rat cardiomyocytes as
            measured by an increase in cell area and enhanced protein: DNA
            ratio
REFERENCE   8  (bases 1 to 1398)
  AUTHORS   Craig,R., Wagner,M., McCardle,T., Craig,A.G. and Glembotski,C.C.
  TITLE     The cytoprotective effects of the glycoprotein 130 receptor-coupled
            cytokine, cardiotrophin-1, require activation of NF-kappa B
  JOURNAL   J Biol Chem 276 (40), 37621-37629 (2001)
   PUBMED   11448959
  REMARK    GeneRIF: CT-1 signals through p38, ERK, and Akt in a parallel
            manner to activate NF-kappa B and that NF-kappa B is required for
            CT-1 to mediate its full cytoprotective effects in cardiac
            myocytes.
REFERENCE   9  (bases 1 to 1398)
  AUTHORS   Erdmann,J., Hassfeld,S., Kallisch,H., Fleck,E. and
            Regitz-Zagrose,V.
  TITLE     Genetic variants in the promoter (g983G>T) and coding region (A92T)
            of the human cardiotrophin-1 gene (CTF1) in patients with dilated
            cardiomyopathy
  JOURNAL   Hum Mutat 16 (5), 448 (2000)
   PUBMED   11058912
REFERENCE   10 (bases 1 to 1398)
  AUTHORS   Ishikawa,M., Saito,Y., Miyamoto,Y., Kuwahara,K., Ogawa,E.,
            Nakagawa,O., Harada,M., Masuda,I. and Nakao,K.
  TITLE     cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of
            CT-1 gene in ventricle of genetically hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 219 (2), 377-381 (1996)
   PUBMED   8604995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D78591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78591.1, BC072690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1398
                     /gene="Ctf1"
                     /note="cardiotrophin 1"
                     /db_xref="GeneID:29201"
                     /db_xref="RGD:2442"
     exon            1..62
                     /gene="Ctf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..649
                     /gene="Ctf1"
                     /note="CT-1"
                     /codon_start=1
                     /product="cardiotrophin-1"
                     /protein_id="NP_058825.1"
                     /db_xref="GeneID:29201"
                     /db_xref="RGD:2442"
                     /translation="MSQREGSLEDHQTDSSFSFLPHLEAKIRQTHNLARLLTKYADQL
                     LEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSALPALLD
                     AVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPVPEPVATSAL
                     FTSNSAAGVFSAKVLGLHVCGLYGEWVSRTEGDLGQLVPGGVA"
     exon            63..181
                     /gene="Ctf1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..1398
                     /gene="Ctf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgtgttga aggaaacagg atcagcctgg ggccagcatg agccagaggg agggaagtct
       61 ggaagaccac cagactgact cctcattctc attcctaccc catttggagg ccaagatccg
      121 acagacacac aaccttgcac gcctcctgac caaatatgca gaccaattgc tggaggaata
      181 tgtgcagcaa cagggagagc cctttgggct gccgggcttc tcaccaccgc ggctgccgct
      241 ggccggcctg agtggcccgg ctccgagcca cgcggggcta ccggtgtccg agcggctgcg
      301 gcaggatgca gccgccttga gtgctctgcc cgcgctattg gatgctgtgc gccgccgcca
      361 ggcggagctg aacccacgcg ccccgcgcct actgcggagc ctggaggacg ctgcccgcca
      421 ggttcgggcc ctgggcgccg cggtggagac cgtgctggcc gctctgggcg ctgcagcccg
      481 cgggcccgtg ccagagcctg tcgccacctc cgccctcttc acctccaaca gtgcggcagg
      541 cgtcttctca gctaaggtgc tggggctcca cgtgtgcggc ctctatggcg agtgggtgag
      601 ccgcaccgag ggtgacctgg gccaactggt gccagggggc gttgcctgag actcagtact
      661 tgttcttgca agctcactct gtcccgcctc ttcggcttct aattctccgt ctctccatct
      721 atgtcatcca tgtgtgttct tgggctgtcc ctatctttct gcattgtgtg atctctttct
      781 cttctgctct cgcctcctca gggagcttct tgtgcccact agtttctcat tttgtctttc
      841 tgtcttgaac tcttctgttt ccaagaggtt tctgtttctg tttccttgtc tcttggttct
      901 ttctttcttt gcttgcttgc ttgtttgttt ttgagacagg gtcttaccat atagctctag
      961 gtggcctgga acttgctgtg taggccagcc tggcctcgaa ctcatagaaa ttcacctgcc
     1021 tctgactccc aatttcccca tctgtctccc tgtggtctat atgggtaggt gtaactctta
     1081 cttcatttca tggaggtgac atttttctcc tttcaatttc tttgttcttt actaaccaga
     1141 aaagtgccta cttgtcccct ggtggcaaga ccacccaccc tcaggacctt ccttcccacc
     1201 agttcctttg taggcaaatc cctccccctt tgaggtcctc ccatttctta cctccctact
     1261 gtgttttcaa tggcccccag tccttaggct ggtcaatggg aagggaaggg cagaaaaaca
     1321 tcttaagagt tttatttgag aataaattaa atttttgtaa ataaattgtt taacaataaa
     1381 actaaagttt tatgaagc
//
