LOCUS       NM_001414395            3743 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus CTD phosphatase subunit 1 (Ctdp1), mRNA.
ACCESSION   NM_001414395 XM_006254942
VERSION     NM_001414395.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Jeronimo,C., Bataille,A.R. and Robert,F.
  TITLE     The writers, readers, and functions of the RNA polymerase II
            C-terminal domain code
  JOURNAL   Chem Rev 113 (11), 8491-8522 (2013)
   PUBMED   23837720
  REMARK    Review article
REFERENCE   2  (bases 1 to 3743)
  AUTHORS   Sakai,S., Kimura,T., Wang,Z., Shimojo,N., Maruyama,H., Homma,S.,
            Kuga,K., Yamaguchi,I., Aonuma,K. and Miyauchi,T.
  TITLE     Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated
            by transcription factor II-F interacting C-terminal domain
            phosphatase of RNA polymerase II
  JOURNAL   Life Sci 91 (13-14), 572-577 (2012)
   PUBMED   22569295
  REMARK    GeneRIF: These findings suggest that FCP1 plays an important role
            in endothelin-1-induced cardiac hypertrophy via controlling
            phosphorylation level of the RNAPII CTD.
REFERENCE   3  (bases 1 to 3743)
  AUTHORS   Egloff,S., Dienstbier,M. and Murphy,S.
  TITLE     Updating the RNA polymerase CTD code: adding gene-specific layers
  JOURNAL   Trends Genet 28 (7), 333-341 (2012)
   PUBMED   22622228
  REMARK    Review article
REFERENCE   4  (bases 1 to 3743)
  AUTHORS   Visconti,R., Palazzo,L., Della Monica,R. and Grieco,D.
  TITLE     Fcp1-dependent dephosphorylation is required for M-phase-promoting
            factor inactivation at mitosis exit
  JOURNAL   Nat Commun 3, 894 (2012)
   PUBMED   22692537
  REMARK    Erratum:[Nat Commun. 2013;4:ncomms2363]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3743)
  AUTHORS   Abbott,K.L., Archambault,J., Xiao,H., Nguyen,B.D., Roeder,R.G.,
            Greenblatt,J., Omichinski,J.G. and Legault,P.
  TITLE     Interactions of the HIV-1 Tat and RAP74 proteins with the RNA
            polymerase II CTD phosphatase FCP1
  JOURNAL   Biochemistry 44 (8), 2716-2731 (2005)
   PUBMED   15723517
REFERENCE   6  (bases 1 to 3743)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J Biol Chem 278 (28), 26078-26085 (2003)
   PUBMED   12721286
REFERENCE   7  (bases 1 to 3743)
  AUTHORS   Nguyen,B.D., Abbott,K.L., Potempa,K., Kobor,M.S., Archambault,J.,
            Greenblatt,J., Legault,P. and Omichinski,J.G.
  TITLE     NMR structure of a complex containing the TFIIF subunit RAP74 and
            the RNA polymerase II carboxyl-terminal domain phosphatase FCP1
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5688-5693 (2003)
   PUBMED   12732728
REFERENCE   8  (bases 1 to 3743)
  AUTHORS   Archambault,J., Pan,G., Dahmus,G.K., Cartier,M., Marshall,N.,
            Zhang,S., Dahmus,M.E. and Greenblatt,J.
  TITLE     FCP1, the RAP74-interacting subunit of a human protein phosphatase
            that dephosphorylates the carboxyl-terminal domain of RNA
            polymerase IIO
  JOURNAL   J Biol Chem 273 (42), 27593-27601 (1998)
   PUBMED   9765293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 23, 2022 this sequence version replaced XM_006254942.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2753516.1,
                                           SRR26643289.41914.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000018.1  76189895-76190354   c
            461-544             JAXUCZ010000018.1  76180449-76180532   c
            545-638             JAXUCZ010000018.1  76179723-76179816   c
            639-767             JAXUCZ010000018.1  76179185-76179313   c
            768-918             JAXUCZ010000018.1  76176608-76176758   c
            919-1009            JAXUCZ010000018.1  76173472-76173562   c
            1010-1176           JAXUCZ010000018.1  76171504-76171670   c
            1177-2223           JAXUCZ010000018.1  76169548-76170594   c
            2224-2365           JAXUCZ010000018.1  76168533-76168674   c
            2366-2575           JAXUCZ010000018.1  76166969-76167178   c
            2576-2738           JAXUCZ010000018.1  76155569-76155731   c
            2739-2926           JAXUCZ010000018.1  76141645-76141832   c
            2927-3743           JAXUCZ010000018.1  76129243-76130059   c
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..3743
                     /gene="Ctdp1"
                     /note="CTD phosphatase subunit 1"
                     /db_xref="GeneID:291414"
                     /db_xref="RGD:1311755"
     exon            1..460
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3068
                     /gene="Ctdp1"
                     /EC_number="3.1.3.16"
                     /note="CTD (carboxy-terminal domain, RNA polymerase II,
                     polypeptide A) phosphatase, subunit 1"
                     /codon_start=1
                     /product="RNA polymerase II subunit A C-terminal domain
                     phosphatase"
                     /protein_id="NP_001401324.1"
                     /db_xref="GeneID:291414"
                     /db_xref="RGD:1311755"
                     /translation="MEAPPLAGVPTECTPAVAGAEVRCPGPAPLRLLEWKVTAGATVR
                     IGSVLAVYEAAVSAQPAGPAPARAASGGCVRASRTERRLRSERAGVVRELCAQPGQVV
                     APGALLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELM
                     VSSEQAEKLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCPQMSNKGIFHFQLGRGE
                     PMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDE
                     CIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFPGTGDVNAPPG
                     ARESQTRKKVNHSSKGADILEQALPVKDPEEGKPPGVEQSNGLGKASRELNGGEAVPG
                     VFSSKTDEKETWSLTRASPASSSGGRELTEAPELPVSCEWDSRTAPGAHPTQGDATQG
                     LDFDLSSDSESSESSRSEGQKSFSSASDGENEERRRRKKSPATQDRTKVPQHSGPHDT
                     SGGRSAASPSGESGPLHPHDKVSDPDTQEEGERDSLCGLGNGSVDRKEAETESQNSEQ
                     SGVTAGESLDQSVGEEEEEDTDDDDHLIHLEEILVRVHTDYYTKYDRYLNKELEEAPD
                     IRKIVPELKSKVLADVAVIFSGLHPTNFPVEKTREHYHATALGAKVLTQLVLSPDAPD
                     RATHLIAARAGTEKVRQAQECKHLHVVSPEWLWSCLERWDKVEEQLFPLMDEDTRTHR
                     DNSPAVFPDRHSMLPTALFHPTPIHSKAHPGPEVRIYDSNTGKLIRMGTQGPAPALSS
                     APLIHGEPSSFRAVQPHQQQMFGEELPESQDGEQPGPARRKRQPSMSETMPLYTLCKE
                     DLESMDKEVDDILGEGSDDSESEKKKAEDQDSEQERARKPRKPRAPGTRREQPAGLPS
                     PGERSAAGTRAPRGHKRKLNEEDAASESSGESSNDDEEGSSSEADEMAAALEAELNDL
                     M"
     exon            461..544
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..638
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..767
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..918
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1009
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1176
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..2223
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2365
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2575
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2738
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2926
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3743
                     /gene="Ctdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgcgcag cgagcggcgg gtgaagccgg tgtcggagcg ggaacagcag tgtcgccgcc
       61 gcccgcggtg ggcgccgcgc cctgagcgcc cggtgttttc gtttctcacc tctgttgtga
      121 ccgtccgtgc cgctcgctgg gtcacgatgg aagcgccgcc cttggccggc gttcccaccg
      181 agtgcactcc ggcggtggcc ggggcagagg tgcgctgccc gggccccgcg ccgctgcgtc
      241 tgctggagtg gaaggtgacg gcgggcgcga ccgtgcgcat tggctcggtg ctggcagtgt
      301 acgaagccgc agtctccgcg cagcccgcag ggccagcccc ggctcgcgcg gcctctgggg
      361 gctgcgtgcg cgcctcgcgg acagagcgca ggctcaggtc ggagcgcgcc ggcgtggtcc
      421 gtgaactgtg tgcgcagcca ggccaggtgg tggcccctgg ggcacttctg gtgcggttgg
      481 aaggatgtag ccaccctgtt gtcatgaagg gcctgtgtgc tgagtgtggc caggacctga
      541 cccagttgca gagtaaaaac ggaaagcagc aggtaccact ttctacagcg actgtttcca
      601 tggtgcacag tgtgccggag ttgatggtga gctctgagca agctgaaaaa ctaggaagag
      661 aagatcagca gcgactacat cgaaacagaa agctggttct catggtagac ttggaccaga
      721 ccctgattca tacgactgag cagcattgtc cccagatgtc caacaaaggc atcttccact
      781 tccagctggg ccgaggggag cccatgctgc acacccgcct gaggcctcac tgcaaggact
      841 tcctggagaa aatcgccaag ctgtatgagc tgcatgtttt cactttcggc agccgtctgt
      901 atgcccacac catcgcgggc tttttggacc ctgagaagaa gcttttttct catcgaatat
      961 tatctagaga tgaatgtatt gacccgtttt ctaaaacagg aaaccttaga aatctctttc
     1021 cctgtggaga ttcaatggtt tgcatcattg atgaccgaga ggatgtgtgg aagttcgccc
     1081 ctaaccttat aactgtgaag aagtatgtct atttcccagg cacaggtgat gtgaacgcac
     1141 cccctggggc ccgggaatct cagacaagga aaaaagtaaa tcattcttcc aaaggagcgg
     1201 acatcttgga acaagctctg ccagtcaagg accctgagga aggcaaacct cctggggtgg
     1261 aacagagcaa tggccttggg aaggcctccc gggagctcaa tggtggtgag gctgtgccag
     1321 gagttttttc cagtaaaaca gatgagaagg aaacctggtc cctcacccgt gcctctcctg
     1381 ccagcagctc tggtggccga gagctgacag aagctccaga gctccctgtg tcttgtgagt
     1441 gggacagtcg gacagcacca ggagcgcacc ctactcaggg agatgccacc caaggtttgg
     1501 acttcgacct gtccagtgac agtgagagca gtgagagcag caggtcagaa ggccagaagt
     1561 ccttctcctc tgcttccgat ggggagaatg aggagaggag acgcagaaag aagtctccag
     1621 ccacccagga tagaacaaaa gttccacagc acagtgggcc ccatgacacg agtgggggga
     1681 ggtctgcagc aagcccctcg ggagagtctg ggcctctcca cccacatgac aaagtgtccg
     1741 acccagatac tcaggaggag ggtgagcgag acagcctctg tggcctgggc aacggcagtg
     1801 tggaccggaa ggaggctgag acagagtcac agaacagtga acagtcaggt gtcactgcag
     1861 gcgagtccct agaccagagt gttggggagg aagaggaaga ggacacagat gacgatgacc
     1921 acttgataca cctcgaggag atcctagtgc gagtacacac tgactattac acaaaatatg
     1981 acagatacct caacaaggag cttgaggaag ctccagatat acggaaaatt gtgccagagc
     2041 tcaagagcaa ggtgctagca gatgtggccg tcattttcag tgggctgcac ccaacaaact
     2101 ttcctgtgga gaagactcgt gagcactatc atgccacagc tctgggagcc aaggtcctca
     2161 cccagctagt gctgagccct gacgctccag acagggccac tcacctcatt gcagcgcggg
     2221 ccggcacaga gaaggtgcgc caggcacagg agtgcaaaca cctgcatgtg gtcagccctg
     2281 aatggctgtg gagctgcctg gagcgctggg acaaggtaga ggagcagctc ttcccgctca
     2341 tggatgagga tacccggaca catagggata acagccctgc agtctttcca gacagacaca
     2401 gtatgcttcc cacagccttg ttccacccaa cacccatcca ttccaaggcc catcctggtc
     2461 ctgaggttcg gatctatgac tctaacacag gcaagctcat ccggatgggc acccagggtc
     2521 ctgcaccagc tctttccagt gccccactta tccatggaga gccctcctcc ttcagagctg
     2581 ttcagccaca tcagcagcaa atgtttggtg aagagctgcc agaatcccaa gatggagagc
     2641 agcctggccc tgctagaaga aagcgacagc ccagtatgtc agagacaatg ccgctgtaca
     2701 ctctctgtaa ggaggactta gagagtatgg acaaagaggt ggacgacatc cttggagaag
     2761 gcagtgatga cagtgagagc gagaagaaga aggcagaaga ccaagacagt gagcaggaga
     2821 gagcacgcaa gcccaggaag cccagggccc caggcacccg aagagagcag ccggcagggc
     2881 tgccctcacc tggcgagagg agcgccgctg gcacgcgtgc gcccagaggc cacaagagaa
     2941 aactgaatga ggaagacgcg gccagcgagt ccagtgggga gtccagcaac gatgatgagg
     3001 agggcagcag ttcggaagca gacgagatgg ccgctgctct ggaggcggag cttaatgacc
     3061 tcatgtgact tggacccgcc ccataccagc ccttggcttg ggtccttttt ctccagaaaa
     3121 acatatattt tgcagagctc cacatacaga aacacattat tttgcagaaa taagtgtttg
     3181 taagaagttt tactatagga aaatctactt ttttaagtga cagtgttctg aggagttggt
     3241 gtgcgatgcc aaagagctca cagggcctcc cacgcaagca tggatatgtg atgtctggtc
     3301 gtgtggtgag ggccttgggg gcttcccttt gaatactaag catatttagt gtgaggactg
     3361 ggaacccagg aagatttaaa gagcaataga gcaaaacctg gcaccttggg ccttttccac
     3421 agctgatgct gtcagaattt tgaaggattt ttaagtaaag cagcagtgta catatgtgtg
     3481 tacagaacac cgagactcac aggcaggcct gagagcccca gcccccttca gtccctcggc
     3541 ggctccgcgg atggcctgga ggtcccggct cgtccttgtc tgcagcctgg gctgcctggg
     3601 ccatccatag cctgccagtg cgggcagtgt gataagagct ggtctgtacc gccctgaaag
     3661 aggtctgatg taaagttttt gtatatttca tattccgccc accagattct tcttccattt
     3721 aataaaatcc tttttgtaag ttg
//
