LOCUS       NM_031824               3708 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Rattus norvegicus CCCTC-binding factor (Ctcf), mRNA.
ACCESSION   NM_031824
VERSION     NM_031824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3708)
  AUTHORS   He,T., You,M., Zhu,H., Chen,P. and Fang,S.
  TITLE     CCCTC-binding factor suppresses alpha-2-macroglobulin transcription
            to improve vascular endothelial cell functions in lower extremity
            arteriosclerosis obliterans
  JOURNAL   Gen Physiol Biophys 43 (3), 231-242 (2024)
   PUBMED   38774923
  REMARK    GeneRIF: CCCTC-binding factor suppresses alpha-2-macroglobulin
            transcription to improve vascular endothelial cell functions in
            lower extremity arteriosclerosis obliterans.
REFERENCE   2  (bases 1 to 3708)
  AUTHORS   Shen,J., Han,Q., Li,W., Chen,X., Lu,J., Zheng,J. and Xue,S.
  TITLE     miR-383-5p Regulated by the Transcription Factor CTCF Affects
            Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase
            HDAC9 Activity
  JOURNAL   Mol Neurobiol 59 (10), 6307-6320 (2022)
   PUBMED   35927544
  REMARK    GeneRIF: miR-383-5p Regulated by the Transcription Factor CTCF
            Affects Neuronal Impairment in Cerebral Ischemia by Mediating
            Deacetylase HDAC9 Activity.
REFERENCE   3  (bases 1 to 3708)
  AUTHORS   Wang,D., Lin,B., Zhang,W. and Wang,X.
  TITLE     Up-regulation of SNHG16 induced by CTCF accelerates cardiac
            hypertrophy by targeting miR-182-5p/IGF1 axis
  JOURNAL   Cell Biol Int 44 (7), 1426-1435 (2020)
   PUBMED   32125046
  REMARK    GeneRIF: Up-regulation of SNHG16 induced by CTCF accelerates
            cardiac hypertrophy by targeting miR-182-5p/IGF1 axis.
REFERENCE   4  (bases 1 to 3708)
  AUTHORS   Akhtar,M.S., Akhter,N., Najm,M.Z., Deo,S.V.S., Shukla,N.K.,
            Almalki,S.S.R., Alharbi,R.A., Sindi,A.A.A., Alruwetei,A., Ahmad,A.
            and Husain,S.A.
  TITLE     Association of mutation and low expression of the CTCF gene with
            breast cancer progression
  JOURNAL   Saudi Pharm J 28 (5), 607-614 (2020)
   PUBMED   32435142
REFERENCE   5  (bases 1 to 3708)
  AUTHORS   Lupey-Green,L.N., Caruso,L.B., Madzo,J., Martin,K.A., Tan,Y.,
            Hulse,M. and Tempera,I.
  TITLE     PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain
            Epstein-Barr Virus Latency Type
  JOURNAL   J Virol 92 (18), e00755-18 (2018)
   PUBMED   29976663
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3708)
  AUTHORS   Chao,W., Huynh,K.D., Spencer,R.J., Davidow,L.S. and Lee,J.T.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
REFERENCE   7  (bases 1 to 3708)
  AUTHORS   Yang,Y., Quitschke,W.W., Vostrov,A.A. and Brewer,G.J.
  TITLE     CTCF is essential for up-regulating expression from the amyloid
            precursor protein promoter during differentiation of primary
            hippocampal neurons
  JOURNAL   J Neurochem 73 (6), 2286-2298 (1999)
   PUBMED   10582586
REFERENCE   8  (bases 1 to 3708)
  AUTHORS   Filippova,G.N., Lindblom,A., Meincke,L.J., Klenova,E.M.,
            Neiman,P.E., Collins,S.J., Doggett,N.A. and Lobanenkov,V.V.
  TITLE     A widely expressed transcription factor with multiple DNA sequence
            specificity, CTCF, is localized at chromosome segment 16q22.1
            within one of the smallest regions of overlap for common deletions
            in breast and prostate cancers
  JOURNAL   Genes Chromosomes Cancer 22 (1), 26-36 (1998)
   PUBMED   9591631
REFERENCE   9  (bases 1 to 3708)
  AUTHORS   Vostrov,A.A. and Quitschke,W.W.
  TITLE     The zinc finger protein CTCF binds to the APBbeta domain of the
            amyloid beta-protein precursor promoter. Evidence for a role in
            transcriptional activation
  JOURNAL   J Biol Chem 272 (52), 33353-33359 (1997)
   PUBMED   9407128
REFERENCE   10 (bases 1 to 3708)
  AUTHORS   Filippova,G.N., Fagerlie,S., Klenova,E.M., Myers,C., Dehner,Y.,
            Goodwin,G., Neiman,P.E., Collins,S.J. and Lobanenkov,V.V.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF133731.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            36 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF133731.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3708              AF133731.2         37-3744
FEATURES             Location/Qualifiers
     source          1..3708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Copenhagen"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3708
                     /gene="Ctcf"
                     /note="CCCTC-binding factor"
                     /db_xref="GeneID:83726"
                     /db_xref="RGD:621344"
     exon            1..42
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            43..159
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            160..949
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2382
                     /gene="Ctcf"
                     /note="CTCFL paralog; 11-zinc finger protein;
                     CCCTC-binding factor (zinc finger protein)"
                     /codon_start=1
                     /product="transcriptional repressor CTCF"
                     /protein_id="NP_114012.1"
                     /db_xref="GeneID:83726"
                     /db_xref="RGD:621344"
                     /translation="MEGEAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQ
                     TDGGEVVQDVNSSVQMVMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVN
                     MEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPL
                     PEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEG
                     KDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCP
                     RRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTS
                     GELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY
                     KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKS
                     DLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER
                     HMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTR
                     RNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEE
                     EEEPAVEIEPEPEPQPQPQPQPQPQPVAPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQ
                     VEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQAAPADAPNGDLTPEMILSMMDR"
     exon            950..1120
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1254
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1375
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1525
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1686
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1869
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2005
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2197
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..3684
                     /gene="Ctcf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggcggc ggagcgggcg ccgcgggggg tgtggcgcga agaatgacca caaatctaga
       61 accaaagaac atgatgcact agcaggcaga cttgaagcta gggaccggag atctgggttc
      121 tgttgtcctt cctcaaactg attttgcagc cacggagagg aaggggaaat ggaaggtgag
      181 gcggttgaag ccattgtgga agagtctgaa actttcatta aaggaaagga aagaaagact
      241 taccagagac gccgggaagg gggccaggaa gaagatgctt gccacctacc ccagaaccag
      301 acagacgggg gtgaggtggt ccaggatgtc aacagtagcg tacagatggt aatgatggaa
      361 cagctggacc ctacccttct ccaaatgaag actgaagtaa tggaggggac agtggctcct
      421 gaagcagaag ctgcagtgga cgatacccaa atcataaccc tgcaggttgt aaacatggag
      481 gaacagccca ttaatatagg agaacttcag cttgtccaag tacctgttcc tgtgactgta
      541 cctgttgcta ctacgtcagt agaagaactt cagggggctt atgagaatga agtgtctaaa
      601 gagggccttg cagaaagtga accgatgata tgtcacacct tacctttacc tgaaggattt
      661 caggtggtaa aagtgggggc caatggagaa gtggagacac tagagcaggg ggagcttcct
      721 cctcaggaag accctagctg gcaaaaagac ccagactatc agccaccagc caaaaaaaca
      781 aagaaaacca aaaagagtaa acttcgttac acagaggagg gcaaagacgt ggatgtgtct
      841 gtgtatgatt ttgaggaaga acagcaggaa ggactgctgt ctgaggttaa tgcagagaaa
      901 gtggttggta atatgaagcc tccgaagcca acaaaaatta aaaaaaaagg tgtaaagaaa
      961 acattccagt gtgagctttg cagttacacg tgtccacggc gttcaaattt ggatcgtcac
     1021 atgaaaagcc acactgatga gagaccacac aagtgccatc tctgtggcag agcattcaga
     1081 acagtaaccc tcctgaggaa tcatcttaac acacacacag gtactcgtcc tcacaagtgc
     1141 cccgactgcg acatggcttt tgtgaccagt ggagagttgg tgcggcatcg tcgttataaa
     1201 cacactcatg agaaaccatt taagtgttcc atgtgtgatt atgccagtgt agaagtcagc
     1261 aaattaaaac gacacattcg ctctcatact ggagagcgcc cgttccagtg cagtttgtgc
     1321 agttatgcca gcagggacac atacaagctg aaaaggcata tgagaaccca ttcaggtgaa
     1381 aaaccttatg aatgttatat ttgtcatgct cggtttaccc agagtggtac catgaagatg
     1441 cacattttac agaagcacac agaaaatgtg gccaaatttc attgtcccca ctgtgacact
     1501 gtcatagccc gaaaaagtga tttgggtgtc cacttgagaa agcagcattc ctatattgag
     1561 cagggcaaaa aatgtcgcta ctgtgatgct gtgtttcatg agagatatgc tcttatccag
     1621 catcaaaaat cacacaaaaa tgagaagcgc ttcaagtgcg accagtgtga ttatgcttgt
     1681 agacaggaga ggcacatgat catgcacaag cgcactcaca cgggggagaa gccttatgcc
     1741 tgcagccact gcgacaagac cttccgccag aaacagctcc ttgacatgca tttcaagcgc
     1801 tatcatgatc ccaactttgt ccccgctgcc tttgtctgtt ctaagtgtgg gaaaacattc
     1861 acacgccgga acacaatggc gagacacgca gataactgtg ctggtccaga cggtgtagaa
     1921 ggggaaaatg gaggagagac aaagaagagc aaacgaggaa gaaaaagaaa gatgcggtct
     1981 aaaaaagaag actcctctga cagtgaaaat gctgagccgg atctcgatga caatgaggag
     2041 gaggaggagc ctgctgtaga aattgaacct gagccagagc cgcagccgca gcctcagcca
     2101 cagccgcagc cgcagcctgt ggccccagcc ccaccacctg ccaagaagag aagagggcga
     2161 cctcctggaa gaaccaacca acccaaacag aaccagccaa cagccatcat ccaggttgaa
     2221 gaccagaata caggtgcaat tgagaacatt atagttgaag tcaaaaaaga gccagatgcc
     2281 gagcctgcgg agggggaaga ggaggaggct caggcagcac ccgcagacgc ccccaacgga
     2341 gacctcacgc ctgagatgat tctcagcatg atggaccggt gatgacgggg ctttgctcgc
     2401 caccaggact gttgggctgt gtttaaacgg cccaaatctt aacttttctc tctttctttc
     2461 tttggctttg ggaacggcat aatttgacac cattttacca aacacactga gagcgaaaac
     2521 ttcaaggatg atgttagaaa aatgtgattt aactagaact tgtttgatgt tagcaaatca
     2581 tggaatgttc taagtctctg agggtttact gtgaagtgct gaggacagtg ttgatgccta
     2641 actagttttc ttagatggaa acagagacat tgagccctct ctcttgattt agtaaaccac
     2701 tccagaatgc ccacgggttt cccagagttc tatggtcttc ccaagagagt ttttaattgt
     2761 aaatgcagac ttgggaaaga cttagacttt taacctggtt ttgcttttgc ttttcctgac
     2821 tccctttgct cagagtcagt tgcacaccag taggatggca tgctacgatc agtttctgtc
     2881 ctgaaagctt tgcctctttc ttggcaaagt ttctggtatg gtcaagcctg taaataacct
     2941 tttttacatt ttaatctttt ccattaatta agaggttgaa aagaagtgca gtgtaagaaa
     3001 acccagcatt ttaattattt gcaaattaag gtgccacaga cacagacttc gtggtatgta
     3061 aatgttgaat cggatcacaa tcatgtagca gaagggcact gggcctgttg cctgctagtc
     3121 atggacaccc aaaagtcctg atttccagct catggagcca gcatttgaac cttgaacaaa
     3181 taattttcat ttatgatttc ttcatcaaca ttttctttac tctgtttgta gctgaatgtt
     3241 acatttttaa atctctgtta aagccagaag agttgattat gagtgggcac agcgaccctg
     3301 ggaagctggg ccaaaacatt tcactgagtc agtaatttaa acttcaaatc tggaaaaaaa
     3361 ttaataataa tgatggtgaa gcaaaacaac ttaaaaagtg attcttgcac atgaattgtc
     3421 acatgttgat atgtcttttt taaagagcct cagtctgact gatttcaaac actttttttc
     3481 ttctgtgtat tgcttttaag agagccatca gttagctatc agaatctagg ttgatgcatt
     3541 tttgtactta gctgtactgt gtgatatttt tcattatttt aggatgccaa catgagacct
     3601 gtaataaaat atgtaatggg gttgaaagct ggggaggagg atctactgct gtacagctaa
     3661 taaatcataa cggattaaca ggcaaaaaaa aaaaaaaaaa aaaaaaaa
//
