LOCUS       NM_001107010            4155 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CST telomere replication complex component 1
            (Ctc1), mRNA.
ACCESSION   NM_001107010 XM_001078525 XM_220595
VERSION     NM_001107010.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4155)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   2  (bases 1 to 4155)
  AUTHORS   Gu,P., Min,J.N., Wang,Y., Huang,C., Peng,T., Chai,W. and Chang,S.
  TITLE     CTC1 deletion results in defective telomere replication, leading to
            catastrophic telomere loss and stem cell exhaustion
  JOURNAL   EMBO J 31 (10), 2309-2321 (2012)
   PUBMED   22531781
REFERENCE   3  (bases 1 to 4155)
  AUTHORS   Surovtseva,Y.V., Churikov,D., Boltz,K.A., Song,X., Lamb,J.C.,
            Warrington,R., Leehy,K., Heacock,M., Price,C.M. and Shippen,D.E.
  TITLE     Conserved telomere maintenance component 1 interacts with STN1 and
            maintains chromosome ends in higher eukaryotes
  JOURNAL   Mol Cell 36 (2), 207-218 (2009)
   PUBMED   19854131
REFERENCE   4  (bases 1 to 4155)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   5  (bases 1 to 4155)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220595.4, XM_001078525.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4155
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /note="CST telomere replication complex component 1"
                     /db_xref="GeneID:303238"
                     /db_xref="RGD:1563106"
     exon            1..253
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..3856
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /note="CTS telomere maintenance complex component 1"
                     /codon_start=1
                     /product="CST complex subunit CTC1"
                     /protein_id="NP_001100480.1"
                     /db_xref="GeneID:303238"
                     /db_xref="RGD:1563106"
                     /translation="MAACRAQPPTSEEAWLEAAQAFIQETLCPVDEEPNEQVTRSVID
                     CVKETWLSQGENQDLTLPLSYSFVSVQNLKTNQHLPCCSHLSWSDNAYQAWTRGAGPG
                     GSVLPREQLLLLGTLVDLLGDLEQESRSGGLYVRDNTGTLDCELIDLDLSWLGHLFLF
                     PSWSYLPPAKRNSLGAGHLELWGTPVPVFPLTVSPGPLTPIPVLYPEKASYLLRYRKK
                     CKIKELNLAGKLVHLSALMVTQNKRYFIMTLGELAQAGSQVSVIVQIPAQMVWHRVLR
                     PGRAYVLTKLRITKTRGHRSCIWTTIPSSTLMPLRPGYVQELELDVAFADAGHKPLPE
                     PTSSRDSRGQEGLVRGSKVLHYLGTVTDVLNESASLYILDGQLILCLAYQKIHGLRRV
                     IRPGVCLELRDVHLLQGLGGGTTKPVLALCLHGTVRLQGFSCLKPQNLPSYKVHGASL
                     YEQLVWKCQLGLPLYLWATKALEELVYKLCPHVLRCQQFLKHSSPGKPSLGLQLLAPS
                     WDVLIPPGSPIRHAHSEILEEPHNCPLQKYTPLQTPYTFPTILALAEEGQHRAWATFD
                     PRALLPFPEAFHLTSCQLNRRLAWSWLCLPSSMFQPAPVLLGVLVASSHKGCLQLRDV
                     RGSLPCIPLPESSQPLIDPKLIGCLVRVEKFQLVVEREVRSSFPSWEELGMASLIQKK
                     QARVYVQFYLADALILPVPRPTVGLEPSETASSCPEGPQVGQSRLFLLFYKEALMKRN
                     FCLLPGDSSRPAEPTLSFRVSGTWLCGTQKREGSGWSPPESLAAENKDQKVFFIFLGS
                     SVQWFPFLYPNQVYRLVAPDSTPALFETNHSSGTPHRPLELTDYVSCLTIQEDWTLEL
                     GSSQDIPNVLEVPRTLSESSLAHLLSDNSPNFLVSFSAEVLSRILCEPPLALRRIKPG
                     NAGAIKAGVKLTVALEMEDCDYPPHLDIYIEDPHLPPPIGLLPGARVHFSQLEKKISR
                     SNVVYCCFRSTTSVQVLSFPPETKASAPLPHICLAELLQGDRPPFQATTSCHIVYVLS
                     LQILWVCAHCTSICPQGKCSRQDPSCPSQRAISQASIRLLVEDGTAEATVTCRNHHVA
                     TTLGLSPSEWSNVLDRARGPGRVALQFKGPGAQTESASKTGEPLTLLLQTLCTSPFVL
                     RPIKLSFALERRPCDITPIEPPRLQQFQCGELPLLTRVNPRLRLVCLSLQEPELPSPP
                     QASAAAS"
     exon            254..417
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            418..655
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            656..867
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1012
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1291
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1420
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1653
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1831
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2032
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2159
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2274
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2590
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2677
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2871
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2960
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3135
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3213
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3358
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3423
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3589
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3716
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..4155
                     /gene="Ctc1"
                     /gene_synonym="RGD1563106"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgtaatt cccgctaggt gatagaagcg gaaaggtcgc tgcaaattta aggccagtgt
       61 gctccttgcg gccagttcta ggcaaaagat ccgtggtggg gtagccagct ggtgggtgct
      121 aggggaggag ccagtgctgc tccctgacgt cacaggctct ctcccgtgag cacttgcgcc
      181 cggagttcgc gcgttcttca gggtaggggt ttggctcatc atggctgctt gccgagcaca
      241 accacctacc tccgaggaag cctggcttga ggctgcccag gccttcatcc aagagaccct
      301 ttgtccagtg gacgaggagc ctaatgaaca ggtgactcgc tcagtaattg actgtgtgaa
      361 ggagacatgg ctgtcccagg gggagaacca ggacttaacc ttgcccctca gctacagctt
      421 tgtctcagta cagaatctga agacgaatca gcatctccca tgctgcagcc acctgtcctg
      481 gagtgacaat gcttaccagg cttggacccg aggagctggg ccaggaggca gtgtcctgcc
      541 ccgggaacag ctgttacttt tagggacact agtagaccta ttaggagatt tggaacaaga
      601 gtctaggagt ggaggcctgt atgtgagaga taacactgga accttggact gtgagcttat
      661 agatctagac ctttcttggt tgggccatct cttcctgttc cccagttgga gttacctccc
      721 tcccgccaag aggaattcct tgggggcagg gcacttggag ctgtggggta cacctgtgcc
      781 agtatttcct ttgactgtca gtcctggccc cctcacgcct atccctgtcc tctacccaga
      841 aaaggcgtcc tacctgctca gatacagaaa gaaatgcaaa ataaaggagc taaatcttgc
      901 tggaaaactg gtccatctga gtgccctgat ggtaactcag aacaaaaggt acttcatcat
      961 gacacttggt gaattagccc aagctggcag ccaggtgtcc gtcattgtcc agattcctgc
     1021 tcagatggtg tggcaccgag tcctccggcc tggtagggcc tatgtgctga caaaattgcg
     1081 aataaccaag acccggggtc accgttcctg tatttggaca accattccat cttcaactct
     1141 gatgccactg agaccaggct atgtgcaaga gctggagctg gacgtagcgt ttgcagacgc
     1201 tggccataaa ccgctgcccg agcccaccag ctccagagac agcagaggcc aagaggggct
     1261 tgtccgaggt tccaaagtct tgcattattt gggaacagtc actgacgtgt tgaacgagtc
     1321 tgccagcctc tacattcttg atgggcagct gattctctgc cttgcatacc agaagatcca
     1381 tggcctcagg cgggttattc gaccaggggt ctgtctggag ctccgtgatg ttcatctcct
     1441 ccagggcctg ggtggaggaa caacaaaacc tgtgctggcc ctttgtctcc atggcactgt
     1501 tcgcctgcaa ggcttttctt gtcttaagcc tcagaacttg ccgtcctaca aagttcatgg
     1561 tgcctccttg tatgagcaat tggtgtggaa atgtcagtta ggacttccct tatacttatg
     1621 ggctaccaag gccctggagg agctggtcta caagctctgt ccccatgtgt tgagatgtca
     1681 acagttcctg aagcactcct ctcctgggaa gcccagcttg ggactgcagc tcctggctcc
     1741 ctcctgggat gttcttattc cacctggcag ccccattcgg catgcacaca gtgagatcct
     1801 ggaagaacca cataactgtc cccttcagaa gtatactccg ctgcagaccc cctacacttt
     1861 ccctactata cttgccctgg cagaggaagg gcagcacagg gcttgggcta cctttgaccc
     1921 aagggccctg ctgcctttcc cagaagcctt tcacctgaca agctgtcaac tgaatcgtcg
     1981 cctagcctgg tcctggctct gtctgccatc cagtatgttc cagccagccc cggttttact
     2041 tggggtcctg gtggcttcgt ctcataaagg ttgtctgcag cttcgggacg taagaggttc
     2101 actgccctgt atacccttgc ctgagagttc acagcccctc attgacccaa agctcatagg
     2161 ctgcctggtg cgggtagaga aattccagct ggtagtagag agagaagtca ggagcagctt
     2221 cccttcctgg gaggagctgg gcatggcaag cctcatccag aagaagcagg ccagagtcta
     2281 tgtccagttc tacctggctg atgccctgat cctgcctgtg cccagaccca ctgttggttt
     2341 agaaccatct gagacagcct cctcctgccc agagggaccc caggtgggac agagccggct
     2401 gttcttactg ttctacaagg aggccctcat gaaacgtaac ttttgtctcc ttccgggaga
     2461 tagttcacga cctgcagagc ccaccctgag tttccgtgtg tcaggaactt ggctttgtgg
     2521 cacacagaag agggagggtt ctggatggag cccacctgag tctctggccg cagagaacaa
     2581 ggaccaaaag gtcttcttca tcttccttgg ctcttcagtt cagtggtttc cgttcttgta
     2641 cccaaaccaa gtctaccggc tcgtggctcc tgactcaaca ccagcgttgt ttgagacaaa
     2701 ccattcatct ggcacacctc accgtcctct ggaattgact gactatgtgt cttgcctcac
     2761 tatccaagag gactggaccc tggaacttgg gagctctcag gacataccta atgtactaga
     2821 ggtccctaga acactgtctg agtcctcact ggctcacctg ctcagtgaca actcccccaa
     2881 tttcttggtg tctttctctg ctgaggtttt gtctcggata ctgtgtgaac cacctctggc
     2941 ccttcgcagg ataaaacctg ggaatgctgg ggctattaaa gcaggtgtga agctaacagt
     3001 agctctagaa atggaggact gtgactatcc ccctcacctg gacatatata tcgaagatcc
     3061 acacttgcct cccccaatag gactccttcc aggagcccga gtccacttta gccagctgga
     3121 gaaaaagatt tccagatcca acgttgttta ctgttgcttc cggtcaacca cttctgtgca
     3181 ggtcctgagc ttccccccag agaccaaagc cagtgctccc ttgccccaca tctgcctggc
     3241 tgaacttctc caaggtgacc ggcctccctt ccaggccact acctcttgcc atattgtgta
     3301 tgtcctgagc cttcagatcc tgtgggtgtg tgcccattgc accagcatct gtccccaggg
     3361 gaagtgtagt cgtcaggacc ccagttgtcc atctcagagg gctataagcc aggccagcat
     3421 caggctcctg gtagaagatg gcaccgcaga agccacagtg acctgtagga atcatcatgt
     3481 ggcaacaaca ctaggactga gtcctagtga gtggtccaat gtcctagatc gtgcaagggg
     3541 gccagggaga gtggccttgc agtttaaagg gccaggagcc caaacagagt ctgcaagcaa
     3601 aaccggtgaa cccttgaccc tgctcctcca gacactttgt accagcccct ttgtcctccg
     3661 acccattaag ctttcctttg cgcttgaaag gagaccttgt gatattaccc caatagaacc
     3721 accccggctg cagcagttcc agtgtggaga gctccctctg ctgaccagag tgaatcccag
     3781 gctccgattg gtctgccttt ctctgcagga gccagagctc cccagccctc cacaagcttc
     3841 tgctgctgct tcttaatgac actgcctaag gtggcctccc agagcttcca gaaccgcaga
     3901 cgctggagtc aggaactcct gccccgctgt gatttctagt tattctggtg tcagcatgcc
     3961 ttggaaacac tgaaaacaga ttgcggcatg ataatggtgt tttctccagt tggcttagaa
     4021 cacctacact cagaggtgtc ctgccctgac cttgggttct gccttgtggg agaaagcaga
     4081 acaaagaact tgccccttat gactgtgttg ttatgataac cctttgggcc acaataaacc
     4141 tctctgagga ctctc
//
