LOCUS       NM_053335               4193 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus C-terminal binding protein 2 (Ctbp2), mRNA.
ACCESSION   NM_053335
VERSION     NM_053335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Han,J.X., Wen,C.X., Sun,R., Tang,M.Y., Li,X.M. and Lian,H.
  TITLE     The dorsal hippocampal CA3 regulates spatial reference memory
            through the CtBP2/GluR2 pathway
  JOURNAL   FASEB J 36 (9), e22456 (2022)
   PUBMED   35969153
  REMARK    GeneRIF: The dorsal hippocampal CA3 regulates spatial reference
            memory through the CtBP2/GluR2 pathway.
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Zhang,L., Zhang,X., Zhang,Y., Xu,N., Wang,J., Zhu,Y. and Xia,C.
  TITLE     Brn4 promotes the differentiation of radial glial cells into
            neurons by inhibiting CtBP2
  JOURNAL   Life Sci 254, 116866 (2020)
   PUBMED   31518606
  REMARK    GeneRIF: esults indicated that Brn4 promoted the neuronal
            differentiation of neural stem cells via inhibition of CtBP2 and is
            a potential tool for generating neurons in cell replacement therapy
            of neurodegenerative diseases and brain injury
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Maxeiner,S., Luo,F., Tan,A., Schmitz,F. and Sudhof,T.C.
  TITLE     How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in
            retinal synapses and disrupts neurotransmitter release
  JOURNAL   EMBO J 35 (10), 1098-1114 (2016)
   PUBMED   26929012
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Karaca,E., Lewicki,J. and Hermanson,O.
  TITLE     Oxygen-dependent acetylation and dimerization of the corepressor
            CtBP2 in neural stem cells
  JOURNAL   Exp Cell Res 332 (1), 128-135 (2015)
   PUBMED   25447313
  REMARK    GeneRIF: Microenvironmental oxygen levels influence the
            dimerization and acetylation levels, and thereby the activity, of
            CtBP2 in proliferating neural stem cells.
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Bajpe,P.K., Heynen,G.J., Mittempergher,L., Grernrum,W., de
            Rink,I.A., Nijkamp,W., Beijersbergen,R.L., Bernards,R. and Huang,S.
  TITLE     The corepressor CTBP2 is a coactivator of retinoic acid
            receptor/retinoid X receptor in retinoic acid signaling
  JOURNAL   Mol Cell Biol 33 (16), 3343-3353 (2013)
   PUBMED   23775127
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Kajimura,S., Seale,P., Tomaru,T., Erdjument-Bromage,H.,
            Cooper,M.P., Ruas,J.L., Chin,S., Tempst,P., Lazar,M.A. and
            Spiegelman,B.M.
  TITLE     Regulation of the brown and white fat gene programs through a
            PRDM16/CtBP transcriptional complex
  JOURNAL   Genes Dev 22 (10), 1397-1409 (2008)
   PUBMED   18483224
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Schmitz,F., Konigstorfer,A. and Sudhof,T.C.
  TITLE     RIBEYE, a component of synaptic ribbons: a protein's journey
            through evolution provides insight into synaptic ribbon function
  JOURNAL   Neuron 28 (3), 857-872 (2000)
   PUBMED   11163272
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Furusawa,T., Moribe,H., Kondoh,H. and Higashi,Y.
  TITLE     Identification of CtBP1 and CtBP2 as corepressors of zinc
            finger-homeodomain factor deltaEF1
  JOURNAL   Mol Cell Biol 19 (12), 8581-8590 (1999)
   PUBMED   10567582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 30, 2020 this sequence version replaced NM_053335.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF222712.1, SRR26643289.3157.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1731              JAXUCZ010000001.1  197240173-197241903 c
            1732-1886           JAXUCZ010000001.1  197225012-197225166 c
            1887-2031           JAXUCZ010000001.1  197224765-197224909 c
            2032-2238           JAXUCZ010000001.1  197220913-197221119 c
            2239-2453           JAXUCZ010000001.1  197216986-197217200 c
            2454-2584           JAXUCZ010000001.1  197216454-197216584 c
            2585-2712           JAXUCZ010000001.1  197215793-197215920 c
            2713-2830           JAXUCZ010000001.1  197215196-197215313 c
            2831-4193           JAXUCZ010000001.1  197212133-197213495 c
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4193
                     /gene="Ctbp2"
                     /note="C-terminal binding protein 2"
                     /db_xref="GeneID:81717"
                     /db_xref="RGD:68372"
     exon            1..1731
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..3011
                     /gene="Ctbp2"
                     /codon_start=1
                     /product="C-terminal-binding protein 2"
                     /protein_id="NP_445787.1"
                     /db_xref="GeneID:81717"
                     /db_xref="RGD:68372"
                     /translation="MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGE
                     GVWCELVNHRAQDTESCLSREAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDY
                     YGDPSRGTRVPKEPPFYRDPGTSRPVPSYGVLGSRIPWEQVQGQLPALQDAGHLYRES
                     GSKTVLHGQRTHCRAPSPGRYGREQPDSRLGIEVPTYSPNSSQVYNDICERPVDSTHA
                     RQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRESIHSKLAYENYEADLSTFQG
                     PGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLEDADIKSVAPNLGQAR
                     VLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTALQFHPAGP
                     LQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCALTA
                     RLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPH
                     ASPQLLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPSIRP
                     QIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMM
                     YHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTV
                     CHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAV
                     RAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLIND
                     FTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDA
                     PNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSTPWSVI
                     DQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSP
                     NQPTKHGDNREHPNEQ"
     exon            1732..1886
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2031
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2238
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2453
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2584
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2712
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2830
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..4193
                     /gene="Ctbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggcctc ctccccacct ctgctgtatt gctttgctct gccaatgccg gttcccagca
       61 ggcacatcaa cattggccgt tctcagagct gggatgccgc tggctggtat gagggccctt
      121 gggagaatgc tggccctcca gggaggagaa gttctctgac ttatggccct ggagaagggg
      181 tctggtgtga gctggtaaac caccgtgccc aggacactga gtcctgcctg tcccgggaag
      241 ctttttataa ctcactggca tcaagaaagg gctccgtgcc tgacttcacc ttctacgaca
      301 gcaggcaggc agtgatgtct ggccgtggct ccgtgctgcc acaagactac tatggcgacc
      361 catccagggg caccagggta cccaaggagc ctcccttcta tcgggaccca ggaaccagcc
      421 ggccggtgcc cagctacgga gtgctgggca gcagaatacc atgggagcag gtacaaggcc
      481 agttacctgc tctgcaggat gctggccacc tgtaccggga atctgggagt aaaactgtcc
      541 tgcatgggca gcggacacac tgcagggctc catctcctgg gaggtatgga agggaacaac
      601 ctgattctag attagggata gaggtaccca cctattcccc caactccagc caggtctaca
      661 acgatatctg cgaaagaccc gttgactcta cccatgccag acaggtggcc ccaacatgcc
      721 tggttgtgga ccccagctcg accgccccta ctgagaacag cacgggggtg gccccaggtt
      781 ccctgaatag aggctacggg cctacccgag aaagcatcca ttcaaagctg gcttatgaga
      841 attatgaagc cgacttgtca acattccaag gacccggggg caagaggacc gtctaccctg
      901 agtttttggc cctgctgagg gcagagggtg tggcagaggc taccctggca gccctgttac
      961 aacaaggctt tgactcccca gctgtcttgg ccaccctaga ggatgctgac atcaagtctg
     1021 ttgcccccaa cctgggccag gcccgtgtcc tgagccgcct ggtcagcagc tgcaggacag
     1081 agatgcagtt tcggcgacag gaccggacag gccctccacc ccgccatcgg tccagtagct
     1141 tcagccaccg aagtgagctg ctgcccaatg acacggcctc gctggggacc acagcactgc
     1201 agtttcaccc agctggacct ttgcagacac cctctccccg aggtggagat ctaggtcgcc
     1261 gcccctccag tgcaccttcc cagcacctcc tggagacagc agctacttac tctgccccag
     1321 tggtggggtc ccagactccc cacttaccct ccaactctgg atatagctct cctacccctt
     1381 gtgccctaac agcacgactg gcctcctcct acccttcaca agctggggta gccttgactg
     1441 ctaacccagg cccctctgtc ccccttcact caagtcccag aacagcctat tccacctcct
     1501 acacggtgcc catggaactg cttaagaggg aacgcagtgt gaccgcctct ccgctgccca
     1561 gcccccatgc cagcccccag ctcctgcgga aacctggagc agcccccgtg gagccggctg
     1621 ccctgccacc agtcaggcaa agtctccaca cacctcatcc gccataccag aaggtggccc
     1681 ggcggacagg ggctcccatc atcgtgtcaa ccatgctaac accagaacca agtatccgcc
     1741 cccagatcat gaacggcccc ctgcaccccc gccccctagt ggcactgctg gatggcagag
     1801 actgcactgt ggaaatgccc atcctgaagg acctggccac tgtggccttc tgtgatgcac
     1861 agtccactca ggaaatccat gagaaggtat tgaatgaggc tgtgggcgcc atgatgtacc
     1921 acaccatcac tctcacccgg gaagacctgg agaagttcaa ggccctgaga gtgattgttc
     1981 gaatcggtag tggctacgac aatgtggaca tcaaggctgc tggcgaactc ggaatcgccg
     2041 tgtgcaacat cccatctgct gcagtggagg agacagcaga ttcgacagtc tgccatatcc
     2101 tcaatctgta tcggcggaac acatggctgt accaggccct acgagaaggc acgcgggtac
     2161 aaagcgtgga acagatccgt gaggtcgcct caggagctgc tcggatccga ggggaaacac
     2221 tgggcctcat tggctttggt cgcactgggc aggcagttgc tgttcgagcc aaggcctttg
     2281 gattcagcgt catattttat gacccctact tacaggatgg gatagagcgg tctctgggcg
     2341 tgcaaagggt ctacaccctg caggacttgt tatatcagag cgactgtgtc tccttgcact
     2401 gcaatctgaa tgaacacaac caccacctca tcaatgactt caccatcaag cagatgaggc
     2461 aaggagcatt ccttgtgaat gcagcccgag gtggcctggt ggatgagaaa gccttagctc
     2521 aggccctcaa agagggcagg atacgaggcg ctgctctgga tgtgcatgag tctgagccct
     2581 tcagctttgc tcagggccca ttgaaggatg ctccaaatct catctgcaca ccacacacag
     2641 cctggtacag cgaacaagca tcactagaga tgagggaagc agctgccacg gagatccgcc
     2701 gagcaatcac aggtcgcatc ccagaaagct tacgaaactg tgtcaacaaa gaattctttg
     2761 ttacttcaac tccttggtca gtcattgacc agcaagcaat tcatcctgag ctcaatggtg
     2821 ccacatacag gtatccacca ggcattgtag gtgtggctcc aggagggctt cctccagcta
     2881 tggaagggat catccctgga ggcatccctg tgactcacaa cctccccact gtggcacacc
     2941 cttcccaagc tccctcccca aaccagccca caaaacacgg ggacaatcga gagcacccca
     3001 acgagcaata gcagagaata cgtgaaggta atcattcaga taaacttggg accaagagac
     3061 agtagaaaac ggatgaattt gatggtcttt taaactgatc ctggacatca ctgatactgc
     3121 agtgtgaaag ctacaaaagc tagaaaacaa gatggtatct gcttccagaa gtgtggaaag
     3181 actaggacgt gattattaac gaccaacttc tgttattgtg tgttaagttt ttcatctgtg
     3241 catcaaatca caaagaatag agcttttcct ttatcaatca atcccctggg cacagcaggt
     3301 cctgcgcagc ttgttgtaga atgttgcatc aagagctccg aatatcaata aaaaaattga
     3361 gaggaaatcc ccatcaaggc tagtcccttt ggtcttcagg ggctggtgcc tcctttgctg
     3421 ataggaagat taaaaataag acaagatggg gaggacattg tttgctggtg tagacatctc
     3481 cgcgcacagg attgaagagg taaaagctcc tgtacagaag gtttcacatc tgagcagcaa
     3541 agtcggttgt gagttcagta aaaccctctg atgacacaaa acaaaaacaa caaacaaaca
     3601 aaaaaaaaaa acaaaaaaag gaaaagaaca aaagaaaaaa gtattaagtt tcacaagctg
     3661 tttgtactca aatatatttt ctcagtttca gatcctcagc tattttattg agtggaaagt
     3721 cttggacgag aagggttcaa gaagaataat gttgcatttc cttatgtctc aggaaacact
     3781 ttttatggta acttgtcaga ttgtctatga acaaacccac ttttttagac attgataaat
     3841 tcttttcttc acgtgatatt ttatacaaga acacttcaga tgtgctatta gatgtgactg
     3901 attttaacaa atcctattag atttgtatca gctagttaca tgttctattc atagtctttt
     3961 gtgaatcatt gcctttttgt ttttaaagat ggcctatttt gagcctttgt ataggtacat
     4021 tcctgttttt gtgacaaaag aaaaacttta aactgtccca aacagaaaat aatggctatc
     4081 agaagtatgt tttgttttag tgtgagttac cgttactgta tttgtttatt gtaaaggtga
     4141 acatttagca ttcagtgcag ttttcaataa aaagtaatta aaatttcttt taa
//
