LOCUS       NM_019201               2420 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus C-terminal binding protein 1 (Ctbp1), mRNA.
ACCESSION   NM_019201 XM_001062979 XM_001063046 XM_001063097
VERSION     NM_019201.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Ivanova,D., Imig,C., Camacho,M., Reinhold,A., Guhathakurta,D.,
            Montenegro-Venegas,C., Cousin,M.A., Gundelfinger,E.D.,
            Rosenmund,C., Cooper,B. and Fejtova,A.
  TITLE     CtBP1-Mediated Membrane Fission Contributes to Effective Recycling
            of Synaptic Vesicles
  JOURNAL   Cell Rep 30 (7), 2444-2459 (2020)
   PUBMED   32075774
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   Hu,K., Li,Y., Yu,H. and Hu,Y.
  TITLE     CTBP1 Confers Protection for Hippocampal and Cortical Neurons in
            Rat Models of Alzheimer's Disease
  JOURNAL   Neuroimmunomodulation 26 (3), 139-152 (2019)
   PUBMED   31340205
  REMARK    GeneRIF: CTBP1 Confers Protection for Hippocampal and Cortical
            Neurons in Rat Models of Alzheimer's Disease.
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Rocca,D.L., Wilkinson,K.A. and Henley,J.M.
  TITLE     SUMOylation of FOXP1 regulates transcriptional repression via CtBP1
            to drive dendritic morphogenesis
  JOURNAL   Sci Rep 7 (1), 877 (2017)
   PUBMED   28408745
  REMARK    GeneRIF: Results shed light on the binding of CtBP1 protein to
            SUMOylated Foxp1 to repress the genetic transcription and drive
            dendritic morphogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Chinnadurai,G.
  TITLE     CtBP, an unconventional transcriptional corepressor in development
            and oncogenesis
  JOURNAL   Mol Cell 9 (2), 213-224 (2002)
   PUBMED   11864595
  REMARK    GeneRIF: CtBp proteins repress transcription in a histone
            deacetylase dependent or independent manner.
            Review article
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Riefler,G.M. and Firestein,B.L.
  TITLE     Binding of neuronal nitric-oxide synthase (nNOS) to
            carboxyl-terminal-binding protein (CtBP) changes the localization
            of CtBP from the nucleus to the cytosol: a novel function for
            targeting by the PDZ domain of nNOS
  JOURNAL   J Biol Chem 276 (51), 48262-48268 (2001)
   PUBMED   11590170
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Spano,S., Silletta,M.G., Colanzi,A., Alberti,S., Fiucci,G.,
            Valente,C., Fusella,A., Salmona,M., Mironov,A., Luini,A. and
            Corda,D.
  TITLE     Molecular cloning and functional characterization of brefeldin
            A-ADP-ribosylated substrate. A novel protein involved in the
            maintenance of the Golgi structure
  JOURNAL   J Biol Chem 274 (25), 17705-17710 (1999)
   PUBMED   10364211
  REMARK    Erratum:[J Biol Chem 1999 Aug 27;274(35):25188. Spanfo S [corrected
            to Spano S]]
REFERENCE   9  (bases 1 to 2420)
  AUTHORS   Di Girolamo,M., Silletta,M.G., De Matteis,M.A., Braca,A.,
            Colanzi,A., Pawlak,D., Rasenick,M.M., Luini,A. and Corda,D.
  TITLE     Evidence that the 50-kDa substrate of brefeldin A-dependent
            ADP-ribosylation binds GTP and is modulated by the G-protein beta
            gamma subunit complex
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7065-7069 (1995)
   PUBMED   7624370
REFERENCE   10 (bases 1 to 2420)
  AUTHORS   Belgrader,P., Dey,R. and Berezney,R.
  TITLE     Molecular cloning of matrin 3. A 125-kilodalton protein of the
            nuclear matrix contains an extensive acidic domain
  JOURNAL   J Biol Chem 266 (15), 9893-9899 (1991)
   PUBMED   2033075
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF067795.2.
            
            On Feb 21, 2013 this sequence version replaced NM_019201.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067795.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2420              AF067795.2         6-2425
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2420
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /note="C-terminal binding protein 1"
                     /db_xref="GeneID:29382"
                     /db_xref="RGD:2441"
     exon            1..196
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            197..389
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1675
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /note="C-terminus binding protein 3/brefeldin A (BFA)
                     adenosine diphosphate-ribosylated substrate; ctBP3;
                     C-terminal-binding protein 3; 50 kDa BFA-dependent
                     ADP-ribosylation substrate; brefeldin A-ADP-riboslyated
                     substrate; 50-kDa BFA-induced ADP-ribosylated substrate"
                     /codon_start=1
                     /product="C-terminal-binding protein 1"
                     /protein_id="NP_062074.2"
                     /db_xref="GeneID:29382"
                     /db_xref="RGD:2441"
                     /translation="MSGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCD
                     AQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDL
                     GIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAAR
                     IRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFH
                     SDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGA
                     ALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPD
                     SLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYSRYPPGVVSVAPTGIPAAVEGIVP
                     SAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHTTDQL"
     exon            390..544
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            545..689
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            690..896
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1111
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1242
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1370
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1488
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2420
                     /gene="Ctbp1"
                     /gene_synonym="50-kDaBFA-inducedADP-ribosylatedsubstrate;
                     Bars; BARS-50; CtBP3/BARS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggctgg cggcgcggtg gcggctcggc acggcggtgg ccggtcgcag gcggccgggc
       61 ggaatagcag actgcgccga agccgcccca ggcgcagggc tcgcggcggc ggagagcgcc
      121 ggactcatcg gggcccgcgg ccacccgcgc ctttcaatgg gcagctcgca cttgctcaac
      181 aagggcctgc cgctggtaag actttgaacc cgacgcaggc ttcagtggct gctgtggagc
      241 agaagcctga gagctttggt tggagacaat aagacgtggg atgaggctcc gtgacagaac
      301 gcggttcggc ctggggattc tgaagacaaa aagctttgga caggcgaatt catggtcgtg
      361 gaaaccccgc cccaattaag caatgtcagg cgtccgacct cccatcatga acgggcccat
      421 gcacccccgg cccctggtgg cgctgctgga tggccgggac tgcacagtgg agatgcctat
      481 cctgaaggat gtggccacag tagccttctg tgatgcgcag tccacacagg agatccatga
      541 gaaggtactg aatgaggcag tgggcgccct gatgtaccat accatcacac tgaccagaga
      601 agatctggag aagtttaaag ctctcagaat catcgtccga attggcagcg ggtttgacaa
      661 catagacatc aagtcagctg gtgatctagg catcgcagtg tgcaatgtac cagcagcatc
      721 tgtggaagaa acagcagact ccaccctgtg ccacattctg aacctatacc gacgaactac
      781 ctggctacac caggcacttc gggaaggcac tcgggtccag agtgtagagc agatccgaga
      841 ggtggcttca ggagctgcca ggatccgtgg agagaccttg ggcatcattg gactaggtcg
      901 tgtgggccag gcggtggcac ttcgggcaaa ggcttttggc ttcaacgtcc tcttctatga
      961 cccataccta tctgatggaa tcgagcgggc cctggggctg cagcgtgtga gcacactgca
     1021 ggacctgctc ttccacagtg actgcgttac cctgcattgc ggcctcaatg agcacaacca
     1081 ccacctcatc aatgacttca cagtcaagca gatgagacaa ggagccttcc tggtgaacac
     1141 agcccgtggt ggcctggtgg atgagaaggc actagcccag gccctgaagg aagggcggat
     1201 ccgtggcgca gcgctggacg tgcatgagtc agagcctttc agctttagcc agggaccctt
     1261 aaaggatgca cccaacctca tctgcacccc ccatgctgca tggtacagtg agcaggcgtc
     1321 cattgagatg cgagaggagg cagcccggga aatccgacga gccatcacag gccggatccc
     1381 agatagcttg aaaaactgtg tcaacaagga ccacctgaca gctgccaccc actgggccag
     1441 catggaccct gctgtggtgc accctgagct caatggggct gcctacagca ggtaccctcc
     1501 aggtgtggtg agtgtggccc ccactggcat cccagctgct gtggaaggta ttgttcccag
     1561 cgccatgtcc ctgtcccatg gcctgccccc tgtggcccac ccaccccacg ctccttctcc
     1621 tggccagact gtcaagcctg aggcggatag agaccatacg actgaccagt tgtagcctgt
     1681 gaggagctct ccagccttga cacctggtgg agggagctgc acacccttgg acccaagtgt
     1741 gcagaggtga catccagtgt ggccctagca ctccagagac tggcccgggc gtgcaccagg
     1801 cggggcaaga ggaagcacgt ccccaagttg attgtagttg tcccgtcctg tgggctggct
     1861 cactgtcctg tgtcctttgc gttcctcgtt taagcaaaag aagttagtag ctaattctat
     1921 cacgaatgtt cttgtctgtg tacagttttt agaacattac caaggatttg tttgcttagc
     1981 tgtcaacaaa aagaaaacct gagggagcat tcagcaagtc agtttgagat tatttttcct
     2041 tttctacgtt ggaacgtgcc ccggaatgtg gccgtcggca cacttctcag gacaatgaat
     2101 ccttcctgtt tttcttttta tgccacacag tgcattgttt ttctatctgc ttgtcttatt
     2161 tttagaataa tttagaaaaa caacaaaggc tgtttttcct aattttggca tgaacccctt
     2221 gttccaaatg aagacggcat cgcgagtggc tctgaggtgt gtctgcagtg cccagtgtgc
     2281 tcaggaccat cggggtctgt cctggggaag gcaggggttg gcagaccctt gcctacgtgg
     2341 tgccgtcctg ctgatgtggt aggctagcaa tattttggtt aaaatcatgt ttgtgactgt
     2401 aaccatttgt atgaattatt
//
