LOCUS       NM_001131014            4361 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cleavage stimulation factor subunit 2 (Cstf2),
            mRNA.
ACCESSION   NM_001131014 XM_001068092
VERSION     NM_001131014.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4361)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4361)
  AUTHORS   Shankarling,G.S. and MacDonald,C.C.
  TITLE     Polyadenylation site-specific differences in the activity of the
            neuronal betaCstF-64 protein in PC-12 cells
  JOURNAL   Gene 529 (2), 220-227 (2013)
   PUBMED   23948079
REFERENCE   3  (bases 1 to 4361)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4361)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4361)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   6  (bases 1 to 4361)
  AUTHORS   Laishram,R.S. and Anderson,R.A.
  TITLE     The poly A polymerase Star-PAP controls 3'-end cleavage by
            promoting CPSF interaction and specificity toward the pre-mRNA
  JOURNAL   EMBO J 29 (24), 4132-4145 (2010)
   PUBMED   21102410
REFERENCE   7  (bases 1 to 4361)
  AUTHORS   Gonzales,M.L., Mellman,D.L. and Anderson,R.A.
  TITLE     CKIalpha is associated with and phosphorylates star-PAP and is also
            required for expression of select star-PAP target messenger RNAs
  JOURNAL   J Biol Chem 283 (18), 12665-12673 (2008)
   PUBMED   18305108
REFERENCE   8  (bases 1 to 4361)
  AUTHORS   Bleoo,S., Sun,X., Hendzel,M.J., Rowe,J.M., Packer,M. and Godbout,R.
  TITLE     Association of human DEAD box protein DDX1 with a cleavage
            stimulation factor involved in 3'-end processing of pre-MRNA
  JOURNAL   Mol Biol Cell 12 (10), 3046-3059 (2001)
   PUBMED   11598190
REFERENCE   9  (bases 1 to 4361)
  AUTHORS   Takagaki,Y., MacDonald,C.C., Shenk,T. and Manley,J.L.
  TITLE     The human 64-kDa polyadenylylation factor contains a
            ribonucleoprotein-type RNA binding domain and unusual auxiliary
            motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1403-1407 (1992)
   PUBMED   1741396
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168251.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001131014.2.
            
            On Aug 15, 2008 this sequence version replaced XM_001068092.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168251.1, SRR8487231.40432.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4361
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..4361
                     /gene="Cstf2"
                     /note="cleavage stimulation factor subunit 2"
                     /db_xref="GeneID:683927"
                     /db_xref="RGD:1596566"
     exon            1..67
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1737
                     /gene="Cstf2"
                     /note="cleavage stimulation factor, 3' pre-RNA subunit 2"
                     /codon_start=1
                     /product="cleavage stimulation factor subunit 2"
                     /protein_id="NP_001124486.1"
                     /db_xref="GeneID:683927"
                     /db_xref="RGD:1596566"
                     /translation="MAGLPVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVS
                     FRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELK
                     SLGTGAPVIESPYGESISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARN
                     MLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPN
                     VSMNQQNPQAPQAQSLSGMHVNGAPPMMQASMPGGVPAPVQMAAAVAGPGPGSLAPAG
                     VMQAQVGMQGAGPVPMERGQVPMQDPRAAMQRGALPANVPTPRGLLGDAPNDPRGGTL
                     MTVTGEVEPRAYLGPPPPPHQGPPMHHVPGHEGRGPPPHDMRGGPLAEPRPLMAEPRG
                     PMLDQRGPPLDARGGRDPRGLDARGMEARAMEARGLEARAMEARAMEARAMEARAMEA
                     RAMEARAMEARGMDTRGPVPGPRGPIPSGIQGPNPMNMGAVVPQGSRQVPVMQGAGMQ
                     GASMQGGSQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKE
                     QIQKSTGAP"
     exon            68..146
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..316
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..453
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..573
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..711
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..835
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..898
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1040
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1225
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1503
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1614
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1740
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..4324
                     /gene="Cstf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgagcca tggcgggttt gcctgttaga gaccctgcgg tggatcgttc tctgcgttct
       61 gtattcgtgg ggaacattcc ttatgaagct actgaagaac aactgaagga catcttctct
      121 gaggttgggc ctgttgttag tttcagattg gtatacgata gggagacagg aaaaccaaag
      181 ggttatggct tctgcgaata ccaagaccaa gagacagcac ttagtgccat gcggaacttg
      241 aatgggcgtg aattcagtgg gagagcactt cgagtggaca atgctgccag tgaaaagaac
      301 aaagaggaac tgaagagcct tggcactggt gcacctgtca tagagtcacc ttatggagaa
      361 agcatcagcc ctgaggatgc ccctgaatcc attagcaaag ctgttgccag tcttccgcca
      421 gaacagatgt ttgaactgat gaaacaaatg aagctctgtg tccagaatag tccccaggaa
      481 gcacgaaaca tgttgcttca gaacccacag ctggcttatg ctttgctgca agcacaggta
      541 gtgatgagaa ttgtggatcc tgagattgcc ctgaaaattc tgcaccgcca gacaaatatc
      601 ccaacgctga tttcaggcaa ccctcagcca gtccatgttg ccggacctgg ctcaggaccc
      661 aatgtttcaa tgaaccagca gaatcctcag gcccctcagg ctcaatcttt gagtggaatg
      721 catgtcaatg gcgcacctcc tatgatgcaa gcttctatgc caggtggagt tccagcacca
      781 gtgcagatgg cagctgctgt agcaggacct ggccctggtt ccttagcccc tgcaggagtc
      841 atgcaagccc aagttggaat gcaaggagct ggaccagtgc ccatggaacg aggacaagtg
      901 ccaatgcaag accccagagc agctatgcag cggggagcct tgcctgccaa cgtcccaact
      961 cctcgtggtc ttttaggtga tgctcccaat gatccacggg gaggcacttt aatgaccgta
     1021 actggagaag tagaacctag agcttacctg ggaccaccac caccacctca tcagggccca
     1081 ccgatgcacc acgttcctgg ccatgaaggt cgtggaccac caccgcatga catgagagga
     1141 ggaccgttag ctgagcccag accgttaatg gcagagccaa gaggacctat gctagatcag
     1201 aggggtccac cgttggatgc cagaggtgga agagatcccc gaggattaga tgcacgaggg
     1261 atggaggcca gagccatgga agccagagga ctggaagccc gtgccatgga agcccgtgcc
     1321 atggaagccc gtgccatgga agctcgtgcc atggaggccc gagccatgga ggctcgtgcc
     1381 atggaggcca gaggcatgga taccagaggc ccagtacctg gacctagagg acctatacct
     1441 agtggaatcc aaggccccaa tccaatgaac atgggggcag ttgttcccca gggatccaga
     1501 caggtcccag tcatgcaggg agcaggcatg caaggagcaa gcatgcaagg tggaagccag
     1561 cctggtggct ttagtcctgg acagagccaa gtcacacccc aggatcatga gaaggctgct
     1621 ttgattatgc aggtccttca actcactgca gaccagattg ccatgctgcc tcctgagcaa
     1681 agacagagca tcctaatctt aaaggaacag atacagaaat ccaccggggc accttgaaag
     1741 gttctcaaaa atacctggca acaaatctgg aaatgtaatt ccataacatt gttgaaatgt
     1801 tgaaaacata gtgacttctg catctaaccc ccctggatga ctcagattgg taccaggtgg
     1861 aggacctgca tcaccatttc tccaaaggaa aacagttcat tctgatgtcg tagtttgtat
     1921 attttctgtg atgttaaata aacattgaac ataagtttaa catattacaa attgaaatac
     1981 ataatccttt tgctgttaag aagctaacac caaggataaa agcttagctg tgatttctga
     2041 ccttactgca gtgtcattct ttaatcttac attgccgtag ctctattctt actttagcat
     2101 aaacatttat tcttcttaat gatacttgag aatttctcag aaacaatgtt tttaggaact
     2161 ttgttttttg ttgaatttgc tttcagcaag gtaataagac tttggccctt gaaaactttc
     2221 cagtcttaga gttttctggg agaaaaaaag catgtggtta gaactacaaa caattagaag
     2281 accaacaagc gaagagcata ccacaggggt gtgtttggtt taaggaatgc caattctcaa
     2341 actgtggttt tagtcagttg caggtctgga catacataag acaaagattg ttttggcact
     2401 ggtttgaatg tgaatcaaca acctaagact gttgtaaagc tcttctgtct atgtatcaac
     2461 tttacaaggt tttctacatg ttcaaattta ataaagaaaa ccaagtgaac aaactatatt
     2521 ccattctttc agaaaattgc aaagctttca gccctatcat cttctctaaa tccattccaa
     2581 aaactcccaa cagaaaaccc taaaactttt acattttcaa gtcttttaag aggaccaagt
     2641 acaggatggc aaattgccca ttatggttgc ctgctacttt caaagtacta cctacttgaa
     2701 aggtaattag tgccattagc ctgtgctaac ttgcaggttg tcttgccttt tgttctcccg
     2761 tagtggcatt aaggaggaac atggtttctc tctaccaggt ccacctcaag acatttgaag
     2821 agttgccgta ataattagtg aagctcacta gcactaattg tgagctcgtt tgtattccca
     2881 gagccctact ctgcattagg attatgggca cgtgaactaa aatcactact tacggcataa
     2941 aaagcataat catgccaagg aaaagaaagc aaagctatta aaatggaggg attcttctcc
     3001 agacattgat aatgaaaatt tgctggatat gtcatactat aagctatgaa gaaaagcgca
     3061 gaacaacaag cactcctacc tgttccactc atccccagtt caatcgggtg ttaattatgc
     3121 atgcagttca ttgttttcat taccttctgt gcctcctgca taagcagtcc ttgatgtgtt
     3181 ggttttgaca gctgttagac ttaaaagcac caatgtattt agatgcagag acaaagagga
     3241 aaatatttct agttgggagc ttgggtttta cacaaccaat tccaaatcaa gataagtaat
     3301 gctgaagtta tttggaaaac agttgtctaa cagaaactat atcctgagaa tccagcagtt
     3361 tcccaaagcc ttcttaaact taatttggtt agtagacctc aggtgaataa gttgacaaga
     3421 gcggtggcat cccagttcat cattatggaa acactcatca gtggtttgtt tgtttgtttg
     3481 tttgtttgtt tgctgttatt tttactgttg taataattca attagctact ccacgtttat
     3541 gatctgcctt tatatgttca gactaatgac tgacaagtga tcccactgat ccttcaagct
     3601 ataggtactt agataaatta cgaaaacaaa gttgttcact cttgatctat ggtacaaatt
     3661 agatggtcca gtgctatcta tagattcatt ctgttaaatg tatgaggtcc attgcctgag
     3721 tacaatgaag tgtgggggtt tttttcttcc tcaaggagcc tgcacctttt cttgaaatcc
     3781 atcataacta acatcccaga gccagtgtgg ttattgtcct ggtggatagg aaaaatgaac
     3841 atgtttgtag gaaaaagaat gacatcttag tggatgattc ctcattgagt aagacctgga
     3901 aaacagtcaa aattataact ttttattttc tttttataac acattcataa acaaaactct
     3961 ttaacaacaa caacaaaaaa tggaaagagc ttctgttaaa ttaccccacg atgtaggtca
     4021 ggcctttcca gttatttcaa acaatacaaa ctggcaatat agttggcttc taactataat
     4081 acaaatttga ttccagttaa tatacttaag atattactag ggaaagtcag caaaattgtt
     4141 caataagcaa agatgaagat tattttggca cagtaaagta taaattgttg gtcacactgg
     4201 atgataagct catgtataac gatgtactta gtgggtatga tatgggagtg ggaatcttgg
     4261 taattttatg tttattattt atgattattg ttttgtcgtg gattcaataa atattttaaa
     4321 atcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
