LOCUS       NP_001124486             575 aa            linear   ROD 26-OCT-2024
DEFINITION  cleavage stimulation factor subunit 2 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001124486 XP_001068092
VERSION     NP_001124486.1
DBSOURCE    REFSEQ: accession NM_001131014.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 575)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (residues 1 to 575)
  AUTHORS   Shankarling,G.S. and MacDonald,C.C.
  TITLE     Polyadenylation site-specific differences in the activity of the
            neuronal betaCstF-64 protein in PC-12 cells
  JOURNAL   Gene 529 (2), 220-227 (2013)
   PUBMED   23948079
REFERENCE   3  (residues 1 to 575)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 575)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 575)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   6  (residues 1 to 575)
  AUTHORS   Laishram,R.S. and Anderson,R.A.
  TITLE     The poly A polymerase Star-PAP controls 3'-end cleavage by
            promoting CPSF interaction and specificity toward the pre-mRNA
  JOURNAL   EMBO J 29 (24), 4132-4145 (2010)
   PUBMED   21102410
REFERENCE   7  (residues 1 to 575)
  AUTHORS   Gonzales,M.L., Mellman,D.L. and Anderson,R.A.
  TITLE     CKIalpha is associated with and phosphorylates star-PAP and is also
            required for expression of select star-PAP target messenger RNAs
  JOURNAL   J Biol Chem 283 (18), 12665-12673 (2008)
   PUBMED   18305108
REFERENCE   8  (residues 1 to 575)
  AUTHORS   Bleoo,S., Sun,X., Hendzel,M.J., Rowe,J.M., Packer,M. and Godbout,R.
  TITLE     Association of human DEAD box protein DDX1 with a cleavage
            stimulation factor involved in 3'-end processing of pre-MRNA
  JOURNAL   Mol Biol Cell 12 (10), 3046-3059 (2001)
   PUBMED   11598190
REFERENCE   9  (residues 1 to 575)
  AUTHORS   Takagaki,Y., MacDonald,C.C., Shenk,T. and Manley,J.L.
  TITLE     The human 64-kDa polyadenylylation factor contains a
            ribonucleoprotein-type RNA binding domain and unusual auxiliary
            motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1403-1407 (1992)
   PUBMED   1741396
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Aug 15, 2008 this sequence version replaced XP_001068092.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168251.1, SRR26360172.2256373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     Protein         1..575
                     /product="cleavage stimulation factor subunit 2 isoform 1"
                     /note="cleavage stimulation factor, 3' pre-RNA subunit 2"
                     /calculated_mol_wt=60708
     Region          10..94
                     /region_name="RRM_CSTF2_CSTF2T"
                     /note="RNA recognition motif (RRM) found in cleavage
                     stimulation factor subunit 2 (CSTF2), cleavage stimulation
                     factor subunit 2 tau variant (CSTF2T) and similar
                     proteins; cd12671"
                     /db_xref="CDD:410072"
     Site            order(19,46..50,59..61,85,88..90)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410072"
     Region          112..191
                     /region_name="CSTF2_hinge"
                     /note="Hinge domain of cleavage stimulation factor subunit
                     2; pfam14327"
                     /db_xref="CDD:433869"
     Region          531..571
                     /region_name="CSTF_C"
                     /note="Transcription termination and cleavage factor
                     C-terminal; pfam14304"
                     /db_xref="CDD:464130"
     CDS             1..575
                     /gene="Cstf2"
                     /coded_by="NM_001131014.2:33..1760"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:683927"
                     /db_xref="RGD:1596566"
ORIGIN      
        1 maglpvrdpa vdrslrsvfv gnipyeatee qlkdifsevg pvvsfrlvyd retgkpkgyg
       61 fceyqdqeta lsamrnlngr efsgralrvd naaseknkee lkslgtgapv iespygesis
      121 pedapesisk avaslppeqm felmkqmklc vqnspqearn mllqnpqlay allqaqvvmr
      181 ivdpeialki lhrqtniptl isgnpqpvhv agpgsgpnvs mnqqnpqapq aqslsgmhvn
      241 gappmmqasm pggvpapvqm aaavagpgpg slapagvmqa qvgmqgagpv pmergqvpmq
      301 dpraamqrga lpanvptprg llgdapndpr ggtlmtvtge vepraylgpp ppphqgppmh
      361 hvpghegrgp pphdmrggpl aeprplmaep rgpmldqrgp pldarggrdp rgldargmea
      421 ramearglea ramearamea ramearamea ramearamea rgmdtrgpvp gprgpipsgi
      481 qgpnpmnmga vvpqgsrqvp vmqgagmqga smqggsqpgg fspgqsqvtp qdhekaalim
      541 qvlqltadqi amlppeqrqs ililkeqiqk stgap
//
