LOCUS       NM_001106523            1140 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cystatin F (Cst7), mRNA.
ACCESSION   NM_001106523 XM_001056457 XM_230714
VERSION     NM_001106523.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K.,
            Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
  TITLE     The balance between cathepsin C and cystatin F controls
            remyelination in the brain of Plp1-overexpressing mouse, a chronic
            demyelinating disease model
  JOURNAL   Glia 65 (6), 917-930 (2017)
   PUBMED   28251676
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Nuvolone,M., Schmid,N., Miele,G., Sorce,S., Moos,R., Schori,C.,
            Beerli,R.R., Bauer,M., Saudan,P., Dietmeier,K., Lachmann,I.,
            Linnebank,M., Martin,R., Kallweit,U., Kana,V., Rushing,E.J.,
            Budka,H. and Aguzzi,A.
  TITLE     Cystatin F is a biomarker of prion pathogenesis in mice
  JOURNAL   PLoS One 12 (2), e0171923 (2017)
   PUBMED   28178353
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Magister,S., Obermajer,N., Mirkovic,B., Svajger,U., Renko,M.,
            Softic,A., Romih,R., Colbert,J.D., Watts,C. and Kos,J.
  TITLE     Regulation of cathepsins S and L by cystatin F during maturation of
            dendritic cells
  JOURNAL   Eur J Cell Biol 91 (5), 391-401 (2012)
   PUBMED   22365146
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Hamilton,G., Colbert,J.D., Schuettelkopf,A.W. and Watts,C.
  TITLE     Cystatin F is a cathepsin C-directed protease inhibitor regulated
            by proteolysis
  JOURNAL   EMBO J 27 (3), 499-508 (2008)
   PUBMED   18256700
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Langerholc,T., Zavasnik-Bergant,V., Turk,B., Turk,V., Abrahamson,M.
            and Kos,J.
  TITLE     Inhibitory properties of cystatin F and its localization in U937
            promonocyte cells
  JOURNAL   FEBS J 272 (6), 1535-1545 (2005)
   PUBMED   15752368
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Cappello,F., Gatti,E., Camossetto,V., David,A., Lelouard,H. and
            Pierre,P.
  TITLE     Cystatin F is secreted, but artificial modification of its
            C-terminus can induce its endocytic targeting
  JOURNAL   Exp Cell Res 297 (2), 607-618 (2004)
   PUBMED   15212960
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Nathanson,C.M., Wasselius,J., Wallin,H. and Abrahamson,M.
  TITLE     Regulated expression and intracellular localization of cystatin F
            in human U937 cells
  JOURNAL   Eur J Biochem 269 (22), 5502-5511 (2002)
   PUBMED   12423348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_001106523.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230714.4, XM_001056457.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680413,
                              SAMN06680421 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1140
                     /gene="Cst7"
                     /note="cystatin F"
                     /db_xref="GeneID:296257"
                     /db_xref="RGD:1309154"
     exon            1..211
                     /gene="Cst7"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..579
                     /gene="Cst7"
                     /note="cystatin F (leukocystatin)"
                     /codon_start=1
                     /product="cystatin-F precursor"
                     /protein_id="NP_001099993.1"
                     /db_xref="GeneID:296257"
                     /db_xref="RGD:1309154"
                     /translation="MHTAMWLAMLLALCCLTSDAHGAYTSDFCSKDLNSGVEPGFPKT
                     IKTNNPGVLKAARHSVEKFNNCTNDIFLFKESHVSKALVQVVKGLKYMLQVEIGRTTC
                     RKTMHRQLDNCDFQTSPALKRTLHCYSEVWVIPWLHSFEVPVLRCH"
     exon            212..384
                     /gene="Cst7"
                     /inference="alignment:Splign:2.1.0"
     exon            385..501
                     /gene="Cst7"
                     /inference="alignment:Splign:2.1.0"
     exon            502..1140
                     /gene="Cst7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgaagcgc ttctggttaa aatgattcag caagaaacca cgccccatca aagctatccc
       61 accctgccct ggtcctggag ctttgcttga caagcacctc tgctcagcct cgccccacta
      121 catgctaccc tcatgcacac agccatgtgg ctggccatgc tgcttgccct ctgctgccta
      181 acatctgacg cccatggggc atacacctca gatttttgtt ccaaagattt gaactccggt
      241 gtggagccgg gattccccaa aacaataaag accaataacc caggagtgct taaggccgcc
      301 aggcacagtg tggaaaagtt caacaactgc acaaatgaca tatttttgtt caaggagtcc
      361 catgtcagca aagccctggt acaggtggta aaaggcctga aatacatgct gcaggtggaa
      421 atcggccgaa ctacatgcag gaagaccatg caccgccaac tggacaactg tgacttccaa
      481 accagccctg ccttgaagcg gacattacac tgctactctg aagtctgggt gatcccctgg
      541 ctccacagtt tcgaggtgcc tgttctccgc tgccactgac ttctgtctct tcagcaagac
      601 cacagctatg ataaagacac tcgtgtgtcc cccgctcctc actttccacc tcagcctggc
      661 catctcagat cctcaaggcc tgcttaccag tgagcagata gacacgccag tgggtcctag
      721 ggggcctggg gtgggagaag agtgccctcc tcgccagatt aaccgtattc acattttctt
      781 ctgaaattaa ttcttccagt gctatacacc tagattcagg atgtgggcat acagagaatc
      841 ctttgatgac attactggag catgggtaga acaaggtggt agtgtgagag gcttcttgat
      901 acctgactgc atgagcagat tctgtatcca gctcatctac caccatcaga ttattactgg
      961 tggggatggt ttaccataaa taaaagactg attatctaaa aagcccttta aatccccctt
     1021 tatttttgtc ctgaccccca ggctaattta attcagggac aatgatagca gcaataacac
     1081 aagacactga cttcacttgg caatttgtgg caccaataaa gccaactctt tttttttttt
//
