LOCUS       NM_133566                836 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus cystatin E/M (Cst6), mRNA.
ACCESSION   NM_133566
VERSION     NM_133566.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 836)
  AUTHORS   Zhang J, Shridhar R, Dai Q, Song J, Barlow SC, Yin L, Sloane BF,
            Miller FR, Meschonat C, Li BD, Abreo F and Keppler D.
  TITLE     Cystatin m: a novel candidate tumor suppressor gene for breast
            cancer
  JOURNAL   Cancer Res 64 (19), 6957-6964 (2004)
   PUBMED   15466187
REFERENCE   2  (bases 1 to 836)
  AUTHORS   Dunnwald M, Zuberi AR, Stephens K, Le R, Sundberg JP, Fleckman P
            and Dale BA.
  TITLE     The ichq mutant mouse, a model for the human skin disorder
            harlequin ichthyosis: mapping, keratinocyte culture, and
            consideration of candidate genes involved in epidermal growth
            regulation
  JOURNAL   Exp Dermatol 12 (3), 245-254 (2003)
   PUBMED   12823437
REFERENCE   3  (bases 1 to 836)
  AUTHORS   Zeeuwen PL, van Vlijmen-Willems IM, Hendriks W, Merkx GF and
            Schalkwijk J.
  TITLE     A null mutation in the cystatin M/E gene of ichq mice causes
            juvenile lethality and defects in epidermal cornification
  JOURNAL   Hum Mol Genet 11 (23), 2867-2875 (2002)
   PUBMED   12393798
REFERENCE   4  (bases 1 to 836)
  AUTHORS   Sotiropoulou G, Anisowicz A and Sager R.
  TITLE     Identification, cloning, and characterization of cystatin M, a
            novel cysteine proteinase inhibitor, down-regulated in breast
            cancer
  JOURNAL   J Biol Chem 272 (2), 903-910 (1997)
   PUBMED   8995380
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY046415.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY046415.1, AW916252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..836
                     /gene="Cst6"
                     /note="cystatin E/M"
                     /db_xref="GeneID:171096"
                     /db_xref="RGD:628799"
     exon            1..514
                     /gene="Cst6"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..724
                     /gene="Cst6"
                     /note="cystatin-M; cystatin N"
                     /codon_start=1
                     /product="cystatin-M precursor"
                     /protein_id="NP_598250.1"
                     /db_xref="GeneID:171096"
                     /db_xref="RGD:628799"
                     /translation="MERPHFPLAMGLGLLAFCLLTLSPDARAELRSRRTGERQNLSPD
                     DPRVLKAAQAAVASYNMDSNSLYYFRDTKVIDAKCQLVAGIKYYMTVDIESTECRKTR
                     VSGDHVDLTTCPLAAGVQQEKLRCNFELLEVPWKNTTQLLKHDCVQV"
     exon            515..640
                     /gene="Cst6"
                     /inference="alignment:Splign:2.1.0"
     exon            641..835
                     /gene="Cst6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaattcaaa cttcagggct ctggtatgaa ttgttctctc cttcctggat ggtaggaatg
       61 ataggccagc atccttacat ttagaggtcc ggggggcctg tgtgccaccc ctggttcgta
      121 cagtgcgtag gtgggggagg tacagccgcc tccaggcacc tgcaagcggg tccaggcttg
      181 ctaggagacc aagcaggcgg tgggcgggtc cgggcgggtc cccggaggct gtaaaagccg
      241 ggcaggatgg agctctgaca ctgaatcggc ggctatggag cgtcctcact tcccgctggc
      301 gatgggcctt ggcctgctcg cattctgcct cctgacccta tccccggatg cccgcgctga
      361 gctgcggagc cgcaggaccg gagaacgcca gaacctgtca cccgacgacc cgcgggtgct
      421 gaaggccgca caggcagctg tggccagcta caatatggac agcaacagcc tctactactt
      481 ccgagacacc aaagtcatcg atgcaaaatg tcagctggtg gctggcatca agtactacat
      541 gactgtggac atagaaagca ccgagtgcag aaagaccaga gtctctggag accacgtgga
      601 cctcaccacc tgccccctgg ctgcaggagt gcaacaggag aaacttcgtt gcaacttcga
      661 gctccttgaa gtcccttgga agaacaccac tcagcttcta aagcatgact gcgtgcaggt
      721 gtgactggcc ccagggtgac agcgtcagga ccccatggga accagcatgg cgggcggagg
      781 cacctcaggg tcatgaacta cacctgctgt aataaatctc cagctgttcc ttgcaa
//
