LOCUS       NM_001108961             742 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus cystatin D (Cst5), mRNA.
ACCESSION   NM_001108961 XM_001058510 XM_345450
VERSION     NM_001108961.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 742)
  AUTHORS   Wang F, Zhang C, Ge W and Zhang G.
  TITLE     Up-regulated CST5 inhibits bone resorption and activation of
            osteoclasts in rat models of osteoporosis via suppression of the
            NF-kappaB pathway
  JOURNAL   J Cell Mol Med 23 (10), 6744-6754 (2019)
   PUBMED   31402549
  REMARK    GeneRIF: Up-regulated CST5 inhibits bone resorption and activation
            of osteoclasts in rat models of osteoporosis via suppression of the
            NF-kappaB pathway.
REFERENCE   2  (bases 1 to 742)
  AUTHORS   Nashida T, Sato R, Haga-Tsujimura M, Yoshie S, Yoshimura K, Imai A
            and Shimomura H.
  TITLE     Antigen-presenting cells in parotid glands contain cystatin D
            originating from acinar cells
  JOURNAL   Arch Biochem Biophys 530 (1), 32-39 (2013)
   PUBMED   23262319
  REMARK    GeneRIF: a function for cystatin D in the regulation of
            antigen-presenting cell activity
REFERENCE   3  (bases 1 to 742)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 742)
  AUTHORS   Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung UI, Kawano H,
            Nakamura Y, Nakamura K, Ikegawa S and Kawaguchi H.
  TITLE     Cystatin 10, a novel chondrocyte-specific protein, may promote the
            last steps of the chondrocyte differentiation pathway
  JOURNAL   J Biol Chem 278 (48), 48259-48266 (2003)
   PUBMED   13679380
REFERENCE   5  (bases 1 to 742)
  AUTHORS   Balbin M, Hall A, Grubb A, Mason RW, Lopez-Otin C and Abrahamson M.
  TITLE     Structural and functional characterization of two allelic variants
            of human cystatin D sharing a characteristic inhibition spectrum
            against mammalian cysteine proteinases
  JOURNAL   J Biol Chem 269 (37), 23156-23162 (1994)
   PUBMED   8083219
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474026.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058510.1, XM_345450.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..742
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /note="cystatin D"
                     /db_xref="GeneID:366219"
                     /db_xref="RGD:1310978"
     exon            1..31
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..486
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /note="cystatin 10 (chondrocytes)"
                     /codon_start=1
                     /product="cystatin-D precursor"
                     /protein_id="NP_001102431.1"
                     /db_xref="GeneID:366219"
                     /db_xref="RGD:1310978"
                     /translation="MSEGALSTPTMASLLSPSLPLLAALALTLALTVNPAASTNAKGK
                     QVAVGGVEPADPNDKEVQKVINFAVKTYNDMNNDLYLSRPIRVMSASQQVVSGKNFYL
                     KIELGQTMCTKAQSDLADCPFNEQPDQQKRAVCNFQINVEPWLNKISLTNFKCYNV"
     exon            32..288
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /inference="alignment:Splign:2.1.0"
     exon            289..402
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /inference="alignment:Splign:2.1.0"
     exon            403..742
                     /gene="Cst5"
                     /gene_synonym="Cst10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaggtgaca tgagtgaagg agcacttagc actccaacca tggcaagttt gctgagcccc
       61 tcgctacccc tgttggctgc tctggcactc acactggccc tgactgtgaa ccctgcagcc
      121 agtactaatg ctaaaggcaa gcaggtggca gtgggtggag tagagcccgc tgacccgaat
      181 gataaggagg tgcagaaagt gatcaacttt gctgttaaaa cctacaatga tatgaacaat
      241 gacctgtacc ttagcaggcc aatacgagtg atgagcgcca gccagcaggt tgtgtctggg
      301 aagaactttt acttgaaaat tgagctaggc caaaccatgt gtaccaaagc ccagtctgat
      361 ttggctgatt gtcccttcaa tgaacagcca gatcaacaga agagggccgt ctgtaatttc
      421 cagatcaatg ttgaaccttg gctgaacaag atatccctga caaacttcaa atgttacaat
      481 gtctgaggat ctatgtcagg ctacacttct gttgaatacc ccttactctt actcaatcat
      541 ctccttaagt tttcctttac ttagacagag agcatagccc tgaagaatga atcgtcaaag
      601 ttctagtacc aagagaaaag tagaaatagg ctctgcacac ctaagtggtg attccctttt
      661 tcctttcttc tacttgattt tcacatgtac cactgtggag tctattgctc atcctttgct
      721 caataaaaaa tattagtagg tc
//
