LOCUS       NM_012837                729 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus cystatin C (Cst3), mRNA.
ACCESSION   NM_012837 XM_342538
VERSION     NM_012837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 729)
  AUTHORS   Zhou,Y., Dong,W., Wang,L., Ren,S., Wei,W. and Wu,G.
  TITLE     Cystatin C Attenuates Perihematomal Secondary Brain Injury by
            Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model
            of Intracerebral Hemorrhage
  JOURNAL   Mol Neurobiol 61 (11), 9646-9662 (2024)
   PUBMED   38676809
  REMARK    GeneRIF: Cystatin C Attenuates Perihematomal Secondary Brain Injury
            by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat
            Model of Intracerebral Hemorrhage.
REFERENCE   2  (bases 1 to 729)
  AUTHORS   Liu,H., Shen,F., Zhang,H. and Zhang,W.
  TITLE     Expression and role of cystatin C in hyperthermia-induced brain
            injury in rats
  JOURNAL   Math Biosci Eng 20 (2), 2716-2731 (2023)
   PUBMED   36899554
  REMARK    GeneRIF: Expression and role of cystatin C in hyperthermia-induced
            brain injury in rats.
REFERENCE   3  (bases 1 to 729)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   4  (bases 1 to 729)
  AUTHORS   Balczon,R., Morrow,K.A., Leavesley,S., Francis,C.M., Stevens,T.C.,
            Agwaramgbo,E., Williams,C., Stevens,R.P., Langham,G., Voth,S.,
            Cioffi,E.A., Weintraub,S.E. and Stevens,T.
  TITLE     Cystatin C regulates the cytotoxicity of infection-induced
            endothelial-derived beta-amyloid
  JOURNAL   FEBS Open Bio 10 (11), 2464-2477 (2020)
   PUBMED   33030263
  REMARK    GeneRIF: Cystatin C regulates the cytotoxicity of infection-induced
            endothelial-derived beta-amyloid.
REFERENCE   5  (bases 1 to 729)
  AUTHORS   Mao,W., Liu,S., Wang,K., Wang,M., Shi,H., Liu,Q., Bao,M., Peng,B.
            and Geng,J.
  TITLE     Cystatin C in Evaluating Renal Function in Ureteral Calculi
            Hydronephrosis in Adults
  JOURNAL   Kidney Blood Press Res 45 (1), 109-121 (2020)
   PUBMED   31801142
  REMARK    GeneRIF: Cystatin C in Evaluating Renal Function in Ureteral
            Calculi Hydronephrosis in Adults.
REFERENCE   6  (bases 1 to 729)
  AUTHORS   Esnard,A., Esnard,F., Guillou,F. and Gauthier,F.
  TITLE     Production of the cysteine proteinase inhibitor cystatin C by rat
            Sertoli cells
  JOURNAL   FEBS Lett 300 (2), 131-135 (1992)
   PUBMED   1563513
REFERENCE   7  (bases 1 to 729)
  AUTHORS   Tavera,C., Leung-Tack,J., Prevot,D., Gensac,M.C., Martinez,J.,
            Fulcrand,P. and Colle,A.
  TITLE     Cystatin C secretion by rat glomerular mesangial cells: autocrine
            loop for in vitro growth-promoting activity
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1082-1088 (1992)
   PUBMED   1540157
REFERENCE   8  (bases 1 to 729)
  AUTHORS   Esnard,F., Esnard,A., Faucher,D., Capony,J.P., Derancourt,J.,
            Brillard,M. and Gauthier,F.
  TITLE     Rat cystatin C: the complete amino acid sequence reveals a site for
            N-glycosylation
  JOURNAL   Biol Chem Hoppe Seyler 371 Suppl, 161-166 (1990)
   PUBMED   2400577
REFERENCE   9  (bases 1 to 729)
  AUTHORS   Thomas,T., Schreiber,G. and Jaworowski,A.
  TITLE     Developmental patterns of gene expression of secreted proteins in
            brain and choroid plexus
  JOURNAL   Dev Biol 134 (1), 38-47 (1989)
   PUBMED   2471663
REFERENCE   10 (bases 1 to 729)
  AUTHORS   Tavera,C., Guillemot,J.C., Capdevielle,J., Ferrara,P.,
            Leung-Tack,J. and Colle,A.
  TITLE     A rapid two-step purification of rat cystatin C, one major
            inhibitor of cysteine proteinases
  JOURNAL   Prep Biochem 19 (4), 279-291 (1989)
   PUBMED   2622871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB692474.1, CB608544.1 and CB314369.1.
            
            On Oct 18, 2004 this sequence version replaced XM_342538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218053.1, FQ212057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CB692474.1         11-27
            18-590              CB608544.1         1-573
            591-729             CB314369.1         363-501
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..729
                     /gene="Cst3"
                     /gene_synonym="CYSC"
                     /note="cystatin C"
                     /db_xref="GeneID:25307"
                     /db_xref="RGD:2432"
     exon            1..294
                     /gene="Cst3"
                     /gene_synonym="CYSC"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..492
                     /gene="Cst3"
                     /gene_synonym="CYSC"
                     /note="cystatin-3; Cystatin C (cysteine proteinase
                     inhibitor)"
                     /codon_start=1
                     /product="cystatin-C precursor"
                     /protein_id="NP_036969.1"
                     /db_xref="GeneID:25307"
                     /db_xref="RGD:2432"
                     /translation="MASPLRSLMLLLAVLAVAWAGTSRPPPRLLGAPQEADASEEGVQ
                     RALDFAVSEYNKGSNDAYHSRAIQVVRARKQLVAGINYYLDVEMGRTTCTKSQTNLTN
                     CPFHDQPHLMRKALCSFQIYSVPWKGTHTLTKSSCKNA"
     exon            295..408
                     /gene="Cst3"
                     /gene_synonym="CYSC"
                     /inference="alignment:Splign:2.1.0"
     exon            409..729
                     /gene="Cst3"
                     /gene_synonym="CYSC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctatctct cacaattggg taaaagccgc gctgtcctct cctctgcacc gactctgtcc
       61 tgcggaacca tggccagccc gctgcgctcc ttgatgctac tgctggccgt cctggccgtg
      121 gcctgggccg gaacctccag gccacccccg cgattgttgg gagctccgca ggaggcagat
      181 gccagcgagg agggcgtgca gcgagcgttg gacttcgccg taagcgagta caacaagggc
      241 agcaacgatg cgtaccacag ccgcgccata caggtggtga gagctcgtaa gcagcttgtg
      301 gctggaataa actattattt ggatgtggag atgggccgaa ctacatgtac caagtcccag
      361 acaaatttga ctaactgtcc tttccacgac cagccccatc tgatgaggaa ggcactctgc
      421 tccttccaga tctacagcgt gccctggaaa ggcacacaca ccctgacaaa atccagctgc
      481 aaaaatgcct aagagctgag tctcatagga ccatgccaat ggtcccttac ttgttcccct
      541 accctgtagt gttttatccc tgagaagggt gctccagctc tggagggcat ctccggggtg
      601 ttcccaccag gagacagtaa agaagctgct gcaggcaggt tctgcacgtc agaacagctg
      661 tcccctggtt ctcttctcct tgcagtacct gtcatacctt gctcttgctc aattaaaaaa
      721 tttaaaaaa
//
