LOCUS       NP_714956                128 aa            linear   ROD 03-APR-2024
DEFINITION  cystatin-12 [Rattus norvegicus].
ACCESSION   NP_714956
VERSION     NP_714956.2
DBSOURCE    REFSEQ: accession NM_153734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 128)
  AUTHORS   Li,Y., Friel,P.J., Robinson,M.O., McLean,D.J. and Griswold,M.D.
  TITLE     Identification and characterization of testis- and
            epididymis-specific genes: cystatin SC and cystatin TE-1
  JOURNAL   Biol Reprod 67 (6), 1872-1880 (2002)
   PUBMED   12444065
  REMARK    GeneRIF: unusual amino acid sequence and highly restricted
            expression suggests that cystatins SC and TE-1 play a very
            specialized role in the testis and epididymis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 8, 2020 this sequence version replaced NP_714956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440736.1, BF406349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..128
                     /product="cystatin-12"
                     /note="cystatin TE-1"
                     /calculated_mol_wt=15033
     Region          23..126
                     /region_name="CY"
                     /note="Cystatin-like domain; Cystatins are a family of
                     cysteine protease inhibitors that occur mainly as single
                     domain proteins. However some extracellular proteins such
                     as kininogen, His-rich glycoprotein and fetuin also
                     contain these domains; cl09238"
                     /db_xref="CDD:447698"
     CDS             1..128
                     /gene="Cst12"
                     /coded_by="NM_153734.2:40..426"
                     /db_xref="GeneID:266776"
                     /db_xref="RGD:708514"
ORIGIN      
        1 mlwksvlpva livlgihdcn fkfieidknd ndfvmsmehv lfhfnenqnd dfaykflrvr
       61 rslrkkytqk ylvdlemgrt lcgkydedid ncplqegpge kkvrctyive trvwvtefti
      121 lnstcvqt
//
