LOCUS       NM_177425                842 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2),
            mRNA.
ACCESSION   NM_177425
VERSION     NM_177425.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 842)
  AUTHORS   Gao,X., Sun,J.Y., Cao,Z.Y., Lin,Y., Zha,D.J., Wang,F., Xue,T.,
            Qiao,L., Lu,L.J. and Qiu,J.H.
  TITLE     Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their
            subcellular localizations in olfactory precursor cells
  JOURNAL   Biochemistry (Mosc) 74 (3), 336-341 (2009)
   PUBMED   19364329
  REMARK    GeneRIF: Results demonstrated that in undifferentiated olfactory
            precursor cells Csrp2 was distributed both in the nucleus and the
            cytoplasm, whereas CRIP2 was predominantly localized in the
            cytoplasm.
REFERENCE   3  (bases 1 to 842)
  AUTHORS   Lin,D.W., Chang,I.C., Tseng,A., Wu,M.L., Chen,C.H., Patenaude,C.A.,
            Layne,M.D. and Yet,S.F.
  TITLE     Transforming growth factor beta up-regulates cysteine-rich protein
            2 in vascular smooth muscle cells via activating transcription
            factor 2
  JOURNAL   J Biol Chem 283 (22), 15003-15014 (2008)
   PUBMED   18387947
  REMARK    GeneRIF: TGFbeta activates ATF2 phosphorylation and Csrp2 gene
            expression via a CRE promoter element.
REFERENCE   4  (bases 1 to 842)
  AUTHORS   Chang,D.F., Belaguli,N.S., Chang,J. and Schwartz,R.J.
  TITLE     LIM-only protein, CRP2, switched on smooth muscle gene activity in
            adult cardiac myocytes
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 157-162 (2007)
   PUBMED   17185421
  REMARK    GeneRIF: CRP2 acted as a potent transcription coadaptor that
            remodeled silent cardiac myocyte chromatin and directed serum
            response factor-dependent smooth muscle gene activity.
REFERENCE   5  (bases 1 to 842)
  AUTHORS   Watanabe,T., Akishita,M., Nakaoka,T., He,H., Miyahara,Y.,
            Yamashita,N., Wada,Y., Aburatani,H., Yoshizumi,M., Kozaki,K. and
            Ouchi,Y.
  TITLE     Caveolin-1, Id3a and two LIM protein genes are upregulated by
            estrogen in vascular smooth muscle cells
  JOURNAL   Life Sci 75 (10), 1219-1229 (2004)
   PUBMED   15219810
  REMARK    GeneRIF: In rats, estrogen was found to up-regulate SmLIM genes in
            smooth muscle vascular cells.
REFERENCE   6  (bases 1 to 842)
  AUTHORS   Weiskirchen,R., Moser,M., Weiskirchen,S., Erdel,M., Dahmen,S.,
            Buettner,R. and Gressner,A.M.
  TITLE     LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a
            novel marker of hepatic stellate cells and binding partner of the
            protein inhibitor of activated STAT1
  JOURNAL   Biochem J 359 (Pt 3), 485-496 (2001)
   PUBMED   11672422
REFERENCE   7  (bases 1 to 842)
  AUTHORS   Jain,M.K., Fujita,K.P., Hsieh,C.M., Endege,W.O., Sibinga,N.E.,
            Yet,S.F., Kashiki,S., Lee,W.S., Perrella,M.A., Haber,E. and
            Lee,M.E.
  TITLE     Molecular cloning and characterization of SmLIM, a developmentally
            regulated LIM protein preferentially expressed in aortic smooth
            muscle cells
  JOURNAL   J Biol Chem 271 (17), 10194-10199 (1996)
   PUBMED   8626582
REFERENCE   8  (bases 1 to 842)
  AUTHORS   Okano,I., Yamamoto,T., Kaji,A., Kimura,T., Mizuno,K. and
            Nakamura,T.
  TITLE     Cloning of CRP2, a novel member of the cysteine-rich protein family
            with two repeats of an unusual LIM/double zinc-finger motif
  JOURNAL   FEBS Lett 333 (1-2), 51-55 (1993)
   PUBMED   8224170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U44948.1 and CD373038.1.
            
            On Oct 28, 2005 this sequence version replaced NM_177425.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44948.1, FM073056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               U44948.1           6-139
            135-470             CD373038.1         126-461
            471-842             U44948.1           476-847
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..842
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /note="cysteine and glycine-rich protein 2"
                     /db_xref="GeneID:29317"
                     /db_xref="RGD:61950"
     exon            1..48
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     exon            49..161
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..631
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /note="CRP2; smooth muscle cell LIM protein; LIM/double
                     zinc-finger protein; cysteine-rich protein 2"
                     /codon_start=1
                     /product="cysteine and glycine-rich protein 2"
                     /protein_id="NP_803174.2"
                     /db_xref="GeneID:29317"
                     /db_xref="RGD:61950"
                     /translation="MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNL
                     DSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESAQPHRPTT
                     NPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTE
                     KEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ"
     exon            162..330
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     exon            331..460
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     exon            461..554
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     exon            555..841
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      842
                     /gene="Csrp2"
                     /gene_synonym="SmLIM"
                     /note="33 A nucleotides"
ORIGIN      
        1 ctagacctcc ctagctccgc ccgccgcgtg ctcccgcctc ccactcggaa tgcctgtctg
       61 gggcggtgga aataagtgcg gggcctgcgg gagaaccgtg taccacgctg aagaggtgca
      121 gtgtgatggg cggagcttcc accgctgctg ctttctgtgc atggtttgca ggaaaaattt
      181 agacagcaca acagtggcaa ttcatgatga agagatctac tgcaaatcat gctacggaaa
      241 gaagtatgga ccaaaaggct atggttatgg ccagggcgct ggcacgctca acatggaccg
      301 tggtgagagg ctgggcatca agccagagag tgctcaacct cacaggccta caacaaatcc
      361 aaacacttct aaatttgccc agaaatatgg aggtgctgag aagtgctcca gatgtgggga
      421 ttctgtgtat gctgctgaga agatcattgg agctggaaag ccctggcaca aaaactgttt
      481 ccgatgtgcc aagtgtggga agagtctgga gtctacaact ctgactgaga aggaaggtga
      541 aatctactgt aaagggtgct acgcaaagaa ctttgggccc aagggattcg gctatggtca
      601 aggagcaggg gcccttgttc atgctcagta gtggtgtaaa cccagtaagc atggcaaaga
      661 acctccatta atgtggatgg ccttaccgca ctcaggctgt gcatcggcca gcactcagca
      721 ctgtgtagca cacacgctat gtgcacaatc gggctggaca ggaagcacta cactctcctg
      781 cccatccgct aacgtttaag aacgttcttt tacatttgga ataaaatttt ggtttgattt
      841 ga
//
