LOCUS       NM_133652               2349 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus chondroitin sulfate proteoglycan 5 (Cspg5),
            transcript variant 2, mRNA.
ACCESSION   NM_133652 XM_001075674
VERSION     NM_133652.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Pinter,A., Hevesi,Z., Zahola,P., Alpar,A. and Hanics,J.
  TITLE     Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix
            assemblies in the adult rat cortex
  JOURNAL   Cell Signal 74, 109710 (2020)
   PUBMED   32653642
  REMARK    GeneRIF: Chondroitin sulfate proteoglycan-5 forms perisynaptic
            matrix assemblies in the adult rat cortex.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Schulz,J., Franke,K., Frick,M. and Schumacher,S.
  TITLE     Different roles of the small GTPases Rac1, Cdc42, and RhoG in
            CALEB/NGC-induced dendritic tree complexity
  JOURNAL   J Neurochem 139 (1), 26-39 (2016)
   PUBMED   27412363
  REMARK    GeneRIF: Rac1, Cdc42, and RhoG perform very specific and
            non-redundant functions at different levels of hierarchy in
            regulating dendritic tree complexity induced by CALEB/NGC
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Brandt,N., Franke,K., Rasin,M.R., Baumgart,J., Vogt,J., Khrulev,S.,
            Hassel,B., Pohl,E.E., Sestan,N., Nitsch,R. and Schumacher,S.
  TITLE     The neural EGF family member CALEB/NGC mediates dendritic tree and
            spine complexity
  JOURNAL   EMBO J 26 (9), 2371-2386 (2007)
   PUBMED   17431398
  REMARK    GeneRIF: PI3K-Akt-mammalian target of rapamycin (mTOR) signaling
            pathway and PKC are important for CALEB/NGC-induced stimulation of
            dendritic branching. CALEB/NGC-induced spine morphogenesis is
            independent of PI3K but depends on PKC.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Ichihara-Tanaka,K., Oohira,A., Rumsby,M. and Muramatsu,T.
  TITLE     Neuroglycan C is a novel midkine receptor involved in process
            elongation of oligodendroglial precursor-like cells
  JOURNAL   J Biol Chem 281 (41), 30857-30864 (2006)
   PUBMED   16901907
  REMARK    GeneRIF: neuroglycan C is a novel component of midkine receptors
            involved in process elongation
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Juttner,R., More,M.I., Das,D., Babich,A., Meier,J., Henning,M.,
            Erdmann,B., Mu Ller,E.C., Otto,A., Grantyn,R. and Rathjen,F.G.
  TITLE     Impaired synapse function during postnatal development in the
            absence of CALEB, an EGF-like protein processed by neuronal
            activity
  JOURNAL   Neuron 46 (2), 233-245 (2005)
   PUBMED   15848802
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Schumacher,S., Jung,M., Norenberg,U., Dorner,A.,
            Chiquet-Ehrismann,R., Stuermer,C.A. and Rathjen,F.G.
  TITLE     CALEB binds via its acidic stretch to the fibrinogen-like domain of
            tenascin-C or tenascin-R and its expression is dynamically
            regulated after optic nerve lesion
  JOURNAL   J Biol Chem 276 (10), 7337-7345 (2001)
   PUBMED   11069908
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Inatani,M., Tanihara,H., Oohira,A., Otori,Y., Nishida,A., Honjo,M.,
            Kido,N. and Honda,Y.
  TITLE     Neuroglycan C, a neural tissue-specific transmembrane chondroitin
            sulfate proteoglycan, in retinal neural network formation
  JOURNAL   Invest Ophthalmol Vis Sci 41 (13), 4338-4346 (2000)
   PUBMED   11095636
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Aono,S., Keino,H., Ono,T., Yasuda,Y., Tokita,Y., Matsui,F.,
            Taniguchi,M., Sonta,S. and Oohira,A.
  TITLE     Genomic organization and expression pattern of mouse neuroglycan C
            in the cerebellar development
  JOURNAL   J Biol Chem 275 (1), 337-342 (2000)
   PUBMED   10617623
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Yasuda,Y., Tokita,Y., Aono,S., Matsui,F., Ono,T., Sonta,S.,
            Watanabe,E., Nakanishi,Y. and Oohira,A.
  TITLE     Cloning and chromosomal mapping of the human gene of neuroglycan C
            (NGC), a neural transmembrane chondroitin sulfate proteoglycan with
            an EGF module
  JOURNAL   Neurosci Res 32 (4), 313-322 (1998)
   PUBMED   9950058
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Watanabe,E., Maeda,N., Matsui,F., Kushima,Y., Noda,M. and Oohira,A.
  TITLE     Neuroglycan C, a novel membrane-spanning chondroitin sulfate
            proteoglycan that is restricted to the brain
  JOURNAL   J Biol Chem 270 (45), 26876-26882 (1995)
   PUBMED   7592931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 27, 2022 this sequence version replaced NM_133652.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF292102.1, SRR22582419.1270556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000008.1  119098932-119099187
            257-1367            JAXUCZ010000008.1  119099790-119100900
            1368-1556           JAXUCZ010000008.1  119104120-119104308
            1557-1713           JAXUCZ010000008.1  119106333-119106489
            1714-2349           JAXUCZ010000008.1  119112556-119113191
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2349
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /note="chondroitin sulfate proteoglycan 5"
                     /db_xref="GeneID:50568"
                     /db_xref="RGD:2431"
     exon            1..256
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1875
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; acidic leucine-rich EGF-like domain-containing
                     brain protein; neuroglycan C"
                     /codon_start=1
                     /product="chondroitin sulfate proteoglycan 5 isoform 2
                     precursor"
                     /protein_id="NP_598413.1"
                     /db_xref="GeneID:50568"
                     /db_xref="RGD:2431"
                     /translation="MGRAGGGGPGWGPPPVLLLLGVTLVLTAGAVPAREAGSAIEAEE
                     LVRSGLAWESRANDTREEAGLPAAGEDETSWTERGSELAAVGPGVGPEETLEASAAVT
                     GTAWLEADGTGLGGVTAEAGSGDAQTLPATLQAPDEALGSSTMPPAIPEATEASGPPS
                     PTLRDKPSLVPELPKEIPLEVWLNLGGSTPDPQRPEPTFPLQGTLETQPASDIIDIDY
                     FEGLDSEGRGTDMGRFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTS
                     FYDDLEEEEEEEEDKDAVGGGDLEDESDLLLPSQKPGVGPGTGQPTSRWHAVPPQHTL
                     GMVPGGSISLRPRPGDPGKDLATSENGTECRVGFVRHNGSCRSVCDLFPSYCHNGGQC
                     YLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAK
                     KLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCDTPCVSSPHARA
                     LAHCDNIVCQDDPSAPHKIQEALKSRLKEEESFNIQNSMSPKLEGGKGDQDDLEVNCL
                     QNNLT"
     exon            257..1367
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1556
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1713
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2349
                     /gene="Cspg5"
                     /gene_synonym="Caleb; Ngc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgcgcg gaggacagcg gctgacggcg gcatgcggcg gctcatgctt cccaccgtgg
       61 gctgaggcgg ccgcagacaa gcggcaggcg cagcggcccg gcaagcggag ggcgcagcca
      121 agccgcgcgc accgcgcacc gcggccgggg ctccgcgcaa tgggccgagc tggaggcggg
      181 ggcccgggct gggggccgcc gccagtgctg ctgcttctgg gggtcacgct ggtgctcacc
      241 gctggggctg taccggcacg ggaagcaggc agtgcgatcg aggctgaaga gctggtgagg
      301 agcggccttg catgggagtc gcgtgccaat gacacgcggg aggaagctgg cctgccagca
      361 gcaggggaag atgagacctc gtggacagag cggggcagtg agctggctgc ggtgggccct
      421 ggggtcgggc cagaggagac actagaggca tcggctgcag tgactggcac tgcctggcta
      481 gaggcagatg gcacaggcct gggtggagtg actgcagagg ctggtagtgg cgacgcccag
      541 acccttccag ctacactcca ggctcctgac gaggcccttg ggtcatctac aatgccccct
      601 gccatccctg aggctactga agccagtgga cctccctccc ccaccctccg tgataaacct
      661 agcctagtcc ctgaactccc taaggagatc cccttggaag tttggctgaa cctgggaggc
      721 agcacacctg accctcaaag gccagagcct acttttcccc ttcagggcac tctagagaca
      781 caaccagcct cagatataat tgacattgat tactttgaag gattggatag cgagggccgc
      841 ggcacagaca tgggcaggtt cccgggctca ccaggaacct cagaaaatca ccctgatact
      901 gaaggagaga ccccctcctg gagcctgctt gacttatatg atgacttcac cccctttgat
      961 gagtctgatt tctaccccac cacatccttc tatgatgact tggaagagga ggaagaggag
     1021 gaggaggata aggatgcagt gggaggcgga gacctggaag atgaaagtga cctcctcctg
     1081 ccctctcaga agcctggtgt ggggcctggg acgggacagc ccaccagtcg atggcatgca
     1141 gttcctccac agcatactct ggggatggta cctggtggca gcatctctct taggccccgc
     1201 cctggagatc caggcaagga cctggccacg agcgaaaatg gaacagagtg ccgagttggc
     1261 tttgtcagac acaatggctc ctgtcggtca gtctgtgacc ttttcccgag ttactgtcac
     1321 aacggcggcc aatgctacct ggtggagaac ataggggctt tctgcaggtg taacacccag
     1381 gactatatct ggcacaaggg gatgcgctgt gagtccatca tcaccgactt ccaggtgatg
     1441 tgcgtggccg tcggctcggc tgcgttggtg ctgctccttc tgttcatgat gactgtgttc
     1501 tttgccaaga aactctatct gctcaagact gagaacacca agctgaggag gaccaacaaa
     1561 ttccggaccc catctgagct ccacaatgat aacttctccc tctccaccat tgccgagggc
     1621 tcccatccaa atgtaaggaa actttgcgac actccctgtg tctcctcccc ccatgcccgt
     1681 gccttggctc actgtgataa cattgtctgt caggatgacc ccagcgctcc ccacaaaatc
     1741 caggaagctc tcaagtcccg cctgaaggag gaagagtcct ttaacatcca gaactccatg
     1801 tcacccaaac tcgagggtgg caaaggtgac caggatgact tggaggtgaa ctgtctccag
     1861 aataacctga cctgagacgg aggagggaga ggggagaggg gggtggggga gggaaggacc
     1921 gtggtctcct ctcgggcagc cggctcctca taaccatttg ttaagctttt cctttgctga
     1981 tctcatggca tgctctgatg tgttttgtag gagggggaaa ctcttaaaat aagcaaagaa
     2041 accgagcagg gttgcgtaca ttggatggtt ctcgtctgtg ctctttgtac gttgcttcta
     2101 cagctgtgat ttctaagcct atgctggcac tcagctgact tgtttttttg gttttttggt
     2161 ttttgttttt tctgggtttt tttttgtttt gttttgtttt gtttctttgt tttttggttt
     2221 gtttttgttt gtttgtttgt ttttgttttt ttgtactttg acccaccttt ttttggaata
     2281 ccagtttaaa aaaacaaaac aaacaaggtt cttgaaataa aactttttaa aaagctgtcc
     2341 acttcctta
//
