LOCUS       NM_031021                915 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus casein kinase 2 beta (Csnk2b), transcript variant
            1, mRNA.
ACCESSION   NM_031021
VERSION     NM_031021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 915)
  AUTHORS   Li,X., Yang,Q., Jiang,P., Wen,J., Chen,Y., Huang,J., Tian,M.,
            Ren,J. and Yang,Q.
  TITLE     Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves
            Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
  JOURNAL   Neurochem Res 49 (5), 1254-1267 (2024)
   PUBMED   38381246
  REMARK    GeneRIF: Inhibition of CK2 Diminishes Fibrotic Scar Formation and
            Improves Outcomes After Ischemic Stroke via Reducing BRD4
            Phosphorylation.
REFERENCE   2  (bases 1 to 915)
  AUTHORS   Barak-Broner,N., Singer-Lahat,D., Chikvashvili,D. and Lotan,I.
  TITLE     CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A
            Activity in Ca2+-Triggered Release in Neuroendocrine Cells
  JOURNAL   Int J Mol Sci 22 (24), 13556 (2021)
   PUBMED   34948351
  REMARK    GeneRIF: CK2 Phosphorylation Is Required for Regulation of Syntaxin
            1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 915)
  AUTHORS   Becker,A., Gotz,C., Montenarh,M. and Philipp,S.E.
  TITLE     Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated
            Phosphorylation in Pancreatic beta-Cells of the Line INS-1
  JOURNAL   Int J Mol Sci 22 (23), 13133 (2021)
   PUBMED   34884938
  REMARK    GeneRIF: Control of TRPM3 Ion Channels by Protein Kinase
            CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line
            INS-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 915)
  AUTHORS   Lee,S.W., Rho,J.H., Lee,S.Y., Yoo,S.H., Kim,H.Y., Chung,W.T. and
            Yoo,Y.H.
  TITLE     Alpha B-Crystallin Protects Rat Articular Chondrocytes against
            Casein Kinase II Inhibition-Induced Apoptosis
  JOURNAL   PLoS One 11 (11), e0166450 (2016)
   PUBMED   27851782
  REMARK    GeneRIF: alphaB-crystallin protects rat articular chondrocytes
            against CK2 inhibition-induced apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 915)
  AUTHORS   Liu,S., Gao,Y., Yu,X., Zhao,B., Liu,L., Zhao,Y., Luo,Z. and Shi,J.
  TITLE     Annexin-1 Mediates Microglial Activation and Migration via the CK2
            Pathway during Oxygen-Glucose Deprivation/Reperfusion
  JOURNAL   Int J Mol Sci 17 (10), 1770 (2016)
   PUBMED   27782092
  REMARK    GeneRIF: ANXA1 promotes microglial activation and migration during
            oxygen-glucose deprivation/reperfusion via FPR, and CK2 target
            alpha-E-catenin phosphorylation is involved in this process.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 915)
  AUTHORS   Kulikova,O.G. and Reikhardt,B.A.
  TITLE     Role of autophosphorylation in regulation of protein kinase CK2
            from rat neuronal chromatin
  JOURNAL   Biochemistry (Mosc) 63 (12), 1400-1406 (1998)
   PUBMED   9916157
REFERENCE   7  (bases 1 to 915)
  AUTHORS   Sarrouilhe,D., Filhol,O., Leroy,D., Bonello,G., Baudry,M.,
            Chambaz,E.M. and Cochet,C.
  TITLE     The tight association of protein kinase CK2 with plasma membranes
            is mediated by a specific domain of its regulatory beta-subunit
  JOURNAL   Biochim Biophys Acta 1403 (2), 199-210 (1998)
   PUBMED   9630630
REFERENCE   8  (bases 1 to 915)
  AUTHORS   Zhang,P., Davis,A.T. and Ahmed,K.
  TITLE     Mechanism of protein kinase CK2 association with nuclear matrix:
            role of disulfide bond formation
  JOURNAL   J Cell Biochem 69 (2), 211-220 (1998)
   PUBMED   9548568
REFERENCE   9  (bases 1 to 915)
  AUTHORS   Pancetti,F., Bosser,R., Itarte,E. and Bachs,O.
  TITLE     Changes in the activity of nuclear protein kinase CK2 during rat
            liver regeneration
  JOURNAL   Biochem Biophys Res Commun 218 (1), 35-39 (1996)
   PUBMED   8573159
REFERENCE   10 (bases 1 to 915)
  AUTHORS   Ahmed,K., Davis,A., Hanten,J., Lambert,D., McIvor,R.S. and
            Goueli,S.A.
  TITLE     Cloning of cDNAs encoding the alpha and beta subunits of rat casein
            kinase 2 (CK-2): investigation of molecular regulation of CK-2 by
            androgens in rat ventral prostate
  JOURNAL   Cell Mol Biol Res 39 (5), 451-462 (1993)
   PUBMED   8173590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1 and EV778558.1.
            
            On Oct 1, 2009 this sequence version replaced NM_031021.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224491.1, FQ214437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BX883045.1         319572-319601       c
            31-733              EV778558.1         35-737
            734-915             BX883045.1         315325-315506       c
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..915
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /note="casein kinase 2 beta"
                     /db_xref="GeneID:81650"
                     /db_xref="RGD:619978"
     exon            1..119
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..202
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..778
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /EC_number="2.7.11.1"
                     /note="phosvitin; CK II beta; casein kinase II beta
                     subunit; casein kinase 2, beta subunit; casein kinase 2,
                     beta polypeptide; Csnk2b-Ly6g5b"
                     /codon_start=1
                     /product="casein kinase II subunit beta"
                     /protein_id="NP_112283.1"
                     /db_xref="GeneID:81650"
                     /db_xref="RGD:619978"
                     /translation="MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVP
                     HYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQ
                     QGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFG
                     TGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR"
     exon            203..305
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..421
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..497
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..687
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..915
                     /gene="Csnk2b"
                     /gene_synonym="Ck2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccccctcc ccacttcgtc tgccgcggcc gggtcggctt tttgcgctgt agcggtctct
       61 gccgttcctt ggaagcacag ctccccttcc ccgccccagt cccagtcccc gtccggccgc
      121 ggacataaag atgagtagct ctgaggaggt gtcctggatt tcctggttct gtgggctccg
      181 tggtaatgaa ttcttctgtg aggtggatga agactacatc caggacaaat ttaatcttac
      241 tggactcaat gagcaggtgc ctcactatcg acaagcccta gacatgatct tggacctgga
      301 acctgatgaa gagctggaag acaaccccaa ccagagtgac ttgattgagc aggcggccga
      361 gatgctctat gggttgatcc acgcccgcta catcctcacc aaccggggca ttgcacaaat
      421 gttggaaaag taccagcaag gagactttgg ctactgtcct cgagtatact gtgagaacca
      481 gccgatgctt cccatcggcc tttcggacat cccaggagag gccatggtga agctctactg
      541 ccccaagtgc atggacgtgt acacacccaa gtcctctagg caccaccaca cggatggcgc
      601 atacttcggc actggtttcc ctcacatgct cttcatggtg catcccgagt accggcccaa
      661 gcggccggcc aaccagtttg tgcccaggct ctacggtttc aagatccatc caatggccta
      721 ccagctgcag ctccaagccg ccagcaactt caagagccca gtcaagacga ttcgctgagt
      781 gccctcccac ctcctctgcc tgtgacacca ccgtccctcc gctgccaccc tttcaggaag
      841 tctatggttt ttagtttaaa ttaaaggaat tgttactgtg gtggggatat gaaataaagg
      901 aagaaaaggc tatga
//
