LOCUS       NM_053824               1546 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus casein kinase 2 alpha 1 (Csnk2a1), mRNA.
ACCESSION   NM_053824
VERSION     NM_053824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Sahoo,P.K., Kar,A.N., Samra,N., Terenzio,M., Patel,P., Lee,S.J.,
            Miller,S., Thames,E., Jones,B., Kawaguchi,R., Coppola,G.,
            Fainzilber,M. and Twiss,J.L.
  TITLE     A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2alpha
            Translation and Drives G3BP1 Granule Disassembly for Axon
            Regeneration
  JOURNAL   Curr Biol 30 (24), 4882-4895 (2020)
   PUBMED   33065005
  REMARK    GeneRIF: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase
            2alpha Translation and Drives G3BP1 Granule Disassembly for Axon
            Regeneration.
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Sager,R.A., Woodford,M.R., Backe,S.J., Makedon,A.M.,
            Baker-Williams,A.J., DiGregorio,B.T., Loiselle,D.R., Haystead,T.A.,
            Zachara,N.E., Prodromou,C., Bourboulia,D., Schmidt,L.S.,
            Linehan,W.M., Bratslavsky,G. and Mollapour,M.
  TITLE     Post-translational Regulation of FNIP1 Creates a Rheostat for the
            Molecular Chaperone Hsp90
  JOURNAL   Cell Rep 26 (5), 1344-1356 (2019)
   PUBMED   30699359
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Wadey,K.S., Brown,B.A., Sala-Newby,G.B., Jayaraman,P.S., Gaston,K.
            and George,S.J.
  TITLE     Protein kinase CK2 inhibition suppresses neointima formation via a
            proline-rich homeodomain-dependent mechanism
  JOURNAL   Vascul Pharmacol 99, 34-44 (2017)
   PUBMED   28927755
  REMARK    GeneRIF: Vascular smooth muscle protein kinase CK2 inhibition
            suppresses neointima formation via a proline-rich
            homeodomain-dependent mechanism.
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Ottaviani,D., Marin,O., Arrigoni,G., Franchin,C., Vilardell,J.,
            Sandre,M., Li,W., Parfitt,D.A., Pinna,L.A., Cheetham,M.E. and
            Ruzzene,M.
  TITLE     Protein kinase CK2 modulates HSJ1 function through phosphorylation
            of the UIM2 domain
  JOURNAL   Hum Mol Genet 26 (3), 611-623 (2017)
   PUBMED   28031292
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Wei,H., Liu,L. and Chen,Q.
  TITLE     Selective removal of mitochondria via mitophagy: distinct pathways
            for different mitochondrial stresses
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt B), 2784-2790 (2015)
   PUBMED   25840011
  REMARK    Review article
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Sarrouilhe,D., Filhol,O., Leroy,D., Bonello,G., Baudry,M.,
            Chambaz,E.M. and Cochet,C.
  TITLE     The tight association of protein kinase CK2 with plasma membranes
            is mediated by a specific domain of its regulatory beta-subunit
  JOURNAL   Biochim Biophys Acta 1403 (2), 199-210 (1998)
   PUBMED   9630630
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Pancetti,F., Bosser,R., Itarte,E. and Bachs,O.
  TITLE     Changes in the activity of nuclear protein kinase CK2 during rat
            liver regeneration
  JOURNAL   Biochem Biophys Res Commun 218 (1), 35-39 (1996)
   PUBMED   8573159
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Diaz-Nido,J., Mizuno,K., Nawa,H. and Marshak,D.R.
  TITLE     Regulation of protein kinase CK2 isoform expression during rat
            brain development
  JOURNAL   Cell Mol Biol Res 40 (5-6), 581-585 (1994)
   PUBMED   7735332
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Ahmed,K., Davis,A., Hanten,J., Lambert,D., McIvor,R.S. and
            Goueli,S.A.
  TITLE     Cloning of cDNAs encoding the alpha and beta subunits of rat casein
            kinase 2 (CK-2): investigation of molecular regulation of CK-2 by
            androgens in rat ventral prostate
  JOURNAL   Cell Mol Biol Res 39 (5), 451-462 (1993)
   PUBMED   8173590
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Meisner,H., Heller-Harrison,R., Buxton,J. and Czech,M.P.
  TITLE     Molecular cloning of the human casein kinase II alpha subunit
  JOURNAL   Biochemistry 28 (9), 4072-4076 (1989)
   PUBMED   2752008
  REMARK    Erratum:[Biochemistry 1989 Aug 22;28(17):7138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091130.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_053824.3.
            
            On Jun 10, 2007 this sequence version replaced NM_053824.1.
            
            Summary: Casein kinase II is a serine/threonine protein kinase that
            phosphorylates acidic proteins such as casein. It is involved in
            various cellular processes, including cell cycle control,
            apoptosis, and circadian rhythms. The kinase exists as a tetramer
            and is composed of an alpha, an alpha-prime, and two beta subunits.
            The alpha subunits contain the catalytic activity while the beta
            subunits undergo autophosphorylation. The protein encoded by this
            gene represents the alpha subunit. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1546
                     /gene="Csnk2a1"
                     /note="casein kinase 2 alpha 1"
                     /db_xref="GeneID:116549"
                     /db_xref="RGD:621663"
     exon            1..63
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..131
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..286
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1361
                     /gene="Csnk2a1"
                     /EC_number="2.7.11.1"
                     /note="CK II alpha; casein kinase II, alpha 1 polypeptide;
                     casein kinase 2, alpha 1 polypeptide"
                     /codon_start=1
                     /product="casein kinase II subunit alpha"
                     /protein_id="NP_446276.1"
                     /db_xref="GeneID:116549"
                     /db_xref="RGD:621663"
                     /translation="MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRK
                     LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK
                     DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPH
                     NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL
                     GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH
                     SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM
                     SSAGMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ"
     exon            287..398
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..500
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..551
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..611
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..695
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..806
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..908
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1009
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1158
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1245
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1514
                     /gene="Csnk2a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccatatt gtctgtgtga ggatagggga gcgcggctag tgccgctgcc gcttccaccg
       61 cagtgcctgt cgaggccaga agaggatgtt cagattcccc cagaaccaac atatggttgg
      121 gaccctgaca gtaactgcca gatcttccaa catcacgttc agctttgtcc gtcaacctgt
      181 ctgacatgtc gggacccgtg ccaagcaggg ccagagttta cacagatgtt aacacacaca
      241 gaccccgaga gtactgggac tatgaatcac atgtggtgga atggggaaat caagatgact
      301 accagcttgt tcgaaaatta ggcaggggca aatacagtga agtgtttgaa gccatcaata
      361 tcacaaataa tgaaaaagtt gttgttaaaa ttctcaagcc agtaaaaaag aagaaaatta
      421 agcgtgaaat aaagattttg gagaatttaa gaggtgggcc caacatcatc acacttgcag
      481 acattgtgaa agaccctgtg tctcgaaccc ctgccttggt ttttgaacat gtaaacaaca
      541 cagacttcaa gcaattgtac cagacgttaa cagactatga cattcgattt tacatgtatg
      601 aaattctgaa agccctggat tattgtcaca gcatggggat tatgcacaga gacgtgaaac
      661 cgcataatgt catgattgat catgagcaca gaaagcttcg gctaatagat tggggtttag
      721 cagagtttta ccatcctggc caagagtata atgtccgagt tgcttcccga tatttcaaag
      781 gtccagagct acttgtagat tatcagatgt acgattatag tttggatatg tggagcttgg
      841 gttgtatgct ggcaagtatg atcttccgga aggagccatt tttccatgga catgacaatt
      901 atgatcagtt ggtgaggata gccaaggttc tgggaacgga agatttatat gactatattg
      961 acaagtacaa cattgaatta gatccacgtt tcaacgatat cttgggcaga cactcccgta
     1021 agcgatggga acgctttgtc cacagtgaaa accagcacct tgtcagcccc gaggccttgg
     1081 attttctgga caagctgctg cgatacgacc accagtctcg gctcactgca agagaggcca
     1141 tggagcaccc ttacttctac actgtcgtga aggaccaggc tcgaatgagt tcggctggca
     1201 tggcaggggg cagcacacct gtcagtagcg ccaatatgat gtcagggatt tcttcagtgc
     1261 caaccccttc acccctggga cctctggcag gctcacccgt gattgctgct gccaactcac
     1321 ttgggatacc tgtaccagct gccgctggcg ctcagcagta atgaccccat ctgtcttctg
     1381 atgcctgggc agaggtgggg acgtccaccc tctccttaat gcagcttgcg cctggttggg
     1441 aggggtgaga acacttcaga agcaccgtgt ctgaaccgtt gcttgtggat ttagtagttg
     1501 agtcataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
