LOCUS       NM_031617               2718 bp    mRNA    linear   ROD 30-OCT-2023
DEFINITION  Rattus norvegicus casein kinase 1, epsilon (Csnk1e), mRNA.
ACCESSION   NM_031617 XM_006242038
VERSION     NM_031617.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2718)
  AUTHORS   Yu Z, Jiang X, Yin J, Han L, Xiong C, Huo Z, Xu J, Shang J, Xi K,
            Nong L, Huang Y and Zhou X.
  TITLE     CK1epsilon drives osteogenic differentiation of bone marrow
            mesenchymal stem cells via activating Wnt/beta-catenin pathway
  JOURNAL   Aging (Albany NY) 15 (19), 10193-10212 (2023)
   PUBMED   37787983
  REMARK    GeneRIF: CK1epsilon drives osteogenic differentiation of bone
            marrow mesenchymal stem cells via activating Wnt/beta-catenin
            pathway.
REFERENCE   2  (bases 1 to 2718)
  AUTHORS   Kennaway DJ, Varcoe TJ, Voultsios A, Salkeld MD, Rattanatray L and
            Boden MJ.
  TITLE     Acute inhibition of casein kinase 1delta/epsilon rapidly delays
            peripheral clock gene rhythms
  JOURNAL   Mol Cell Biochem 398 (1-2), 195-206 (2015)
   PUBMED   25245819
  REMARK    GeneRIF: Data show that casein kinases CSNK1D and CSNK1E inhibition
            resulted in rhythmic expression of clock genes in the liver,
            pancreas and suprachiasmatic nucleus.
REFERENCE   3  (bases 1 to 2718)
  AUTHORS   Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A,
            Li Y, Kumaran R, Nalls MA and Cookson MR.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2718)
  AUTHORS   Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C and
            Kutay U.
  TITLE     CK1delta and CK1epsilon are components of human 40S subunit
            precursors required for cytoplasmic 40S maturation
  JOURNAL   J Cell Sci 127 (Pt 6), 1242-1253 (2014)
   PUBMED   24424021
REFERENCE   5  (bases 1 to 2718)
  AUTHORS   Cajanek L, Ganji RS, Henriques-Oliveira C, Theofilopoulos S, Konik
            P, Bryja V and Arenas E.
  TITLE     Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the
            differentiation of midbrain dopaminergic neurons
  JOURNAL   Mol Cell Biol 33 (1), 59-70 (2013)
   PUBMED   23109420
REFERENCE   6  (bases 1 to 2718)
  AUTHORS   Lee C, Weaver DR and Reppert SM.
  TITLE     Direct association between mouse PERIOD and CKIepsilon is critical
            for a functioning circadian clock
  JOURNAL   Mol Cell Biol 24 (2), 584-594 (2004)
   PUBMED   14701732
REFERENCE   7  (bases 1 to 2718)
  AUTHORS   Hino S, Michiue T, Asashima M and Kikuchi A.
  TITLE     Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and
            is essential for Wnt-3a-induced accumulation of beta-catenin
  JOURNAL   J Biol Chem 278 (16), 14066-14073 (2003)
   PUBMED   12556519
REFERENCE   8  (bases 1 to 2718)
  AUTHORS   Sillibourne JE, Milne DM, Takahashi M, Ono Y and Meek DW.
  TITLE     Centrosomal anchoring of the protein kinase CK1delta mediated by
            attachment to the large, coiled-coil scaffolding protein
            CG-NAP/AKAP450
  JOURNAL   J Mol Biol 322 (4), 785-797 (2002)
   PUBMED   12270714
REFERENCE   9  (bases 1 to 2718)
  AUTHORS   Takano A, Shimizu K, Kani S, Buijs RM, Okada M and Nagai K.
  TITLE     Cloning and characterization of rat casein kinase 1epsilon
  JOURNAL   FEBS Lett 477 (1-2), 106-112 (2000)
   PUBMED   10899319
REFERENCE   10 (bases 1 to 2718)
  AUTHORS   Ghoshal N, Smiley JF, DeMaggio AJ, Hoekstra MF, Cochran EJ, Binder
            LI and Kuret J.
  TITLE     A new molecular link between the fibrillar and granulovacuolar
            lesions of Alzheimer's disease
  JOURNAL   Am J Pathol 155 (4), 1163-1172 (1999)
   PUBMED   10514399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000186.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031617.3.
            
            On or before Oct 11, 2022 this sequence version replaced
            XM_006242038.3, NM_031617.1.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase and a member of the casein kinase I protein family,
            whose members have been implicated in the control of cytoplasmic
            and nuclear processes, including DNA replication and repair. The
            encoded protein is found in the cytoplasm as a monomer and can
            phosphorylate a variety of proteins, including itself. This protein
            has been shown to phosphorylate period, a circadian rhythm protein.
            Multiple transcript variants have been detected for this gene, but
            their full-length natures have not been characterized. [provided by
            RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB042191.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JACYVU010000186.1  4249495-4249654     c
            161-248             JACYVU010000186.1  4246347-4246434     c
            249-359             JACYVU010000186.1  4237720-4237830     c
            360-508             JACYVU010000186.1  4237200-4237348     c
            509-737             JACYVU010000186.1  4234439-4234667     c
            738-908             JACYVU010000186.1  4233596-4233766     c
            909-1057            JACYVU010000186.1  4232965-4233113     c
            1058-1250           JACYVU010000186.1  4228991-4229183     c
            1251-1390           JACYVU010000186.1  4228754-4228893     c
            1391-1454           JACYVU010000186.1  4228140-4228203     c
            1455-2718           JACYVU010000186.1  4226065-4227328     c
FEATURES             Location/Qualifiers
     source          1..2718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2718
                     /gene="Csnk1e"
                     /note="casein kinase 1, epsilon"
                     /db_xref="GeneID:58822"
                     /db_xref="RGD:62045"
     exon            1..160
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            161..248
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1423
                     /gene="Csnk1e"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="casein kinase I"
                     /protein_id="NP_113805.1"
                     /db_xref="GeneID:58822"
                     /db_xref="RGD:62045"
                     /translation="MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKT
                     KHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPT
                     GATANRLRSAAEPVASTPASRIQQAGNTSPRAISRADRERKVSMRLHRGAPANVSSSD
                     LTGRQEVSRIAASQTSVPFDHLGK"
     exon            249..359
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            360..508
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            509..737
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            738..908
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1057
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1250
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1390
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1454
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..2718
                     /gene="Csnk1e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgcgcga gccggcggcg ggggcgggcg gcgggaggcg gcggagcgcg gagcctgagc
       61 ccggccgggc cgagcgcagc gcagcgggcc ggggagaggc tggcgcgccc gcggcccggc
      121 gaatcctctg gcatccgccc cggcgggccg ccccggcgcg caaggttgaa gcatggagct
      181 gcgtgtggga aacaagtatc gcttgggccg gaagatcggc agtgggtcct ttggcgacat
      241 ctacctgggt gccaacattg cctctggtga ggaagtagcc atcaagctcg aatgtgtgaa
      301 gacgaagcac ccacagctcc acatcgagag caagttctac aagatgatgc agggaggagt
      361 ggggatccca tccatcaagt ggtgcggggc tgagggtgac tataacgtga tggtcatgga
      421 gttgctgggg cccagcctgg aagacctctt caacttctgt tcccgaaagt tcagcctcaa
      481 gacggtgctg ctgctggccg accagatgat cagccgcatc gagtatatcc actccaagaa
      541 cttcatccac cgggacgtga agcctgacaa cttcctcatg ggcctgggga agaaaggcaa
      601 tctggtatac atcattgact tcggcctggc caagaagtac cgggatgccc gtacacacca
      661 gcatattccc taccgggaaa acaagaacct gaccggcact gcccgctatg cctctatcaa
      721 cacccacctg ggcattgagc aaagccgtcg agatgacctg gagagcctgg gctatgtgct
      781 catgtacttc aacctgggct ccctgccctg gcaaggcctc aaagcagcca ccaagcgtca
      841 gaagtacgag cggatcagcg agaagaagat gtcaacgccg atcgaggtcc tctgcaaagg
      901 ctacccctct gagttctcaa cttacctcaa cttctgccgc tccctgcggt tcgatgacaa
      961 acctgactac tcctacctgc gccagctctt ccgcaatctc tttcaccggc agggtttctc
     1021 ctatgactac gtcttcgact ggaacatgct caaattcggt gcagcccgga atcccgagga
     1081 cgtagaccgg gagagacgag agcacgaacg ggaagagagg atgggacagt tgcgagggtc
     1141 cgcgaccaga gccctgcccc ctggcccacc aacaggggct accgccaacc gactccgaag
     1201 tgcagccgag cctgtggctt ccaccccggc ctcccgcatc cagcaagctg gcaatacttc
     1261 tcccagagcg atctcacggg cagaccgaga gaggaaggtg agcatgagac tccacagagg
     1321 tgcgcctgcc aatgtctcat cctcagacct cactgggcga caagaggtct cccgaattgc
     1381 agcctcacag acaagcgtgc catttgacca tcttgggaaa tgaggagtgc gaccacagac
     1441 cagtgtttgc gtagtgtctt cactgcattt tatttaaaca aattaaaaac agataagaga
     1501 gaggacagag agaaccgttc aaacgaacga aggaaaaaca aacaaaccac aaaaaccaca
     1561 acccagcaca aagtcgacaa tggattttgt ttctttgatt tattttgcca atggcaaaaa
     1621 gacaagacgt ccttagcact gaggatgctt gtccccttgc cttgcccact gctcccaacc
     1681 tgaaggctgc caacactcct ctggtgacac tgggtcacac tccagccacc tgttctcacc
     1741 accgcccacc acgtgccggg ccgccatcgg aggtgcctga agagcttgca tcagggagtg
     1801 gtttggccag tcaaagacaa gtcctaggag atttcatcga gccttggatg acgcgccatc
     1861 agccctcagg tgatgacagt ggccagcttt gtattggact ttcccacaat cccctccctg
     1921 agcatcccgg tcaccacaca cacttctcac ctctctgcag agatcctgag ggtgcagtga
     1981 gatggtgacc atgatgcgtt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2041 gtgtgtgtgt atgagagaga gagagagaga gagagagaga gagagagaga gagagagaga
     2101 gagagtgact agtatttttc agagctgcag gtggcctgcc acacctgcct ggccaagttt
     2161 ttgttctcct ctcctaaagt caaggtgggg tggacaatga tctccacatc cctcagggca
     2221 tagagtcctt gccaccacct gtccccagat gccagtattt ggcaccccct gccccatctt
     2281 ccattcctga tcttaggcaa gctcttggag tctgctccca gctggcatcg gctctgagtt
     2341 accagttagt tccctggtcc tgagcgtcac ctgtggtcac ccctcttccc aggcctgact
     2401 tctgagtagg accctgggtc agggctaagt gttgaattta cccttcctgg ttaacacctg
     2461 gttttttatt attttatttt tgtttgtttt ctcagtgtgt gtatttccta atttatttac
     2521 ctcttttttc cctttctttt tttttaatta aagagcaaaa ctttttatta ctttgtaatt
     2581 taaaaaactg aaaaaaaaat tactgaagaa ctttgggggg aattttgtac ttttttcctg
     2641 tgtaaatatt ggactttttt gagctttatt gtggttgtta atttgaagta ataaagtaga
     2701 aaaggacaaa gtgatgta
//
