LOCUS       NM_139060               3646 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus casein kinase 1, delta (Csnk1d), transcript
            variant 1, mRNA.
ACCESSION   NM_139060
VERSION     NM_139060.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3646)
  AUTHORS   Wang,Z., Zhou,L., Wang,Y., Peng,Q., Li,H., Zhang,X., Su,Z.,
            Song,J., Sun,Q., Sayed,S., Liu,S. and Lu,D.
  TITLE     The CK1delta/epsilon-AES axis regulates tumorigenesis and
            metastasis in colorectal cancer
  JOURNAL   Theranostics 11 (9), 4421-4435 (2021)
   PUBMED   33754069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3646)
  AUTHORS   Kennaway,D.J., Varcoe,T.J., Voultsios,A., Salkeld,M.D.,
            Rattanatray,L. and Boden,M.J.
  TITLE     Acute inhibition of casein kinase 1delta/epsilon rapidly delays
            peripheral clock gene rhythms
  JOURNAL   Mol Cell Biochem 398 (1-2), 195-206 (2015)
   PUBMED   25245819
  REMARK    GeneRIF: Data show that casein kinases CSNK1D and CSNK1E inhibition
            resulted in rhythmic expression of clock genes in the liver,
            pancreas and suprachiasmatic nucleus.
REFERENCE   3  (bases 1 to 3646)
  AUTHORS   Chia,R., Haddock,S., Beilina,A., Rudenko,I.N., Mamais,A.,
            Kaganovich,A., Li,Y., Kumaran,R., Nalls,M.A. and Cookson,M.R.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3646)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3646)
  AUTHORS   Greer,Y.E., Westlake,C.J., Gao,B., Bharti,K., Shiba,Y.,
            Xavier,C.P., Pazour,G.J., Yang,Y. and Rubin,J.S.
  TITLE     Casein kinase 1delta functions at the centrosome and Golgi to
            promote ciliogenesis
  JOURNAL   Mol Biol Cell 25 (10), 1629-1640 (2014)
   PUBMED   24648492
REFERENCE   6  (bases 1 to 3646)
  AUTHORS   Yasojima,K., Kuret,J., DeMaggio,A.J., McGeer,E. and McGeer,P.L.
  TITLE     Casein kinase 1 delta mRNA is upregulated in Alzheimer disease
            brain
  JOURNAL   Brain Res 865 (1), 116-120 (2000)
   PUBMED   10814741
REFERENCE   7  (bases 1 to 3646)
  AUTHORS   Ghoshal,N., Smiley,J.F., DeMaggio,A.J., Hoekstra,M.F.,
            Cochran,E.J., Binder,L.I. and Kuret,J.
  TITLE     A new molecular link between the fibrillar and granulovacuolar
            lesions of Alzheimer's disease
  JOURNAL   Am J Pathol 155 (4), 1163-1172 (1999)
   PUBMED   10514399
REFERENCE   8  (bases 1 to 3646)
  AUTHORS   Longenecker,K.L., Roach,P.J. and Hurley,T.D.
  TITLE     Three-dimensional structure of mammalian casein kinase I: molecular
            basis for phosphate recognition
  JOURNAL   J Mol Biol 257 (3), 618-631 (1996)
   PUBMED   8648628
REFERENCE   9  (bases 1 to 3646)
  AUTHORS   Graves,P.R. and Roach,P.J.
  TITLE     Role of COOH-terminal phosphorylation in the regulation of casein
            kinase I delta
  JOURNAL   J Biol Chem 270 (37), 21689-21694 (1995)
   PUBMED   7665585
REFERENCE   10 (bases 1 to 3646)
  AUTHORS   Graves,P.R., Haas,D.W., Hagedorn,C.H., DePaoli-Roach,A.A. and
            Roach,P.J.
  TITLE     Molecular cloning, expression, and characterization of a
            49-kilodalton casein kinase I isoform from rat testis
  JOURNAL   J Biol Chem 268 (9), 6394-6401 (1993)
   PUBMED   8454611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV112274.1, AB063114.1, CB615084.1, DY312461.1 and BM392381.1.
            
            On Oct 24, 2007 this sequence version replaced NM_139060.2.
            
            Summary: This gene encodes a member of the casein kinase I (CKI)
            family of serine/threonine protein kinases. A highly similar human
            protein regulates an array of cellular processes by influencing the
            Wnt and hedgehog signaling pathways. The encoded protein may also
            be involved in the regulation of apoptosis, circadian rhythm,
            microtubule dynamics, chromosome segregation, and p53-mediated
            effects on growth. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063114.1, SRR8487227.232449.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               CV112274.1         1-535
            536-1820            AB063114.1         528-1812
            1821-2371           CB615084.1         23-573
            2372-2992           DY312461.1         82-702
            2993-3646           BM392381.1         1-654               c
FEATURES             Location/Qualifiers
     source          1..3646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..3646
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /note="casein kinase 1, delta"
                     /db_xref="GeneID:64462"
                     /db_xref="RGD:71031"
     exon            1..390
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1562
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tau-protein kinase CSNK1D; casein kinase I"
                     /codon_start=1
                     /product="casein kinase I isoform delta isoform 1"
                     /protein_id="NP_620691.2"
                     /db_xref="GeneID:64462"
                     /db_xref="RGD:71031"
                     /translation="MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKT
                     KHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRL
                     RGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDT
                     SRMSTSQIPGRVASSGLQSVVHR"
     exon            391..501
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            502..650
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            651..879
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1050
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1199
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1371
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1511
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..3628
                     /gene="Csnk1d"
                     /gene_synonym="CKI-delta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcgcgat ggcggcggct cctttaggca gctgaagggg gatttaggcc cggaagatcc
       61 gagtccatcc gcggcgggga gagggcgagc ggggccggca ggggccggag cagcggcggc
      121 ggcgctcgga ctgtcccatc cgccccgtat tgaggcgctg agagcgacgg ggcgaccaga
      181 aagcgatggt gaaagcgggg ccgtgagggg ggcggagtcg gaccggaccc gcagtagcgg
      241 cagcagcggc gccgcctccc ggagcgcaga cccaggaagc ggccgggcgg gcagtagcga
      301 gccgcaccgc tgccatggag ctgagggtcg ggaacaggta ccgactgggc cgcaagatcg
      361 gcagcggctc cttcggagac atctatctcg gtacggacat tgctgcagga gaagaagttg
      421 ccatcaagct tgaatgtgtc aaaaccaaac atcctcagct ccacattgag agcaagatct
      481 acaaaatgat gcagggagga gtgggcatcc ctaccatcag atggtgtggg gctgaggggg
      541 actacaatgt catggtgatg gagctactgg gacccagcct ggaagaccta ttcaacttct
      601 gttcaaggaa gtttagtctc aaaactgttc tgttgcttgc tgaccaaatg ataagtcgta
      661 ttgagtacat tcattcgaag aattttatcc accgagacgt gaaaccagat aacttcctca
      721 tggggctggg aaagaaaggc aacctggtct acatcattga ctttgggctg gccaagaagt
      781 atcgggatgc ccgcacccac cagcatatcc cctatcgaga gaacaagaac ctcacaggga
      841 cagcacgcta tgcctccatc aacacacacc ttggcattga acaatctcga agggatgact
      901 tggagtctct ggggtacgtg ctgatgtact tcaacctggg ctctctcccc tggcaggggc
      961 tgaaggccgc caccaagagg cagaagtatg agaggatcag tgagaagaag atgtccactc
     1021 caattgaagt gctgtgcaag ggctatcctt ctgaatttgc cacatacctg aatttctgcc
     1081 gttccttacg ttttgatgac aaacctgact actcctacct gagacagctc ttcagaaatc
     1141 tgttccatcg ccagggcttc tcctacgact atgtgttcga ctggaacatg ctcaaatttg
     1201 gtgccagccg ggctgcagat gatgctgagc gggaacgccg ggaccgagaa gaacgattaa
     1261 gacactcccg gaatccagcc actcgtggcc tcccttctac agcttccggc cgtctgcggg
     1321 gaacccagga agtggctccc ccaacgcccc ttacccctac ctcacatacg gccaacacct
     1381 ctcctagacc cgtctctggc atggaacgag aacggaaagt gagtatgcgg ctgcaccgtg
     1441 gggccccagt caacgtctcc tcatctgatc tcacgggccg acaagatacc tctcgcatgt
     1501 ccacctcaca gattcccggt cgggtggctt ccagtggtct tcagtctgtc gtgcaccgat
     1561 gagaactctc ctttttgctg tgaagggcag acaatgcatg gctgatctac tctgttacca
     1621 atggctttac tagtgacacg ccccccggtc taaacccgaa atgttaacgc cgggagctct
     1681 ccaggccact cacccagcga tgcacatggg gaatcaaaac acaaactaaa tggacaggct
     1741 ccaagagctg ccatcgccag gggctgccac catggcccca tgtgagctca gttgtcatgg
     1801 ggctgggacg aagagcagag gctgggaaac cattgcagag agaacccgac tccctgtgaa
     1861 gagcctctca gctcccacca gtggtggcgg acctgcgctc cctgatgatc ccaccgcagc
     1921 taccagtctt ctacttggtt aagacagttt tgtatcattt tgctaaaaat tactggctta
     1981 aatctgtgta aagaaatctg tctttttatt gtttctttct tgtctgtttt tgcggtctta
     2041 aacaaaaaag atgttgacct taaagaatcc taagacacgc tggcttggag cttctgtgta
     2101 aaatggaggc aggcaagaga ggggcacatg tgagtgtcga ggatgtgtgt tttgttttgt
     2161 tttcttgtgt tgtgctgttc actttggaaa ggaaattctc atcagttgtg tatgtgtgtg
     2221 tgtgtcttgt gggctcccat cagcctaatt tgggcatctt gcttactctt tcccactgta
     2281 aacggatatg cctgcagcca tcagagcagg tagggtacaa catcatggag tagtagggtt
     2341 cagcagttct agcctcagct gagcaccatg gcatggcatt cttcccaaag gaggcaagaa
     2401 ggaagccaag actgaagaac ccacgtgcag agaccttgag agccatatag gctgctggag
     2461 aattccaaga ttcaaagctg agcttgtgtt tgtggtttct agggagagga ttgatttttg
     2521 ggtaggattg gttgcctcta tgcctttgca cttgggaagt tgtggaactg actgcatagt
     2581 cccatgcaga tgccacttgg gtttgtcatt gcctctcaga gccagggagc aggctgtcct
     2641 agacaccatg gtttgcccag agggaccagt ggccaaaggg aatccaccct gaagtgccaa
     2701 gaagcaggtg actgcctacc tgactctaga accttcacct ccagaaaggt gtggtgccac
     2761 acgcctcatg atcttcagct ggacacatct gcgggctggg ctgctctgcc gctggcggtt
     2821 aggatgccaa catgctcttc cctaccatgt gcaccggata tgaagagaca gcaggacctg
     2881 agctccccat ctgagaaatg gggtgcagta catgggtgtg ggtccatctc tttatttttc
     2941 ctgtcagcct gtggagagag ttatgctggg taccttgttc cctgtggagg tttgggctct
     3001 aatggtgcca ccatggcttc tcccttcttc ccagagttcc ttggctctga gcactggccc
     3061 aaggttgggg gacacactgc tgatgtgtga tagcatccca gaatgtggct gttaattgtg
     3121 cctgccagcc acgtgagcct gtgggtgctt tctgaatcct gagctggtta ctctgcaagc
     3181 attttagggt ggagagactt gactcggtgg gattgtgtgt cgaggagtgc agagggaggt
     3241 tgggggggtt gggcgagttt gagatctttg ttgcaaattc tttatcagag ttggcccttc
     3301 cctctccagt ggcaggcctg cctggcaagt gttcttgtag atacctgtgg tgctggaggg
     3361 gtacagggtg gtcttgagac taatccaggt tcagcctggc tttgttgggt tgtgctcaga
     3421 ttaggcccat tggaagtctc cagggtgtgg ccctgacagt tcttgcccaa tatttaatcc
     3481 caccatccct cgcaggaagc gtagttagaa tgtgtgtatc aacctgtgtc ttggtgagca
     3541 gtctctgagc tgtgcgtttg tactaccact gtgtttgtgt actttaacaa ttgtgtaaat
     3601 aataaattca taatgacttc tacctttcaa aaaaaaaaaa aaaaaa
//
