LOCUS       NM_053615               2363 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus casein kinase 1, alpha 1 (Csnk1a1), mRNA.
ACCESSION   NM_053615
VERSION     NM_053615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Chong,Y.C., Mann,R.K., Zhao,C., Kato,M. and Beachy,P.A.
  TITLE     Bifurcating action of Smoothened in Hedgehog signaling is mediated
            by Dlg5
  JOURNAL   Genes Dev 29 (3), 262-276 (2015)
   PUBMED   25644602
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Chia,R., Haddock,S., Beilina,A., Rudenko,I.N., Mamais,A.,
            Kaganovich,A., Li,Y., Kumaran,R., Nalls,M.A. and Cookson,M.R.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Kaneko,N., Hwang,J.Y., Gertner,M., Pontarelli,F. and Zukin,R.S.
  TITLE     Casein kinase 1 suppresses activation of REST in insulted
            hippocampal neurons and halts ischemia-induced neuronal death
  JOURNAL   J Neurosci 34 (17), 6030-6039 (2014)
   PUBMED   24760862
  REMARK    GeneRIF: CK1 associates with and phosphorylates REST at two
            neighboring, but distinct, motifs within the C terminus of REST
            critical for binding of beta-TrCP and targeting of REST for
            proteasomal degradation.
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Kuga,T., Kume,H., Kawasaki,N., Sato,M., Adachi,J., Shiromizu,T.,
            Hoshino,I., Nishimori,T., Matsubara,H. and Tomonaga,T.
  TITLE     A novel mechanism of keratin cytoskeleton organization through
            casein kinase Ialpha and FAM83H in colorectal cancer
  JOURNAL   J Cell Sci 126 (Pt 20), 4721-4731 (2013)
   PUBMED   23902688
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Lee,H.M., Chen,R., Kim,H., Etchegaray,J.P., Weaver,D.R. and Lee,C.
  TITLE     The period of the circadian oscillator is primarily determined by
            the balance between casein kinase 1 and protein phosphatase 1
  JOURNAL   Proc Natl Acad Sci U S A 108 (39), 16451-16456 (2011)
   PUBMED   21930935
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Liu,C., Li,Y., Semenov,M., Han,C., Baeg,G.H., Tan,Y., Zhang,Z.,
            Lin,X. and He,X.
  TITLE     Control of beta-catenin phosphorylation/degradation by a
            dual-kinase mechanism
  JOURNAL   Cell 108 (6), 837-847 (2002)
   PUBMED   11955436
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Ghoshal,N., Smiley,J.F., DeMaggio,A.J., Hoekstra,M.F.,
            Cochran,E.J., Binder,L.I. and Kuret,J.
  TITLE     A new molecular link between the fibrillar and granulovacuolar
            lesions of Alzheimer's disease
  JOURNAL   Am J Pathol 155 (4), 1163-1172 (1999)
   PUBMED   10514399
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Gross,S.D., Loijens,J.C. and Anderson,R.A.
  TITLE     The casein kinase Ialpha isoform is both physically positioned and
            functionally competent to regulate multiple events of mRNA
            metabolism
  JOURNAL   J Cell Sci 112 (Pt 16), 2647-2656 (1999)
   PUBMED   10413673
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Zhang,J., Gross,S.D., Schroeder,M.D. and Anderson,R.A.
  TITLE     Casein kinase I alpha and alpha L: alternative splicing-generated
            kinases exhibit different catalytic properties
  JOURNAL   Biochemistry 35 (50), 16319-16327 (1996)
   PUBMED   8973207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 3, 2020 this sequence version replaced NM_053615.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127486.1, SRR22399481.558.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               JAXUCZ010000018.1  57287412-57288027
            617-723             JAXUCZ010000018.1  57288570-57288676
            724-850             JAXUCZ010000018.1  57299461-57299587
            851-949             JAXUCZ010000018.1  57300277-57300375
            950-1089            JAXUCZ010000018.1  57306319-57306458
            1090-1168           JAXUCZ010000018.1  57306917-57306995
            1169-1243           JAXUCZ010000018.1  57307319-57307393
            1244-1350           JAXUCZ010000018.1  57308813-57308919
            1351-1499           JAXUCZ010000018.1  57310679-57310827
            1500-2363           JAXUCZ010000018.1  57317688-57318551
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2363
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /note="casein kinase 1, alpha 1"
                     /db_xref="GeneID:113927"
                     /db_xref="RGD:71098"
     exon            1..616
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..1507
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /EC_number="2.7.11.1"
                     /note="CKI-alpha; casein kinase I"
                     /codon_start=1
                     /product="casein kinase I isoform alpha"
                     /protein_id="NP_446067.2"
                     /db_xref="GeneID:113927"
                     /db_xref="RGD:71098"
                     /translation="MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA
                     VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFN
                     FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGL
                     AKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS
                     LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMY
                     LRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNM
                     KGF"
     exon            617..723
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..850
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..949
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1089
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1168
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1243
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1350
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1499
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2363
                     /gene="Csnk1a1"
                     /gene_synonym="CK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctaccga aagagcgccc gagatccctt tcccagagtg ctccgcgccg tgaagaagcg
       61 gctcccgggg actgggggca ttttgtgttg gctggagctg gagtaacaag atggcggcat
      121 cggcggagtg acgggttccc tccgggccgg agccggcggc agtggtggca gcggtactgc
      181 cgccctaatt caccgcgccc cttccccagc ccgcgacgtc gccgcgaaca agaaacagcg
      241 gcggccgccc aaatagcaag tggccgagct tcagcagccg cgaccaccct taactaactg
      301 cggccaggcc ctcagcgagc ggcggcgatc cggcttctct cagccgcctt tgcgccctga
      361 aacgccaaca aagccttggt tttaggttgc ctgccgcgct cctcagatct gccgggtgga
      421 acagccccgg aggcttccat cctcttccag aggtgtcggg gcttggcccc cgcctccatc
      481 ttcgcgtctc aggatggcga gcagcagcgg ctccaaggcc gaatttatcg tcggtgggaa
      541 atacaaactg gtgcggaaga tcggatctgg ttccttcggg gacatttatc tagcgatcaa
      601 catcaccaat ggcgaggaag tggcagtgaa actagaatcc cagaaggcca ggcatcccca
      661 gttgctgtac gagagcaaac tgtataagat tcttcaaggt ggggttggca tccctcacat
      721 acggtggtat gggcaagaaa aagactataa tgtgctagtc atggatcttc tgggacccag
      781 cctcgaagac ctcttcaatt tctgttcaag aaggttcact atgaagactg tacttatgtt
      841 agctgaccag atgatcagta gaattgaata tgtgcataca aagaatttta tacacagaga
      901 cattaaacca gataacttcc taatgggtat tgggcgtcac tgtaataagt tattccttat
      961 tgattttggt ttggccaaaa agtacagaga caacaggaca aggcaacaca taccatacag
     1021 ggaagataaa aacctcactg gcactgcccg gtatgccagc atcaatgcac atcttggcat
     1081 tgagcagagt cgccgagatg acatggaatc tttaggatat gttttgatgt attttaatag
     1141 aaccagtctg ccatggcaag ggctaaaggc tgcaacaaag aaacaaaaat atgaaaagat
     1201 tagtgaaaag aagatgtcca ctcctgttga agttttgtgt aaggggtttc ctgcagaatt
     1261 tgccatgtac ttaaattact gtcgtgggct gcgctttgag gaagctccgg attacatgta
     1321 tctgaggcag ctgttccgca tcctcttcag gaccctgaac caccagtatg actacacgtt
     1381 tgattggacg atgttaaagc agaaagcagc ccagcaggca gcctcttcca gtgggcaggg
     1441 tcagcaggcc caaaccccca caggcaagca aactgacaaa accaagagta acatgaaagg
     1501 tttctaagca tggaggaaga gaagcagcag agcagaagat tggagcaaca tttgtttctc
     1561 cccagatcta gaccttttag ttcatatgta cactagccag tggttgtgga caaccattta
     1621 cttggtgtaa aggacttact ttccgtataa actggctctg ggtagcactg ctgatcctga
     1681 gctgtagccg ctgtaattgt gaatattaac tgaggtagtg aaacatggtg tccggttttc
     1741 tattgcattt ttttcaagtg gaaaagttaa ctaaatggtt gacacacaaa ttggtggaga
     1801 aattgtgcat atgccaattt ttttgttaaa atcttttatt ttgaactata ctgctttgag
     1861 atctcatttc agaagaacgg catgaacagt cttcagccac agttgtgatg gttgtaaatg
     1921 ttcacaattg tgtgttctta gggttttcca tccctggggt ttgcaagttg ttgacgtaaa
     1981 aacattcttt aaatggctgg cttcttgttt gcaagctagc tgatagggta gcaaccaaag
     2041 attccagtgt tcgagcattt gaaagactct gcctgcttac tgtgctagaa ataacagcat
     2101 ctaaagtgaa gacttacgaa aaaaaacata gcgactacta gattatcttt aggactctgc
     2161 attaactcta taatgttctt gctattaaaa aaagcatatt tgtcacagaa atttagttac
     2221 cgtcttacaa ctgaacatgt atgtgtgttg cttagataaa tgtaatcact gtaaacatct
     2281 atatgatctg ggattttgtt tttattttga aatgggagct ttttgtttac aagttcatta
     2341 aaaactaaaa actgtttctg taa
//
