LOCUS       NM_017120               1130 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus casein beta (Csn2), mRNA.
ACCESSION   NM_017120 NM_001301723
VERSION     NM_017120.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Wright,L.E., Frye,J.B., Lukefahr,A.L., Marion,S.L., Hoyer,P.B.,
            Besselsen,D.G. and Funk,J.L.
  TITLE     4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial
            differentiation and induces fibroadenoma formation in female
            Sprague Dawley rats
  JOURNAL   Reprod Toxicol 32 (1), 26-32 (2011)
   PUBMED   21621605
  REMARK    GeneRIF: 4-Vinylcyclohexene diepoxide administration to 1-month
            rats acutely decreased mammary alveolar bud number and expression
            of beta-casein.
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   O'Dowd,R., Wlodek,M.E. and Nicholas,K.R.
  TITLE     Uteroplacental insufficiency alters the mammary gland response to
            lactogenic hormones in vitro
  JOURNAL   Reprod Fertil Dev 20 (4), 460-465 (2008)
   PUBMED   18462607
  REMARK    GeneRIF: Mammary tissue from late pregnant Restricted rats had
            elevated alpha-lactalbumin, but not beta-casein mRNA.
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Shekar,P.C., Goel,S., Rani,S.D., Sarathi,D.P., Alex,J.L., Singh,S.
            and Kumar,S.
  TITLE     kappa-casein-deficient mice fail to lactate
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8000-8005 (2006)
   PUBMED   16698927
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Shan,L., Yu,M. and Snyderwine,E.G.
  TITLE     Global gene expression profiling of chemically induced rat mammary
            gland carcinomas and adenomas
  JOURNAL   Toxicol Pathol 33 (7), 768-775 (2005)
   PUBMED   16316942
REFERENCE   6  (bases 1 to 1130)
  AUTHORS   Ohashi,A., Murata,E., Yamamoto,K., Majima,E., Sano,E., Le,Q.T. and
            Katunuma,N.
  TITLE     New functions of lactoferrin and beta-casein in mammalian milk as
            cysteine protease inhibitors
  JOURNAL   Biochem Biophys Res Commun 306 (1), 98-103 (2003)
   PUBMED   12788072
REFERENCE   7  (bases 1 to 1130)
  AUTHORS   Beales,P.E., Elliott,R.B., Flohe,S., Hill,J.P., Kolb,H.,
            Pozzilli,P., Wang,G.S., Wasmuth,H. and Scott,F.W.
  TITLE     A multi-centre, blinded international trial of the effect of A(1)
            and A(2) beta-casein variants on diabetes incidence in two rodent
            models of spontaneous Type I diabetes
  JOURNAL   Diabetologia 45 (9), 1240-1246 (2002)
   PUBMED   12242456
REFERENCE   8  (bases 1 to 1130)
  AUTHORS   Dev,B.C., Sood,S.M., DeWind,S. and Slattery,C.W.
  TITLE     Kappa-casein and beta-caseins in human milk micelles: structural
            studies
  JOURNAL   Arch Biochem Biophys 314 (2), 329-336 (1994)
   PUBMED   7979373
REFERENCE   9  (bases 1 to 1130)
  AUTHORS   Jones,W.K., Yu-Lee,L.Y., Clift,S.M., Brown,T.L. and Rosen,J.M.
  TITLE     The rat casein multigene family. Fine structure and evolution of
            the beta-casein gene
  JOURNAL   J Biol Chem 260 (11), 7042-7050 (1985)
   PUBMED   3997858
REFERENCE   10 (bases 1 to 1130)
  AUTHORS   Blackburn,D.E., Hobbs,A.A. and Rosen,J.M.
  TITLE     Rat beta casein cDNA: sequence analysis and evolutionary
            comparisons
  JOURNAL   Nucleic Acids Res 10 (7), 2295-2307 (1982)
   PUBMED   6283475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            J00711.1, JAXUCZ010000014.1 and AA964718.1.
            
            On or before Sep 16, 2014 this sequence version replaced
            NM_001301723.1, NM_017120.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J00711.1, SRR26643295.48554.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               J00711.1           1-262
            263-634             JAXUCZ010000014.1  20606809-20607180
            635-767             J00711.1           635-767
            768-1022            J00711.1           769-1023
            1023-1130           AA964718.1         1-108               c
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1130
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="casein beta"
                     /db_xref="GeneID:29173"
                     /db_xref="RGD:61981"
     exon            1..40
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            41..103
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..748
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="beta-casein"
                     /codon_start=1
                     /product="beta-casein precursor"
                     /protein_id="NP_058816.2"
                     /db_xref="GeneID:29173"
                     /db_xref="RGD:61981"
                     /translation="MKVFILACLVALALAREKDAFTVSSETGSISSEESVEHINEKLQ
                     KVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGP
                     IISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQA
                     QIVQAFPQTPAVVSSQPQLSLPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTL
                     QFLATQQLHSTSV"
     exon            104..130
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            131..151
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            152..175
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            176..217
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            218..742
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            743..789
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1116
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctctgag cttcatcttc tctcttgtcc tccgctaaag gacttgacag ccatgaaggt
       61 cttcatcctt gcctgccttg tggcacttgc tcttgcaagg gagaaggatg cattcactgt
      121 gtcctctgag actggtagta tttccagtga ggaatccgtt gaacatatca atgagaaact
      181 tcagaaggtg aaactcatgg gacaggtgca gtccgaggat gtgctccaga ataaatttca
      241 ctccggcatt cagtcagaac cccaggccat tccatatgcc cagaccatct cttgcagtcc
      301 cattccacaa aacatccagc ctattgctca accccctgtg gtgccaactg ttgggcctat
      361 catttctcct gaactggaat ccttccttaa agctaaagcc actgtccttc ccaagcacaa
      421 acagatgccc ttccttaact ctgaaaccgt gctccgcctc tttaactctc aaatccccag
      481 tcttgatctt gctaatctgc accttcctca gtctccagcc cagctccagg cacaaattgt
      541 gcaggctttt cctcagactc ccgcggtggt ttcttctcag ccccagctgt ctcttcctca
      601 gtccaaaagt cagtaccttg tgcagcaact agcacccctc ttccaacaag gtatgcctgt
      661 tcaagacctt ctgcagtacc tagatcttct gcttaacccc accctccagt tccttgccac
      721 tcaacaactt cattccactt ctgtctaaga ggatttccgg gttattttct cctcatcatt
      781 ttttttttga attgactgaa actggaaatg tacaatcatt ttcatcttgg gatcatgcta
      841 caaaagtgat atatttctga atgaaactac atggaaaaaa agaaatttta ttcttttatt
      901 tattctatgt attatatgat attcatttga atttgaccca tggactctat atgtgtctca
      961 attatatttc atataatact acaaatgttc aatattgagt ttaaatgaaa gtcaataatg
     1021 tatacaaaat agctcatgaa aaattggatt tactattatt tctttgggaa cctatttcct
     1081 ttccagtcat ttcaataaaa taatccttta ggcataaaaa aaaaaaaaaa
//
