LOCUS       NM_001030039            2108 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus C-terminal Src kinase (Csk), mRNA.
ACCESSION   NM_001030039 XM_236290
VERSION     NM_001030039.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2108)
  AUTHORS   Gonzalez-Sanchez,A., Jaraiz-Rodriguez,M., Dominguez-Prieto,M.,
            Herrero-Gonzalez,S., Medina,J.M. and Tabernero,A.
  TITLE     Connexin43 recruits PTEN and Csk to inhibit c-Src activity in
            glioma cells and astrocytes
  JOURNAL   Oncotarget 7 (31), 49819-49833 (2016)
   PUBMED   27391443
  REMARK    GeneRIF: recruitment of Csk and PTEN to the region between residues
            266 and 283 within the C-terminus of Cx43 leads to c-Src inhibition
            in glioma cells and astrocytes
REFERENCE   2  (bases 1 to 2108)
  AUTHORS   Zhang,L., Ren,Z., Yang,Q. and Ding,G.
  TITLE     Csk regulates angiotensin II-induced podocyte apoptosis
  JOURNAL   Apoptosis 21 (7), 846-855 (2016)
   PUBMED   27225249
  REMARK    GeneRIF: Ang II increased Csk expression and induced podocyte
            apoptosis, stimulated Csk translocation and binding to Caveolin-1.
REFERENCE   3  (bases 1 to 2108)
  AUTHORS   Senda,Y., Murata-Kamiya,N. and Hatakeyama,M.
  TITLE     C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin
            creates a feed-forward C-terminal Src kinase activation loop that
            promotes cell motility
  JOURNAL   Cancer Sci 107 (7), 972-980 (2016)
   PUBMED   27116701
REFERENCE   4  (bases 1 to 2108)
  AUTHORS   Sarmiento,J., Wallis,R.H., Ning,T., Marandi,L., Chao,G.,
            Veillette,A., Lernmark,A., Paterson,A.D. and Poussier,P.
  TITLE     A functional polymorphism of Ptpn22 is associated with type 1
            diabetes in the BioBreeding rat
  JOURNAL   J Immunol 194 (2), 615-629 (2015)
   PUBMED   25505293
REFERENCE   5  (bases 1 to 2108)
  AUTHORS   Tanaka,H., Akagi,K., Oneyama,C., Tanaka,M., Sasaki,Y., Kanou,T.,
            Lee,Y.H., Yokogawa,D., Dobenecker,M.W., Nakagawa,A., Okada,M. and
            Ikegami,T.
  TITLE     Identification of a new interaction mode between the Src homology 2
            domain of C-terminal Src kinase (Csk) and Csk-binding
            protein/phosphoprotein associated with glycosphingolipid
            microdomains
  JOURNAL   J Biol Chem 288 (21), 15240-15254 (2013)
   PUBMED   23548896
  REMARK    GeneRIF: an allosteric connection between Cbp binding and Csk
            activation that arises from residues in the betaB/betaC loop of the
            SH2 domain.
REFERENCE   6  (bases 1 to 2108)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   7  (bases 1 to 2108)
  AUTHORS   Inomata,M., Takayama,Y., Kiyama,H., Nada,S., Okada,M. and
            Nakagawa,H.
  TITLE     Regulation of Src family kinases in the developing rat brain:
            correlation with their regulator kinase, Csk
  JOURNAL   J Biochem 116 (2), 386-392 (1994)
   PUBMED   7529760
REFERENCE   8  (bases 1 to 2108)
  AUTHORS   Bougeret,C., Rothhut,B., Jullien,P., Fischer,S. and Benarous,R.
  TITLE     Recombinant Csk expressed in Escherichia coli is autophosphorylated
            on tyrosine residue(s)
  JOURNAL   Oncogene 8 (5), 1241-1247 (1993)
   PUBMED   7683130
REFERENCE   9  (bases 1 to 2108)
  AUTHORS   Okada,M., Nada,S., Yamanashi,Y., Yamamoto,T. and Nakagawa,H.
  TITLE     CSK: a protein-tyrosine kinase involved in regulation of src family
            kinases
  JOURNAL   J Biol Chem 266 (36), 24249-24252 (1991)
   PUBMED   1722201
REFERENCE   10 (bases 1 to 2108)
  AUTHORS   Nada,S., Okada,M., MacAuley,A., Cooper,J.A. and Nakagawa,H.
  TITLE     Cloning of a complementary DNA for a protein-tyrosine kinase that
            specifically phosphorylates a negative regulatory site of p60c-src
  JOURNAL   Nature 351 (6321), 69-72 (1991)
   PUBMED   1709258
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098863.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by
            NM_001030039.2.
            
            On Aug 5, 2005 this sequence version replaced XM_236290.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2108
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2108
                     /gene="Csk"
                     /note="C-terminal Src kinase"
                     /db_xref="GeneID:315707"
                     /db_xref="RGD:1308800"
     exon            1..62
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1400
                     /gene="Csk"
                     /EC_number="2.7.10.2"
                     /note="protein-tyrosine kinase (CSK); C-SRC kinase; c-src
                     tyrosine kinase; CSK, non-receptor tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase CSK"
                     /protein_id="NP_001025210.1"
                     /db_xref="GeneID:315707"
                     /db_xref="RGD:1308800"
                     /translation="MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKD
                     PNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETG
                     LFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDA
                     DGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK
                     VAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
                     YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG
                     LTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL
                     KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL
                     "
     exon            63..176
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            177..289
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            290..509
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            510..603
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            604..669
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            670..769
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            770..860
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            861..934
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1130
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1217
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2080
                     /gene="Csk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaacagacc ggccttcctg tagcacgggg acgccagatc tcagaagatg tcggctatac
       61 aggcctcctg gccatccggt acagaatgta ttgccaagta caacttccat ggcactgccg
      121 agcaagacct tcccttctgc aaaggagatg tgctcaccat tgtggctgtc accaaggacc
      181 ccaactggta caaagccaaa aacaaagtgg gccgtgaggg catcatccca gccaactatg
      241 tccagaagcg tgagggtgtg aaggcaggca ccaagctcag ccttatgccc tggttccacg
      301 gcaagatcac acgggagcag gcggagcggc ttctctaccc accagagaca ggcctgttcc
      361 tggtgcggga aagcaccaac taccctgggg actacacact gtgtgtgagc tgtgaaggca
      421 aggtggagca ctaccgcatc atgtatcacg cgagcaagct gagcattgat gaggaggtgt
      481 acttcgagaa cctcatgcag ctggtggagc actacaccac agatgccgac ggactctgca
      541 ctcgcctcat caaaccaaag gtcatggagg gcacagtggc ggcccaagat gaattctacc
      601 gcagtggctg ggccctgaac atgaaggaac tgaagctgct acagacgata ggaaaggggg
      661 agtttggaga tgtgatgctg ggggattacc gaggcaacaa agttgcagtc aagtgcatta
      721 agaatgatgc tacagcccag gccttcctgg ctgaagcctc tgtcatgacg cagcttcggc
      781 acagcaacct agtccagcta ctgggtgtga ttgtggagga gaagggtggg ctctacatcg
      841 tcacagagta catggccaag gggagtttgg tggactatct tcgatcacgt ggtcgttcgg
      901 tgctaggcgg agactgtctc ctcaaattct cactagacgt ctgtgaagcc atggagtacc
      961 tggagggtaa caattttgtg caccgggact tggctgcccg gaatgtgctg gtgtctgagg
     1021 acaacgtggc caaagtcagt gactttggcc tcactaagga agcttccagc actcaggaca
     1081 caggcaaact gccagtcaag tggacagctc ctgaagcctt gagagagaag aaattttcca
     1141 ccaagtctga tgtgtggagt ttcggaatcc ttctctggga aatctattcc ttcgggcgag
     1201 tgccttaccc aagaattccc ctgaaggacg tcgtccctcg ggtggaaaag ggctataaga
     1261 tggacgctcc ggatggctgc ccacccgcag tctatgatgt tatgaagaac tgctggcacc
     1321 tggatgctgc cacgcggccc acctttctgc agcttcgaga gcagctcgag cacatcagaa
     1381 cccatgagct gcacctgtga cctctgcctc cacctaggcc atggccttgc agggatgggg
     1441 cctagaagat acagatttgg tgccctgctg cttgctgggc ctgaacttga actgagcccc
     1501 agcgggctgg taggcttctt gcctctgacc tgcctgtccc ttctggcccc ccagagaccc
     1561 cacctaggcc tggcatcttc tctcatggac ccacctatag ggcttagggc gcccactgaa
     1621 ggggctgaga agagaggagg ccgaggagcg ggaggcagtg ctcctgtggt cggccttctc
     1681 tcggccccat cattcgcctt cttagagttt tattcctttc cttttttgag atttttttcc
     1741 gtgtgtttat tttttattat ttttcaacat aaggagaaag aaagtaccca gcaaatgggc
     1801 attttacaag aagtacgaat cttatttttc ctgtcctgcc cctgggggtg gggaggaatc
     1861 agcctctctc tagggaccca tcaccccagc ctgtccccca tcctgtgttc catgtccagt
     1921 gttgcctcgg tcgcctatgt ttgcgcttga ccatgtgcgc tgtttgcatg tgcccaaggc
     1981 aggcatctgt caggggcttg gatttcatgt gctgtggccg ctcacccaca ctgccttgtg
     2041 agatggaatc gtaataaacc actccatgag gacaccgcca aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaa
//
