LOCUS       NM_001107309            2314 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus chondroitin sulfate
            N-acetylgalactosaminyltransferase 1 (Csgalnact1), mRNA.
ACCESSION   NM_001107309 XM_001070564 XM_001070610 XM_001070654 XM_224757
VERSION     NM_001107309.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Sato,T., Kudo,T., Ikehara,Y., Ogawa,H., Hirano,T., Kiyohara,K.,
            Hagiwara,K., Togayachi,A., Ema,M., Takahashi,S., Kimata,K.,
            Watanabe,H. and Narimatsu,H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is
            necessary for normal endochondral ossification and aggrecan
            metabolism
  JOURNAL   J Biol Chem 286 (7), 5803-5812 (2011)
   PUBMED   21148564
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Watanabe,Y., Takeuchi,K., Higa Onaga,S., Sato,M., Tsujita,M.,
            Abe,M., Natsume,R., Li,M., Furuichi,T., Saeki,M., Izumikawa,T.,
            Hasegawa,A., Yokoyama,M., Ikegawa,S., Sakimura,K., Amizuka,N.,
            Kitagawa,H. and Igarashi,M.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required
            for normal cartilage development
  JOURNAL   Biochem J 432 (1), 47-55 (2010)
   PUBMED   20812917
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Gotoh,M., Sato,T., Akashima,T., Iwasaki,H., Kameyama,A.,
            Mochizuki,H., Yada,T., Inaba,N., Zhang,Y., Kikuchi,N., Kwon,Y.D.,
            Togayachi,A., Kudo,T., Nishihara,S., Watanabe,H., Kimata,K. and
            Narimatsu,H.
  TITLE     Enzymatic synthesis of chondroitin with a novel chondroitin sulfate
            N-acetylgalactosaminyltransferase that transfers
            N-acetylgalactosamine to glucuronic acid in initiation and
            elongation of chondroitin sulfate synthesis
  JOURNAL   J Biol Chem 277 (41), 38189-38196 (2002)
   PUBMED   12163485
REFERENCE   4  (bases 1 to 2314)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474045.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070564.1, XM_001070654.1, XM_224757.4, XM_001070610.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2314
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
     CDS             1..1593
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /EC_number="2.4.1.174"
                     /note="chondroitin beta1,4
                     N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001100779.1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
                     /translation="MVRRGLVGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLP
                     RANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGQDQASDAT
                     SLRSGWDPEPKAQADILAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETG
                     LTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRPYTAADFIEGIYRTERDK
                     GTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKKEKLNMANTLINVIVPLARRVDKFRH
                     FMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSR
                     GKGLDVGARFWKGSNVVLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGI
                     IYGHHDAVPALEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVH
                     LYRKYLHSNLIVIRTPVRGLFHLWHEKHCMDELTPEQYRMCMQSKAMNEASHGQLGML
                     VFRHEIEAHLRKQKLKASSKKT"
     exon            1..628
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            629..845
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            846..947
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1126
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1221
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1303
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2314
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtccgac gcgggctggt ggggtggatt tcccgggtag tgattctgct ggtgctgctc
       61 tgttgtgcca tctctgttct ctacatgtta gcctgcaccc caaaaggcga ccaagagcag
      121 ctgggactgc cacgggccaa cggccccaca ggcaaagatg gctaccaagc ggtgctacag
      181 gagcgtgagg aacagcatcg caactatgtg aatagtctta agcgacagat cgcgcagctc
      241 aaggatgaac tgcaggcacg cagtgagcag ctccgcagtg ggcaggacca ggccagcgat
      301 gccaccagcc tgcggtcagg ctgggaccct gaacccaaag cccaggctga tatactggcc
      361 ttcctgcgtg ggcaggtgga caaggctgag gtccacgccg gtgtcaagct ggccaccgaa
      421 tatgctgctg tgccttttga tagcttcact ctgcagaaag tataccagct ggagactggt
      481 ctgacccgcc accctgagga gaaaccagtg aggaaggaca agcgagatga gctagtggaa
      541 gctatcgaat cagccctgga gagtctaaac agccctgtgg aaagcagccc acaccagcgc
      601 ccttacacgg ctgcagactt catagaaggg atctaccgaa cagaaaggga taaaggcact
      661 ttgtatgagc tgaccttcaa aggggaccat aagcatgaat tccaacgact tgtcctattt
      721 cgaccttttg gccccatcat gaaagtgaag aaggaaaagc tcaacatggc caacacactt
      781 atcaacgtta tcgtgcccct agcgaggagg gtggacaagt tccggcactt catgcagaac
      841 ttcagggaga tgtgcatcca acaagatggg agagttcatc ttaccgttgt ttattttggg
      901 aaagaagaaa tgaatgaagt caaaggaata cttgaaaaca cttccaaggc tgccaatttt
      961 agaaacttca ccttcatcca gctgaatgga gagttctccc ggggaaaggg actggatgtt
     1021 ggagcccgct tctggaaggg aagtaatgtc gtgctctttt tctgtgatgt ggacatctac
     1081 ttcacctctg agttcctcaa cacatgtagg ctgaacacac agccagggaa gaaggtattt
     1141 tatccggttc ttttcagtca gtataaccct ggcataatct acggccatca tgatgctgtc
     1201 cctgccctag aacagcagct ggtcataaag aaggaaacag gattttggag ggactttgga
     1261 ttcggaatga cttgtcagta ccggtcagac ttcatcaaca taggtggatt tgacctggac
     1321 atcaaaggct ggggcggtga agatgtgcac ctgtaccgga aatatctcca tagcaacctc
     1381 atagtgatac gcacgcctgt acggggactt ttccaccttt ggcatgagaa gcactgtatg
     1441 gatgaactga cccctgagca gtacaggatg tgcatgcaat caaaggctat gaatgaagca
     1501 tcccacgggc agctgggaat gcttgtcttc cggcatgaaa tagaggctca ccttcgcaaa
     1561 cagaagctca aagccagcag taaaaagaca tgacctccta ggtaaagatt agccaagacg
     1621 tttaaatttt gtgcctttgg cagttactga agaagtagat gcaacaaggt atagacttcc
     1681 acaaagggca acagagaatc tgactgatga gtgacagatg aatgaagagt ctcgggtttc
     1741 tgttggctct gtgtatgctg gtgactctga ctgtgtttac agccaaatga gctctctggt
     1801 ccctgctccc tgaaatagtc acaaccggtt tcagaaaacc agaaggagct gcaagcccac
     1861 tgacttctct tctttggatt ggttacatca gagggctttg gtactactag gactaccaaa
     1921 ggctcagatg gagctctcgg acggagcaga ggacctgtgt gaaaagtgga gctctgacat
     1981 tagtgtcctc caccagaccg tgagcaaaat caaagggacc tggaaacaaa ccatccaaac
     2041 tgtcatttcc ctagtattaa ctgaaaaaca aacaaacaaa caaacaaaaa ccctaaaaaa
     2101 caaaaaaaag acaaaaacaa aaacaaaaaa caaagccaac aacaactaca acaaaaaccc
     2161 ctctctttcc cattattgtt tagtcatctc tgttctaaaa atgcactttt tttgcttctg
     2221 agcattatgc ttatttaatt acccatttcc aagccttagt aggagtacat tgtagtacac
     2281 acatttttat gattttttta aagatttgtt ttta
//
