LOCUS       NM_001106685            3125 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus colony stimulating factor 3 receptor (Csf3r),
            mRNA.
ACCESSION   NM_001106685 XM_001057564 XM_233514
VERSION     NM_001106685.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Zhang,E., Lee,S., Yi,M.H., Nan,Y., Xu,Y., Shin,N., Ko,Y., Lee,Y.H.,
            Lee,W. and Kim,D.W.
  TITLE     Expression of granulocyte colony-stimulating factor 3 receptor in
            the spinal dorsal horn following spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Mol Med Rep 16 (2), 2009-2015 (2017)
   PUBMED   28656207
  REMARK    GeneRIF: the expression of GCSFR in neurons following peripheral
            nerve injury may be involved in the induction and maintenance of
            neuropathic pain through the STAT3 and TRPV1 signaling pathway.
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Aref,S., El-Ghonemy,M., Abouzeid,T., El-Sabbagh,A. and El-Baiomy,M.
  TITLE     Prevalence and impact of colony stimulating factor 3 receptor
            (CSF3R) mutations among Egyptian acute myeloid leukemia patients
  JOURNAL   Leuk Res 38 (6), 722-725 (2014)
   PUBMED   24746896
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Fleischman,A.G., Maxson,J.E., Luty,S.B., Agarwal,A., Royer,L.R.,
            Abel,M.L., MacManiman,J.D., Loriaux,M.M., Druker,B.J. and
            Tyner,J.W.
  TITLE     The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in
            mice that is responsive to therapeutic JAK inhibition
  JOURNAL   Blood 122 (22), 3628-3631 (2013)
   PUBMED   24081659
REFERENCE   4  (bases 1 to 3125)
  AUTHORS   Kosmider,O., Itzykson,R., Chesnais,V., Lasho,T., Laborde,R.,
            Knudson,R., Gauthier,A., Merlevede,J., Ades,L., Morabito,M.,
            Fontenay,M., Tefferi,A., Droin,N. and Solary,E.
  TITLE     Mutation of the colony-stimulating factor-3 receptor gene is a rare
            event with poor prognosis in chronic myelomonocytic leukemia
  JOURNAL   Leukemia 27 (9), 1946-1949 (2013)
   PUBMED   23774674
REFERENCE   5  (bases 1 to 3125)
  AUTHORS   Hanumanthu,V.S. and Pirruccello,S.J.
  TITLE     GCSF-R expression in myelodysplastic and myeloproliferative
            disorders and blast dysmaturation in CML
  JOURNAL   Am J Clin Pathol 140 (2), 155-164 (2013)
   PUBMED   23897249
REFERENCE   6  (bases 1 to 3125)
  AUTHORS   Semerad,C.L., Poursine-Laurent,J., Liu,F. and Link,D.C.
  TITLE     A role for G-CSF receptor signaling in the regulation of
            hematopoietic cell function but not lineage commitment or
            differentiation
  JOURNAL   Immunity 11 (2), 153-161 (1999)
   PUBMED   10485650
REFERENCE   7  (bases 1 to 3125)
  AUTHORS   Otsuji,W., Tanase,S., Yoshida,S. and Bawden,J.W.
  TITLE     The immunohistochemical localization of the interferon-gamma and
            granulocyte colony-stimulating factor receptors during early
            amelogenesis in rat molars
  JOURNAL   Arch Oral Biol 44 (2), 173-181 (1999)
   PUBMED   10206335
REFERENCE   8  (bases 1 to 3125)
  AUTHORS   Hermans,M.H., Ward,A.C., Antonissen,C., Karis,A., Lowenberg,B. and
            Touw,I.P.
  TITLE     Perturbed granulopoiesis in mice with a targeted mutation in the
            granulocyte colony-stimulating factor receptor gene associated with
            severe chronic neutropenia
  JOURNAL   Blood 92 (1), 32-39 (1998)
   PUBMED   9639496
REFERENCE   9  (bases 1 to 3125)
  AUTHORS   Dong,F., Dale,D.C., Bonilla,M.A., Freedman,M., Fasth,A.,
            Neijens,H.J., Palmblad,J., Briars,G.L., Carlsson,G., Veerman,A.J.,
            Welte,K., Lowenberg,B. and Touw,I.P.
  TITLE     Mutations in the granulocyte colony-stimulating factor receptor
            gene in patients with severe congenital neutropenia
  JOURNAL   Leukemia 11 (1), 120-125 (1997)
   PUBMED   9001427
REFERENCE   10 (bases 1 to 3125)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            [WARNING] On Mar 19, 2025 this sequence was replaced by
            NM_001106685.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057564.1, XM_233514.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3125
                     /gene="Csf3r"
                     /note="colony stimulating factor 3 receptor"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
     exon            1..56
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            57..147
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            148..231
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2684
                     /gene="Csf3r"
                     /note="granulocyte colony-stimulating factor receptor;
                     colony stimulating factor 3 receptor (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     precursor"
                     /protein_id="NP_001100155.1"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
                     /translation="MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLA
                     SCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFC
                     LVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKL
                     CIDPMDVVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQECELRYQPQLE
                     GANWTLVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWSPGLQLRPTIKA
                     PTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCPDGQGRIMHLCN
                     TTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLHAMAQDLGSIWV
                     DWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHPFQLYRITVAPL
                     YPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIF
                     WTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNSTGLTLMTMALDS
                     SDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLSAWVPTIMTEET
                     FQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAYVLQGDPREISN
                     QFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPKSYENIWFHSRP
                     QETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     exon            232..531
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            532..655
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            656..843
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1013
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1167
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1247
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1461
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1644
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1746
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1893
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2034
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2125
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2207
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..3125
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacaagag aagagagagc aaacgtgggg gctgggcaca gcgccccagc cccaatcatt
       61 gctgagacat gagcataagc cccttttccc aaatggagaa attgagactc agaaaggtga
      121 agtaacccat ccaagttcac caggcaggta aacaccaagc tggcgaaatg gtggggctgg
      181 gagcctgcaa cctgactgga gttaccctga ttgtcttgct actccccaga agtctggagg
      241 gctgcgggca aatcaggatc tcacccccca ttgtccatct tggggatcct gtcctggcct
      301 cctgcaccat cagcccaaac tgcagcaaac tggaccgaca gccaaagatc ctatggagac
      361 tgcaagatga accaaaccag cctggggaca gacagcatca cctgcctgac gggtcccagg
      421 agtccatcat cactctgcct catctgaact acactcaggc cttcctcttc tgcttggtgc
      481 catggaacaa cagcttccag gtcctggatc aagctgagct tcgtgcaggc tatcctcctg
      541 ccagcccctc caacctatcc tgcctcatgt acctcaccac caacagcctg gtctgccagt
      601 gggagccagg ccccgagacc cacctgccca ctagcttcat cctaaagagc ttcaggagcc
      661 gcaccggctg tcagtaccag gggggcacca tcctggactg tatgcccaag aagagacaca
      721 gcaactgctc catcccccgc aaacacttgc ttctgtacca gaatatggtc atctgggtgc
      781 aagcggagaa tatgctaggg tccagcgagt ccccaaagct gtgcattgac cccatggatg
      841 ttgtgaaatt ggagcctccc atgctgcagg ccctggacat tggccatgat atagtctctc
      901 gccagcctgg ctgcctatgg ctgagctgga agccatggaa gcccagtgag ttcatggagc
      961 aggagtgtga actccgttac cagccacagc ttgaaggagc caactggacc ctggtgtccc
     1021 acctgccttc cagcacggac cggttcgagc tctgcagcct tcatcaagcc ccagtttaca
     1081 ccctacagtt gcgatgcatc cgctcatctc tgcctggact ctggagcagc tggagccctg
     1141 gccttcagct gaggcccacc attaaggccc ccaccatcag actggacaca tggtggcaga
     1201 agaagcatct ggatcctgag acagtgagaa tgcagctgtt ctggaagcca acacccctgc
     1261 agaaagacag tggacagatc cagggctacc tgctctcctg gagttgccca gatgggcaag
     1321 ggcggatcat gcacctctgt aacaccacag agctcagctg caccttccac ctgccctcag
     1381 aggcccagaa cgtgaccctt gtggcctaca actcggcggg gacctcctcc cctactctgg
     1441 tggttttcct ggagcacgaa ggtccagctg tgaccagcct gcatgccatg gcccaagacc
     1501 ttggtagcat ctgggtagac tgggaagccc ccagccttct gcctcagggc tatctcattg
     1561 agtggggccc ggattcccac aaatacagca ataattcctg gaggatagag cccaatggga
     1621 acaccactgg aattctgtta gaggacaata tacatccctt tcaactctac agaatcacag
     1681 tggctcccct gtacccaggc accgtgggac cccctgtaaa tgtctacacc tactctggag
     1741 agaaagccct tcctcatgct ccagagctat atctaaagca tgttggcagg acctgggcac
     1801 agttggagtg ggtacctgag accccttggc tggggatgat acccctcacc aactacacca
     1861 tcttctggac cgatgctcgg gaccactcct tctctgtcac cctgaacatc tcctttcatg
     1921 actttgtcct ggaccacctg aaacctgcca gtttgtatca cgtctacctc atggccacca
     1981 gccgggcagg gtccaccaac agtacaggcc ttaccctgat gaccatggcc ctagattcat
     2041 ctgatgtaaa cattttcctg ggcatacttt gcttcgtact tttgtccatt acctgtgcaa
     2101 ctgcctggtt ctgctgcaag caaagcagaa agactttctt ctggccaaat gtgccagacc
     2161 cagcccacag cagtctgagc gcctgggtgc ccaccatcat gacagaggaa accttccagc
     2221 tgcccagctt ctggggctcc agtgtgccgt caatcaccaa gatcactgaa ctggaggagg
     2281 acaagaaacc gacccactgg gatcccagtg agagctctgg gactgggagc cttccagccg
     2341 tggttcaggc ttacgtgctc caaggagacc caagagaaat ttccaaccag ttccagcctc
     2401 cctctagcac taatgaccag gttctctatg gtcaggtgct tgggagcccc accagcccag
     2461 aagtagtggg ataccttcgg tgtgactcca ctcagcccct cttgggaggc cccacaccca
     2521 gccctaaatc ctatgaaaac atctggttcc attcaagacc ccaggagacc tttatacccc
     2581 aacctccaag ccaggaagat gactgtgtct ttggacctcc atttgatttc cccctcttcc
     2641 aggggctcca ggtccatgga gttgaagaac aagggggttt ctaggacttt tggggtcctt
     2701 acatcctgaa ggccctggcc tattcaggaa agatcccacc actaatatct actggtcctg
     2761 agggaaacag aaaggcccta tttgtctcca gctgtggccc ctaggacctc tccttcactc
     2821 taacctccac aggctacacc cctaggtctt tctcacactc caaggtccag atacatactg
     2881 tttacagccc actagtcacc ttgtgtctct catataattt cagtccgtta aactgagtgt
     2941 aggttttgag cagggactag cacgttcaca aatcctggct ggacgtagtg atacatgcct
     3001 agcatcccaa ctcaaacgtt tgggaggaag atgcaggagg attgcaagtt ccaggccagc
     3061 ctgggctata tgaagagatc ctgcctcaga aattaagcaa aagccaaata aaattttttt
     3121 attac
//
