LOCUS       NM_017104               1297 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus colony stimulating factor 3 (Csf3), mRNA.
ACCESSION   NM_017104 XM_006247265
VERSION     NM_017104.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Jan 30;:. PMID: 32007144]
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Wei,X., Xu,Y., Jin,Y., Feng,H., Xiao,Y. and Dong,S.
  TITLE     Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain
            Barrier Damage and Improves Cognitive Function in Spontaneously
            Hypertensive Rats
  JOURNAL   CNS Neurol Disord Drug Targets 16 (7), 781-788 (2017)
   PUBMED   28176642
  REMARK    GeneRIF: findings demonstrated that the administration of exogenous
            G-CSF can improve cognitive function in a model of Cerebral small
            vessel diseases, possibly due to the recovery of endothelial and
            Blood Brain Barrier function.
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   dela Pena,I.C., Yoo,A., Tajiri,N., Acosta,S.A., Ji,X., Kaneko,Y.
            and Borlongan,C.V.
  TITLE     Granulocyte colony-stimulating factor attenuates delayed
            tPA-induced hemorrhagic transformation in ischemic stroke rats by
            enhancing angiogenesis and vasculogenesis
  JOURNAL   J Cereb Blood Flow Metab 35 (2), 338-346 (2015)
   PUBMED   25425079
  REMARK    GeneRIF: The use of G-CSF to protect the vasculature may improve
            the clinical outcome of tPA even outside the currently indicated
            therapeutic window for ischemic stroke.
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Lee,Y., Song,Y.S., Fang,C.H., So,B.I., Park,J.Y., Joo,H.W.,
            Park,I.H., Shen,G.Y., Shin,J.H., Kim,H., Ahn,Y.H. and Kim,K.S.
  TITLE     Anti-obesity effects of granulocyte-colony stimulating factor in
            Otsuka-Long-Evans-Tokushima fatty rats
  JOURNAL   PLoS One 9 (8), e105603 (2014)
   PUBMED   25144367
  REMARK    GeneRIF: G-CSF treatment reduced body weight and increased energy
            expenditure in a diabetic model, and enhanced UCP-1 expression and
            decreased inflammatory cytokine levels may be associated with the
            effects of G-CSF treatment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Dunne,J.R., Dunkin,B.J., Nelson,S. and White,J.C.
  TITLE     Effects of granulocyte colony stimulating factor in a
            nonneutropenic rodent model of Escherichia coli peritonitis
  JOURNAL   J Surg Res 61 (2), 348-354 (1996)
   PUBMED   8656607
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Saitoh,H. and Shibata,A.
  TITLE     Levels of serum granulocyte colony-stimulating factor in patients
            with chronic myeloid leukemia
  JOURNAL   Leuk Lymphoma 11 (5-6), 443-446 (1993)
   PUBMED   7510191
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
REFERENCE   9  (bases 1 to 1297)
  AUTHORS   Tani,K., Ozawa,K., Ogura,H., Takahashi,T., Okano,A., Watari,K.,
            Matsudaira,T., Tajika,K., Karasuyama,H., Nagata,S. et al.
  TITLE     Implantation of fibroblasts transfected with human granulocyte
            colony-stimulating factor cDNA into mice as a model of
            cytokine-supplement gene therapy
  JOURNAL   Blood 74 (4), 1274-1280 (1989)
   PUBMED   2475183
REFERENCE   10 (bases 1 to 1297)
  AUTHORS   Glaspy,J.A., Baldwin,G.C., Robertson,P.A., Souza,L., Vincent,M.,
            Ambersley,J. and Golde,D.W.
  TITLE     Therapy for neutropenia in hairy cell leukemia with recombinant
            human granulocyte colony-stimulating factor
  JOURNAL   Ann Intern Med 109 (10), 789-795 (1988)
   PUBMED   2461131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Apr 28, 2015 this sequence version replaced
            XM_006247265.2, NM_017104.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37101.1, SRR23984936.350372.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                JAXUCZ010000010.1  84157485-84157518
            35-207              JAXUCZ010000010.1  84157604-84157776
            208-315             JAXUCZ010000010.1  84158090-84158197
            316-462             JAXUCZ010000010.1  84158632-84158778
            463-1297            JAXUCZ010000010.1  84159026-84159860
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1297
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /note="colony stimulating factor 3"
                     /db_xref="GeneID:25610"
                     /db_xref="RGD:2426"
     exon            1..34
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..621
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /note="granulocyte colony-stimulating factor; colony
                     stimulating factor 3 (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor precursor"
                     /protein_id="NP_058800.2"
                     /db_xref="GeneID:25610"
                     /db_xref="RGD:2426"
                     /translation="MKLMALQLLLWHSALWSGQEAIPLLTVSSLPPSLPLPRSFLLKS
                     LEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQALQQTKCL
                     SQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAPTVQPT
                     QSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHLA"
     exon            35..207
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            208..315
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            316..462
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1297
                     /gene="Csf3"
                     /gene_synonym="Gcsf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caactttctg ctcaaggacg catgaagctg atggccctac agctgctgct gtggcacagt
       61 gcactatggt caggacaaga ggccattccc ctgctcaccg tcagctctct gccaccatcc
      121 ctgcctttgc cccgaagctt tctgcttaag tccttggagc aagtgaggaa gattcaggcc
      181 aggaacactg aactgctgga gcagctgtgt gccacctaca agctgtgtca tccggaggag
      241 ctggtgctgt ttggccactc tctgggtatc cccaaggctt ccctgagcag ctgctccagc
      301 caggccttgc agcagacaaa gtgcctgagc caactgcaca gcgggctctt cctctaccaa
      361 ggtctcctgc aggccctagc aggcatttcc tctgagctgg cccccacctt ggatatgctt
      421 cacctggatg tcgacaactt tgccaccacc atctggcagc agatggaaag cctcggggtg
      481 gcccctactg tgcagcccac ccagagcacc atgccaatct tcacttctgc cttccagcgt
      541 cgggcaggag gagtcctggt cacttcatac ctgcagagct tcctggagac agctcaccac
      601 gctctgcacc acttggccta ggcctgcgca gaaagcactt tccagaaagt ttatttatct
      661 ctatttaata tttatgtgta tttaagccca ctatttaaag acaaacaaga gaaaatggag
      721 ctctaagctt ctagatcctt ctctccactt ctgagttttg ttctcctgct tggagcagag
      781 agagaaggct cttgtgtcct cctgtggagg gcagggaagg agataggtaa ataccgagta
      841 ttgattcctg ccgctgctcc aggcacccca ttctgtggtg gtacccaaga aatcacattg
      901 agccctgctg tgctgaggca cctgtctcag gggcccaggc agcatctggt ctcccttctg
      961 ggggacaaga catccctgtt taatatttaa acagcagtgt tcccaaactg ggttcttaca
     1021 tcccttgctc tggtcaacca ggttgtaggt tttcctgacc ccgtaggaat gaagtcccta
     1081 aagaaacagt ggcggccagg tttggccctg gaattgaccg gattcttttt tagggccttg
     1141 ctggcctaga actgggagtg tgggagggaa aaggcacaag gaatcctgtg gggagtgcgt
     1201 ggcatagagg aaggctgacc tgtctaccct ccctctcgac cccacttgtc actgtaacca
     1261 agcttgcgga taataaagtg tgtgtgtgcc cagtaaa
//
