LOCUS       NM_053852                441 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus colony stimulating factor 2 (Csf2), mRNA.
ACCESSION   NM_053852 XM_001074265 XM_340799
VERSION     NM_053852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Ganesan,R. and Rasool,M.
  TITLE     Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61,
            IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis
            by fibroblast-like synoviocytes in rheumatoid arthritis
  JOURNAL   Mol Immunol 91, 134-144 (2017)
   PUBMED   28898718
  REMARK    GeneRIF: findings demonstrate that IL-17 regulates SHP-2 expression
            and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and
            RANKL in AA-FLS and may reveal a new insight into the pathogenesis
            of RA.
REFERENCE   3  (bases 1 to 441)
  AUTHORS   Sterpetti,A.V., Borrelli,V., Ventura,M. and Cucina,A.
  TITLE     Cross talk between inflammatory cytokines and
            granulocyte-macrophage colony-stimulating factor in transplant
            vasculopathy
  JOURNAL   J Surg Res 212, 114-121 (2017)
   PUBMED   28550897
  REMARK    GeneRIF: Transplant vasculopathy depends on the simultaneous and
            complementary additive effects of granulocyte-macrophage
            colony-stimulating factor and cytokines, which have a continuous
            'cross talk.'
REFERENCE   4  (bases 1 to 441)
  AUTHORS   Katz,S., Zsiros,V., Doczi,N., Szabo,A., Biczo,A. and Kiss,A.L.
  TITLE     GM-CSF and GM-CSF receptor have regulatory role in transforming rat
            mesenteric mesothelial cells into macrophage-like cells
  JOURNAL   Inflamm Res 65 (10), 827-836 (2016)
   PUBMED   27364613
  REMARK    GeneRIF: Mesenteric mesothelial cells express GM-CSF receptor on
            the plasma membrane; during inflammation they synthesize and
            secrete GM-CSF that can stimulate GM-CSF receptor expression and
            mesothelial cell to macrophage-like cell transformation; in this
            transformation, GM-CSF (together with its receptor and other
            cytokines) has a major autocrine regulatory role; receptor-ligand
            internalization is essential for GM-CSF signalling
REFERENCE   5  (bases 1 to 441)
  AUTHORS   Li,M., Wang,B., Wu,Z., Zhang,J., Shi,X., Cheng,W. and Han,S.
  TITLE     A novel recombinant protein of ephrinA1-PE38/GM-CSF activate
            dendritic cells vaccine in rats with glioma
  JOURNAL   Tumour Biol 36 (7), 5497-5503 (2015)
   PUBMED   25677907
  REMARK    GeneRIF: The findings that ephrinA1-PE38/GM-CSF had a high efficacy
            in the activation of the dendritic cells would facilitate the
            development of in vivo dendritic-cell vaccines for the treatment of
            gliomas in rats
REFERENCE   6  (bases 1 to 441)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   7  (bases 1 to 441)
  AUTHORS   Cannistra,S.A., DiCarlo,J., Groshek,P., Kanakura,Y., Berg,D.,
            Mayer,R.J. and Griffin,J.D.
  TITLE     Simultaneous administration of granulocyte-macrophage
            colony-stimulating factor and cytosine arabinoside for the
            treatment of relapsed acute myeloid leukemia
  JOURNAL   Leukemia 5 (3), 230-238 (1991)
   PUBMED   1826536
REFERENCE   8  (bases 1 to 441)
  AUTHORS   Frenck,R.W., Sarman,G., Harper,T.E. and Buescher,E.S.
  TITLE     The ability of recombinant murine granulocyte-macrophage
            colony-stimulating factor to protect neonatal rats from septic
            death due to Staphylococcus aureus
  JOURNAL   J Infect Dis 162 (1), 109-114 (1990)
   PUBMED   2192004
REFERENCE   9  (bases 1 to 441)
  AUTHORS   Bermudez,L.E., Martinelli,J.C., Gascon,R., Wu,M. and Young,L.S.
  TITLE     Protection against gram-negative bacteremia in neutropenic mice
            with recombinant granulocyte-macrophage colony-stimulating factor
  JOURNAL   Cytokine 2 (4), 287-293 (1990)
   PUBMED   1966550
REFERENCE   10 (bases 1 to 441)
  AUTHORS   Lee,F., Yokota,T., Otsuka,T., Gemmell,L., Larson,N., Luh,J.,
            Arai,K. and Rennick,D.
  TITLE     Isolation of cDNA for a human granulocyte-macrophage
            colony-stimulating factor by functional expression in mammalian
            cells
  JOURNAL   Proc Natl Acad Sci U S A 82 (13), 4360-4364 (1985)
   PUBMED   3925454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Feb 10, 2013 this sequence version replaced
            XM_001074265.1, XM_340799.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U00620.1, SRR21887623.3367204.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000010.1  38889524-38889673   c
            151-201             JAXUCZ010000010.1  38889378-38889428   c
            202-327             JAXUCZ010000010.1  38888541-38888666   c
            328-441             JAXUCZ010000010.1  38887692-38887805   c
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..441
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /note="colony stimulating factor 2"
                     /db_xref="GeneID:116630"
                     /db_xref="RGD:621065"
     CDS             1..435
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /note="granulocyte-macrophage colony-stimulating factor;
                     CSF; colony stimulating factor 2 (granulocyte-macrophage)"
                     /codon_start=1
                     /product="granulocyte-macrophage colony-stimulating factor
                     precursor"
                     /protein_id="NP_446304.1"
                     /db_xref="GeneID:116630"
                     /db_xref="RGD:621065"
                     /translation="MWLQNLLFLGIVVYSFSAPTRSPNPVTRPWKHVDAIKEALSLLN
                     DMRALENEKNEDVDIISNEFSIQRPTCVQTRLKLYKQGLRGNLTKLNGALTMIASHYQ
                     TNCPPTPETDCEIEVTTFEDFIKNLKGFLFDIPFDCWKPVQK"
     exon            1..150
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            151..201
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            202..327
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /inference="alignment:Splign:2.1.0"
     exon            328..441
                     /gene="Csf2"
                     /gene_synonym="Gm-csf; Gmcsf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggctgc agaatttact tttcctgggc attgtggtct acagtttctc agcacccacc
       61 cgctcgccca accctgtcac ccggccctgg aagcatgtag atgccatcaa agaagctctg
      121 agcctcctaa atgacatgcg tgctctggag aacgaaaaga acgaagacgt agacatcatc
      181 tctaatgagt tctccatcca gaggccgaca tgtgtgcaga cccgcctgaa gctatacaag
      241 cagggtctac ggggcaacct caccaaactc aatggcgcct tgaccatgat agccagccac
      301 taccagacga actgccctcc aaccccggaa actgactgtg aaatagaagt caccaccttt
      361 gaggatttca taaagaacct taaaggcttt ctgtttgata tcccttttga ctgctggaag
      421 ccggtccaga aatgaggagg c
//
