LOCUS       NM_001029901            3698 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus colony stimulating factor 1 receptor (Csf1r),
            mRNA.
ACCESSION   NM_001029901 XM_225897
VERSION     NM_001029901.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Hume,D.A., Teakle,N., Keshvari,S. and Irvine,K.M.
  TITLE     Macrophage deficiency in CSF1R-knockout rat embryos does not
            compromise placental or embryo development
  JOURNAL   J Leukoc Biol 114 (5), 421-433 (2023)
   PUBMED   37167456
  REMARK    GeneRIF: Macrophage deficiency in CSF1R-knockout rat embryos does
            not compromise placental or embryo development.
REFERENCE   2  (bases 1 to 3698)
  AUTHORS   Sehgal,A., Carter-Cusack,D., Keshvari,S., Patkar,O., Huang,S.,
            Summers,K.M., Hume,D.A. and Irvine,K.M.
  TITLE     Intraperitoneal transfer of wild-type bone marrow repopulates
            tissue macrophages in the Csf1r knockout rat without contributing
            to monocytopoiesis
  JOURNAL   Eur J Immunol 53 (8), e2250312 (2023)
   PUBMED   37059596
  REMARK    GeneRIF: Intraperitoneal transfer of wild-type bone marrow
            repopulates tissue macrophages in the Csf1r knockout rat without
            contributing to monocytopoiesis.
REFERENCE   3  (bases 1 to 3698)
  AUTHORS   Keshvari,S., Caruso,M., Teakle,N., Batoon,L., Sehgal,A.,
            Patkar,O.L., Ferrari-Cestari,M., Snell,C.E., Chen,C., Stevenson,A.,
            Davis,F.M., Bush,S.J., Pridans,C., Summers,K.M., Pettit,A.R.,
            Irvine,K.M. and Hume,D.A.
  TITLE     CSF1R-dependent macrophages control postnatal somatic growth and
            organ maturation
  JOURNAL   PLoS Genet 17 (6), e1009605 (2021)
   PUBMED   34081701
  REMARK    GeneRIF: CSF1R-dependent macrophages control postnatal somatic
            growth and organ maturation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3698)
  AUTHORS   Patkar,O.L., Caruso,M., Teakle,N., Keshvari,S., Bush,S.J.,
            Pridans,C., Belmer,A., Summers,K.M., Irvine,K.M. and Hume,D.A.
  TITLE     Analysis of homozygous and heterozygous Csf1r knockout in the rat
            as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations
  JOURNAL   Neurobiol Dis 151, 105268 (2021)
   PUBMED   33450391
  REMARK    GeneRIF: Analysis of homozygous and heterozygous Csf1r knockout in
            the rat as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations.
REFERENCE   5  (bases 1 to 3698)
  AUTHORS   Sharon,A., Jankowski,M.M., Shmoel,N., Erez,H. and Spira,M.E.
  TITLE     Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat
            Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and
            Its Implications
  JOURNAL   Front Neurosci 15, 646914 (2021)
   PUBMED   33841088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3698)
  AUTHORS   Storga,D., Pecina-Slaus,N., Pavelic,J., Pavelic,Z.P. and Pavelic,K.
  TITLE     c-fms is present in primary tumours as well as in their metastases
            in bone marrow
  JOURNAL   Int J Exp Pathol 73 (4), 527-533 (1992)
   PUBMED   1390197
REFERENCE   7  (bases 1 to 3698)
  AUTHORS   Borycki,A.G., Guillier,M., Leibovitch,M.P. and Leibovitch,S.A.
  TITLE     Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence
            analysis and regulation during myogenesis
  JOURNAL   Growth Factors 6 (3), 209-218 (1992)
   PUBMED   1389227
REFERENCE   8  (bases 1 to 3698)
  AUTHORS   Claycomb,W.C. and Lanson,N.A. Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   9  (bases 1 to 3698)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 3698)
  AUTHORS   Sherr,C.J., Rettenmier,C.W., Sacca,R., Roussel,M.F., Look,A.T. and
            Stanley,E.R.
  TITLE     The c-fms proto-oncogene product is related to the receptor for the
            mononuclear phagocyte growth factor, CSF-1
  JOURNAL   Cell 41 (3), 665-676 (1985)
   PUBMED   2408759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jul 28, 2005 this sequence version replaced XM_225897.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000018.1  56834379-56834427
            50-80               JAXUCZ010000018.1  56834512-56834542
            81-120              JAXUCZ010000018.1  56834641-56834680
            121-181             JAXUCZ010000018.1  56836599-56836659
            182-439             JAXUCZ010000018.1  56838153-56838410
            440-724             JAXUCZ010000018.1  56838717-56839001
            725-861             JAXUCZ010000018.1  56840670-56840806
            862-1021            JAXUCZ010000018.1  56841407-56841566
            1022-1208           JAXUCZ010000018.1  56844188-56844374
            1209-1324           JAXUCZ010000018.1  56846766-56846881
            1325-1445           JAXUCZ010000018.1  56847022-56847142
            1446-1636           JAXUCZ010000018.1  56847259-56847449
            1637-1752           JAXUCZ010000018.1  56848724-56848839
            1753-1879           JAXUCZ010000018.1  56853763-56853889
            1880-1984           JAXUCZ010000018.1  56854006-56854110
            1985-2095           JAXUCZ010000018.1  56854387-56854497
            2096-2258           JAXUCZ010000018.1  56855134-56855296
            2259-2347           JAXUCZ010000018.1  56857334-56857422
            2348-2445           JAXUCZ010000018.1  56857539-56857636
            2446-2568           JAXUCZ010000018.1  56858446-56858568
            2569-2680           JAXUCZ010000018.1  56858645-56858756
            2681-2780           JAXUCZ010000018.1  56859399-56859498
            2781-2889           JAXUCZ010000018.1  56859804-56859912
            2890-3698           JAXUCZ010000018.1  56859996-56860804
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3698
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="colony stimulating factor 1 receptor"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
     CDS             1..3069
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /EC_number="2.7.10.1"
                     /note="macrophage colony-stimulating factor 1 receptor;
                     fms proto-oncogene; proto-oncogene fms; proto-oncogene
                     c-Fms; CSF-1 receptor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 receptor
                     precursor"
                     /protein_id="NP_001025072.1"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
                     /translation="MELGAPLVLLLATAWHGVQILSGEKSRTTIHIYLLAGRRAVTTE
                     IVLMGQRSTDVQRVNDCQGAPVIEPSGPELVVEPGATVTLRCVSNGSVEWDGPISPYW
                     TLDSESPGSILITKNATFKNTGTYRCTELEDPMRGSTAIHLYVKDPVRPWNLLAQEVT
                     VFEGQEAVLPCLITDPTLKDSVSLVREWGRPVSRKTVYSFLPWRGFIIHKAKFLDSHT
                     YMCKAVVNARESTSIGIRLKVNRAHPGPPHIILEPTKLVRIRGEAAQIVCSATHSEVE
                     FNVILKRGDTKLEIPINSDFQDNAYKKVLTLNLNAVDFQDAGIYSCVANNAAGSNTAT
                     MNFQVVESAYLNLTSEQSLLQEVSVGENLDLTVIADAYPGLQRYNWTYLGPFFEDPHN
                     LEFRTQWTTYSYSFKLHLNRVKPLEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTW
                     IPVNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDDTQPEVLSQKPFHRV
                     ILQSQLPIGTLKHNMTYVCRAHNNVGNSSQFFRAISLGQSKQLPDEYLFTPVVVACIS
                     VMSLLVLLLLLLLYKYKQKPKYQVRWKIIESYEGNNYTFIDPTQLPYNEKWEFPRNNL
                     QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHL
                     GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSS
                     YKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLL
                     HFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGN
                     ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDG
                     YQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICFLLQEQARLERREQDYANLPSSS
                     SSSSSSSDSGGGSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFC"
     exon            1..49
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            50..80
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            81..120
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            121..181
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            182..439
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            440..724
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            725..861
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1021
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1208
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1324
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1445
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1636
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1752
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1879
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1984
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2095
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2258
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2347
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2445
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2568
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2680
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2780
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2889
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3698
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagctgg gggctcctct ggtcctgctg ctggccacag cttggcatgg agtgcagatt
       61 ttatctgggg agaagagtag gaccaccatc cacatctacc ttctggcagg caggagggcg
      121 gtgaccactg agattgttct catgggtcag aggagcactg atgtccagag ggtcaatgac
      181 tgtcaagggg cccctgtcat cgagcctagt ggcccagagc tggttgtaga gccaggtgca
      241 acagtgaccc tgcgatgtgt gagcaatggc agtgtggaat gggatggccc catctctccc
      301 tactggacct tggactctga atctcctgga agcatcctga tcacaaaaaa cgccaccttc
      361 aaaaacactg ggacctaccg ttgtactgag cttgaagacc ctatgcgggg cagtaccgcc
      421 atccacttgt acgtcaaaga tcctgtccgg ccctggaatt tgctagcaca ggaggtgaca
      481 gtgtttgagg gccaggaagc tgtgctgccc tgtctgatca ctgaccccac actgaaggac
      541 agtgtctcac tggtgaggga gtggggcaga ccagtctcac gcaaaacggt ctactccttc
      601 ttaccatggc gagggttcat tatccacaag gctaaattcc ttgacagtca tacctacatg
      661 tgcaaggctg ttgtgaacgc tagggaatcc acctccattg gcatccggct taaggtgaat
      721 cgagcccacc cagggccccc acacatcata ttggaaccta ctaagctggt gaggattcga
      781 ggggaggctg cccagatcgt gtgctcggcc actcactcag aagttgaatt caacgttatc
      841 ctcaaacgtg gagacaccaa gttggaaatc cccataaaca gtgacttcca agacaacgct
      901 tataaaaagg tcctgactct taacctcaat gctgtggact tccaagatgc tggcatatat
      961 tcctgtgtgg ccaacaacgc agctggctcg aacacggcca ccatgaactt ccaggtggtg
     1021 gagagtgcct acttaaactt gacctctgag cagagcctct tgcaggaggt gtctgtgggt
     1081 gagaacctcg acctcacagt cattgcagat gcctaccctg gcctacagcg ttacaactgg
     1141 acctacctag ggccgttctt tgaagaccca cacaatcttg agtttagaac ccaatggacc
     1201 acatacagct actcattcaa actccacctg aaccgtgtaa agcccttgga ggccggccgc
     1261 tactccttaa tggcacaaaa caaggcaggc tggaataatc tgacctttga gctcaccctg
     1321 cgataccccc cagaagtcag tgttacatgg atacctgtga acggctctga tgtcctgctc
     1381 tgtgatgtct ctgggtatcc tcagcccaac gtgacatgga tggagtgcag gggccacacc
     1441 gataggtgtg atgaggccca ggcctcgcag gtttgggatg acacacaacc tgaagtcctg
     1501 agtcagaagc ccttccacag agtgatcctt cagagccagc tgcccattgg gaccctaaag
     1561 cacaacatga cttatgtttg cagagcccac aacaatgtgg gtaacagctc ccagttcttc
     1621 agggccatct ccctaggaca aagcaagcag ctccctgatg agtacctgtt cactccagtg
     1681 gtggtggcct gtatatctgt catgtctctg ctggtactac tgctgctgct gctcttgtac
     1741 aagtacaagc agaagccgaa atatcaggtg cgctggaaga tcattgagag ctacgagggc
     1801 aacaactaca ccttcatcga ccctacccag ttgccctaca atgagaagtg ggagtttccc
     1861 cggaacaacc tgcaatttgg taagactctc ggagctggtg cctttgggaa ggtggtggag
     1921 gccacagcct ttggtctggg caaagaagat gcagtgctga aggtggctgt gaagatgctc
     1981 aagtccacgg ctcatgccga tgagaaggag gccctaatgt cagaactgaa gatcatgagt
     2041 cacctgggac agcatgagaa cattgtcaac ctcttgggag cctgtactca tggagggcct
     2101 gtcctggtca tcaccgaata ctgctgctac ggagaccttc tcaacttcct tcgaaggaag
     2161 gccgaggcta tgctgggacc cagcctgagt cctggtcagg accccgaggg ggactccagc
     2221 tacaagaaca tccacctgga gaagaaatat gtgcgcaggg acagtggctt ctccagtcag
     2281 ggcgtagata cctatgtgga gatgaggcct gtttcgactt cctcaaatga ctccttcttt
     2341 aagcaagatc tggacaaaga ggccagccgg ccgctggagc tctgggacct gcttcacttc
     2401 tctagccaag tggctcaggg catggctttc cttgcttcta aaaattgcat ccatcgtgat
     2461 gtagctgctc gaaatgtgct gttgaccagc ggacatgtgg ccaagattgg ggactttggg
     2521 ctggctaggg acatcatgaa tgactctaac tatgttgtca agggcaatgc ccgcctgcct
     2581 gtaaagtgga tggccccaga gagcatcttc gactgcgtct acacagttca gagtgatgtg
     2641 tggtcctacg gcatcctcct ctgggagatt ttctcacttg gtctgaaccc ctacccaggc
     2701 atcttagtga acaacaagtt ctacaaactg gtgaaggatg gataccaaat ggcccagcct
     2761 gtatttgcac cggagaacat atacagcatc atgcagtcct gctgggacct ggagcctacc
     2821 aaaagaccta ccttccagca gatctgcttc ctcctccagg aacaggcccg actggagagg
     2881 agagagcagg actatgctaa cctgccaagc agcagcagca gcagtagcag cagcagtgac
     2941 agtggtggtg gcagtggtgg tagcagcagt gagcctgaag aggagagctc cagtgagcac
     3001 ctggcctgct gtgagccagg ggacatcgcc cagcccctgc tgcagcctaa caactaccag
     3061 ttctgctgaa gcgggacagc agagtcctgc tgccctccac gtcccagctc gacctcctcc
     3121 atggatgggc gacatgggga gagcatatga acttcgtcct cagctcggcc cagctctgac
     3181 gcttctgaac atgaggggtt cccagagcct gggccatcac tgccagtggg gttctcacag
     3241 tgctagcctc tatttactac accaactggt gaacccatac ttcactttct tcatcctgtt
     3301 cccacttgaa aaaactgtcc ccaactctcg tttcaatgga aagactgatt tgtgtctcaa
     3361 aaagacaggt ctcaggttgt aggtgagcag aagcttgcct ccctgacaga ggctcagact
     3421 gcaggcttct tggggcaggc ggcccttccc aagctcacag actggtcgcc actcttacct
     3481 tctctttatc tacagtcccg tctcatcctg gatcttgtac actaggagcc cagtggcagc
     3541 tgagagccag ggatgcttta cttagtgccc tgcattctag gctggcaggc atgggacctt
     3601 ggtgcaaggc tgacaacgcc aagcaaatac tgcgtgctcc tctccaaact gactcgtcct
     3661 cattaacagt caacattaaa ctaacagcat taacacag
//
