LOCUS       NM_023981               3975 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus colony stimulating factor 1 (Csf1), mRNA.
ACCESSION   NM_023981
VERSION     NM_023981.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Liu,F., Shen,X., Su,S., Cui,H., Fang,Y., Wang,T., Zhang,L.,
            Huang,Y. and Ma,C.
  TITLE     Fcgamma Receptor I-Coupled Signaling in Peripheral Nociceptors
            Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 72 (10), 1668-1678 (2020)
   PUBMED   32510872
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Wlodarczyk,A., Benmamar-Badel,A., Cedile,O., Jensen,K.N.,
            Kramer,I., Elsborg,N.B. and Owens,T.
  TITLE     CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+
            Microglia in EAE
  JOURNAL   Front Cell Neurosci 12, 523 (2019)
   PUBMED   30687013
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3975)
  AUTHORS   Hoshino,S., Kurotani,R., Miyano,Y., Sakahara,S., Koike,K.,
            Maruyama,M., Ishikawa,F., Sakatai,I., Abe,H. and Sakai,T.
  TITLE     Macrophage colony-stimulating factor induces prolactin expression
            in rat pituitary gland
  JOURNAL   Zoolog Sci 31 (6), 390-397 (2014)
   PUBMED   24882100
REFERENCE   6  (bases 1 to 3975)
  AUTHORS   Weir,E.C., Horowitz,M.C., Baron,R., Centrella,M., Kacinski,B.M. and
            Insogna,K.L.
  TITLE     Macrophage colony-stimulating factor release and receptor
            expression in bone cells
  JOURNAL   J Bone Miner Res 8 (12), 1507-1518 (1993)
   PUBMED   8304053
REFERENCE   7  (bases 1 to 3975)
  AUTHORS   Clinton,S.K., Underwood,R., Hayes,L., Sherman,M.L., Kufe,D.W. and
            Libby,P.
  TITLE     Macrophage colony-stimulating factor gene expression in vascular
            cells and in experimental and human atherosclerosis
  JOURNAL   Am J Pathol 140 (2), 301-316 (1992)
   PUBMED   1739124
REFERENCE   8  (bases 1 to 3975)
  AUTHORS   Manos,M.M.
  TITLE     Expression and processing of a recombinant human macrophage
            colony-stimulating factor in mouse cells
  JOURNAL   Mol Cell Biol 8 (11), 5035-5039 (1988)
   PUBMED   3264878
REFERENCE   9  (bases 1 to 3975)
  AUTHORS   Cerretti,D.P., Wignall,J., Anderson,D., Tushinski,R.J.,
            Gallis,B.M., Stya,M., Gillis,S., Urdal,D.L. and Cosman,D.
  TITLE     Human macrophage-colony stimulating factor: alternative RNA and
            protein processing from a single gene
  JOURNAL   Mol Immunol 25 (8), 761-770 (1988)
   PUBMED   2460758
REFERENCE   10 (bases 1 to 3975)
  AUTHORS   Sherr,C.J., Rettenmier,C.W., Sacca,R., Roussel,M.F., Look,A.T. and
            Stanley,E.R.
  TITLE     The c-fms proto-oncogene product is related to the receptor for the
            mononuclear phagocyte growth factor, CSF-1
  JOURNAL   Cell 41 (3), 665-676 (1985)
   PUBMED   2408759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074007.1.
            
            On Jul 8, 2004 this sequence version replaced NM_023981.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074007.1, AF515736.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3975
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /note="colony stimulating factor 1"
                     /db_xref="GeneID:78965"
                     /db_xref="RGD:621063"
     exon            1..199
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1861
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /EC_number="2.7.10.1"
                     /note="macrophage colony-stimulating factor 1; MCSF;
                     CSF-1; colony stimulating factor 1 (macrophage);
                     proteoglycan macrophage colony-stimulating factor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1
                     precursor"
                     /protein_id="NP_076471.3"
                     /db_xref="GeneID:78965"
                     /db_xref="RGD:621063"
                     /translation="MTARGAAGRCPSSTWMGSRLLLVCLLVSRSVAEVSEHCSHMIGN
                     GHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNT
                     PNANATERLQELSMKLNSCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLE
                     KDWNIFSKNCNDSLAKCSSRDVVTKPDCNCLYPKATPSSDLASASPHQPPAPSMAPLA
                     DLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHEDPQPHPS
                     AGAPIPGVEDIIESSMGTNWVLEEASGEASEGFLTQERKFSPSNPVGGSIQAETDRPW
                     ARSASSPFPKLTEDQQPTNITDTPLTEVNPMRPTGQTLNNTPEKTDGSSTLREDQQEP
                     RSPHFATLNPQRVGNSATPYAKLLPPKSHSWGIVLPLGELEGKKSTRDRRSPAELKGG
                     PASEGAARPVAQSTRDRRSPAELKGGPASEGAARPVARFNSIPLTDTGSSIQDPQTSA
                     FVFWVLGIILVLLAVGGLLFYSWKRRSHRDPRTLDSSVGRPEGSSLAQDEDRQVELPV
                     "
     exon            200..319
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            320..382
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            383..553
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            554..701
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            702..1762
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1815
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1874
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..3953
                     /gene="Csf1"
                     /gene_synonym="PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaagttt gcctcggtgc tctcggtgtc gctgcggctc tctgcatccc gggacagcag
       61 cgtggccctc gaccgcggcg caggctctcc agccactagc gagcaaggaa gcgaacgaac
      121 cagggcggcc aacacgccgt gccgggaccc agctgcccgt atgaccgcgc ggggcgccgc
      181 ggggcgctgc ccttcttcga catggatggg ctcccggctg ctgctggtct gtctcctcgt
      241 gagcaggagt gttgccgagg tgtcggagca ctgtagccac atgattggga atggacacct
      301 acagattttg cagcagttga tcgacagcca aatggagact gcatgcctga tcgaatataa
      361 atttgtagac caggaacagc tggacgatcc cgtttgctac ctaaagaagg cctttgtttt
      421 ggtacaagtc ataatcgagg aaaccatgcg ctttaaagac aacaccccca acgccaacgc
      481 caccgagagg ctacaggaac tctctatgaa actgaacagc tgctttatca aggactataa
      541 ggaacagaac gaggcctgtg tccaaactta caaagagagt cctctccggt tgctggagaa
      601 aatcaagaat ttctttaacg aaacaaagaa tttccttgaa aaggactgga atatttttag
      661 caagaactgc aatgacagcc ttgctaaatg ctctagcaga gatgtggtga ccaagcctga
      721 ttgcaactgc ctgtacccta aagccacccc tagcagcgac ctggcctctg cctcccctca
      781 ccagccccct gccccctcca tggcccctct ggctgacttg gcttgggatg attctcagag
      841 gacagaggga agctccctct tgcccagtga tctgcctctt cgcatagagg acccaggcag
      901 tgctaagcag cgaccgccca ggagtacctg ccagaccctc gagtcaacag agcaaccaaa
      961 tcacgaggac ccacaacctc atccttctgc gggggccccc atccctgggg tggaagacat
     1021 tattgaatct tcaatgggca ctaactgggt cttagaagaa gcttctggag aggctagtga
     1081 gggatttttg acccaggaaa ggaagttttc cccctccaat cctgtagggg gcagcatcca
     1141 ggcagagact gacagaccct gggcccgctc agcatcttct ccattcccta aattaacaga
     1201 ggatcaacag ccaacgaata taacagacac cccgttgaca gaggtgaacc ctatgagacc
     1261 cactggccag acactgaata atactcctga gaagacggat ggttcatcta cactgcgcga
     1321 agaccagcag gagccacgct ctccccattt tgccacactg aatccccaac gagtcggcaa
     1381 ctcagccacc ccctatgcta agttactgcc tcccaaaagc cactcttggg gcattgtact
     1441 gccccttggg gagctcgagg gcaagaaaag tactagagat cgaaggagcc ccgcagagct
     1501 gaaaggagga ccagcaagtg agggggcagc caggcctgtg gcccaaagta ctagagatcg
     1561 aaggagcccc gcagagctga aaggaggacc agcaagtgag ggggcagcca ggcctgtggc
     1621 ccgttttaat tccattcctt tgaccgacac aggctcttct attcaggatc cccagacctc
     1681 tgcgtttgtc ttctgggtgc taggcatcat cctagtcttg ctggctgtcg ggggcctcct
     1741 gttctacagt tggaagcgga ggagccatcg agaccctcgg acattggatt cttctgtggg
     1801 gcgaccagag ggcagctccc tggcccagga tgaggacaga caggtggaac tgccagtgta
     1861 gaaaggattc taagctgggc acacaggact atctctttat gggaggagac attatggcaa
     1921 cgtccaccac taccctctcc tgtcatcttc ctgggaatgt ggtctgccac taccagagct
     1981 cctgcctacc aagactggat gaaagcagct ttgatgggga tctttccatc ctaaccctta
     2041 gactctcaac taaagagaga gggctggagg atgcccccag tatcctgcca ctatttattg
     2101 tgggccctgg aggctcgctg catttgagga agggcagctc aacagctcag gaccctttcc
     2161 cttaggggct gttccctcct ctcaaaacca gaacctggca agggccacac tagcctgtat
     2221 ggcccatggg agatcaggac agatgagaag gagcagaaga gccctgtgcc cagaagaccc
     2281 aactggtgcc aaggaatccc aacgtggaca ggcaggggcc tgtttcccaa gaagagagcc
     2341 tgacattcaa agggtgggac agcatctgcc caacttcccg taaaggcata aaggcacgaa
     2401 gcccaaaaaa cgggaagagg aggcctttgg ctgcttgtga tgacagctta aaggggtcta
     2461 caccctcaac ttgcctaagt gccctctgct gatagccagg aaggagggag accagccctc
     2521 cggacctatc tgacctggct catgatgcca agaggaagac tgagctctaa cctcatctcc
     2581 tcctgcccat agcccctgcc agagttcttt tgccagcaga ggcacccctc atgaaggaag
     2641 ccattgcact gtgaatactg aacctgcctg ctgaacagcc tgtccaatcc atccctatga
     2701 gcgatcatcc gtccgaatgt tctcccactt ccttcaacct ctcctcagct tcttgcactg
     2761 agctggcctc acatgttgac tgagggagcc cctaagcccg accttccccc gcctcagcct
     2821 ttgattgtcc agggtgaagc tgtgggagaa ctgcctgggc taccagtcag agctggtctt
     2881 taggctgtgt tccttaccca ggtttttgca tcttgcactt tgacattccc aggagggaag
     2941 tgactagggg aagggagaga agaaggggag acagagacaa aggccacagg cagagctata
     3001 aatgagaatg ggtcttgaaa atatgtgtgt acccctaagc ttgaagttga tctctatact
     3061 ccagtccctt gccagctgcc ttcccctact gcctgaagcc tggagctgag caggttgtct
     3121 ggtcctgagc tctgggtatg gagctctgtg ctccagcccc accctcttct ggcctttgct
     3181 ctccagacct gactctggta gggaaggata ccttcccagt ctcacctacc cccccccctg
     3241 ccatctctag ccaagcaagc caggtctaga gagggatcaa aaaaaaatgg gtcatttact
     3301 tccaactctg ctctgatgct ctgtttcctg agccaggcta gtctgtggtg acctgggcat
     3361 gggtgacagg gctcttactt gctccttggt ctctttatgc tgctgccccg cctcccccct
     3421 ttcctgccct ccctggctac tgggtcgcta atctttcagg ccatggatcc ggaggagagt
     3481 ggtctatagg ctccaccagc cctgtcctga gacaacagag ggggtgagga cactggagac
     3541 tttcccgtgg ggcttactta gccttctagt tacagactat ttccacacta gaaaatacgt
     3601 atttttaaat agaagaaaaa cacagaaaca aacaaaaggc attctcctac ccctccatct
     3661 taaacataca ttattaaaga cagaagagca aatccaaccc attgcaagag gctctttgtg
     3721 ggtgcctggt tgcataagag caggaggagc cccaaaccca cctttggagc ttccctgcac
     3781 aggaacccct tcttccctcc aagaaagccc agagggagca ctgcctcacc aactgtgaga
     3841 ctgcgttttt ttatacttgg aagtggtgaa ttattttata taaggtcatt taaatatcta
     3901 tttaaaaaat aggaagctgc ttttatattt aataataaaa gaagtgcaca agcaaaaaaa
     3961 aaaaaaaaaa aaaaa
//
