LOCUS       NM_001170542            2485 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cold shock domain containing C2 (Csdc2), mRNA.
ACCESSION   NM_001170542
VERSION     NM_001170542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2485)
  AUTHORS   Vallejo,G., Mestre-Citrinovitz,A.C., Winterhager,E. and
            Saragueta,P.E.
  TITLE     CSDC2, a cold shock domain RNA-binding protein in decidualization
  JOURNAL   J Cell Physiol 234 (1), 740-748 (2018)
   PUBMED   30078185
  REMARK    GeneRIF: Uterine suppression of CSDC2 through
            intrauterine-injected-specific small interfering RNA (siRNA) led to
            abnormal decidualization in early pregnancy, with more extended
            antimesometrial area and with poor M development if compared with
            control siRNA-injected animals. These results suggest that CSDC2
            could be a regulator during decidua development.
REFERENCE   2  (bases 1 to 2485)
  AUTHORS   Di Liegro,C.M., Schiera,G., Proia,P., Saladino,P. and Di Liegro,I.
  TITLE     Identification in the rat brain of a set of nuclear proteins
            interacting with H1 degrees mRNA
  JOURNAL   Neuroscience 229, 71-76 (2013)
   PUBMED   23159318
REFERENCE   3  (bases 1 to 2485)
  AUTHORS   Bono,E., Compagno,V., Proia,P., Raimondi,L., Schiera,G.,
            Favaloro,V., Campo,V., Donatelli,M. and Di Liegro,I.
  TITLE     Thyroid hormones induce sumoylation of the cold shock
            domain-containing protein PIPPin in developing rat brain and in
            cultured neurons
  JOURNAL   Endocrinology 148 (1), 252-257 (2007)
   PUBMED   17053029
  REMARK    GeneRIF: significant difference among euthyroid and hypothyroid
            newborn rats concerns sumoylation of nuclear PIPPin, which is
            abolished by hypothyroidism
REFERENCE   4  (bases 1 to 2485)
  AUTHORS   Raimondi,L., D'Asaro,M., Proia,P., Nastasi,T. and Di Liegro,I.
  TITLE     RNA-binding ability of PIPPin requires the entire protein
  JOURNAL   J Cell Mol Med 7 (1), 35-42 (2003)
   PUBMED   12767259
  REMARK    GeneRIF: Data show that only recombinant proteins that contain all
            the putative PIPPin domains show RNA-binding ability.
REFERENCE   5  (bases 1 to 2485)
  AUTHORS   Nastasi,T., Muzi,P., Beccari,S., Bellafiore,M., Dolo,V.,
            Bologna,M., Cestelli,A. and Di Liegro,I.
  TITLE     Specific neurons of brain cortex and cerebellum are PIPPin positive
  JOURNAL   Neuroreport 11 (10), 2233-2236 (2000)
   PUBMED   10923677
REFERENCE   6  (bases 1 to 2485)
  AUTHORS   Nastasi,T., Scaturro,M., Bellafiore,M., Raimondi,L., Beccari,S.,
            Cestelli,A. and di Liegro,I.
  TITLE     PIPPin is a brain-specific protein that contains a cold-shock
            domain and binds specifically to H1 degrees and H3.3 mRNAs
  JOURNAL   J Biol Chem 274 (34), 24087-24093 (1999)
   PUBMED   10446180
REFERENCE   7  (bases 1 to 2485)
  AUTHORS   Castiglia,D., Scaturro,M., Nastasi,T., Cestelli,A. and Di Liegro,I.
  TITLE     PIPPin, a putative RNA-binding protein specifically expressed in
            the rat brain
  JOURNAL   Biochem Biophys Res Commun 218 (1), 390-394 (1996)
   PUBMED   8573167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO405729.1, DY318921.1, CO401519.1, X89962.1 and CK844327.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO405729.1, X89962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               CO405729.1         1-660
            661-1280            DY318921.1         61-680
            1281-1751           CO401519.1         242-712
            1752-2361           X89962.1           1644-2253
            2362-2485           CK844327.1         1-124               c
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2485
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /note="cold shock domain containing C2"
                     /db_xref="GeneID:266600"
                     /db_xref="RGD:628780"
     exon            1..199
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /inference="alignment:Splign:2.1.0"
     exon            200..501
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..787
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /note="RNA-binding protein pippin; cold shock domain
                     containing C2, RNA binding"
                     /codon_start=1
                     /product="cold shock domain-containing protein C2"
                     /protein_id="NP_001164013.1"
                     /db_xref="GeneID:266600"
                     /db_xref="RGD:628780"
                     /translation="MTSESTSPPVVPPLHSPKSPVWPTFPFHRESSRIWERGGGVSPR
                     DLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDI
                     EGEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS"
     exon            502..624
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /inference="alignment:Splign:2.1.0"
     exon            625..2468
                     /gene="Csdc2"
                     /gene_synonym="Pippin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcgtgtg tgagtgagtg agtgaggggc tgaggtgcct cctgcacaca cacacacaca
       61 cacacacaca cgcgcgcgcg cgcgcgccac ggagagtgca tcatccagac gtgacccttg
      121 ccagccagct ccacggtcca gagagatcgg gtgctgccca ctacaggaga cagtacctgg
      181 acccagctgc cagggcgaga cggagtccat agctggtgag gccagtgagc agggcgaggc
      241 caggccctgc ccggaaggac accagagtcc ttcaccggcc cctgtgctcc agagccctcc
      301 cggctctcct gctggccccg ccatgacatc agagtctaca tcacctccgg tggtgccacc
      361 tctgcactcc cccaagtccc ctgtctggcc cactttcccc ttccacaggg agagcagtag
      421 gatctgggaa cgtggtggtg gcgtctctcc tcgggacctg cccagccctt tgcctaccaa
      481 acggaccagg acatactccg cgacagctcg agcctcggct ggccctgtgt tcaagggcgt
      541 ctgtaagcag ttctcacgct cccagggcca cggcttcatc acgcctgaga atggctccga
      601 ggacatcttc gtgcatgttt ctgacatcga gggggagtac gtgcccgtag aaggagatga
      661 ggtgacctac aagatgtgtc ccatcccacc caagaaccag aagtttcagg ctgtggaggt
      721 ggtgctcacc cagttggctc ctcatacccc ccacgagaca tggtctggcc aggttgtggg
      781 atcctagtca ggatcctccc acaagaaggc aggcagcagc cagtctgtgc ccccactgtg
      841 ctgctgacca gcccttgggt gagcttgttt gtccgcctgt ctgtctgtgc ttgtggctgt
      901 gaatgtgtgc ttccacctgt gacccatgac ctgtatgatc cggcctaggg ttggatggag
      961 tgcagctacc agccccgcct tggcctgtct ctccttcctc ccaactctgt cacgtaaaca
     1021 taccttctcc ccctcttgcc cactatctat atactgagtc tctgtgggtc tgcgtcatgt
     1081 tcttgagaac ccagggggac ccctctcctg tgagcccatt cctcactgct gtcctcagat
     1141 ctaccgtctc cagtccccag gcctgtctgc ttacgtccct gtctccagtg ctggacctgg
     1201 gtgtctgcca cacctggact cgtcctcaga agccaggccc ctgagtgctt tgtaggggcc
     1261 tcctttaggg aggaagaggg caaaccatgg aggttcatgg ccagtccctg ctaaaaccta
     1321 gctcatcttc ctgtccccac ccgtttggtg ccctgaagag aacacagctg cgagcaggag
     1381 ggaactgagg cactcctgtt gtgtaggcca gtcctctctc ctcagctagc agatgatctt
     1441 tcaagcccac agagctaagg tccctcactc tgaggtgagg aggggacatg gtttcctcca
     1501 gcttgcttgg gcagaaccgt ctcttctgct gggatgccca aaccctgtgg atgctctgcc
     1561 cagtgctggc caccacagca gctaaggatg cagcgacaga ctgacatgtc acctcaggca
     1621 aggccaggtc cagacacccc aaaagaatgg tcctcagcca gggagaccac tggccttgcc
     1681 cctctgctcc cattagacac atttcccaga gctatgcaat ggctctaagt ccctgacagg
     1741 tcagcagctg aggtggctct tatcccgttc atcccaaagt gtgactgtcc ctcttacctg
     1801 gagtcccttt ggagttaaga tgtgtcccct ctagagagcc cattacttaa tgagaggata
     1861 agggcctgac acaataatga cctttatgag acccagtctg gaagtaaaat gtgagcacag
     1921 atggccggga tgaaggggtc agtggttgtc taggtggcct tgtaggtgtt ccgggaccac
     1981 agggtaatca tttggggcat ttgcacccca acttggccta gcaccctttg cacagagccc
     2041 agcaacttag agctgctaac aagtgctggc cagtcctcca ccctaggaag gacctgtctg
     2101 acaccccact gtgaacgagg attctccagc aaggcctgtc cctggagaac ggtcctcggc
     2161 aagcttgagg acctgagttc aaatctccag catgcctgta acccagtatt gggtgataag
     2221 acataggcct ttgacaagaa cttattggtt caggtgaacc ccaaggccac ccaggcctcc
     2281 ctgttgtgag taggtccttt gcagccatca ccctgaggct gccttagtgg tggggacaac
     2341 aggcctcctc cctactcttg ggccctgcag tgcccagtca gaaacttctc cactcagacc
     2401 ccagccacgg attccccaac cctcctaaca ctggcaataa actcaactgt gacccactct
     2461 gcccctgaaa aaaaaaaaaa aaaaa
//
