LOCUS       NM_021750               2390 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cysteine sulfinic acid decarboxylase (Csad),
            mRNA.
ACCESSION   NM_021750 XM_006242442
VERSION     NM_021750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2390)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   2  (bases 1 to 2390)
  AUTHORS   Stipanuk,M.H. and Ueki,I.
  TITLE     Dealing with methionine/homocysteine sulfur: cysteine metabolism to
            taurine and inorganic sulfur
  JOURNAL   J Inherit Metab Dis 34 (1), 17-32 (2011)
   PUBMED   20162368
  REMARK    Review article
REFERENCE   3  (bases 1 to 2390)
  AUTHORS   Ueki,I. and Stipanuk,M.H.
  TITLE     Enzymes of the taurine biosynthetic pathway are expressed in rat
            mammary gland
  JOURNAL   J Nutr 137 (8), 1887-1894 (2007)
   PUBMED   17634260
  REMARK    GeneRIF: Mammary and hepatic cysteine dioxygenase and cysteine
            sulfinic acid decarboxylase in pregnant and nursing rats are
            reported.
REFERENCE   4  (bases 1 to 2390)
  AUTHORS   Tappaz,M., Bitoun,M., Reymond,I. and Sergeant,A.
  TITLE     Characterization of the cDNA coding for rat brain cysteine
            sulfinate decarboxylase: brain and liver enzymes are identical
            proteins encoded by two distinct mRNAs
  JOURNAL   J Neurochem 73 (3), 903-912 (1999)
   PUBMED   10461879
REFERENCE   5  (bases 1 to 2390)
  AUTHORS   Tappaz,M., Reymond,I., Bitoun,M. and Sergeant,A.
  TITLE     Cysteine sulfinate decarboxylase (CSD): molecular cloning, sequence
            and genomic expression in brain
  JOURNAL   Adv Exp Med Biol 442, 25-32 (1998)
   PUBMED   9635011
REFERENCE   6  (bases 1 to 2390)
  AUTHORS   Reymond,I., Almarghini,K. and Tappaz,M.
  TITLE     Immunocytochemical localization of cysteine sulfinate decarboxylase
            in astrocytes in the cerebellum and hippocampus: a quantitative
            double immunofluorescence study with glial fibrillary acidic
            protein and S-100 protein
  JOURNAL   Neuroscience 75 (2), 619-633 (1996)
   PUBMED   8931024
REFERENCE   7  (bases 1 to 2390)
  AUTHORS   Reymond,I., Sergeant,A. and Tappaz,M.
  TITLE     Molecular cloning and sequence analysis of the cDNA encoding rat
            liver cysteine sulfinate decarboxylase (CSD)
  JOURNAL   Biochim Biophys Acta 1307 (2), 152-156 (1996)
   PUBMED   8679699
REFERENCE   8  (bases 1 to 2390)
  AUTHORS   Kaisaki,P.J., Jerkins,A.A., Goodspeed,D.C., Steele,R.D. and
            Kaisakia,P.J.
  TITLE     Cloning and characterization of rat cysteine sulfinic acid
            decarboxylase
  JOURNAL   Biochim Biophys Acta 1262 (1), 79-82 (1995)
   PUBMED   7772604
  REMARK    Erratum:[Biochim Biophys Acta 1995 Aug 22;1263(2):179]
REFERENCE   9  (bases 1 to 2390)
  AUTHORS   Ito,K., Tsutsumi,K., Kuzumaki,T., Gomez,P.F., Otsu,K. and
            Ishikawa,K.
  TITLE     A novel growth-inducible gene that encodes a protein with a
            conserved cold-shock domain
  JOURNAL   Nucleic Acids Res 22 (11), 2036-2041 (1994)
   PUBMED   8029009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_006242442.3, NM_021750.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ132661.1, SRR26643298.42503.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  135215537-135215581 c
            46-122              JAXUCZ010000007.1  135199609-135199685 c
            123-259             JAXUCZ010000007.1  135199287-135199423 c
            260-386             JAXUCZ010000007.1  135198910-135199036 c
            387-477             JAXUCZ010000007.1  135198735-135198825 c
            478-584             JAXUCZ010000007.1  135198308-135198414 c
            585-700             JAXUCZ010000007.1  135197787-135197902 c
            701-780             JAXUCZ010000007.1  135197111-135197190 c
            781-835             JAXUCZ010000007.1  135196786-135196840 c
            836-952             JAXUCZ010000007.1  135190262-135190378 c
            953-1017            JAXUCZ010000007.1  135190120-135190184 c
            1018-1099           JAXUCZ010000007.1  135189815-135189896 c
            1100-1299           JAXUCZ010000007.1  135189307-135189506 c
            1300-1351           JAXUCZ010000007.1  135189131-135189182 c
            1352-1441           JAXUCZ010000007.1  135188901-135188990 c
            1442-2390           JAXUCZ010000007.1  135187175-135188123 c
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2390
                     /gene="Csad"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:60356"
                     /db_xref="RGD:621030"
     exon            1..45
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            46..122
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            123..259
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1615
                     /gene="Csad"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase"
                     /protein_id="NP_068518.1"
                     /db_xref="GeneID:60356"
                     /db_xref="RGD:621030"
                     /translation="MADSKPLRTLDGDPVAVEALLRDVFGIVVDEAIRKGTNASEKVC
                     EWKEPEELKQLLDLELQSQGESRERILERCRAVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNTGDGVFCPGGSISNMYAI
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGK
                     MIPEDLERQISLAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWLHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYNVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLEWRIDQAFALTRYLV
                     EEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGT
                     MMIGYQPHGTRANFFRMVVANPILVQADIDFLLGELERLGQDL"
     exon            260..386
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            387..477
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            478..584
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            585..700
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            701..780
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            781..835
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            836..952
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1017
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1099
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1299
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1351
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1441
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..2390
                     /gene="Csad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccgggct cgggagccgc gacaggaggg ggcctctgaa aagggtcctg ttctgagaag
       61 tccattgtgt accttgtcac cagcgcgtct gaaccctctc tgaaccttcc tgaagctgga
      121 agatttcacc ctgatggctg actcaaaacc actcagaacc ctggatgggg accctgtggc
      181 tgtggaggct ttgctccggg acgtgtttgg gattgtcgta gatgaggcca ttcggaaggg
      241 gaccaatgcc tctgagaagg tctgcgaatg gaaggagcct gaagagctca agcagctgct
      301 ggacttggag ctgcagagcc agggcgagtc tagggagcgg atcctggagc gctgccgggc
      361 tgtgattcat tacagtgtca agactggtca cccccggttc ttcaaccagc tcttctcagg
      421 attagatccc catgctctgg ccgggcgcat cattacggag agcctcaata ccagccagta
      481 cacatatgag attgcccccg tgtttgtgct catggaagag gaggtgctga agaaactccg
      541 tgcccttgtg ggctggaaca ctggggatgg ggtcttctgt cctggtggtt ccatctctaa
      601 catgtacgcc ataaacctgg cccgctttca gcgctaccca gactgcaagc agaggggcct
      661 ccgggccctg ccacccttgg ccctcttcac ttcaaaggag tgccactact ccatcaccaa
      721 gggagctgct tttctgggac ttggcaccga cagtgtccga gtggtcaagg ctgatgagag
      781 agggaagatg atccctgagg atctggagag gcagatcagt ctggcagagg ctgagggctc
      841 ggtgccattt ctggtcagtg ccacctctgg taccaccgtg ctaggggcct ttgaccccct
      901 ggatgcaatt gccgatgttt gccagcgtca cgggctgtgg ttacacgtgg atgccgcctg
      961 gggtgggagc gtcctgctgt cccggacaca caggcatctc ctggatggga tccagagggc
     1021 tgactccgtg gcctggaacc ctcacaagct tctcgccgcg gggctgcagt gctctgctct
     1081 tcttctccgg gacacctcga acctgctcaa gcgctgccac gggtcccagg ccagctacct
     1141 cttccagcaa gacaagttct acaacgtggc tctggacacc ggagacaagg tggtgcagtg
     1201 tggccgccgc gtggactgtc tgaagctgtg gctcatgtgg aaggcgcagg gtgggcaagg
     1261 gctggagtgg cgcatcgacc aggcctttgc tctcactcgg tacttggtgg aggagataaa
     1321 aaagcgggaa ggatttgagt tggtcatgga gcccgagttc gtcaacgtgt gcttctggtt
     1381 tgtgcctccc agcctgcggg ggaagaagga gagcccagat tacagccaga ggctgtctca
     1441 ggtggcccct gtgctcaagg agcgcatggt gaagaaggga accatgatga tcggctacca
     1501 gccccatggg acccgggcca acttcttccg aatggtggtg gccaacccca tactggtcca
     1561 ggccgatata gacttccttc tgggcgagct ggagcgtctg ggccaggacc tgtgagctgc
     1621 ttcctctctc tgccccaccc aagctctgca taagctcctg ggttcccaaa agcgaccttt
     1681 ctaggaaaca gtggccttga ctgtgtgagc ccccacacac taactctcct agctaagtat
     1741 tggctgccag gacggtgtct aagcacacta cagtctgttc ttacgaaatg tgcttctttt
     1801 aagtcggtca tagtggtaca caccgttaat accagcactg gggaggcaga ggcagacaca
     1861 agcagatctc ttgagtttga ggccagcctg gtctacagag ctggcctaca cagaaaaaaa
     1921 acctgtctca aaaaaaaaga aaggaaggaa gaaagaaagg aaaagaaaga aatatttttc
     1981 attaagatta tgtctataaa aaattgttat taatatgaga gatatggtac gatgtattaa
     2041 gaaagctaga tatgggggtt ggggatttag ctcagtggta gagcccttgc ctaggaagcg
     2101 caaggccctg ggttcggtcc ccagctccga aaaaaagaac cacaaaaaaa aaaaaaaaaa
     2161 aaagaaagct agatatgagt ttatatatca tggtatctga gttaaactaa aaaaaaaaaa
     2221 tacataggaa aaggcggtga gtggaactgt gccaaaggtc agcagttttc cctggaagag
     2281 gataacaggc tgttcctaag tcagcctctc agaccttccc tgcttcccca ctttattatg
     2341 taaccacatc acctacttct gagatacaac aataaagctt tgtcactata
//
