LOCUS       NP_068518                493 aa            linear   ROD 31-MAR-2024
DEFINITION  cysteine sulfinic acid decarboxylase [Rattus norvegicus].
ACCESSION   NP_068518 XP_006242504
VERSION     NP_068518.1
DBSOURCE    REFSEQ: accession NM_021750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Stipanuk,M.H. and Ueki,I.
  TITLE     Dealing with methionine/homocysteine sulfur: cysteine metabolism to
            taurine and inorganic sulfur
  JOURNAL   J Inherit Metab Dis 34 (1), 17-32 (2011)
   PUBMED   20162368
  REMARK    Review article
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Ueki,I. and Stipanuk,M.H.
  TITLE     Enzymes of the taurine biosynthetic pathway are expressed in rat
            mammary gland
  JOURNAL   J Nutr 137 (8), 1887-1894 (2007)
   PUBMED   17634260
  REMARK    GeneRIF: Mammary and hepatic cysteine dioxygenase and cysteine
            sulfinic acid decarboxylase in pregnant and nursing rats are
            reported.
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Tappaz,M., Bitoun,M., Reymond,I. and Sergeant,A.
  TITLE     Characterization of the cDNA coding for rat brain cysteine
            sulfinate decarboxylase: brain and liver enzymes are identical
            proteins encoded by two distinct mRNAs
  JOURNAL   J Neurochem 73 (3), 903-912 (1999)
   PUBMED   10461879
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Tappaz,M., Reymond,I., Bitoun,M. and Sergeant,A.
  TITLE     Cysteine sulfinate decarboxylase (CSD): molecular cloning, sequence
            and genomic expression in brain
  JOURNAL   Adv Exp Med Biol 442, 25-32 (1998)
   PUBMED   9635011
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Reymond,I., Almarghini,K. and Tappaz,M.
  TITLE     Immunocytochemical localization of cysteine sulfinate decarboxylase
            in astrocytes in the cerebellum and hippocampus: a quantitative
            double immunofluorescence study with glial fibrillary acidic
            protein and S-100 protein
  JOURNAL   Neuroscience 75 (2), 619-633 (1996)
   PUBMED   8931024
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Reymond,I., Sergeant,A. and Tappaz,M.
  TITLE     Molecular cloning and sequence analysis of the cDNA encoding rat
            liver cysteine sulfinate decarboxylase (CSD)
  JOURNAL   Biochim Biophys Acta 1307 (2), 152-156 (1996)
   PUBMED   8679699
REFERENCE   8  (residues 1 to 493)
  AUTHORS   Kaisaki,P.J., Jerkins,A.A., Goodspeed,D.C., Steele,R.D. and
            Kaisakia,P.J.
  TITLE     Cloning and characterization of rat cysteine sulfinic acid
            decarboxylase
  JOURNAL   Biochim Biophys Acta 1262 (1), 79-82 (1995)
   PUBMED   7772604
  REMARK    Erratum:[Biochim Biophys Acta 1995 Aug 22;1263(2):179]
REFERENCE   9  (residues 1 to 493)
  AUTHORS   Ito,K., Tsutsumi,K., Kuzumaki,T., Gomez,P.F., Otsu,K. and
            Ishikawa,K.
  TITLE     A novel growth-inducible gene that encodes a protein with a
            conserved cold-shock domain
  JOURNAL   Nucleic Acids Res 22 (11), 2036-2041 (1994)
   PUBMED   8029009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 5, 2020 this sequence version replaced XP_006242504.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ132661.1, SRR26643298.42503.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     Protein         1..493
                     /product="cysteine sulfinic acid decarboxylase"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /calculated_mol_wt=55118
     Region          21..492
                     /region_name="GadA"
                     /note="Glutamate or tyrosine decarboxylase or a related
                     PLP-dependent protein [Amino acid transport and
                     metabolism]; COG0076"
                     /db_xref="CDD:439846"
     CDS             1..493
                     /gene="Csad"
                     /coded_by="NM_021750.3:134..1615"
                     /db_xref="GeneID:60356"
                     /db_xref="RGD:621030"
ORIGIN      
        1 madskplrtl dgdpvaveal lrdvfgivvd eairkgtnas ekvcewkepe elkqlldlel
       61 qsqgesreri lercravihy svktghprff nqlfsgldph alagriites lntsqytyei
      121 apvfvlmeee vlkklralvg wntgdgvfcp ggsisnmyai nlarfqrypd ckqrglralp
      181 plalftskec hysitkgaaf lglgtdsvrv vkadergkmi pedlerqisl aeaegsvpfl
      241 vsatsgttvl gafdpldaia dvcqrhglwl hvdaawggsv llsrthrhll dgiqradsva
      301 wnphkllaag lqcsalllrd tsnllkrchg sqasylfqqd kfynvaldtg dkvvqcgrrv
      361 dclklwlmwk aqggqglewr idqafaltry lveeikkreg felvmepefv nvcfwfvpps
      421 lrgkkespdy sqrlsqvapv lkermvkkgt mmigyqphgt ranffrmvva npilvqadid
      481 fllgelerlg qdl
//
