LOCUS       NM_130755               1498 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus citrate synthase (Cs), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_130755
VERSION     NM_130755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Teng,F., Han,X., Yu,P., Li,P.B., Li,H.H. and Zhang,Y.L.
  TITLE     Time series proteome profile analysis reveals a protective role of
            citrate synthase in angiotensin II-induced atrial fibrillation
  JOURNAL   J Hypertens 40 (4), 765-775 (2022)
   PUBMED   35013064
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Hahn,D., Kumar,R.A., Muscato,D.R., Ryan,T.E., Schroder,K. and
            Ferreira,L.F.
  TITLE     Nox4 Knockout Does Not Prevent Diaphragm Atrophy, Contractile
            Dysfunction, or Mitochondrial Maladaptation in the Early Phase
            Post-Myocardial Infarction in Mice
  JOURNAL   Cell Physiol Biochem 55 (4), 489-504 (2021)
   PUBMED   34416105
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Gunasti,O., Ozdemir,C., Ozgunen,K.T., Yilmaz,M.B., Oksuz,H.,
            Zorludemir,S. and Kurdak,S.S.
  TITLE     The effects of exercise on skeletal and heart muscle citrate
            synthase and carnitine palmitoyltransferase mRNA expressions in
            high-calorie fed rats
  JOURNAL   Gen Physiol Biophys 40 (4), 341-350 (2021)
   PUBMED   34350838
  REMARK    GeneRIF: The effects of exercise on skeletal and heart muscle
            citrate synthase and carnitine palmitoyltransferase mRNA
            expressions in high-calorie fed rats.
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Mathias,L.M.B.S., Alegre,P.H.C., Dos Santos,I.O.F., Bachiega,T.,
            Figueiredo,A.M., Chiuso-Minicucci,F., Fernandes,A.A., Bazan,S.G.Z.,
            Minicucci,M.F., Azevedo,P.S., Okoshi,M.P., Zornoff,L.A.M.,
            Paiva,S.A.R. and Polegato,B.F.
  TITLE     Euterpe oleracea Mart. (Acai) Supplementation Attenuates Acute
            Doxorubicin-Induced Cardiotoxicity in Rats
  JOURNAL   Cell Physiol Biochem 53 (2), 388-399 (2019)
   PUBMED   31403269
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Montalvo,D., Perez-Trevino,P., Madrazo-Aguirre,K.,
            Gonzalez-Mondellini,F.A., Miranda-Roblero,H.O.,
            Ramonfaur-Gracia,D., Jacobo-Antonio,M., Mayorga-Luna,M.,
            Gomez-Viquez,N.L., Garcia,N. and Altamirano,J.
  TITLE     Underlying mechanism of the contractile dysfunction in atrophied
            ventricular myocytes from a murine model of hypothyroidism
  JOURNAL   Cell Calcium 72, 26-38 (2018)
   PUBMED   29748131
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Arnolda,L., Brosnan,J., Rajagopalan,B. and Radda,G.K.
  TITLE     Skeletal muscle metabolism in heart failure in rats
  JOURNAL   Am J Physiol 261 (2 Pt 2), H434-H442 (1991)
   PUBMED   1877670
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Bass,A., Gutmann,E., Hanzlikova,V. and Teisinger,J.
  TITLE     Effects of ischaemia on enzyme-activities in the soleus muscle of
            the rat
  JOURNAL   Pflugers Arch 379 (2), 203-208 (1979)
   PUBMED   571116
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Mukherjee,A., Srere,P.A. and Frenkel,E.P.
  TITLE     Studies of the mechanism by which hepatic citrate synthase activity
            increases in vitamin B12 deprivation
  JOURNAL   J Biol Chem 251 (7), 2155-2160 (1976)
   PUBMED   818082
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Lai,J.C. and Clark,J.B.
  TITLE     Preparation and properties of mitochondria derived from
            synaptosomes
  JOURNAL   Biochem J 154 (2), 423-432 (1976)
   PUBMED   938457
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Shepherd,D. and Garland,P.B.
  TITLE     The kinetic properties of citrate synthase from rat liver
            mitochondria
  JOURNAL   Biochem J 114 (3), 597-610 (1969)
   PUBMED   5820645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF461496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461496.1, FQ214951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1498
                     /gene="Cs"
                     /note="citrate synthase"
                     /db_xref="GeneID:170587"
                     /db_xref="RGD:620330"
     exon            1..113
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1472
                     /gene="Cs"
                     /EC_number="2.3.3.1"
                     /note="citrate synthase, mitochondrial; citrate
                     (Si)-synthase"
                     /codon_start=1
                     /product="citrate synthase, mitochondrial precursor"
                     /protein_id="NP_570111.1"
                     /db_xref="GeneID:170587"
                     /db_xref="RGD:620330"
                     /translation="MALLTAAARLLGAKNSSCLVLAARHASASSTNLKDILSNLIPKE
                     QARVKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQ
                     KLLPKAKGGEEPLPEGLFWLLVTGQMPTEEQVSWLSQEWAKRAALPSHVVTMLDNFPT
                     NLHPMSQLSAAITALNSESNFARAYAEGINRTKYWELIYEDCMDLIAKLPCVAAKIYR
                     NLYREGSSIGAIDSKLDWSHNFTNMLCYTEPQFTELMRLYLTIHSDHDGGNVSAHTSH
                     LVGSALSDTYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWN
                     TLNSGRVVPGYGHAVLRKTDPRYSCQREFALKHLPKDPMFKLVAQLYKIVPNILLEQG
                     KAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPK
                     SMSTDGLMKFVDSKSG"
     exon            114..164
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            165..272
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            273..338
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            339..470
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            471..659
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            660..859
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            860..989
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1091
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1301
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1498
                     /gene="Cs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctcc tgttgcagct gcagctctct ctctccgatc ccttcccgcc aggtcccgga
       61 gttcgccctc catggctcta ctcactgcgg cagcccggct cttgggagcc aagaactcat
      121 cctgcctcgt ccttgctgcc cggcacgcca gtgcttcttc cacgaatttg aaagacatac
      181 tgagcaatct gatacctaag gagcaggcca gagttaagac cttcagacag cagcatggga
      241 agacagtggt tggccaaatc actgtggaca tgatgtacgg tggcatgaga ggcatgaagg
      301 gacttgtgta tgagacatcg gttcttgatc ctgatgaggg catccgcttc cgaggctata
      361 gtatccctga gtgccagaaa ctgctaccta aggctaaagg tggggaagag cccctacctg
      421 agggcttatt ttggctgctg gtaactggac agatgcccac agaggaacag gtctcttggc
      481 tctcacaaga atgggcaaaa agggcagctc tgccttccca tgtggtcacc atgctggaca
      541 attttccgac caatctgcac cccatgtctc agctcagtgc agccatcaca gccctcaaca
      601 gtgaaagcaa cttcgcccgg gcatatgcag agggaataaa ccgaactaag tactgggagc
      661 tcatctatga agactgtatg gacctgattg ccaagctgcc gtgcgttgca gcaaagatct
      721 accggaatct gtaccgggag ggcagcagta ttggggcaat tgactctaag ctggactggt
      781 cccacaattt taccaacatg ttatgctaca cagaacctca gttcacagaa ctcatgcgtt
      841 tgtaccttac catccacagt gaccatgacg gtggcaatgt aagtgcccac acaagccact
      901 tggtgggcag cgccctttca gacacttacc tgtcctttgc agcagctatg aatgggctgg
      961 cagggcctct gcatggacta gcaaaccagg aggtgcttgt ctggctgacg cagctacaga
     1021 aggaagtcgg caaagacgtg tcagatgaga agttacgaga ctacatctgg aacacactca
     1081 actcgggacg ggttgtccca ggatatggtc atgcagtcct aaggaagact gatccacgat
     1141 attcctgtca gcgagagttt gctctgaaac atctgcccaa ggatcccatg tttaagctgg
     1201 ttgctcagct gtacaagatt gtgcccaata tcctcttaga gcaaggaaag gctaagaacc
     1261 cctggcccaa cgtagatgct cacagtgggg tgctgctcca gtactatggc atgacggaga
     1321 tgaattacta cacagtcctg ttcggagtgt cgagggcact gggtgtgttg gcccagctta
     1381 tctggagcag agccctaggc tttcctctag aaaggcccaa gtccatgagc acggatggtc
     1441 tgatgaagtt tgtggactct aagtcagggt aaaatgggag attatgggaa aactgact
//
