LOCUS       NM_053955               1202 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus crystallin, mu (Crym), mRNA.
ACCESSION   NM_053955
VERSION     NM_053955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   Hommyo,R., Suzuki,S.O., Abolhassani,N., Hamasaki,H., Shijo,M.,
            Maeda,N., Honda,H., Nakabeppu,Y. and Iwaki,T.
  TITLE     Expression of CRYM in different rat organs during development and
            its decreased expression in degenerating pyramidal tracts in
            amyotrophic lateral sclerosis
  JOURNAL   Neuropathology 38 (3), 247-259 (2018)
   PUBMED   29603402
  REMARK    GeneRIF: Results suggest that mu-crystallin may play roles in
            development of cortical and hippocampal pyramidal cells in the
            early postnatal period, and in the later period, performs
            cell-specific functions in selected neuronal populations.
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Takeshige,K., Sekido,T., Kitahara,J., Ohkubo,Y., Hiwatashi,D.,
            Ishii,H., Nishio,S., Takeda,T., Komatsu,M. and Suzuki,S.
  TITLE     Cytosolic T3-binding protein modulates dynamic alteration of
            T3-mediated gene expression in cells
  JOURNAL   Endocr J 61 (6), 561-570 (2014)
   PUBMED   24646676
  REMARK    GeneRIF: CRYM expression increases and sustains the T3
            responsiveness of genes in cells, especially with alteration of the
            pericellular T3 concentration.
REFERENCE   3  (bases 1 to 1202)
  AUTHORS   Al-Kafaji,G. and Malik,A.N.
  TITLE     Hyperglycemia induces elevated expression of thyroid hormone
            binding protein in vivo in kidney and heart and in vitro in
            mesangial cells
  JOURNAL   Biochem Biophys Res Commun 391 (4), 1585-1591 (2010)
   PUBMED   20018174
  REMARK    GeneRIF: This is the first report linking hyperglycemia with
            thyroid hormone binding protein CRYM and suggests that the role of
            CRYM in diabetic complications should be further investigated.
REFERENCE   4  (bases 1 to 1202)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1202)
  AUTHORS   Usami,S., Takumi,Y., Suzuki,N., Oguchi,T., Oshima,A., Suzuki,H.,
            Kitoh,R., Abe,S., Sasaki,A. and Matsubara,A.
  TITLE     The localization of proteins encoded by CRYM, KIAA1199, UBA52,
            COL9A3, and COL9A1, genes highly expressed in the cochlea
  JOURNAL   Neuroscience 154 (1), 22-28 (2008)
   PUBMED   18448257
  REMARK    GeneRIF: Crym protein was predominantly distributed in the
            fibrocytes in the spiral ligament, as well as the stria vascularis
            of cochlea in rats.
REFERENCE   6  (bases 1 to 1202)
  AUTHORS   Segovia,L., Horwitz,J., Gasser,R. and Wistow,G.
  TITLE     Two roles for mu-crystallin: a lens structural protein in diurnal
            marsupials and a possible enzyme in mammalian retinas
  JOURNAL   Mol Vis 3, 9 (1997)
   PUBMED   9285773
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1202)
  AUTHORS   Kim,R.Y., Gasser,R. and Wistow,G.J.
  TITLE     mu-crystallin is a mammalian homologue of Agrobacterium ornithine
            cyclodeaminase and is expressed in human retina
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9292-9296 (1992)
   PUBMED   1384048
REFERENCE   8  (bases 1 to 1202)
  AUTHORS   Nishii,Y., Hashizume,K., Ichikawa,K., Miyamoto,T., Suzuki,S.,
            Takeda,T., Yamauchi,K., Kobayashi,M. and Yamada,T.
  TITLE     Changes in cytosolic 3,5,3'-tri-iodo-L-thyronine (T3) binding
            activity during administration of L-thyroxine to thyroidectomized
            rats: cytosolic T3-binding protein and its activator act as
            intracellular regulators for nuclear T3 binding
  JOURNAL   J Endocrinol 123 (1), 99-104 (1989)
   PUBMED   2809492
REFERENCE   9  (bases 1 to 1202)
  AUTHORS   Hashizume,K., Kobayashi,M., Miyamoto,T. and Yamauchi,K.
  TITLE     Dependence of the mitochondrial uptake of triiodothyronine (T3) in
            rat kidney on cytosolic T3-binding protein
  JOURNAL   Endocrinology 119 (3), 1063-1070 (1986)
   PUBMED   3015565
REFERENCE   10 (bases 1 to 1202)
  AUTHORS   Francon,J., Osty,J., Chantoux,F. and Lennon,A.M.
  TITLE     Cellular location of cytosolic triiodothyronine binding protein in
            primary cultures of fetal rat brain
  JOURNAL   Mol Cell Endocrinol 39 (3), 197-207 (1985)
   PUBMED   2984063
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053955.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y17328.1, BC088121.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000001.1  184006731-184006923 c
            194-344             JAXUCZ010000001.1  184006060-184006210 c
            345-407             JAXUCZ010000001.1  184004202-184004264 c
            408-509             JAXUCZ010000001.1  184002623-184002724 c
            510-693             JAXUCZ010000001.1  184000934-184001117 c
            694-815             JAXUCZ010000001.1  183995631-183995752 c
            816-900             JAXUCZ010000001.1  183994914-183994998 c
            901-1202            JAXUCZ010000001.1  183991752-183992053 c
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1202
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /note="crystallin, mu"
                     /db_xref="GeneID:117024"
                     /db_xref="RGD:620943"
     exon            1..193
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..965
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /EC_number="1.5.1.25"
                     /note="mu-crystallin homolog; NADP-regulated
                     thyroid-hormone-binding protein;
                     thiomorpholine-carboxylate dehydrogenase"
                     /codon_start=1
                     /product="ketimine reductase mu-crystallin"
                     /protein_id="NP_446407.1"
                     /db_xref="GeneID:117024"
                     /db_xref="RGD:620943"
                     /translation="MRRAPAFLSADEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQ
                     PVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEGHSNNAVPSHQASVLLFDPSN
                     GSLLAVMDGNVITAKRTAAVSAIATKFLKPPGSDVLCILGAGVQAYSHYEIFTEQFSF
                     KEVRMWNRTRENAEKFASSVQGDVRVCSSVQEAVTGADVIITVTMATEPILFGEWVKP
                     GAHINAVGASRPDWRELDDELMKQAVLYVDSREAALKESGDVLLSGADIFAELGEVVS
                     GAKPAYCEKTTVFKSLGMAVEDLVAAKLVYDSWSSGK"
     exon            194..344
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            408..509
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            510..693
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            694..815
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            816..900
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1202
                     /gene="Crym"
                     /gene_synonym="CDK108"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggttcgaa ggcaggcggc gagatgaggc gggcgccagc gtttctgagc gccgacgagg
       61 tgcaggacca cctccgcagc tccagcctcc tcatcccgcc cctggaggcc gcactggcca
      121 acttctccaa aggtcccgac ggaggggtca tgcaaccggt gcgcaccgtg gtgcctgtgg
      181 ccaagcaccg aggcttcttg ggagtcatgc cagcctacag tgccgctgag gatgcactca
      241 ccaccaagtt agtcaccttc tatgagggcc acagcaacaa tgctgtcccc tcccaccagg
      301 catcagtgct tctctttgat cccagcaatg gttccctgct ggcggtcatg gatggaaatg
      361 tcataactgc aaagaggaca gcagccgtct ctgccatcgc caccaagttt ttgaagcccc
      421 caggcagtga tgtgctgtgc attcttgggg ctggggtcca ggcgtacagt cactatgaga
      481 tcttcacaga acagttctcc ttcaaggagg tgagaatgtg gaaccgcacc agggaaaatg
      541 ctgagaagtt tgcaagctca gtgcaaggag atgttcgggt ctgttcatca gtgcaggagg
      601 ctgtgacagg tgccgatgtc atcatcacag tcaccatggc aacggagccc attttatttg
      661 gtgaatgggt gaagcccggg gctcacatca atgctgttgg agccagtaga cctgactggc
      721 gagaactgga tgacgagctc atgaagcaag cagtgctgta tgtggactcc cgggaggctg
      781 ccctaaagga gtcaggagat gttctgttgt caggggctga catctttgct gagcttggag
      841 aagtggtttc aggagcgaag cctgcatact gtgagaagac cacggtgttc aagtctttgg
      901 ggatggcagt ggaggacctg gtcgcagcca aattagtgta cgattcgtgg tcatctggca
      961 agtgagcaga aggagctgtg cctgagctgg atggacgtca cggctcaaac gctggctcag
     1021 tgtctagatc aaaggaggcc tagtccccag tgaacgggag tgagagtcac tcataagtat
     1081 tgacatccct attcatgttt gtggttggat agctaaaccc ttctgttagg gggtgatggc
     1141 cacattacct acccttgatc ttactagcct tgtgtgtctc tgaaataaat catttccagt
     1201 tc
//
